DrLLPS - Data resource of LLPS

LLPS-Hos-0392
POLR2L

▼ OVERVIEW


Status:	Reviewed
Protein Name:	DNA-directed RNA polymerases I, II, and III subunit RPABC5
Gene Name:	POLR2L
Ensembl Gene:	ENSG00000177700.5
Ensembl Protein:	ENSP00000432807.1
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Others

PDB: 5IY9 (A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, 0, 1, 2, 3, X, Y, Z) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Nucleolus	"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."	N/A	26980300
Nucleolus	"...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli."	HeLa cells	15635413

▼ FUNCTION

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000534030.1	ENSP00000432807.1
Ensembl	ENST00000322028.4	ENSP00000324124.4
UniProt		P62875, RPAB5_HUMAN, P52436, Q6FHX3
GeneBank	AK311997, BC018649, Z47728, Z47729, CR536565, U37690, BC005903	CAA87657.1, BAG34935.1, AAH18649.1, CAG38802.1, AAA91459.1, CAA87658.1, AAH05903.1
RefSeq	NM_021128.4	NP_066951.1
Entrez	5441

▼ SEQUENCE

Protein Sequence (FASTA)
1 MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL AHVDLIEKLL 60 61 NYAPLEK 67
Nucleotide CDS Sequence (FASTA)
1 ATGATCATCC CTGTACGCTG CTTCACTTGT GGCAAGATCG TCGGCAACAA GTGGGAGGCT 60 61 TACCTGGGGC TGCTGCAGGC CGAGTACACC GAGGGGGATG CGCTGGATGC CCTGGGCCTG 120 121 AAGCGCTACT GCTGCCGCCG GATGCTGCTG GCCCACGTGG ACCTGATCGA GAAGCTGCTC 180 181 AATTATGCAC CCCTGGAGAA GTGA 204

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0181	Complete proteome
KW-0240	DNA-directed RNA polymerase
KW-0479	Metal-binding
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0804	Transcription
KW-0862	Zinc

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005829	Cellular Component	Cytosol
GO:0005654	Cellular Component	Nucleoplasm
GO:0005634	Cellular Component	Nucleus
GO:0005736	Cellular Component	RNA polymerase I complex
GO:0005665	Cellular Component	RNA polymerase II, core complex
GO:0005666	Cellular Component	RNA polymerase III complex
GO:0003677	Molecular Function	DNA binding
GO:0003899	Molecular Function	DNA-directed 5'-3' RNA polymerase activity
GO:0008270	Molecular Function	Zinc ion binding
GO:0006370	Biological Process	7-methylguanosine mRNA capping
GO:0008543	Biological Process	Fibroblast growth factor receptor signaling pathway
GO:0000398	Biological Process	MRNA splicing, via spliceosome
GO:0045815	Biological Process	Positive regulation of gene expression, epigenetic
GO:0032481	Biological Process	Positive regulation of type I interferon production
GO:0050434	Biological Process	Positive regulation of viral transcription
GO:0060964	Biological Process	Regulation of gene silencing by miRNA
GO:0006356	Biological Process	Regulation of transcription by RNA polymerase I
GO:0016070	Biological Process	RNA metabolic process
GO:0042795	Biological Process	SnRNA transcription by RNA polymerase II
GO:0035019	Biological Process	Somatic stem cell population maintenance
GO:0006363	Biological Process	Termination of RNA polymerase I transcription
GO:0006366	Biological Process	Transcription by RNA polymerase II
GO:0006383	Biological Process	Transcription by RNA polymerase III
GO:0006362	Biological Process	Transcription elongation from RNA polymerase I promoter
GO:0006368	Biological Process	Transcription elongation from RNA polymerase II promoter
GO:0006361	Biological Process	Transcription initiation from RNA polymerase I promoter
GO:0006367	Biological Process	Transcription initiation from RNA polymerase II promoter
GO:0006351	Biological Process	Transcription, DNA-templated
GO:0006283	Biological Process	Transcription-coupled nucleotide-excision repair

▼ KEGG

hsa:5441

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	CDD	PROSITE
Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	BioGRID
mUbiSiDa	PTMcode

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	RAIN	Mentha
PINA	IID	iRefIndex	MIST	DifferentialNET
RNAct

Disease
PancanQTL	OMIM	ActiveDriverDB

Drug
CTD

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	CORUM	CellMarker

Proteomics
THPA	HPM

Structure
PDB

Localization
COMPARTMENTS	NLSdb

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	CircNet	miRTarBase	miRWalk	miRcode
RAID	OverGeneDB	microRNA.org

Methylation
TCGA	ICGC	COSMIC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Caj-3722	Callithrix jacchus	100.0	2e-42	138
LLPS-Fud-1693	Fukomys damarensis	100.0	2e-42	138
LLPS-Gog-2837	Gorilla gorilla	100.0	2e-42	138
LLPS-Sus-1220	Sus scrofa	100.0	2e-42	138
LLPS-Cea-0434	Cercocebus atys	100.0	2e-42	138
LLPS-Aon-1210	Aotus nancymaae	100.0	2e-42	138
LLPS-Chs-4342	Chlorocebus sabaeus	100.0	2e-42	138
LLPS-Maf-0450	Macaca fascicularis	100.0	2e-42	138
LLPS-Mum-3392	Mus musculus	100.0	2e-42	138
LLPS-Mea-0219	Mesocricetus auratus	100.0	2e-42	138
LLPS-Ova-0570	Ovis aries	100.0	1e-16	71.6
LLPS-Paa-2640	Papio anubis	100.0	2e-42	138
LLPS-Ran-0754	Rattus norvegicus	100.0	9e-44	149
LLPS-Bot-2573	Bos taurus	100.0	2e-42	138
LLPS-Rhb-1556	Rhinopithecus bieti	100.0	2e-42	138
LLPS-Fia-0808	Ficedula albicollis	100.0	2e-42	138
LLPS-Pes-1487	Pelodiscus sinensis	100.0	2e-42	138
LLPS-Otg-2368	Otolemur garnettii	100.0	2e-42	138
LLPS-Anp-3069	Anas platyrhynchos	100.0	2e-42	138
LLPS-Man-2272	Macaca nemestrina	100.0	2e-42	138
LLPS-Fec-2128	Felis catus	100.0	2e-42	138
LLPS-Meg-1041	Meleagris gallopavo	100.0	2e-42	138
LLPS-Pat-3206	Pan troglodytes	100.0	2e-42	138
LLPS-Anc-0600	Anolis carolinensis	100.0	2e-42	138
LLPS-Nol-1803	Nomascus leucogenys	100.0	2e-42	138
LLPS-Gaga-1555	Gallus gallus	100.0	2e-42	138
LLPS-Xet-3898	Xenopus tropicalis	100.0	2e-42	138
LLPS-Cap-0747	Cavia porcellus	100.0	2e-42	138
LLPS-Eqc-0902	Equus caballus	100.0	2e-42	138
LLPS-Asm-2052	Astyanax mexicanus	98.51	3e-42	137
LLPS-Orl-1218	Oryzias latipes	98.51	4e-42	137
LLPS-Myl-0455	Myotis lucifugus	98.51	1e-41	136
LLPS-Xim-1095	Xiphophorus maculatus	98.51	3e-42	137
LLPS-Scm-3070	Scophthalmus maximus	98.51	3e-42	137
LLPS-Dar-3649	Danio rerio	98.51	3e-42	137
LLPS-Pof-1952	Poecilia formosa	98.51	3e-42	137
LLPS-Icp-2633	Ictalurus punctatus	97.01	6e-42	137
LLPS-Tut-0709	Tursiops truncatus	97.01	7e-39	129
LLPS-Tar-1705	Takifugu rubripes	97.01	6e-42	137
LLPS-Lac-1104	Latimeria chalumnae	97.01	5e-42	137
LLPS-Scf-2629	Scleropages formosus	95.52	9e-42	136
LLPS-Poa-1390	Pongo abelii	94.03	3e-39	130
LLPS-Drm-1306	Drosophila melanogaster	92.54	7e-41	134
LLPS-Cis-1293	Ciona savignyi	89.55	2e-39	130
LLPS-Tag-2108	Taeniopygia guttata	86.57	8e-36	121
LLPS-Cae-1413	Caenorhabditis elegans	85.07	3e-38	127
LLPS-Orni-1296	Oryza nivara	83.58	5e-36	122
LLPS-Mua-1532	Musa acuminata	83.58	2e-36	123
LLPS-Thc-0223	Theobroma cacao	83.58	9e-37	125
LLPS-Orb-0670	Oryza barthii	83.58	5e-36	122
LLPS-Tra-1204	Triticum aestivum	83.58	4e-36	122
LLPS-Brd-0682	Brachypodium distachyon	83.58	4e-36	122
LLPS-Lep-0047	Leersia perrieri	83.58	6e-36	122
LLPS-Orgl-1741	Oryza glumaepatula	83.58	6e-36	122
LLPS-Amt-1317	Amborella trichopoda	83.58	2e-36	123
LLPS-Orbr-1436	Oryza brachyantha	83.58	6e-36	122
LLPS-Pot-1504	Populus trichocarpa	83.58	2e-36	122
LLPS-Orp-0028	Oryza punctata	83.58	4e-36	122
LLPS-Ors-0245	Oryza sativa	83.58	3e-36	123
LLPS-Gor-1039	Gossypium raimondii	83.58	1e-36	123
LLPS-Viv-1018	Vitis vinifera	83.58	1e-36	123
LLPS-Tru-0305	Triticum urartu	83.58	3e-36	122
LLPS-Org-1987	Oryza glaberrima	83.58	6e-36	122
LLPS-Prp-1614	Prunus persica	83.58	2e-36	123
LLPS-Coc-0511	Corchorus capsularis	83.58	1e-36	123
LLPS-Orm-0905	Oryza meridionalis	83.58	5e-36	122
LLPS-Orr-0045	Oryza rufipogon	83.58	5e-36	122
LLPS-Sot-1109	Solanum tuberosum	82.26	6e-33	114
LLPS-Zem-0120	Zea mays	82.26	2e-31	113
LLPS-Dac-0736	Daucus carota	82.09	2e-35	120
LLPS-Hea-2581	Helianthus annuus	82.09	3e-36	122
LLPS-Brn-2085	Brassica napus	82.09	3e-36	122
LLPS-Sei-0221	Setaria italica	82.09	2e-35	120
LLPS-Abg-1015	Absidia glauca	82.09	2e-36	123
LLPS-Mae-0208	Manihot esculenta	82.09	5e-36	122
LLPS-Brr-0440	Brassica rapa	82.09	3e-36	122
LLPS-Bro-2939	Brassica oleracea	82.09	2e-35	120
LLPS-Sem-1728	Selaginella moellendorffii	80.65	5e-32	111
LLPS-Glm-1586	Glycine max	80.6	1e-35	120
LLPS-Sol-0213	Solanum lycopersicum	80.6	1e-34	118
LLPS-Vir-1010	Vigna radiata	80.6	2e-35	120
LLPS-Arl-1672	Arabidopsis lyrata	80.6	1e-34	118
LLPS-Met-0713	Medicago truncatula	80.6	7e-36	121
LLPS-Cus-1601	Cucumis sativus	80.6	2e-35	120
LLPS-Via-1368	Vigna angularis	80.6	1e-35	120
LLPS-Phv-1565	Phaseolus vulgaris	80.6	2e-35	120
LLPS-Sob-0178	Sorghum bicolor	80.6	2e-34	118
LLPS-Art-0761	Arabidopsis thaliana	80.6	1e-34	118
LLPS-Cym-0427	Cyanidioschyzon merolae	79.37	2e-28	103
LLPS-Php-1300	Physcomitrella patens	79.1	6e-35	119
LLPS-Hov-0632	Hordeum vulgare	78.57	3e-26	98.2
LLPS-Gas-0921	Galdieria sulphuraria	76.19	6e-27	99.0
LLPS-Mel-0280	Melampsora laricipopulina	76.12	1e-32	113
LLPS-Chr-1680	Chlamydomonas reinhardtii	76.12	5e-33	114
LLPS-Osl-0681	Ostreococcus lucimarinus	76.12	5e-33	114
LLPS-Ere-0653	Erinaceus europaeus	74.63	4e-28	102
LLPS-Kop-0444	Komagataella pastoris	74.63	1e-30	108
LLPS-Miv-0232	Microbotryum violaceum	74.63	1e-32	113
LLPS-Asg-0120	Ashbya gossypii	73.53	7e-30	106
LLPS-Sac-0385	Saccharomyces cerevisiae	73.53	9e-30	106
LLPS-Yal-1254	Yarrowia lipolytica	73.13	2e-30	108
LLPS-Scj-0893	Schizosaccharomyces japonicus	73.13	3e-31	109
LLPS-Scc-0296	Schizosaccharomyces cryophilus	71.64	4e-31	109
LLPS-Scp-1376	Schizosaccharomyces pombe	71.64	4e-31	109
LLPS-Ict-1554	Ictidomys tridecemlineatus	71.64	6e-25	94.4
LLPS-Cas-2957	Carlito syrichta	71.64	2e-25	94.7
LLPS-Nec-0213	Neurospora crassa	70.77	6e-28	102
LLPS-Mal-3230	Mandrillus leucophaeus	69.86	4e-22	86.3
LLPS-Asfu-0521	Aspergillus fumigatus	69.84	1e-25	97.4
LLPS-Scs-0458	Sclerotinia sclerotiorum	69.7	2e-09	54.7
LLPS-Cog-0830	Colletotrichum gloeosporioides	68.75	8e-28	101
LLPS-Cogr-1122	Colletotrichum graminicola	68.75	8e-28	101
LLPS-Crn-0525	Cryptococcus neoformans	68.66	8e-28	100
LLPS-Tum-1305	Tuber melanosporum	68.66	3e-28	102
LLPS-Spr-0557	Sporisorium reilianum	68.66	9e-27	98.6
LLPS-Usm-0486	Ustilago maydis	68.66	1e-26	98.2
LLPS-Chc-0165	Chondrus crispus	67.74	1e-27	102
LLPS-Orc-2247	Oryctolagus cuniculus	67.5	7e-12	59.3
LLPS-Pyt-0955	Pyrenophora teres	67.19	2e-27	100
LLPS-Ved-0818	Verticillium dahliae	67.19	7e-27	99.0
LLPS-Asn-0523	Aspergillus nidulans	67.16	1e-27	100
LLPS-Asc-0914	Aspergillus clavatus	67.16	1e-27	100
LLPS-Nef-1074	Neosartorya fischeri	67.16	1e-27	100
LLPS-Phn-0337	Phaeosphaeria nodorum	67.16	7e-29	103
LLPS-Map-0550	Magnaporthe poae	66.67	3e-25	94.7
LLPS-Gag-0677	Gaeumannomyces graminis	66.67	2e-25	95.1
LLPS-Pug-0794	Puccinia graminis	66.18	3e-28	102
LLPS-Fuv-1178	Fusarium verticillioides	66.15	3e-26	97.4
LLPS-Trr-1068	Trichoderma reesei	66.15	2e-26	97.4
LLPS-Beb-0845	Beauveria bassiana	66.15	3e-26	97.4
LLPS-Fuo-0927	Fusarium oxysporum	66.15	3e-26	97.4
LLPS-Trv-0372	Trichoderma virens	66.15	2e-26	97.4
LLPS-Blg-1069	Blumeria graminis	65.67	5e-29	104
LLPS-Coo-0925	Colletotrichum orbiculare	65.62	4e-27	99.4
LLPS-Urm-2960	Ursus maritimus	64.18	2e-18	77.8
LLPS-Lem-0061	Leptosphaeria maculans	63.24	5e-27	99.4
LLPS-Pytr-0963	Pyrenophora triticirepentis	62.69	3e-26	97.4
LLPS-Mao-0483	Magnaporthe oryzae	62.5	1e-26	98.2
LLPS-Nia-0671	Nicotiana attenuata	59.04	6e-26	97.1
LLPS-Zyt-0311	Zymoseptoria tritici	56.16	6e-24	91.3
LLPS-Dos-1243	Dothistroma septosporum	54.79	5e-23	89.4
LLPS-Ori-0878	Oryza indica	51.38	3e-27	100

LLPS-Hos-0392POLR2L

Protein Sequence

Nucleotide Sequence

LLPS-Hos-0392
POLR2L