LLPS-Hos-0840
PFN4
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Profilin-4; Profilin IV |
| Gene Name: | PFN4 |
| Ensembl Gene: | ENSG00000176732.6 |
| Ensembl Protein: | ENSP00000322170.4 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins." | N/A | 26980300 |
▼ FUNCTION
| Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin (PubMed:19419568), contrary to other family members. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000313213.4 | ENSP00000322170.4 |
| Ensembl | ENST00000436622.1 | ENSP00000393504.1 |
| UniProt | Q8NHR9, PROF4_HUMAN, Q53TL9 | |
| GeneBank | AC008073, BC029523, CH471053, AK292601 | BAF85290.1, AAY14666.1, AAH29523.1, EAX00760.1, EAX00761.1 |
| RefSeq | NM_199346.2, XM_005264292.2, XM_006712007.3, XM_011532823.2 | NP_955378.1, XP_005264349.1, XP_006712070.1, XP_011531125.1 |
| Entrez | 375189 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSHLQSLLLD TLLGTKHVDS AALIKIQERS LCVASPGFNV TPSDVRTLVN GFAKNPLQAR 60 61 REGLYFKGKD YRCVRADEYS LYAKNENTGV VVVKTHLYLL VATYTEGMYP SICVEATESL 120 121 GDYLRKKGS 129 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCCATT TGCAGAGCTT ATTGTTAGAC ACCCTCTTGG GAACCAAGCA TGTGGACAGT 60 61 GCAGCCCTCA TCAAAATCCA GGAGCGGAGC TTGTGTGTAG CATCACCAGG TTTCAATGTA 120 121 ACGCCCAGTG ATGTCCGAAC ACTGGTGAAT GGATTTGCCA AGAACCCTTT GCAAGCCCGA 180 181 AGAGAAGGAC TGTATTTCAA GGGAAAAGAT TACAGATGTG TCCGGGCAGA TGAATATTCT 240 241 CTTTATGCCA AAAATGAGAA CACTGGTGTG GTTGTCGTGA AGACCCATCT GTATCTTCTG 300 301 GTAGCAACTT ACACTGAGGG CATGTATCCT AGCATCTGTG TGGAAGCCAC AGAGAGCCTG 360 361 GGAGACTACC TAAGAAAAAA AGGAAGTTAA 390 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell cortex | |
Cellular Component | Cytoskeleton | |
Molecular Function | Actin monomer binding | |
Molecular Function | Lipid binding | |
Biological Process | Sequestering of actin monomers |
▼ ANNOTATION
| Disease | ||||
| PancanQTL | ActiveDriverDB | |||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-0217 | Pan paniscus | 100.0 | 4e-82 | 244 |
| LLPS-Pat-1084 | Pan troglodytes | 100.0 | 4e-82 | 244 |
| LLPS-Gog-0558 | Gorilla gorilla | 99.22 | 2e-81 | 242 |
| LLPS-Poa-1207 | Pongo abelii | 96.9 | 3e-79 | 236 |
| LLPS-Mam-0604 | Macaca mulatta | 96.12 | 2e-78 | 234 |
| LLPS-Man-1613 | Macaca nemestrina | 96.12 | 2e-78 | 234 |
| LLPS-Mal-0464 | Mandrillus leucophaeus | 96.12 | 2e-78 | 234 |
| LLPS-Maf-1182 | Macaca fascicularis | 96.12 | 2e-78 | 234 |
| LLPS-Chs-2630 | Chlorocebus sabaeus | 96.12 | 2e-78 | 234 |
| LLPS-Cea-0658 | Cercocebus atys | 96.12 | 2e-78 | 234 |
| LLPS-Rhb-0413 | Rhinopithecus bieti | 95.35 | 3e-78 | 234 |
| LLPS-Nol-2350 | Nomascus leucogenys | 94.44 | 1e-75 | 227 |
| LLPS-Cas-2136 | Carlito syrichta | 93.02 | 4e-77 | 231 |
| LLPS-Loa-2191 | Loxodonta africana | 91.47 | 4e-74 | 223 |
| LLPS-Aon-1678 | Aotus nancymaae | 91.47 | 1e-73 | 222 |
| LLPS-Orc-2824 | Oryctolagus cuniculus | 89.15 | 6e-71 | 215 |
| LLPS-Fec-0502 | Felis catus | 89.15 | 2e-73 | 222 |
| LLPS-Caj-2755 | Callithrix jacchus | 89.15 | 3e-71 | 216 |
| LLPS-Bot-1927 | Bos taurus | 88.37 | 7e-74 | 223 |
| LLPS-Caf-3122 | Canis familiaris | 87.6 | 9e-73 | 220 |
| LLPS-Myl-1390 | Myotis lucifugus | 87.6 | 7e-73 | 220 |
| LLPS-Ova-1010 | Ovis aries | 87.6 | 4e-74 | 223 |
| LLPS-Fud-0408 | Fukomys damarensis | 87.6 | 3e-71 | 216 |
| LLPS-Eqc-3761 | Equus caballus | 86.82 | 2e-71 | 217 |
| LLPS-Urm-1656 | Ursus maritimus | 86.82 | 1e-73 | 222 |
| LLPS-Aim-1203 | Ailuropoda melanoleuca | 86.82 | 1e-73 | 222 |
| LLPS-Mea-3423 | Mesocricetus auratus | 86.42 | 9e-46 | 150 |
| LLPS-Mup-3978 | Mustela putorius furo | 86.05 | 2e-72 | 219 |
| LLPS-Tut-1464 | Tursiops truncatus | 86.05 | 1e-69 | 212 |
| LLPS-Sus-1840 | Sus scrofa | 84.92 | 2e-67 | 207 |
| LLPS-Ict-3219 | Ictidomys tridecemlineatus | 84.38 | 1e-70 | 214 |
| LLPS-Mum-3477 | Mus musculus | 83.72 | 4e-69 | 211 |
| LLPS-Otg-1513 | Otolemur garnettii | 82.17 | 1e-69 | 212 |
| LLPS-Paa-2830 | Papio anubis | 82.17 | 3e-59 | 185 |
| LLPS-Cap-0564 | Cavia porcellus | 81.4 | 3e-68 | 208 |
| LLPS-Ran-0157 | Rattus norvegicus | 81.4 | 2e-66 | 204 |
| LLPS-Dio-0677 | Dipodomys ordii | 81.4 | 1e-67 | 207 |
| LLPS-Mod-1907 | Monodelphis domestica | 70.54 | 1e-57 | 181 |
| LLPS-Ora-1190 | Ornithorhynchus anatinus | 61.4 | 2e-47 | 155 |
| LLPS-Gaga-3645 | Gallus gallus | 57.39 | 2e-42 | 143 |
| LLPS-Meg-1585 | Meleagris gallopavo | 57.39 | 2e-43 | 145 |
| LLPS-Anp-1002 | Anas platyrhynchos | 54.72 | 8e-37 | 128 |
| LLPS-Pes-0033 | Pelodiscus sinensis | 54.55 | 1e-38 | 133 |
| LLPS-Lac-0815 | Latimeria chalumnae | 53.51 | 2e-38 | 132 |
| LLPS-Anc-1678 | Anolis carolinensis | 49.57 | 2e-35 | 125 |
| LLPS-Leo-1674 | Lepisosteus oculatus | 49.12 | 4e-33 | 119 |
| LLPS-Dar-2442 | Danio rerio | 46.96 | 2e-29 | 109 |
| LLPS-Cii-0610 | Ciona intestinalis | 42.74 | 2e-27 | 104 |
| LLPS-Cis-1052 | Ciona savignyi | 41.88 | 1e-26 | 102 |
| LLPS-Yal-0168 | Yarrowia lipolytica | 38.39 | 7e-19 | 82.0 |
| LLPS-Pug-0137 | Puccinia graminis | 37.93 | 9e-16 | 73.6 |
| LLPS-Cym-0364 | Cyanidioschyzon merolae | 36.17 | 2e-13 | 68.2 |
| LLPS-Dos-0468 | Dothistroma septosporum | 35.9 | 9e-18 | 79.0 |
| LLPS-Cus-0577 | Cucumis sativus | 35.09 | 3e-10 | 58.5 |
| LLPS-Zyt-0688 | Zymoseptoria tritici | 35.0 | 3e-17 | 78.6 |
| LLPS-Scp-0129 | Schizosaccharomyces pombe | 34.78 | 1e-16 | 76.3 |
| LLPS-Scc-0640 | Schizosaccharomyces cryophilus | 34.78 | 2e-16 | 75.5 |
| LLPS-Via-0945 | Vigna angularis | 34.21 | 7e-10 | 57.4 |
| LLPS-Abg-0846 | Absidia glauca | 33.91 | 3e-14 | 70.1 |
| LLPS-Put-0015 | Puccinia triticina | 33.62 | 1e-07 | 50.8 |
| LLPS-Nec-0514 | Neurospora crassa | 33.33 | 4e-15 | 72.0 |
| LLPS-Thc-0594 | Theobroma cacao | 33.04 | 6e-10 | 57.4 |
| LLPS-Brd-0110 | Brachypodium distachyon | 32.97 | 3e-08 | 52.8 |
| LLPS-Prp-0319 | Prunus persica | 32.46 | 2e-08 | 53.5 |
| LLPS-Phv-0257 | Phaseolus vulgaris | 32.46 | 9e-09 | 53.9 |
| LLPS-Scj-1071 | Schizosaccharomyces japonicus | 32.17 | 1e-15 | 73.6 |
| LLPS-Mae-0444 | Manihot esculenta | 31.9 | 3e-09 | 55.8 |
| LLPS-Asg-1037 | Ashbya gossypii | 31.82 | 2e-13 | 67.0 |
| LLPS-Kop-0987 | Komagataella pastoris | 31.58 | 2e-12 | 64.3 |
| LLPS-Glm-0200 | Glycine max | 31.58 | 4e-08 | 52.4 |
| LLPS-Amt-1240 | Amborella trichopoda | 31.53 | 2e-07 | 50.1 |
| LLPS-Gor-2542 | Gossypium raimondii | 31.3 | 3e-10 | 58.5 |
| LLPS-Met-2271 | Medicago truncatula | 30.77 | 1e-07 | 50.8 |
| LLPS-Cog-0145 | Colletotrichum gloeosporioides | 30.7 | 2e-12 | 64.3 |
| LLPS-Nia-1270 | Nicotiana attenuata | 30.7 | 5e-09 | 54.7 |
| LLPS-Sot-2059 | Solanum tuberosum | 30.7 | 7e-09 | 54.7 |
| LLPS-Fuo-0375 | Fusarium oxysporum | 30.51 | 9e-13 | 65.5 |
| LLPS-Tum-0802 | Tuber melanosporum | 30.51 | 1e-11 | 62.0 |
| LLPS-Fuv-0520 | Fusarium verticillioides | 30.51 | 8e-13 | 65.5 |
| LLPS-Sol-1809 | Solanum lycopersicum | 30.43 | 1e-08 | 53.9 |
| LLPS-Map-0061 | Magnaporthe poae | 30.25 | 8e-10 | 57.4 |
| LLPS-Dac-1353 | Daucus carota | 29.91 | 6e-07 | 48.9 |
| LLPS-Ved-0294 | Verticillium dahliae | 29.82 | 2e-13 | 67.4 |
| LLPS-Cogr-0954 | Colletotrichum graminicola | 29.82 | 2e-11 | 61.6 |
| LLPS-Hea-2775 | Helianthus annuus | 29.82 | 2e-08 | 53.5 |
| LLPS-Mel-0560 | Melampsora laricipopulina | 29.82 | 4e-10 | 57.8 |
| LLPS-Coo-1096 | Colletotrichum orbiculare | 29.82 | 4e-12 | 64.3 |
| LLPS-Nef-1322 | Neosartorya fischeri | 29.73 | 5e-09 | 54.7 |
| LLPS-Sac-0327 | Saccharomyces cerevisiae | 29.73 | 3e-12 | 63.9 |
| LLPS-Spr-0049 | Sporisorium reilianum | 29.57 | 5e-08 | 52.0 |
| LLPS-Asni-0127 | Aspergillus niger | 29.46 | 3e-11 | 61.2 |
| LLPS-Blg-0039 | Blumeria graminis | 29.31 | 5e-13 | 66.2 |
| LLPS-Fus-0813 | Fusarium solani | 29.06 | 1e-09 | 57.0 |
| LLPS-Org-0964 | Oryza glaberrima | 28.95 | 3e-07 | 49.7 |
| LLPS-Orr-0341 | Oryza rufipogon | 28.95 | 3e-07 | 49.7 |
| LLPS-Orm-1864 | Oryza meridionalis | 28.95 | 3e-07 | 49.7 |
| LLPS-Ors-1388 | Oryza sativa | 28.95 | 3e-07 | 49.7 |
| LLPS-Orp-0970 | Oryza punctata | 28.95 | 1e-07 | 50.4 |
| LLPS-Orni-1355 | Oryza nivara | 28.95 | 3e-07 | 49.7 |
| LLPS-Orb-2103 | Oryza barthii | 28.95 | 3e-07 | 49.7 |
| LLPS-Ori-1858 | Oryza indica | 28.95 | 3e-07 | 49.7 |
| LLPS-Asfu-0404 | Aspergillus fumigatus | 28.83 | 2e-08 | 53.1 |
| LLPS-Tra-1606 | Triticum aestivum | 28.83 | 9e-08 | 51.2 |
| LLPS-Asf-0926 | Aspergillus flavus | 28.83 | 8e-10 | 57.0 |
| LLPS-Beb-0163 | Beauveria bassiana | 28.81 | 2e-11 | 61.6 |
| LLPS-Gag-1091 | Gaeumannomyces graminis | 28.81 | 5e-11 | 60.8 |
| LLPS-Usm-1129 | Ustilago maydis | 28.7 | 2e-08 | 52.8 |
| LLPS-Sob-0471 | Sorghum bicolor | 28.7 | 2e-08 | 52.8 |
| LLPS-Gas-0097 | Galdieria sulphuraria | 28.7 | 8e-09 | 54.3 |
| LLPS-Asn-1046 | Aspergillus nidulans | 28.57 | 3e-14 | 69.3 |
| LLPS-Asc-0147 | Aspergillus clavatus | 28.57 | 1e-08 | 53.5 |
| LLPS-Miv-0110 | Microbotryum violaceum | 27.93 | 7e-09 | 54.3 |
| LLPS-Ast-0200 | Aspergillus terreus | 26.88 | 2e-07 | 50.4 |
| LLPS-Phn-0494 | Phaeosphaeria nodorum | 26.5 | 9e-07 | 48.5 |
| LLPS-Trr-0086 | Trichoderma reesei | 26.5 | 1e-10 | 59.3 |
| LLPS-Lem-1003 | Leptosphaeria maculans | 26.5 | 1e-06 | 47.8 |
| LLPS-Mao-0219 | Magnaporthe oryzae | 26.27 | 3e-09 | 55.8 |
| LLPS-Viv-2521 | Vitis vinifera | 26.09 | 7e-07 | 48.5 |
| LLPS-Pytr-1200 | Pyrenophora triticirepentis | 25.64 | 2e-06 | 47.8 |
| LLPS-Pyt-0975 | Pyrenophora teres | 25.64 | 8e-07 | 48.5 |
| LLPS-Trv-0456 | Trichoderma virens | 24.58 | 3e-08 | 52.8 |