LLPS-Hos-0344
TMOD3
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Tropomodulin-3; Ubiquitous tropomodulin; U-Tmod |
| Gene Name: | TMOD3 |
| Ensembl Gene: | ENSG00000138594.13 |
| Ensembl Protein: | ENSP00000308753.7 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Stress granule | "...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell." | U2OS cells | 26777405 |
▼ FUNCTION
| Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000308580.11 | ENSP00000308753.7 |
| Ensembl | ENST00000561438.5 | ENSP00000452939.1 |
| Ensembl | ENST00000558455.1 | ENSP00000454161.1 |
| Ensembl | ENST00000560549.5 | ENSP00000454040.1 |
| UniProt | Q9NYL9, TMOD3_HUMAN, B2R6G7, Q9NT43, Q9NZR0 | |
| GeneBank | AK312569, AF177171, AL137543, AF237631, BC020542 | AAF31670.1, CAB70801.1, BAG35464.1, AAF45299.1, AAH20542.1 |
| RefSeq | NM_014547.4, XM_017022087.1, XM_017022088.1 | NP_055362.1, XP_016877576.1, XP_016877577.1 |
| Entrez | 29766 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MALPFRKDLE KYKDLDEDEL LGNLSETELK QLETVLDDLD PENALLPAGF RQKNQTSKST 60 61 TGPFDREHLL SYLEKEALEH KDREDYVPYT GEKKGKIFIP KQKPVQTFTE EKVSLDPELE 120 121 EALTSASDTE LCDLAAILGM HNLITNTKFC NIMGSSNGVD QEHFSNVVKG EKILPVFDEP 180 181 PNPTNVEESL KRTKENDAHL VEVNLNNIKN IPIPTLKDFA KALETNTHVK CFSLAATRSN 240 241 DPVATAFAEM LKVNKTLKSL NVESNFITGV GILALIDALR DNETLAELKI DNQRQQLGTA 300 301 VELEMAKMLE ENTNILKFGY QFTQQGPRTR AANAITKNND LVRKRRVEGD HQ 352 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCACTGC CATTCCGTAA GGACTTAGAA AAGTACAAAG ACCTTGATGA AGATGAGCTC 60 61 CTTGGGAATC TGTCAGAAAC AGAACTGAAA CAACTGGAAA CTGTTTTGGA TGATCTTGAC 120 121 CCCGAGAATG CCCTTCTGCC TGCAGGGTTC CGGCAGAAGA ACCAGACATC AAAGTCCACC 180 181 ACAGGGCCAT TTGATAGAGA GCATCTCCTT TCATATCTGG AGAAAGAAGC ATTGGAGCAT 240 241 AAAGACAGGG AAGACTATGT GCCCTACACT GGAGAAAAAA AAGGGAAAAT ATTTATCCCC 300 301 AAACAGAAAC CTGTACAGAC TTTTACAGAA GAAAAAGTGT CTCTTGATCC AGAATTAGAA 360 361 GAAGCTTTGA CAAGTGCTTC TGATACAGAA TTGTGTGACC TCGCAGCAAT TCTTGGGATG 420 421 CACAATTTGA TAACGAATAC AAAGTTCTGT AATATAATGG GAAGTAGTAA TGGTGTTGAC 480 481 CAAGAACATT TTTCAAATGT GGTCAAAGGT GAAAAGATTC TTCCGGTATT TGATGAGCCA 540 541 CCAAATCCAA CCAATGTAGA AGAGAGTTTG AAGAGAACTA AAGAAAACGA TGCTCATCTT 600 601 GTTGAAGTTA ATTTGAATAA TATAAAGAAT ATCCCAATTC CAACCCTAAA AGATTTTGCA 660 661 AAGGCTTTGG AAACCAACAC ACATGTGAAA TGTTTCAGTC TTGCAGCCAC CCGGAGCAAT 720 721 GACCCTGTTG CTACTGCTTT TGCAGAAATG CTGAAAGTGA ACAAAACTTT GAAGAGCTTA 780 781 AATGTGGAGT CCAACTTTAT CACGGGAGTT GGGATTCTGG CACTGATTGA TGCGTTAAGA 840 841 GATAATGAAA CCCTGGCAGA GCTCAAGATT GACAATCAGA GGCAGCAGTT GGGGACAGCT 900 901 GTAGAATTGG AAATGGCCAA GATGCTTGAG GAAAATACAA ATATCCTTAA ATTTGGATAT 960 961 CAGTTTACAC AGCAGGGACC ACGAACCAGA GCAGCTAATG CTATAACAAA AAACAATGAC 1020 1021 TTAGTGCGTA AGAGACGAGT TGAAGGAGAT CACCAGTAA 1059 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell-cell adherens junction | |
Cellular Component | Myofibril | |
Cellular Component | Striated muscle thin filament | |
Molecular Function | Actin binding | |
Molecular Function | Cadherin binding involved in cell-cell adhesion | |
Molecular Function | Tropomyosin binding | |
Biological Process | Erythrocyte development | |
Biological Process | Muscle contraction | |
Biological Process | Myofibril assembly | |
Biological Process | Pointed-end actin filament capping | |
Biological Process | Positive regulation of mitotic cell cycle phase transition |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-2214 | Pan troglodytes | 99.43 | 0.0 | 679 |
| LLPS-Pap-2155 | Pan paniscus | 99.43 | 0.0 | 679 |
| LLPS-Poa-3770 | Pongo abelii | 99.43 | 0.0 | 679 |
| LLPS-Nol-3393 | Nomascus leucogenys | 99.15 | 0.0 | 677 |
| LLPS-Gog-1281 | Gorilla gorilla | 98.86 | 0.0 | 676 |
| LLPS-Rhb-0509 | Rhinopithecus bieti | 98.58 | 0.0 | 673 |
| LLPS-Cea-2990 | Cercocebus atys | 98.3 | 0.0 | 672 |
| LLPS-Mal-0440 | Mandrillus leucophaeus | 98.3 | 0.0 | 672 |
| LLPS-Paa-3486 | Papio anubis | 98.29 | 0.0 | 669 |
| LLPS-Mam-3057 | Macaca mulatta | 98.01 | 0.0 | 669 |
| LLPS-Aon-3677 | Aotus nancymaae | 98.01 | 0.0 | 671 |
| LLPS-Chs-3895 | Chlorocebus sabaeus | 98.01 | 0.0 | 669 |
| LLPS-Maf-4496 | Macaca fascicularis | 98.01 | 0.0 | 669 |
| LLPS-Man-1231 | Macaca nemestrina | 97.73 | 0.0 | 667 |
| LLPS-Caj-4019 | Callithrix jacchus | 96.88 | 0.0 | 663 |
| LLPS-Cas-1404 | Carlito syrichta | 96.02 | 0.0 | 659 |
| LLPS-Otg-0519 | Otolemur garnettii | 95.75 | 0.0 | 650 |
| LLPS-Mup-1081 | Mustela putorius furo | 95.44 | 0.0 | 653 |
| LLPS-Bot-1281 | Bos taurus | 95.29 | 0.0 | 626 |
| LLPS-Caf-0247 | Canis familiaris | 95.17 | 0.0 | 651 |
| LLPS-Ova-3062 | Ovis aries | 94.89 | 0.0 | 646 |
| LLPS-Sus-3213 | Sus scrofa | 94.6 | 0.0 | 647 |
| LLPS-Fec-2364 | Felis catus | 94.32 | 0.0 | 644 |
| LLPS-Aim-4006 | Ailuropoda melanoleuca | 94.32 | 0.0 | 645 |
| LLPS-Urm-1437 | Ursus maritimus | 94.03 | 0.0 | 646 |
| LLPS-Orc-4287 | Oryctolagus cuniculus | 93.75 | 0.0 | 648 |
| LLPS-Myl-3167 | Myotis lucifugus | 93.75 | 0.0 | 641 |
| LLPS-Eqc-1809 | Equus caballus | 93.16 | 0.0 | 627 |
| LLPS-Ict-0410 | Ictidomys tridecemlineatus | 92.9 | 0.0 | 635 |
| LLPS-Fud-3428 | Fukomys damarensis | 92.9 | 0.0 | 644 |
| LLPS-Loa-3129 | Loxodonta africana | 92.59 | 0.0 | 627 |
| LLPS-Dio-2199 | Dipodomys ordii | 91.19 | 0.0 | 620 |
| LLPS-Ran-3463 | Rattus norvegicus | 90.34 | 0.0 | 623 |
| LLPS-Mum-3863 | Mus musculus | 90.06 | 0.0 | 622 |
| LLPS-Cap-2712 | Cavia porcellus | 90.03 | 0.0 | 623 |
| LLPS-Mod-3002 | Monodelphis domestica | 89.18 | 0.0 | 595 |
| LLPS-Ora-3540 | Ornithorhynchus anatinus | 89.17 | 0.0 | 615 |
| LLPS-Sah-4099 | Sarcophilus harrisii | 88.07 | 0.0 | 611 |
| LLPS-Pes-1644 | Pelodiscus sinensis | 83.58 | 0.0 | 562 |
| LLPS-Anp-0490 | Anas platyrhynchos | 83.52 | 0.0 | 584 |
| LLPS-Anc-2282 | Anolis carolinensis | 83.33 | 0.0 | 553 |
| LLPS-Fia-2323 | Ficedula albicollis | 83.19 | 0.0 | 577 |
| LLPS-Tag-1726 | Taeniopygia guttata | 83.14 | 0.0 | 575 |
| LLPS-Gaga-3816 | Gallus gallus | 82.1 | 0.0 | 576 |
| LLPS-Meg-1598 | Meleagris gallopavo | 81.34 | 0.0 | 548 |
| LLPS-Mea-3040 | Mesocricetus auratus | 79.42 | 2e-175 | 498 |
| LLPS-Lac-3219 | Latimeria chalumnae | 77.27 | 0.0 | 538 |
| LLPS-Scf-2555 | Scleropages formosus | 73.91 | 4e-173 | 493 |
| LLPS-Orn-0050 | Oreochromis niloticus | 73.14 | 5e-178 | 505 |
| LLPS-Pof-0038 | Poecilia formosa | 72.08 | 7e-174 | 494 |
| LLPS-Ten-1487 | Tetraodon nigroviridis | 71.71 | 5e-174 | 495 |
| LLPS-Orl-1855 | Oryzias latipes | 71.64 | 3e-164 | 473 |
| LLPS-Gaa-0013 | Gasterosteus aculeatus | 71.59 | 5e-172 | 490 |
| LLPS-Xim-0821 | Xiphophorus maculatus | 71.55 | 2e-166 | 476 |
| LLPS-Xet-2968 | Xenopus tropicalis | 71.22 | 1e-172 | 492 |
| LLPS-Scm-2014 | Scophthalmus maximus | 70.57 | 5e-170 | 485 |
| LLPS-Tar-0934 | Takifugu rubripes | 70.29 | 4e-159 | 457 |
| LLPS-Cii-0839 | Ciona intestinalis | 52.15 | 2e-110 | 334 |
| LLPS-Cis-1881 | Ciona savignyi | 51.83 | 2e-111 | 336 |