LLPS-Hos-1219
MAP3K21
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Mitogen-activated protein kinase kinase kinase 21; Mitogen-activated protein kinase kinase kinase MLK4; Mixed lineage kinase 4 |
| Gene Name: | MAP3K21, KIAA1804, MLK4 |
| Ensembl Gene: | ENSG00000143674.10 |
| Ensembl Protein: | ENSP00000355582.3 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...Finally, 221 proteins were found as nucleolar with No/Cyto > 1 and No/Nuc > 1." | HCT116 cells | 20026476 |
▼ FUNCTION
| Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000366623.7 | ENSP00000355582.3 |
| Ensembl | ENST00000366622.1 | ENSP00000355581.1 |
| Ensembl | ENST00000366624.7 | ENSP00000355583.3 |
| UniProt | Q5TCX8, M3K21_HUMAN, A0A1W2PKR9, B2RN34, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1, X6R610 | |
| GeneBank | AJ311797, AJ311798, BC136648, AL133380, CH471098, AB058707, BC136649 | EAW69988.1, BAB47433.1, CAC84639.1, AAI36649.1, AAI36650.1, CAC84640.1 |
| RefSeq | NM_032435.2 | NP_115811.2 |
| Entrez | 84451 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MALRGAAGAT DTPVSSAGGA PGGSASSSST SSGGSASAGA GLWAALYDYE ARGEDELSLR 60 61 RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC RPAASPAPPP SRPSSPVHVA 120 121 FERLELKELI GAGGFGQVYR ATWQGQEVAV KAARQDPEQD AAAAAESVRR EARLFAMLRH 180 181 PNIIELRGVC LQQPHLCLVL EFARGGALNR ALAAANAAPD PRAPGPRRAR RIPPHVLVNW 240 241 AVQIARGMLY LHEEAFVPIL HRDLKSSNIL LLEKIEHDDI CNKTLKITDF GLAREWHRTT 300 301 KMSTAGTYAW MAPEVIKSSL FSKGSDIWSY GVLLWELLTG EVPYRGIDGL AVAYGVAVNK 360 361 LTLPIPSTCP EPFAKLMKEC WQQDPHIRPS FALILEQLTA IEGAVMTEMP QESFHSMQDD 420 421 WKLEIQQMFD ELRTKEKELR SREEELTRAA LQQKSQEELL KRREQQLAER EIDVLERELN 480 481 ILIFQLNQEK PKVKKRKGKF KRSRLKLKDG HRISLPSDFQ HKITVQASPN LDKRRSLNSS 540 541 SSSPPSSPTM MPRLRAIQLT SDESNKTWGR NTVFRQEEFE DVKRNFKKKG CTWGPNSIQM 600 601 KDRTDCKERI RPLSDGNSPW STILIKNQKT MPLASLFVDQ PGSCEEPKLS PDGLEHRKPK 660 661 QIKLPSQAYI DLPLGKDAQR ENPAEAESWE EAASANAATV SIEMTPTNSL SRSPQRKKTE 720 721 SALYGCTVLL ASVALGLDLR ELHKAQAAEE PLPKEEKKKR EGIFQRASKS RRSASPPTSL 780 781 PSTCGEASSP PSLPLSSALG ILSTPSFSTK CLLQMDSEDP LVDSAPVTCD SEMLTPDFCP 840 841 TAPGSGREPA LMPRLDTDCS VSRNLPSSFL QQTCGNVPYC ASSKHRPSHH RRTMSDGNPT 900 901 PTGATIISAT GASALPLCPS PAPHSHLPRE VSPKKHSTVH IVPQRRPASL RSRSDLPQAY 960 961 PQTAVSQLAQ TACVVGRPGP HPTQFLAAKE RTKSHVPSLL DADVEGQSRD YTVPLCRMRS 1020 1021 KTSRPSIYEL EKEFLS 1036 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTTCTTTT TAGTGACTTC AGATGAAAGC AATAAAACTT GGGGAAGGAA CACAGTCTTT 60 61 CGACAAGAAG AATTTGAGGA TGTAAAAAGG AATTTTAAGA AAAAAGGTTG TACCTGGGGA 120 121 CCAAATTCCA TTCAAATGAA AGATAGAACA GATTGCAAAG AAAGGATAAG ACCTCTCTCC 180 181 GATGGCAACA GTCCTTGGTC AACTATCTTA ATAAAAAATC AGAAAACCAT GCCCTTGGCT 240 241 TCATTGTTTG TGGACCAGCC AGGGTCCTGT GAAGAGCCAA AACTTTCCCC TGATGGATTA 300 301 GAACACAGAA AACCAAAACA AATAAAATTG CCTAGTCAGG CCTACATTGA TCTACCTCTT 360 361 GGGAAAGATG CTCAGAGAGA GAATCCTGCA GAAGCTGAAA GCTGGGAGGA GGCAGCCTCT 420 421 GCGAATGCTG CCACAGTCTC CATTGAGATG ACTCCTACGA ATAGTCTGAG TAGATCCCCC 480 481 CAGAGAAAGA AAACGGAGTC AGCTCTGTAT GGGTGCACCG TCCTTCTGGC ATCGGTGGCT 540 541 CTGGGACTGG ACCTCAGAGA GCTTCATAAA GCACAGGCTG CTGAAGAACC GTTGCCCAAG 600 601 GAAGAGAAGA AGAAACGAGA GGGAATCTTC CAGCGGGCTT CCAAGTCCCG CAGAAGCGCC 660 661 AGTCCTCCCA CAAGCCTGCC ATCCACCTGT GGGGAGGCCA GCAGCCCACC CTCCCTGCCA 720 721 CTGTCAAGTG CCCTGGGCAT CCTCTCCACA CCTTCTTTCT CCACAAAGTG CCTGCTGCAG 780 781 ATGGACAGTG AAGATCCACT GGTGGACAGT GCACCTGTCA CTTGTGACTC TGAGATGCTC 840 841 ACTCCGGATT TTTGTCCCAC TGCCCCAGGA AGTGGTCGTG AGCCAGCCCT CATGCCAAGA 900 901 CTTGACACTG ATTGTAGTGT ATCAAGAAAC TTGCCGTCTT CCTTCCTACA GCAGACATGT 960 961 GGGAATGTAC CTTACTGTGC TTCTTCAAAA CATAGACCGT CACATCACAG ACGGACCATG 1020 1021 TCTGATGGAA ATCCGACCCC AACTGGTGCA ACTATTATCT CAGCCACTGG AGCCTCTGCA 1080 1081 CTGCCACTCT GCCCCTCACC TGCTCCTCAC AGTCATCTGC CAAGGGAGGT CTCACCCAAG 1140 1141 AAGCACAGCA CTGTCCACAT CGTGCCTCAG CGTCGCCCTG CCTCCCTGAG AAGCCGCTCA 1200 1201 GATCTGCCTC AGGCTTACCC ACAGACAGCA GTGTCTCAGC TGGCACAGAC TGCCTGTGTA 1260 1261 GTGGGTCGCC CAGGACCACA TCCCACCCAA TTCCTCGCTG CCAAGGAGAG AACTAAATCC 1320 1321 CATGTGCCTT CATTACTGGA TGCTGACGTG GAAGGTCAGA GCAGGGACTA CACTGTGCCA 1380 1381 CTGTGCAGAA TGAGGAGCAA AACCAGCCGG CCATCTATAT ATGAACTGGA GAAAGAATTC 1440 1441 CTGTCTTAA 1449 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase kinase activity | |
Molecular Function | Protein homodimerization activity | |
Biological Process | Activation of JUN kinase activity | |
Biological Process | Protein autophosphorylation | |
Biological Process | Protein phosphorylation |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Proteomics | ||||
| THPA | ||||
| Structure | ||||
| PDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| TCGA | ArrayExpress | TISSUES | BioXpress | THPA |
| Methylation | ||||
| MethyCancer | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-1665 | Pan troglodytes | 99.23 | 0.0 | 1565 |
| LLPS-Pap-0104 | Pan paniscus | 98.54 | 0.0 | 782 |
| LLPS-Gog-3559 | Gorilla gorilla | 97.67 | 0.0 | 1523 |
| LLPS-Nol-4224 | Nomascus leucogenys | 96.06 | 0.0 | 1333 |
| LLPS-Paa-3137 | Papio anubis | 95.27 | 0.0 | 1484 |
| LLPS-Mam-3779 | Macaca mulatta | 95.17 | 0.0 | 1487 |
| LLPS-Cea-3689 | Cercocebus atys | 94.71 | 0.0 | 1487 |
| LLPS-Chs-3518 | Chlorocebus sabaeus | 94.52 | 0.0 | 1485 |
| LLPS-Maf-1743 | Macaca fascicularis | 94.52 | 0.0 | 1482 |
| LLPS-Rhb-2895 | Rhinopithecus bieti | 94.42 | 0.0 | 1477 |
| LLPS-Man-0855 | Macaca nemestrina | 94.23 | 0.0 | 1475 |
| LLPS-Caj-0681 | Callithrix jacchus | 92.12 | 0.0 | 1444 |
| LLPS-Mal-1700 | Mandrillus leucophaeus | 91.84 | 0.0 | 716 |
| LLPS-Aon-3483 | Aotus nancymaae | 89.97 | 0.0 | 1169 |
| LLPS-Poa-2007 | Pongo abelii | 89.9 | 0.0 | 1147 |
| LLPS-Cas-0295 | Carlito syrichta | 84.35 | 0.0 | 1043 |
| LLPS-Otg-4008 | Otolemur garnettii | 84.13 | 0.0 | 1294 |
| LLPS-Mod-3846 | Monodelphis domestica | 83.78 | 0.0 | 1014 |
| LLPS-Eqc-3648 | Equus caballus | 83.17 | 0.0 | 1279 |
| LLPS-Fec-4378 | Felis catus | 81.54 | 0.0 | 1227 |
| LLPS-Orc-1547 | Oryctolagus cuniculus | 80.9 | 0.0 | 1230 |
| LLPS-Bot-3398 | Bos taurus | 79.58 | 0.0 | 1221 |
| LLPS-Sus-3000 | Sus scrofa | 78.83 | 0.0 | 1198 |
| LLPS-Caf-4350 | Canis familiaris | 78.03 | 0.0 | 1162 |
| LLPS-Ova-1991 | Ovis aries | 77.34 | 0.0 | 1008 |
| LLPS-Mup-1387 | Mustela putorius furo | 76.9 | 0.0 | 1011 |
| LLPS-Ten-2428 | Tetraodon nigroviridis | 75.79 | 0.0 | 674 |
| LLPS-Urm-3497 | Ursus maritimus | 75.59 | 0.0 | 897 |
| LLPS-Loa-1028 | Loxodonta africana | 74.64 | 0.0 | 996 |
| LLPS-Scf-1414 | Scleropages formosus | 74.36 | 3e-08 | 62.4 |
| LLPS-Leo-0340 | Lepisosteus oculatus | 74.36 | 7e-09 | 64.3 |
| LLPS-Sah-4035 | Sarcophilus harrisii | 73.15 | 0.0 | 1036 |
| LLPS-Icp-4168 | Ictalurus punctatus | 71.79 | 3e-08 | 62.4 |
| LLPS-Aim-0669 | Ailuropoda melanoleuca | 71.38 | 0.0 | 1023 |
| LLPS-Scm-2514 | Scophthalmus maximus | 70.4 | 0.0 | 729 |
| LLPS-Cap-0235 | Cavia porcellus | 69.42 | 0.0 | 1028 |
| LLPS-Mea-4508 | Mesocricetus auratus | 69.35 | 0.0 | 1051 |
| LLPS-Xim-3404 | Xiphophorus maculatus | 69.23 | 1e-07 | 60.5 |
| LLPS-Orl-3926 | Oryzias latipes | 69.23 | 2e-07 | 59.7 |
| LLPS-Pof-2922 | Poecilia formosa | 69.23 | 1e-07 | 60.5 |
| LLPS-Orn-1948 | Oreochromis niloticus | 69.23 | 7e-08 | 61.2 |
| LLPS-Pes-1528 | Pelodiscus sinensis | 68.62 | 0.0 | 939 |
| LLPS-Gaa-0608 | Gasterosteus aculeatus | 68.32 | 0.0 | 805 |
| LLPS-Ran-2153 | Rattus norvegicus | 68.11 | 0.0 | 999 |
| LLPS-Tar-1282 | Takifugu rubripes | 67.96 | 0.0 | 813 |
| LLPS-Cii-0743 | Ciona intestinalis | 67.93 | 1e-81 | 270 |
| LLPS-Tag-3553 | Taeniopygia guttata | 67.7 | 0.0 | 827 |
| LLPS-Mum-3576 | Mus musculus | 67.6 | 0.0 | 1017 |
| LLPS-Ict-1566 | Ictidomys tridecemlineatus | 67.47 | 0.0 | 808 |
| LLPS-Fia-2648 | Ficedula albicollis | 66.56 | 0.0 | 972 |
| LLPS-Anp-1678 | Anas platyrhynchos | 66.02 | 0.0 | 897 |
| LLPS-Gaga-2175 | Gallus gallus | 65.18 | 0.0 | 1052 |
| LLPS-Asm-3943 | Astyanax mexicanus | 64.35 | 0.0 | 567 |
| LLPS-Fud-4243 | Fukomys damarensis | 63.95 | 0.0 | 818 |
| LLPS-Anc-0054 | Anolis carolinensis | 63.63 | 0.0 | 1023 |
| LLPS-Myl-3857 | Myotis lucifugus | 60.81 | 0.0 | 561 |
| LLPS-Lac-2792 | Latimeria chalumnae | 58.29 | 3e-161 | 504 |
| LLPS-Meg-1818 | Meleagris gallopavo | 57.45 | 0.0 | 654 |
| LLPS-Dio-1305 | Dipodomys ordii | 57.14 | 0.0 | 563 |
| LLPS-Dar-2258 | Danio rerio | 56.43 | 0.0 | 841 |
| LLPS-Gas-1313 | Galdieria sulphuraria | 38.38 | 2e-37 | 157 |
| LLPS-Xet-3886 | Xenopus tropicalis | 37.53 | 2e-58 | 219 |
| LLPS-Cis-0922 | Ciona savignyi | 37.14 | 3e-52 | 191 |
| LLPS-Thc-1708 | Theobroma cacao | 36.88 | 4e-38 | 158 |
| LLPS-Sob-1379 | Sorghum bicolor | 36.88 | 2e-36 | 154 |
| LLPS-Gor-1018 | Gossypium raimondii | 36.52 | 2e-39 | 162 |
| LLPS-Orbr-1937 | Oryza brachyantha | 36.52 | 2e-36 | 153 |
| LLPS-Nia-0177 | Nicotiana attenuata | 36.36 | 8e-37 | 153 |
| LLPS-Mae-1655 | Manihot esculenta | 36.36 | 3e-39 | 162 |
| LLPS-Coc-1219 | Corchorus capsularis | 36.17 | 2e-39 | 162 |
| LLPS-Sol-1847 | Solanum lycopersicum | 36.01 | 1e-38 | 159 |
| LLPS-Art-2307 | Arabidopsis thaliana | 35.89 | 3e-39 | 162 |
| LLPS-Orgl-1886 | Oryza glumaepatula | 35.59 | 1e-36 | 154 |
| LLPS-Arl-1871 | Arabidopsis lyrata | 35.54 | 5e-39 | 161 |
| LLPS-Pot-1684 | Populus trichocarpa | 35.46 | 3e-37 | 155 |
| LLPS-Ora-2947 | Ornithorhynchus anatinus | 35.38 | 6e-52 | 200 |
| LLPS-Zem-1095 | Zea mays | 35.27 | 5e-37 | 154 |
| LLPS-Ori-1776 | Oryza indica | 35.25 | 5e-37 | 152 |
| LLPS-Ors-2339 | Oryza sativa | 35.25 | 5e-38 | 155 |
| LLPS-Brn-1860 | Brassica napus | 35.19 | 2e-38 | 159 |
| LLPS-Bro-1982 | Brassica oleracea | 35.19 | 2e-38 | 159 |
| LLPS-Brr-2708 | Brassica rapa | 35.19 | 1e-38 | 159 |
| LLPS-Tut-2479 | Tursiops truncatus | 35.1 | 1e-50 | 196 |
| LLPS-Sem-0236 | Selaginella moellendorffii | 34.25 | 3e-37 | 149 |
| LLPS-Prp-2263 | Prunus persica | 34.15 | 2e-41 | 165 |
| LLPS-Viv-2444 | Vitis vinifera | 34.15 | 4e-39 | 158 |
| LLPS-Tra-2921 | Triticum aestivum | 33.92 | 1e-39 | 160 |
| LLPS-Org-0754 | Oryza glaberrima | 33.68 | 3e-39 | 159 |
| LLPS-Sot-1080 | Solanum tuberosum | 33.57 | 5e-40 | 161 |
| LLPS-Glm-0241 | Glycine max | 33.45 | 9e-40 | 160 |
| LLPS-Phv-2181 | Phaseolus vulgaris | 33.45 | 2e-40 | 162 |
| LLPS-Php-1333 | Physcomitrella patens | 32.99 | 1e-39 | 160 |
| LLPS-Vir-0968 | Vigna radiata | 32.77 | 1e-41 | 166 |
| LLPS-Met-1944 | Medicago truncatula | 32.75 | 4e-39 | 159 |