LLPS-Hos-0363
MINDY3
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Ubiquitin carboxyl-terminal hydrolase MINDY-3; Dermal papilla-derived protein 5; Deubiquitinating enzyme MINDY-3; Protein CARP |
| Gene Name: | MINDY3, C10orf97, CARP, DERP5, FAM188A, MSTP126, My042 |
| Ensembl Gene: | ENSG00000148481.13 |
| Ensembl Protein: | ENSP00000389883.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...In total, we identified 325 proteins localized to distinct nuclear bodies, including nucleoli, promyelocytic leukemia nuclear bodies, nuclear speckles, paraspeckles, Cajal bodies, Sam68 nuclear bodies, Polycomb bodies, and uncharacterized nuclear bodies." | HeLa cells | 24127217 |
▼ FUNCTION
| Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000436829.1 | ENSP00000389883.1 |
| Ensembl | ENST00000418767.5 | ENSP00000388661.1 |
| Ensembl | ENST00000277632.7 | ENSP00000277632.3 |
| Ensembl | ENST00000378036.5 | ENSP00000367275.1 |
| UniProt | Q9H8M7, MINY3_HUMAN, Q5SZ68, Q5SZ69, Q5SZ70, Q6IA40, Q6P7P0, Q7Z2S1, Q8WUF1, Q9H3I4 | |
| GeneBank | BC067799, CH471072, BC061585, AB014761, AF176916, AL833873, AK023459, CR457315, AF063600, BC020605, AL590439 | EAW86233.1, AAH61585.1, EAW86234.1, BAB14582.1, BAB87802.1, CAD38730.1, AAG43159.1, CAG33596.1, AAH20605.1, AAH67799.1, AAQ13660.1 |
| RefSeq | NM_001318330.1, NM_024948.3, XM_005252600.2, XM_005252602.2, XM_011519694.1, XM_017016673.1 | NP_001305259.1, NP_079224.1, XP_005252657.1, XP_005252659.1, XP_011517996.1, XP_016872162.1 |
| Entrez | 80013 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSELTKELME LVWGTKSSPG LSDTIFCRWT QGFVFSESEG SALEQFEGGP CAVIAPVQAF 60 61 LLKKLLFSSE KSSWRDCSEE EQKELLCHTL CDILESACCD HSGSYCLVSW LRGKTTEETA 120 121 SISGSPAESS CQVEHSSALA VEELGFERFH ALIQKRSFRS LPELKDAVLD QYSMWGNKFG 180 181 VLLFLYSVLL TKGIENIKNE IEDASEPLID PVYGHGSQSL INLLLTGHAV SNVWDGDREC 240 241 SGMKLLGIHE QAAVGFLTLM EALRYCKVGS YLKSPKFPIW IVGSETHLTV FFAKDMALVA 300 301 PEAPSEQARR VFQTYDPEDN GFIPDSLLED VMKALDLVSD PEYINLMKNK LDPEGLGIIL 360 361 LGPFLQEFFP DQGSSGPESF TVYHYNGLKQ SNYNEKVMYV EGTAVVMGFE DPMLQTDDTP 420 421 IKRCLQTKWP YIELLWTTDR SPSLN 445 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCCGAAC TGACTAAAGA GCTGATGGAG CTGGTGTGGG GCACCAAGAG CAGCCCCGGT 60 61 CTCTCGGACA CCATTTTCTG CCGCTGGACG CAAGGGTTTG TGTTTAGTGA ATCAGAGGGA 120 121 TCTGCATTAG AACAGTTTGA AGGTGGCCCC TGTGCTGTTA TTGCACCTGT TCAGGCATTT 180 181 CTTTTGAAGA AGCTCCTGTT TTCTTCGGAG AAGTCTTCTT GGCGGGATTG TTCAGAGGAA 240 241 GAGCAGAAGG AACTCCTTTG TCATACCTTG TGTGATATTT TAGAAAGTGC TTGTTGTGAC 300 301 CACTCTGGAT CATACTGCTT GGTTTCATGG TTAAGAGGAA AGACAACTGA GGAAACTGCT 360 361 AGTATTTCTG GGAGTCCTGC AGAGTCTAGT TGCCAAGTGG AACATTCTTC TGCCTTGGCT 420 421 GTCGAAGAGC TTGGCTTTGA GCGATTTCAT GCATTAATTC AAAAAAGATC GTTCAGAAGT 480 481 TTACCAGAAT TAAAAGATGC TGTCTTGGAC CAGTATTCAA TGTGGGGAAA TAAATTTGGA 540 541 GTATTGCTTT TTCTGTATTC TGTATTACTG ACAAAGGGCA TTGAAAACAT AAAAAACGAA 600 601 ATTGAAGATG CAAGTGAACC CTTGATAGAT CCTGTATATG GACATGGCAG CCAAAGTTTA 660 661 ATTAATCTCC TGCTGACGGG ACATGCTGTT TCTAATGTAT GGGATGGTGA TAGAGAGTGC 720 721 TCAGGAATGA AACTTCTTGG TATACATGAA CAAGCAGCAG TAGGATTTTT AACACTAATG 780 781 GAAGCTTTAA GATACTGTAA GGTTGGTTCT TACTTGAAAT CTCCAAAATT CCCTATTTGG 840 841 ATTGTTGGCA GTGAGACTCA CCTCACCGTA TTTTTTGCCA AGGATATGGC TTTAGTTGCC 900 901 CCTGAAGCTC CTTCAGAACA AGCCAGAAGA GTTTTTCAAA CCTACGACCC AGAAGATAAT 960 961 GGATTCATAC CCGATTCACT TCTGGAAGAT GTGATGAAAG CATTGGACCT TGTTTCAGAT 1020 1021 CCTGAATATA TAAATCTCAT GAAGAATAAA TTAGATCCAG AAGGATTAGG AATCATATTA 1080 1081 TTGGGCCCAT TTCTTCAAGA ATTTTTTCCT GATCAGGGCT CCAGTGGTCC AGAATCTTTT 1140 1141 ACTGTCTACC ACTACAATGG ATTGAAGCAG TCAAATTATA ATGAAAAGGT CATGTACGTA 1200 1201 GAAGGGACTG CAGTTGTGAT GGGTTTTGAA GATCCCATGC TACAGACAGA TGACACTCCT 1260 1261 ATTAAACGCT GTCTGCAAAC CAAATGGCCA TACATTGAGT TACTCTGGAC CACAGATCGC 1320 1321 TCTCCTTCAC TAAATTAA 1338 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nuclear membrane | |
Cellular Component | Nucleoplasm | |
Molecular Function | Cysteine-type carboxypeptidase activity | |
Molecular Function | Lys48-specific deubiquitinase activity | |
Molecular Function | Thiol-dependent ubiquitinyl hydrolase activity | |
Biological Process | Apoptotic process |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Proteomics | ||||
| THPA | ||||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Expression | ||||
| TCGA | ArrayExpress | TISSUES | BioXpress | THPA |
| Methylation | ||||
| MethyCancer | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Paa-1407 | Papio anubis | 100.0 | 0.0 | 887 |
| LLPS-Mal-1218 | Mandrillus leucophaeus | 100.0 | 0.0 | 887 |
| LLPS-Maf-2401 | Macaca fascicularis | 100.0 | 0.0 | 887 |
| LLPS-Chs-3654 | Chlorocebus sabaeus | 100.0 | 0.0 | 887 |
| LLPS-Cea-1952 | Cercocebus atys | 100.0 | 0.0 | 887 |
| LLPS-Gog-0018 | Gorilla gorilla | 100.0 | 0.0 | 887 |
| LLPS-Mam-2735 | Macaca mulatta | 100.0 | 0.0 | 887 |
| LLPS-Nol-3215 | Nomascus leucogenys | 100.0 | 0.0 | 887 |
| LLPS-Urm-2324 | Ursus maritimus | 100.0 | 4e-105 | 315 |
| LLPS-Man-2056 | Macaca nemestrina | 100.0 | 0.0 | 887 |
| LLPS-Poa-0473 | Pongo abelii | 99.78 | 0.0 | 884 |
| LLPS-Pap-1383 | Pan paniscus | 99.78 | 0.0 | 885 |
| LLPS-Pat-3021 | Pan troglodytes | 99.78 | 0.0 | 885 |
| LLPS-Aon-0213 | Aotus nancymaae | 99.33 | 0.0 | 881 |
| LLPS-Caj-3198 | Callithrix jacchus | 99.1 | 0.0 | 879 |
| LLPS-Eqc-0999 | Equus caballus | 98.88 | 0.0 | 877 |
| LLPS-Cas-0955 | Carlito syrichta | 98.88 | 0.0 | 876 |
| LLPS-Orc-0581 | Oryctolagus cuniculus | 98.65 | 0.0 | 872 |
| LLPS-Sus-1210 | Sus scrofa | 98.2 | 0.0 | 873 |
| LLPS-Ict-1568 | Ictidomys tridecemlineatus | 98.2 | 0.0 | 875 |
| LLPS-Aim-1068 | Ailuropoda melanoleuca | 97.98 | 0.0 | 866 |
| LLPS-Mup-1958 | Mustela putorius furo | 97.66 | 0.0 | 654 |
| LLPS-Otg-2747 | Otolemur garnettii | 97.54 | 0.0 | 863 |
| LLPS-Bot-0377 | Bos taurus | 97.53 | 0.0 | 866 |
| LLPS-Fec-0432 | Felis catus | 97.53 | 0.0 | 866 |
| LLPS-Dio-2219 | Dipodomys ordii | 97.33 | 9e-101 | 304 |
| LLPS-Ova-2258 | Ovis aries | 97.3 | 0.0 | 865 |
| LLPS-Loa-2623 | Loxodonta africana | 97.3 | 0.0 | 860 |
| LLPS-Fud-3544 | Fukomys damarensis | 97.08 | 0.0 | 865 |
| LLPS-Cap-1883 | Cavia porcellus | 96.63 | 0.0 | 860 |
| LLPS-Myl-1011 | Myotis lucifugus | 95.96 | 0.0 | 853 |
| LLPS-Mea-3086 | Mesocricetus auratus | 95.96 | 0.0 | 853 |
| LLPS-Rhb-3170 | Rhinopithecus bieti | 95.96 | 0.0 | 840 |
| LLPS-Mum-4418 | Mus musculus | 95.73 | 0.0 | 847 |
| LLPS-Ran-1392 | Rattus norvegicus | 95.06 | 0.0 | 847 |
| LLPS-Caf-2398 | Canis familiaris | 94.44 | 0.0 | 777 |
| LLPS-Sah-3767 | Sarcophilus harrisii | 91.01 | 0.0 | 824 |
| LLPS-Mod-1458 | Monodelphis domestica | 91.01 | 0.0 | 824 |
| LLPS-Ora-0694 | Ornithorhynchus anatinus | 88.09 | 0.0 | 795 |
| LLPS-Pes-0861 | Pelodiscus sinensis | 87.97 | 0.0 | 645 |
| LLPS-Tag-0655 | Taeniopygia guttata | 87.92 | 0.0 | 738 |
| LLPS-Anp-2210 | Anas platyrhynchos | 86.61 | 0.0 | 641 |
| LLPS-Gaga-1788 | Gallus gallus | 85.87 | 0.0 | 780 |
| LLPS-Fia-1364 | Ficedula albicollis | 85.78 | 0.0 | 748 |
| LLPS-Anc-2660 | Anolis carolinensis | 83.63 | 0.0 | 759 |
| LLPS-Lac-3623 | Latimeria chalumnae | 79.96 | 0.0 | 724 |
| LLPS-Leo-0372 | Lepisosteus oculatus | 77.51 | 0.0 | 698 |
| LLPS-Scf-3334 | Scleropages formosus | 76.29 | 0.0 | 698 |
| LLPS-Asm-1238 | Astyanax mexicanus | 74.72 | 0.0 | 691 |
| LLPS-Dar-2631 | Danio rerio | 74.22 | 0.0 | 677 |
| LLPS-Icp-3612 | Ictalurus punctatus | 74.12 | 0.0 | 681 |
| LLPS-Xet-0121 | Xenopus tropicalis | 72.75 | 0.0 | 648 |
| LLPS-Ten-2357 | Tetraodon nigroviridis | 71.59 | 0.0 | 654 |
| LLPS-Tar-2100 | Takifugu rubripes | 70.09 | 0.0 | 648 |
| LLPS-Gaa-3963 | Gasterosteus aculeatus | 69.96 | 0.0 | 635 |
| LLPS-Orn-3470 | Oreochromis niloticus | 69.8 | 0.0 | 617 |
| LLPS-Orl-3755 | Oryzias latipes | 69.15 | 0.0 | 636 |
| LLPS-Scm-3662 | Scophthalmus maximus | 68.23 | 0.0 | 625 |
| LLPS-Xim-1395 | Xiphophorus maculatus | 68.2 | 0.0 | 637 |
| LLPS-Pof-2529 | Poecilia formosa | 67.76 | 0.0 | 632 |
| LLPS-Drm-1093 | Drosophila melanogaster | 44.12 | 1e-125 | 383 |
| LLPS-Cis-0608 | Ciona savignyi | 42.48 | 8e-107 | 330 |
| LLPS-Cii-0762 | Ciona intestinalis | 42.21 | 5e-112 | 344 |
| LLPS-Meg-2223 | Meleagris gallopavo | 40.68 | 4e-18 | 91.3 |
| LLPS-Gor-0560 | Gossypium raimondii | 35.31 | 5e-39 | 152 |
| LLPS-Met-2243 | Medicago truncatula | 34.62 | 5e-38 | 150 |
| LLPS-Thc-0071 | Theobroma cacao | 34.43 | 2e-38 | 151 |
| LLPS-Coc-1869 | Corchorus capsularis | 34.19 | 1e-37 | 148 |
| LLPS-Pot-1331 | Populus trichocarpa | 34.17 | 2e-38 | 151 |
| LLPS-Vir-1315 | Vigna radiata | 33.96 | 8e-39 | 152 |
| LLPS-Phv-0119 | Phaseolus vulgaris | 33.58 | 9e-39 | 152 |
| LLPS-Amt-1821 | Amborella trichopoda | 32.78 | 2e-42 | 161 |
| LLPS-Prp-0282 | Prunus persica | 31.61 | 1e-38 | 152 |
| LLPS-Tut-1050 | Tursiops truncatus | 31.25 | 8e-12 | 70.5 |
| LLPS-Ors-1012 | Oryza sativa | 31.21 | 2e-34 | 135 |
| LLPS-Dac-1117 | Daucus carota | 30.75 | 5e-43 | 164 |
| LLPS-Brn-1943 | Brassica napus | 30.67 | 1e-45 | 172 |
| LLPS-Bro-1195 | Brassica oleracea | 30.67 | 1e-45 | 172 |
| LLPS-Art-0566 | Arabidopsis thaliana | 30.56 | 8e-44 | 167 |
| LLPS-Brr-2235 | Brassica rapa | 30.3 | 7e-46 | 172 |
| LLPS-Tra-3103 | Triticum aestivum | 30.28 | 2e-47 | 177 |
| LLPS-Sei-0281 | Setaria italica | 30.23 | 2e-42 | 159 |
| LLPS-Sem-0068 | Selaginella moellendorffii | 30.22 | 8e-40 | 155 |
| LLPS-Chr-1642 | Chlamydomonas reinhardtii | 30.17 | 1e-26 | 117 |
| LLPS-Glm-1427 | Glycine max | 29.66 | 5e-42 | 162 |
| LLPS-Hov-0990 | Hordeum vulgare | 29.22 | 6e-47 | 174 |
| LLPS-Arl-1256 | Arabidopsis lyrata | 28.87 | 4e-43 | 165 |
| LLPS-Zem-1040 | Zea mays | 28.67 | 9e-46 | 172 |
| LLPS-Sob-1974 | Sorghum bicolor | 28.67 | 8e-45 | 170 |
| LLPS-Nia-0066 | Nicotiana attenuata | 28.6 | 2e-37 | 148 |
| LLPS-Viv-1065 | Vitis vinifera | 28.26 | 7e-42 | 161 |
| LLPS-Hea-1700 | Helianthus annuus | 28.01 | 4e-35 | 141 |
| LLPS-Sol-0846 | Solanum lycopersicum | 27.97 | 1e-39 | 154 |
| LLPS-Mae-0056 | Manihot esculenta | 27.75 | 1e-42 | 163 |
| LLPS-Via-1369 | Vigna angularis | 27.44 | 1e-40 | 157 |
| LLPS-Cus-0913 | Cucumis sativus | 27.39 | 2e-41 | 159 |
| LLPS-Brd-1845 | Brachypodium distachyon | 27.22 | 1e-45 | 172 |
| LLPS-Lep-1048 | Leersia perrieri | 27.06 | 1e-45 | 172 |
| LLPS-Ori-1107 | Oryza indica | 26.67 | 4e-43 | 163 |
| LLPS-Php-1397 | Physcomitrella patens | 26.51 | 1e-35 | 143 |
| LLPS-Orbr-0418 | Oryza brachyantha | 26.41 | 6e-44 | 166 |
| LLPS-Mua-0204 | Musa acuminata | 26.36 | 1e-39 | 154 |
| LLPS-Orp-1722 | Oryza punctata | 26.35 | 2e-44 | 168 |
| LLPS-Orgl-1401 | Oryza glumaepatula | 26.3 | 1e-44 | 169 |
| LLPS-Orb-1699 | Oryza barthii | 26.3 | 4e-45 | 169 |
| LLPS-Orni-0921 | Oryza nivara | 26.3 | 9e-45 | 169 |
| LLPS-Orr-1645 | Oryza rufipogon | 26.3 | 9e-45 | 169 |
| LLPS-Org-0304 | Oryza glaberrima | 26.3 | 9e-45 | 169 |
| LLPS-Tru-0069 | Triticum urartu | 24.81 | 3e-24 | 109 |