• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caf-4350
MAP3K21

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Mitogen-activated protein kinase kinase kinase
Gene Name: MAP3K21
Ensembl Gene: ENSCAFG00000011566.5
Ensembl Protein: ENSCAFP00000042412.1
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAWPGAEGAA  DRPVSPGRGG  PVGSASSSSA  SSGGSASASA  SASASASASA  SAGAGLWAAL  60
61    YDYEARGEDE  LSLRRGQLVE  VLSQDAAVSG  DEGWWAGQVQ  RRLGIFPANY  VAPCRPAASL  120
121   PPPPPPPPPR  PGSPVHVDFA  RLQLQELIGA  GGFGQVYRAT  WQGQEVAVKA  ARRDPEQDAA  180
181   AAAESVRREA  RLFAMLRHPN  IIELRGVCLQ  QPHLCLVLEF  ARGGALNRAL  AAAAASPDPR  240
241   APGPRRARRI  PPHVLVNWAV  QIARGMLYLH  EEAFVPILHR  DLKSSNILLL  ERIEHDDFCN  300
301   KTLKITDFGL  AREWHRTTKM  SAAGTYAWMA  PEVIKSSLFS  KGSDIWSYGV  LLWELLTGEV  360
361   PYRGIDGLAV  AYGVAVNKLT  LPIPSTCPEP  FAKLMKECWQ  QDPHIRPSFA  LILEQLTAIE  420
421   GTVMTEMPQE  SFHSMQDDWK  LEIQQMFDEL  RTKEKELRSR  EEELTRAALQ  QKSQEALLRR  480
481   REQQLAEREI  DVLERELNIL  IFQLNQEKPN  VKKRKGKFRR  SRLKLKDGHR  ISLPSDFQHK  540
541   ITVQASPNLD  KRRSLNSNGS  SPPSSPTVIP  RLRAIQLTSD  ESNKTWGRNT  VCRQEEFEDV  600
601   KKNFKKKGCT  WGPNSIQMKE  RSDSKERMRP  LSDGNSPWST  LIIKNQKTMP  LASLFVDQPG  660
661   ASEESKLSPD  GSEYRKPKQI  KSPAQAYVDL  PLWKDGQREN  PVEPGSCEEG  PSLSPAASTP  720
721   QVTPTSNLSR  SPQRKKTESA  LYGCSMLLAS  VALGLDIREL  NKTQAAEELL  PKEEKKRREG  780
781   IFQWAPKARG  SAIPCTRPPS  TGERASSLPP  LPLSSTMSLL  SMSSLSTKCL  LQTDGEDLSE  840
841   GSTHITPDPE  TPTPDFCAAI  RGCSGEPASM  PRLETDHSRW  KSPSPPFLEQ  IYGNVPYYAS  900
901   SKEQASHHRR  TLSDGNAFQT  PAGATPSTAS  ADWDLPPEPA  PGAPHSSAGP  QAHLPGKAPP  960
961   RKPRAGSTVP  GPHLAALGSR  TESRPALRGP  GPTGAKDRTA  AHLPSLLDAG  AAGQSRDSAV  1020
1021  PLRAVRSRTS  PPPIQQLEKE  FLS  1043
Nucleotide CDS Sequence (FASTA)
1     ATGGCTTGGC  CGGGCGCCGA  GGGTGCGGCT  GACAGGCCGG  TGTCCCCGGG  CCGGGGCGGC  60
61    CCGGTTGGCT  CCGCGTCGTC  GTCGTCCGCC  TCCTCCGGCG  GCTCGGCCTC  CGCGGGAGCG  120
121   GGGCTGTGGG  CCGCGCTGTA  CGACTACGAG  GCGCGCGGCG  AGGACGAGCT  GAGCCTGCGG  180
181   CGCGGCCAGC  TGGTGGAGGT  GCTGTCCCAG  GACGCCGCCG  TGTCGGGCGA  CGAGGGCTGG  240
241   TGGGCCGGCC  AGGTGCAGCG  GCGCCTCGGC  ATCTTCCCCG  CCAACTACGT  GGCGCCGTGC  300
301   CGCCCGGCCG  CCAGCCTCCC  GCCGCCGCCG  CCGCCGCCGC  CGCCCCGGCC  CGGCTCGCCC  360
361   GTGCACGTCG  ACTTCGCGCG  GCTGCAGCTC  CAGGAGCTCA  TCGGCGCCGG  CGGCTTCGGG  420
421   CAGGTGTACC  GCGCCACCTG  GCAGGGCCAG  GAGGTGGCGG  TGAAGGCGGC  GCGCCGGGAC  480
481   CCCGAGCAGG  ACGCGGCGGC  GGCGGCCGAG  AGCGTGCGGC  GGGAGGCGAG  GCTCTTCGCC  540
541   ATGCTGCGGC  ACCCCAACAT  CATCGAGCTG  CGCGGCGTGT  GCCTGCAGCA  GCCGCACCTC  600
601   TGCTTGGTGC  TCGAGTTCGC  CCGCGGCGGA  GCGCTCAACC  GCGCCCTGGC  CGCCGCCGCC  660
661   GCCAGCCCCG  ACCCGCGCGC  GCCCGGCCCG  CGCCGCGCGC  GCCGCATCCC  TCCGCACGTG  720
721   CTGGTCAACT  GGGCGGTGCA  GATCGCGCGC  GGCATGCTCT  ACCTGCACGA  GGAGGCCTTC  780
781   GTGCCCATCC  TGCATCGGGA  CCTCAAGTCC  AGCAACATTT  TGCTACTTGA  GAGGATAGAG  840
841   CATGATGACT  TCTGCAATAA  AACTTTGAAG  ATTACAGATT  TTGGGTTGGC  GAGAGAATGG  900
901   CACAGGACTA  CCAAAATGAG  TGCAGCAGGC  ACCTATGCCT  GGATGGCGCC  TGAAGTCATC  960
961   AAGTCTTCCT  TGTTTTCTAA  AGGAAGTGAC  ATCTGGAGCT  ACGGAGTCCT  ACTGTGGGAG  1020
1021  CTGCTCACGG  GAGAAGTCCC  CTACCGTGGC  ATTGATGGGC  TCGCTGTGGC  TTATGGGGTA  1080
1081  GCAGTCAATA  AGCTCACCTT  GCCCATTCCA  TCCACCTGCC  CTGAGCCATT  TGCCAAGCTC  1140
1141  ATGAAAGAAT  GCTGGCAACA  GGACCCTCAC  ATTCGTCCCT  CATTTGCCTT  AATTCTTGAA  1200
1201  CAACTGACGG  CTATTGAAGG  GACAGTTATG  ACCGAAATGC  CTCAGGAATC  TTTTCATTCC  1260
1261  ATGCAAGATG  ACTGGAAGCT  AGAAATTCAA  CAAATGTTTG  ATGAGCTAAG  AACAAAGGAA  1320
1321  AAGGAGCTGC  GGTCCCGCGA  GGAGGAGCTG  ACACGGGCTG  CCCTCCAGCA  GAAGTCCCAG  1380
1381  GAGGCGCTGC  TCAGGCGGCG  GGAGCAGCAG  CTCGCCGAGC  GGGAGATTGA  CGTGCTCGAG  1440
1441  CGGGAGCTGA  ACATTTTGAT  ATTCCAGTTA  AACCAGGAGA  AGCCCAATGT  CAAGAAGAGG  1500
1501  AAGGGAAAGT  TCAGGAGAAG  TCGGTTAAAG  CTCAAAGATG  GCCATCGGAT  CAGTTTACCT  1560
1561  TCAGATTTCC  AGCATAAAAT  CACTGTCCAG  GCCTCTCCCA  ACTTGGACAA  ACGGAGGAGT  1620
1621  TTGAACAGCA  ATGGCTCCAG  TCCACCGAGT  AGCCCCACAG  TGATTCCTCG  GCTCCGAGCT  1680
1681  ATACAGCTAA  CTTCAGATGA  AAGCAATAAA  ACTTGGGGAA  GGAACACTGT  CTGTCGACAA  1740
1741  GAAGAATTTG  AAGATGTGAA  AAAGAATTTC  AAGAAAAAAG  GTTGTACCTG  GGGACCTAAT  1800
1801  TCAATTCAAA  TGAAAGAAAG  AAGCGATAGC  AAAGAAAGAA  TGAGACCTCT  CTCAGACGGC  1860
1861  AACAGTCCTT  GGTCAACTCT  CATAATAAAG  AATCAGAAAA  CCATGCCGTT  GGCATCATTA  1920
1921  TTTGTGGACC  AGCCAGGTGC  TTCTGAAGAG  TCAAAACTTT  CCCCTGACGG  ATCAGAATAC  1980
1981  AGAAAACCAA  AGCAAATAAA  ATCACCTGCT  CAAGCCTATG  TTGATCTACC  TCTTTGGAAA  2040
2041  GATGGCCAGA  GAGAGAATCC  AGTGGAACCT  GGAAGCTGCG  AGGAGGGACC  CTCTTTGAGC  2100
2101  CCTGCTGCTA  GCACTCCTCA  GGTGACCCCT  ACAAGTAATC  TGAGCAGATC  CCCCCAGAGA  2160
2161  AAGAAGACAG  AGTCTGCTCT  CTATGGCTGC  TCCATGTTGT  TGGCATCAGT  AGCTCTGGGA  2220
2221  CTGGATATCA  GAGAGCTTAA  TAAAACACAG  GCTGCTGAAG  AACTCTTGCC  CAAAGAAGAA  2280
2281  AAGAAGAGAC  GTGAGGGAAT  CTTCCAATGG  GCTCCCAAGG  CCCGAGGCAG  TGCCATTCCC  2340
2341  TGTACAAGGC  CACCATCTAC  AGGCGAGAGG  GCCAGCAGCC  TACCCCCACT  CCCTCTGTCA  2400
2401  AGCACCATGA  GCCTTCTGTC  CATGTCCTCT  CTTTCCACAA  AGTGCTTGCT  ACAGACCGAC  2460
2461  GGGGAAGATT  TGTCTGAAGG  TAGCACACAC  ATCACTCCTG  ACCCCGAGAC  ACCCACTCCA  2520
2521  GATTTTTGTG  CCGCCATCAG  AGGATGTAGT  GGTGAGCCAG  CTTCTATGCC  AAGACTTGAG  2580
2581  ACTGATCATA  GTAGATGGAA  AAGCCCATCT  CCTCCTTTCT  TAGAGCAGAT  ATATGGGAAT  2640
2641  GTGCCTTATT  ATGCTTCTTC  GAAAGAACAA  GCATCACATC  ACAGACGAAC  CCTGTCTGAT  2700
2701  GGAAATGCTT  TTCAGACC  2718

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-0669Ailuropoda melanoleuca88.190.01109
LLPS-Urm-3497Ursus maritimus84.270.01031
LLPS-Fec-4378Felis catus83.290.01337
LLPS-Mod-3846Monodelphis domestica81.840.01031
LLPS-Mup-1387Mustela putorius furo81.420.01133
LLPS-Eqc-3648Equus caballus80.080.01305
LLPS-Gog-3559Gorilla gorilla78.280.01162
LLPS-Hos-1219Homo sapiens77.650.01164
LLPS-Bot-3398Bos taurus77.630.01249
LLPS-Sus-3000Sus scrofa76.620.01219
LLPS-Orc-1547Oryctolagus cuniculus76.490.01150
LLPS-Man-0855Macaca nemestrina76.480.01181
LLPS-Maf-1743Macaca fascicularis76.450.01184
LLPS-Cea-3689Cercocebus atys76.450.01176
LLPS-Otg-4008Otolemur garnettii76.290.01181
LLPS-Pat-1665Pan troglodytes76.270.01172
LLPS-Mam-3779Macaca mulatta76.170.01185
LLPS-Chs-3518Chlorocebus sabaeus76.170.01175
LLPS-Caj-0681Callithrix jacchus76.110.01188
LLPS-Paa-3137Papio anubis75.980.01171
LLPS-Rhb-2895Rhinopithecus bieti75.890.01164
LLPS-Ten-2428Tetraodon nigroviridis75.730.0 681
LLPS-Nol-4224Nomascus leucogenys75.540.01010
LLPS-Ova-1991Ovis aries75.320.01010
LLPS-Cas-0295Carlito syrichta74.480.0 909
LLPS-Cap-0235Cavia porcellus73.980.0 997
LLPS-Loa-1028Loxodonta africana72.130.0 978
LLPS-Aon-3483Aotus nancymaae71.750.0 888
LLPS-Tag-3553Taeniopygia guttata71.740.0 762
LLPS-Ict-1566Ictidomys tridecemlineatus71.470.0 782
LLPS-Sah-4035Sarcophilus harrisii70.860.01008
LLPS-Leo-0340Lepisosteus oculatus70.070.0 873
LLPS-Poa-2007Pongo abelii69.770.0 852
LLPS-Scf-1414Scleropages formosus69.190.0 746
LLPS-Tar-1282Takifugu rubripes68.40.0 833
LLPS-Scm-2514Scophthalmus maximus68.370.0 737
LLPS-Cii-0743Ciona intestinalis67.933e-81 269
LLPS-Gaa-0608Gasterosteus aculeatus67.110.0 824
LLPS-Asm-3943Astyanax mexicanus66.230.0 577
LLPS-Orl-3926Oryzias latipes66.10.0 818
LLPS-Mea-4508Mesocricetus auratus66.090.01004
LLPS-Icp-4168Ictalurus punctatus65.930.0 824
LLPS-Pes-1528Pelodiscus sinensis65.90.0 871
LLPS-Ran-2153Rattus norvegicus65.50.0 946
LLPS-Orn-1103Oreochromis niloticus64.560.0 563
LLPS-Fia-2648Ficedula albicollis64.260.0 928
LLPS-Mum-3576Mus musculus63.830.0 964
LLPS-Anp-1678Anas platyrhynchos63.650.0 856
LLPS-Gaga-2175Gallus gallus63.070.01012
LLPS-Meg-1818Meleagris gallopavo62.630.0 611
LLPS-Fud-4243Fukomys damarensis60.620.0 763
LLPS-Dar-2258Danio rerio60.510.0 842
LLPS-Anc-0054Anolis carolinensis60.190.0 945
LLPS-Myl-3857Myotis lucifugus60.070.0 560
LLPS-Pap-0104Pan paniscus60.03e-142 442
LLPS-Mal-3629Mandrillus leucophaeus59.91e-180 555
LLPS-Lac-2792Latimeria chalumnae58.26e-168 521
LLPS-Pof-2922Poecilia formosa57.050.0 850
LLPS-Xim-3404Xiphophorus maculatus54.440.0 839
LLPS-Dio-1305Dipodomys ordii52.910.0 558
LLPS-Xet-3886Xenopus tropicalis40.263e-56 214
LLPS-Gas-1313Galdieria sulphuraria37.722e-37 157
LLPS-Tut-2479Tursiops truncatus37.582e-50 196
LLPS-Ora-2947Ornithorhynchus anatinus37.424e-52 201
LLPS-Cis-0922Ciona savignyi36.315e-51 188
LLPS-Thc-1708Theobroma cacao36.18e-37 154
LLPS-Coc-1219Corchorus capsularis35.745e-38 158
LLPS-Gor-1018Gossypium raimondii35.744e-38 158
LLPS-Mae-1655Manihot esculenta35.599e-38 157
LLPS-Art-2307Arabidopsis thaliana35.119e-38 157
LLPS-Sol-1847Solanum lycopersicum34.889e-37 153
LLPS-Arl-1871Arabidopsis lyrata34.752e-37 156
LLPS-Org-0754Oryza glaberrima34.723e-40 162
LLPS-Ors-1284Oryza sativa34.724e-40 162
LLPS-Ori-1963Oryza indica34.723e-40 162
LLPS-Viv-2444Vitis vinifera34.62e-40 162
LLPS-Bro-1982Brassica oleracea34.44e-37 155
LLPS-Brr-2708Brassica rapa34.44e-37 155
LLPS-Brn-1860Brassica napus34.44e-37 155
LLPS-Prp-2263Prunus persica34.369e-43 170
LLPS-Orbr-1889Oryza brachyantha34.272e-38 156
LLPS-Sem-0236Selaginella moellendorffii34.232e-36 147
LLPS-Tra-2921Triticum aestivum34.022e-40 163
LLPS-Sot-1080Solanum tuberosum34.023e-41 165
LLPS-Phv-2181Phaseolus vulgaris33.682e-41 166
LLPS-Pot-2737Populus trichocarpa33.683e-38 156
LLPS-Glm-0241Glycine max33.684e-41 165
LLPS-Orgl-1886Oryza glumaepatula33.562e-35 150
LLPS-Vir-0968Vigna radiata33.221e-42 169
LLPS-Php-1333Physcomitrella patens33.224e-41 164
LLPS-Met-1944Medicago truncatula32.992e-40 162
LLPS-Cae-0870Caenorhabditis elegans31.731e-35 149