LLPS-Hos-0992
CSDE1

▼ OVERVIEW

Status: Reviewed
Protein Name: Cold shock domain-containing protein E1; N-ras upstream gene protein; Protein UNR
Gene Name: CSDE1, D1S155E, KIAA0885, NRU, UNR
Ensembl Gene: ENSG00000009307.15
Ensembl Protein: ENSP00000431770.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Regulator
PDB: 2YTX (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...Analysis of correlated patterns between endogenous preys uncovers the spatial organization of RNA regulatory structures and enables the definition of 144 core components of SGs and PBs."
N/A29395067
Stress granule
"...We report preexisting contacts between most core SG proteins under normal growth conditions and demonstrate that several core SG proteins are critical for the formation of microscopically visible SGs."
HeLa cells29395067
Stress granule
"...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell."
U2OS cells26777405
Stress granule
"...A list of candidate SG proteins identified by mass spectrometry in NPCs, including statistical analysis."
Neural progenitor cells29373831
Stress granule
"...Together, our APEX and IF screening approaches identified 260 SG proteins, including ~150 candidates that had not previously been associated with SGs."
HEK293T cells, Neural progenitor cells29373831

▼ FUNCTION

RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MENVFTVSSD  PHPSPAAPPS  LSLPLSSSST  SSGTKKQKRT  PTYQRSMSFD  PNLLHNNGHN  60
61    GYPNGTSAAL  RETGVIEKLL  TSYGFIQCSE  RQARLFFHCS  QYNGNLQDLK  VGDDVEFEVS  120
121   SDRRTGKPIA  VKLVKIKQEI  LPEERMNGQV  VCAVPHNLES  KSPAAPGQSP  TGSVCYERNG  180
181   EVFYLTYTPE  DVEGNVQLET  GDKINFVIDN  NKHTGAVSAR  NIMLLKKKQA  RCQGVVCAMK  240
241   EAFGFIERGD  VVKEIFFHYS  EFKGDLETLQ  PGDDVEFTIK  DRNGKEVATD  VRLLPQGTVI  300
301   FEDISIEHFE  GTVTKVIPKV  PSKNQNDPLP  GRIKVDFVIP  KELPFGDKDT  KSKVTLLEGD  360
361   HVRFNISTDR  RDKLERATNI  EVLSNTFQFT  NEAREMGVIA  AMRDGFGFIK  CVDRDVRMFF  420
421   HFSEILDGNQ  LHIADEVEFT  VVPDMLSAQR  NHAIRIKKLP  KGTVSFHSHS  DHRFLGTVEK  480
481   EATFSNPKTT  SPNKGKEKEA  EDGIIAYDDC  GVKLTIAFQA  KDVEGSTSPQ  IGDKVEFSIS  540
541   DKQRPGQQVA  TCVRLLGRNS  NSKRLLGYVA  TLKDNFGFIE  TANHDKEIFF  HYSEFSGDVD  600
601   SLELGDMVEY  SLSKGKGNKV  SAEKVNKTHS  VNGITEEADP  TIYSGKVIRP  LRSVDPTQTE  660
661   YQGMIEIVEE  GDMKGEVYPF  GIVGMANKGD  CLQKGESVKF  QLCVLGQNAQ  TMAYNITPLR  720
721   RATVECVKDQ  FGFINYEVGD  SKKLFFHVKE  VQDGIELQAG  DEVEFSVILN  QRTGKCSACN  780
781   VWRVCEGPKA  VAAPRPDRLV  NRLKNITLDD  ASAPRLMVLR  QPRGPDNSMG  FGAERKIRQA  840
841   GVID  844
Nucleotide CDS Sequence (FASTA)
1     ATGAGCTTTG  ATCCAAACCT  TCTCCACAAC  AATGGACATA  ATGGGTACCC  TAATGGTACT  60
61    TCAGCAGCAC  TGCGTGAAAC  TGGGGTTATT  GAAAAACTGT  TAACCTCTTA  CGGATTTATT  120
121   CAGTGTTCAG  AACGTCAAGC  TAGACTTTTC  TTCCACTGTT  CACAGTATAA  TGGCAACCTG  180
181   CAAGACTTAA  AAGTAGGAGA  TGATGTTGAA  TTTGAAGTAT  CATCGGACCG  ACGGACTGGG  240
241   AAACCCATTG  CTGTTAAACT  GGTGAAGATA  AAACAAGAAA  TCCTCCCTGA  AGAACGAATG  300
301   AATGGACAAG  AAGTGTTTTA  TCTGACTTAC  ACCCCTGAAG  ATGTCGAAGG  GAACGTTCAG  360
361   CTGGAAACTG  GAGATAAAAT  AAACTTTGTA  ATTGATAACA  ATAAACATAC  TGGTGCTGTA  420
421   AGTGCTCGCA  ACATTATGCT  GTTGAAAAAG  AAACAAGCCC  GCTGTCAGGG  AGTAGTTTGT  480
481   GCCATGAAGG  AGGCATTTGG  CTTTATTGAA  AGAGGTGATG  TTGTAAAAGA  GATATTCTTT  540
541   CACTATAGTG  AATTTAAGGG  TGACTTAGAA  ACCTTACAGC  CTGGCGATGA  TGTGGAATTC  600
601   ACAATCAAGG  ACAGAAATGG  TAAAGAAGTT  GCAACAGATG  TCAGACTATT  GCCTCAAGGA  660
661   ACAGTCATTT  TTGAAGATAT  CAGCATTGAA  CATTTTGAAG  GAACTGTAAC  CAAAGTTATC  720
721   CCAAAAGTAC  CCAGTAAAAA  CCAGAATGAC  CCATTGCCAG  GACGCATCAA  AGTTGACTTT  780
781   GTGATCCCTA  AAGAACTTCC  CTTTGGAGAC  AAAGATACGA  AATCCAAGGT  GACCCTGCTG  840
841   GAAGGTGACC  ATGTTAGGTT  TAATATTTCA  ACAGACCGAC  GTGACAAATT  AGAGCGAGCA  900
901   ACCAATATAG  AAGTTCTGTC  AAATACATTT  CAGTTCACTA  ATGAAGCCCG  AGAAATGGGT  960
961   GTGATTGCTG  CCATGAGAGA  TGGTTTTGGT  TTCATCAAGT  GTGTGGATCG  TGATGTTCGT  1020
1021  ATGTTCTTCC  ACTTCAGTGA  AATTCTGGAT  GGGAACCAGC  TCCATATTGC  AGATGAAGTA  1080
1081  GAGTTTACTG  TGGTTCCTGA  TATGCTCTCT  GCTCAAAGAA  ATCATGCTAT  TAGGATTAAA  1140
1141  AAACTTCCCA  AGGGCACGGT  TTCATTTCAT  TCCCATTCAG  ATCACCGTTT  TCTGGGCACG  1200
1201  GTAGAAAAAG  AAGCCACTTT  TTCCAATCCT  AAAACCACTA  GCCCAAATAA  AGGCAAAGAG  1260
1261  AAGGAGGCTG  AGGATGGCAT  TATTGCTTAT  GATGACTGTG  GGGTGAAACT  GACTATTGCT  1320
1321  TTTCAAGCCA  AGGATGTGGA  AGGATCTACT  TCTCCTCAAA  TAGGAGATAA  GGTTGAATTT  1380
1381  AGTATTAGTG  ACAAACAGAG  GCCTGGACAG  CAGGTTGCAA  CTTGTGTGCG  ACTTTTAGGT  1440
1441  CGTAATTCTA  ACTCCAAGAG  GCTCTTGGGT  TATGTGGCAA  CTCTGAAGGA  TAATTTTGGA  1500
1501  TTTATTGAAA  CAGCCAATCA  TGATAAGGAA  ATCTTTTTCC  ATTACAGTGA  GTTCTCTGGT  1560
1561  GATGTTGATA  GCCTGGAACT  GGGGGACATG  GTCGAGTATA  GCTTGTCCAA  AGGCAAAGGC  1620
1621  AACAAAGTCA  GTGCAGAAAA  AGTGAACAAA  ACACACTCAG  TGAATGGCAT  TACTGAGGAA  1680
1681  GCTGATCCCA  CCATTTACTC  TGGCAAAGTA  ATTCGCCCCC  TGAGGAGTGT  TGATCCAACA  1740
1741  CAGACTGAGT  ACCAAGGAAT  GATTGAGATT  GTGGAGGAGG  GCGATATGAA  AGGTGAGGTC  1800
1801  TATCCATTTG  GCATCGTTGG  GATGGCCAAC  AAAGGGGATT  GCCTGCAGAA  AGGGGAGAGC  1860
1861  GTCAAGTTCC  AATTGTGTGT  CCTGGGCCAA  AATGCACAAA  CTATGGCTTA  CAACATCACA  1920
1921  CCCCTGCGCA  GGGCCACAGT  GGAATGTGTG  AAAGATCAGT  TTGGCTTCAT  TAACTATGAA  1980
1981  GTAGGAGATA  GCAAGAAGCT  CTTTTTCCAT  GTGAAAGAAG  TTCAGGATGG  CATTGAGCTA  2040
2041  CAGGCAGGAG  ATGAGGTGGA  GTTCTCAGTG  ATTCTTAATC  AGCGCACTGG  CAAGTGCAGC  2100
2101  GCCTGTAATG  TTTGGCGAGT  CTGTGAGGGC  CCCAAGGCTG  TTGCAGCTCC  TCGACCTGAT  2160
2161  CGGTTGGTCA  ATCGCTTGAA  GAATATCACT  CTGGATGATG  CCAGTGCTCC  TCGCCTAATG  2220
2221  GTTCTTCGTC  AGCCAAGGGG  ACCAGATAAC  TCAATGGGGT  TTGGTGCAGA  AAGAAAGATC  2280
2281  CGTCAAGCTG  GTGTCATTGA  CTAA  2304

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Isopeptide bond
Phosphoprotein
Reference proteome
Repeat
RNA-binding
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
CRD-mediated mRNA stability complex
Cellular Component
Cytosol
Cellular Component
Golgi apparatus
Cellular Component
Plasma membrane
Molecular Function
RNA binding
Biological Process
Male gonad development
Biological Process
Nuclear-transcribed mRNA catabolic process, no-go decay

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Paa-0890Papio anubis100.00.01684
LLPS-Cea-3568Cercocebus atys100.00.01684
LLPS-Maf-3099Macaca fascicularis100.00.01684
LLPS-Chs-2488Chlorocebus sabaeus100.00.01684
LLPS-Gog-4013Gorilla gorilla100.00.01684
LLPS-Mam-2040Macaca mulatta100.00.01684
LLPS-Man-3838Macaca nemestrina100.00.01684
LLPS-Pap-3463Pan paniscus100.00.01684
LLPS-Nol-2832Nomascus leucogenys99.880.01681
LLPS-Pat-4587Pan troglodytes99.880.01684
LLPS-Poa-2476Pongo abelii99.870.01645
LLPS-Mal-3126Mandrillus leucophaeus99.760.01679
LLPS-Caj-4003Callithrix jacchus99.760.01681
LLPS-Aon-4623Aotus nancymaae99.640.01674
LLPS-Mup-4187Mustela putorius furo99.360.01612
LLPS-Fec-1216Felis catus99.290.01677
LLPS-Sus-2809Sus scrofa99.170.01678
LLPS-Fud-3822Fukomys damarensis99.00.01633
LLPS-Bot-3117Bos taurus98.820.01669
LLPS-Orc-1222Oryctolagus cuniculus98.650.01665
LLPS-Ran-2484Rattus norvegicus98.620.01627
LLPS-Mea-2699Mesocricetus auratus98.620.01630
LLPS-Mum-4786Mus musculus98.50.01628
LLPS-Dio-3195Dipodomys ordii98.120.01625
LLPS-Cas-2577Carlito syrichta97.630.01658
LLPS-Caf-3218Canis familiaris95.540.01562
LLPS-Pes-3339Pelodiscus sinensis95.350.0 892
LLPS-Otg-2416Otolemur garnettii95.260.01590
LLPS-Eqc-3913Equus caballus95.20.01585
LLPS-Ova-2194Ovis aries95.140.01587
LLPS-Tut-0212Tursiops truncatus94.790.01584
LLPS-Myl-2253Myotis lucifugus94.550.01581
LLPS-Aim-3374Ailuropoda melanoleuca94.460.01570
LLPS-Rhb-2845Rhinopithecus bieti94.440.01552
LLPS-Loa-1334Loxodonta africana93.640.01537
LLPS-Cap-2966Cavia porcellus93.610.01516
LLPS-Anc-3629Anolis carolinensis92.230.01536
LLPS-Sah-1337Sarcophilus harrisii92.220.01539
LLPS-Gaga-3733Gallus gallus92.20.01503
LLPS-Meg-1046Meleagris gallopavo92.070.01502
LLPS-Fia-0904Ficedula albicollis91.980.01528
LLPS-Mod-3935Monodelphis domestica91.170.01502
LLPS-Tag-2238Taeniopygia guttata91.00.01507
LLPS-Anp-1607Anas platyrhynchos88.350.01448
LLPS-Urm-3954Ursus maritimus87.660.01412
LLPS-Xet-0043Xenopus tropicalis86.020.01442
LLPS-Ten-1743Tetraodon nigroviridis81.375e-152 453
LLPS-Ict-0607Ictidomys tridecemlineatus80.020.01269
LLPS-Ora-0449Ornithorhynchus anatinus79.680.01255
LLPS-Leo-0081Lepisosteus oculatus79.560.01337
LLPS-Lac-3102Latimeria chalumnae79.290.01322
LLPS-Gaa-3484Gasterosteus aculeatus77.620.01296
LLPS-Xim-1665Xiphophorus maculatus76.680.01298
LLPS-Scf-2710Scleropages formosus76.280.01274
LLPS-Pof-4134Poecilia formosa75.790.01092
LLPS-Dar-3070Danio rerio75.440.01290
LLPS-Orn-1943Oreochromis niloticus75.210.01266
LLPS-Scm-0270Scophthalmus maximus75.00.01279
LLPS-Orl-3384Oryzias latipes74.610.01293
LLPS-Asm-3771Astyanax mexicanus74.190.01217
LLPS-Icp-3463Ictalurus punctatus73.940.01214
LLPS-Tar-2566Takifugu rubripes71.620.01180
LLPS-Drm-0438Drosophila melanogaster46.413e-124 407
LLPS-Cii-1759Ciona intestinalis43.030.0 561
LLPS-Cis-0946Ciona savignyi42.53e-176 536
LLPS-Osl-1376Ostreococcus lucimarinus27.514e-1480.5