DrLLPS - Data resource of LLPS

LLPS-Hos-0259
RPL8

▼ OVERVIEW


Status:	Reviewed
Protein Name:	60S ribosomal protein L8; Large ribosomal subunit protein uL2
Gene Name:	RPL8
Ensembl Gene:	ENSG00000161016.17
Ensembl Protein:	ENSP00000436460.1
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	LLPS regulator

PDB: 4CCO (A, C) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Nucleolus	"...SILAC-based approaches identified 351 proteins with 24 proteins showing at least a 2-fold change after infection."	HeLa cells	19812395
Postsynaptic density	"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."	Human cortex	23071613

▼ FUNCTION

Component of the large ribosomal subunit.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000527914.5	ENSP00000436460.1
Ensembl	ENST00000532702.1	ENSP00000434535.1
Ensembl	ENST00000531975.5	ENSP00000437062.1
Ensembl	ENST00000528957.5	ENSP00000433464.2
Ensembl	ENST00000533397.5	ENSP00000435313.1
Ensembl	ENST00000394920.6	ENSP00000378378.2
Ensembl	ENST00000529920.5	ENSP00000433703.1
Ensembl	ENST00000262584.7	ENSP00000262584.3
UniProt		P62917, RL8_HUMAN, A8K094, D3DWN2, P25120, Q567Q7, Q969V7, Q9BWQ9
GeneBank	AB007168, BC093064, AK289459, CH471162, AB061821, BC000077, CR457046, BC012197, Z28407, BC013104, BC000047, BT007379	EAW82048.1, AAH93064.1, CAG33327.1, AAH12197.1, BAF82148.1, AAH13104.1, BAA25829.1, CAA82248.1, EAW82051.1, AAH00047.2, EAW82052.1, AAH00077.1, BAB79459.1, AAP36043.1
RefSeq	NM_000973.4, NM_001317771.1, NM_001317782.1, NM_033301.2	NP_000964.1, NP_001304700.1, NP_001304711.1, NP_150644.1
Entrez	102465978

▼ SEQUENCE

Protein Sequence (FASTA)
1 MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH DPGRGAPLAK 60 61 VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN VLPVGTMPEG TIVCCLEEKP 120 121 GDRGKLARAS GNYATVISHN PETKKTRVKL PSGSKKVISS ANRAVVGVVA GGGRIDKPIL 180 181 KAGRAYHKYK AKRNCWPRVR GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA 240 241 RRTGRLRGTK TVQEKEN 257
Nucleotide CDS Sequence (FASTA)
1 ATGGGCCGTG TGATCCGTGG ACAGAGGAAG GGCGCCGGGT CTGTGTTCCG CGCGCACGTG 60 61 AAGCACCGTA AAGGCGCTGC GCGCCTGCGC GCCGTGGATT TCGCTGAGCG GCACGGCTAC 120 121 ATCAAGGGCA TCGTCAAGGA CATCATCCAC GACCCGGGCC GCGGCGCGCC CCTCGCCAAG 180 181 GTGGTCTTCC GGGATCCGTA TCGGTTTAAG AAGCGGACGG AGCTGTTCAT TGCCGCCGAG 240 241 GGCATTCACA CGGGCCAGTT TGTGTATTGC GGCAAGAAGG CCCAGCTCAA CATTGGCAAT 300 301 GTGCTCCCTG TGGGCACCAT GCCTGAGGGT ACAATCGTGT GCTGCCTGGA GGAGAAGCCT 360 361 GGAGACCGTG GCAAGCTGGC CCGGGCATCA GGGAACTATG CCACCGTTAT CTCCCACAAC 420 421 CCTGAGACCA AGAAGACCCG TGTGAAGCTG CCCTCCGGCT CCAAGAAGGT TATCTCCTCA 480 481 GCCAACAGAG CTGTGGTTGG TGTGGTGGCT GGAGGTGGCC GAATTGACAA ACCCATCTTG 540 541 AAGGCTGGCC GGGCGTACCA CAAATATAAG GCAAAGAGGA ACTGCTGGCC ACGAGTACGG 600 601 GGTGTGGCCA TGAATCCTGT GGAGCATCCT TTTGGAGGTG GCAACCACCA GCACATCGGC 660 661 AAGCCCTCCA CCATCCGCAG AGATGCCCCT GCTGGCCGCA AAGTGGGTCT CATTGCTGCC 720 721 CGCCGGACTG GACGTCTCCG GGGAACCAAG ACTGTGCAGG AGAAAGAGAA CTAG 774

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0379	Hydroxylation
KW-1017	Isopeptide bond
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0689	Ribosomal protein
KW-0694	RNA-binding
KW-0699	rRNA-binding
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005829	Cellular Component	Cytosol
GO:0022625	Cellular Component	Cytosolic large ribosomal subunit
GO:0005925	Cellular Component	Focal adhesion
GO:0016020	Cellular Component	Membrane
GO:0042788	Cellular Component	Polysomal ribosome
GO:0098794	Cellular Component	Postsynapse
GO:0014069	Cellular Component	Postsynaptic density
GO:1990932	Molecular Function	5.8S rRNA binding
GO:0003723	Molecular Function	RNA binding
GO:0003735	Molecular Function	Structural constituent of ribosome
GO:1990090	Biological Process	Cellular response to nerve growth factor stimulus
GO:0002181	Biological Process	Cytoplasmic translation
GO:0000184	Biological Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006614	Biological Process	SRP-dependent cotranslational protein targeting to membrane
GO:0006412	Biological Process	Translation
GO:0006413	Biological Process	Translational initiation
GO:0019083	Biological Process	Viral transcription

▼ KEGG

hsa:6132

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
PROSITE	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
mUbiSiDa	PTMcode

Variation
VarCards	rSNPBase

Mutation
ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	RAIN	Mentha
PINA	IID	iRefIndex	DifferentialNET	RNAct

Disease
PancanQTL	TumorFusions	OMIM	ActiveDriverDB

Drug
DrugBank

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	ENPD	CORUM	CellMarker	RaftProt

Proteomics
THPA	HPM

Structure
PDB

Localization
COMPARTMENTS

Expression
ICGC	COSMIC	GEO	ArrayExpress	TISSUES
BioXpress	THPA

Element
UTRdb	circBase	miRWalk	miRcode	RAID

Methylation
TCGA	ICGC	COSMIC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Tut-0353	Tursiops truncatus	100.0	2e-177	496
LLPS-Bot-0034	Bos taurus	100.0	2e-177	496
LLPS-Dio-0210	Dipodomys ordii	100.0	2e-177	496
LLPS-Ran-2757	Rattus norvegicus	100.0	2e-177	496
LLPS-Ova-1019	Ovis aries	100.0	2e-177	496
LLPS-Myl-1364	Myotis lucifugus	100.0	2e-177	496
LLPS-Aim-0092	Ailuropoda melanoleuca	100.0	2e-177	496
LLPS-Mup-1527	Mustela putorius furo	100.0	2e-177	496
LLPS-Paa-0355	Papio anubis	100.0	2e-177	496
LLPS-Mal-1488	Mandrillus leucophaeus	100.0	2e-143	408
LLPS-Chs-1131	Chlorocebus sabaeus	100.0	2e-177	496
LLPS-Mum-0364	Mus musculus	100.0	2e-177	496
LLPS-Maf-2553	Macaca fascicularis	100.0	2e-177	496
LLPS-Aon-2435	Aotus nancymaae	100.0	2e-177	496
LLPS-Cea-0161	Cercocebus atys	100.0	2e-177	496
LLPS-Sus-3192	Sus scrofa	100.0	2e-177	496
LLPS-Gog-1292	Gorilla gorilla	100.0	2e-177	496
LLPS-Caj-0961	Callithrix jacchus	100.0	2e-177	496
LLPS-Fud-0583	Fukomys damarensis	100.0	2e-177	496
LLPS-Cap-0281	Cavia porcellus	100.0	2e-177	496
LLPS-Caf-0926	Canis familiaris	100.0	2e-177	496
LLPS-Poa-0387	Pongo abelii	100.0	2e-177	496
LLPS-Mam-2351	Macaca mulatta	100.0	2e-177	496
LLPS-Cas-0012	Carlito syrichta	100.0	2e-177	496
LLPS-Ict-1029	Ictidomys tridecemlineatus	100.0	2e-177	496
LLPS-Nol-2721	Nomascus leucogenys	100.0	2e-177	496
LLPS-Fec-2446	Felis catus	100.0	2e-177	496
LLPS-Pap-0396	Pan paniscus	100.0	2e-177	496
LLPS-Urm-0175	Ursus maritimus	100.0	1e-131	379
LLPS-Pat-1950	Pan troglodytes	100.0	2e-177	496
LLPS-Loa-0805	Loxodonta africana	100.0	2e-137	392
LLPS-Man-0587	Macaca nemestrina	100.0	2e-177	496
LLPS-Otg-0453	Otolemur garnettii	100.0	2e-177	496
LLPS-Rhb-0883	Rhinopithecus bieti	100.0	2e-177	496
LLPS-Orc-0105	Oryctolagus cuniculus	100.0	2e-177	496
LLPS-Eqc-0755	Equus caballus	99.61	2e-176	493
LLPS-Sah-0542	Sarcophilus harrisii	99.22	3e-176	493
LLPS-Anc-1036	Anolis carolinensis	99.22	9e-177	494
LLPS-Mod-1466	Monodelphis domestica	98.83	4e-176	493
LLPS-Gaga-2348	Gallus gallus	98.05	8e-175	489
LLPS-Tag-0832	Taeniopygia guttata	98.05	5e-175	490
LLPS-Meg-1323	Meleagris gallopavo	98.05	8e-175	489
LLPS-Pes-0316	Pelodiscus sinensis	98.05	8e-175	489
LLPS-Fia-0655	Ficedula albicollis	98.05	8e-175	489
LLPS-Scf-0558	Scleropages formosus	97.67	6e-174	488
LLPS-Xet-1703	Xenopus tropicalis	97.67	5e-175	490
LLPS-Xim-1530	Xiphophorus maculatus	97.28	3e-174	488
LLPS-Pof-0743	Poecilia formosa	97.28	3e-174	488
LLPS-Dar-2186	Danio rerio	96.89	1e-173	486
LLPS-Ten-2378	Tetraodon nigroviridis	96.5	6e-172	482
LLPS-Gaa-0559	Gasterosteus aculeatus	96.11	1e-172	484
LLPS-Leo-0337	Lepisosteus oculatus	96.11	5e-174	487
LLPS-Orl-1517	Oryzias latipes	96.11	3e-172	483
LLPS-Lac-0899	Latimeria chalumnae	96.11	1e-173	486
LLPS-Scm-0641	Scophthalmus maximus	96.11	5e-173	484
LLPS-Orn-1098	Oreochromis niloticus	96.11	2e-172	484
LLPS-Anp-2489	Anas platyrhynchos	95.62	9e-164	461
LLPS-Icp-2935	Ictalurus punctatus	95.33	8e-171	479
LLPS-Asm-0072	Astyanax mexicanus	93.77	7e-169	474
LLPS-Tar-0306	Takifugu rubripes	92.89	2e-151	431
LLPS-Drm-0687	Drosophila melanogaster	80.8	2e-138	397
LLPS-Cii-0097	Ciona intestinalis	78.12	2e-142	407
LLPS-Cis-0536	Ciona savignyi	77.34	2e-140	402
LLPS-Gas-0970	Galdieria sulphuraria	75.71	1e-128	372
LLPS-Abg-0563	Absidia glauca	74.8	4e-130	376
LLPS-Coc-0534	Corchorus capsularis	72.98	2e-125	364
LLPS-Cae-0113	Caenorhabditis elegans	72.97	8e-133	383
LLPS-Gor-0341	Gossypium raimondii	72.58	2e-126	367
LLPS-Chc-0873	Chondrus crispus	72.44	2e-126	366
LLPS-Brn-0216	Brassica napus	72.18	2e-125	364
LLPS-Thc-0779	Theobroma cacao	72.18	2e-125	364
LLPS-Bro-0742	Brassica oleracea	72.18	2e-125	364
LLPS-Viv-0019	Vitis vinifera	72.18	1e-124	362
LLPS-Chr-0146	Chlamydomonas reinhardtii	71.94	1e-123	360
LLPS-Via-0366	Vigna angularis	71.77	1e-126	367
LLPS-Vir-0621	Vigna radiata	71.77	5e-126	366
LLPS-Dac-0565	Daucus carota	71.77	2e-125	364
LLPS-Phv-0755	Phaseolus vulgaris	71.77	1e-126	367
LLPS-Sac-1102	Saccharomyces cerevisiae	71.65	3e-129	374
LLPS-Yal-0127	Yarrowia lipolytica	71.65	5e-128	370
LLPS-Crn-0732	Cryptococcus neoformans	71.6	2e-119	348
LLPS-Orgl-0993	Oryza glumaepatula	71.37	7e-125	363
LLPS-Lep-1163	Leersia perrieri	71.37	7e-125	363
LLPS-Cus-0219	Cucumis sativus	71.37	1e-123	360
LLPS-Arl-2342	Arabidopsis lyrata	71.37	1e-123	360
LLPS-Glm-0054	Glycine max	71.37	3e-125	363
LLPS-Ori-0484	Oryza indica	71.37	7e-125	363
LLPS-Orb-1064	Oryza barthii	71.37	7e-125	363
LLPS-Orni-1105	Oryza nivara	71.37	7e-125	363
LLPS-Orm-0320	Oryza meridionalis	71.37	7e-125	363
LLPS-Orr-0867	Oryza rufipogon	71.37	7e-125	363
LLPS-Prp-0110	Prunus persica	71.37	5e-125	363
LLPS-Org-0747	Oryza glaberrima	71.37	7e-125	363
LLPS-Art-0484	Arabidopsis thaliana	71.37	6e-124	360
LLPS-Ors-0371	Oryza sativa	71.37	7e-125	363
LLPS-Brr-1239	Brassica rapa	71.37	2e-124	362
LLPS-Orp-1596	Oryza punctata	71.37	7e-125	363
LLPS-Pot-1889	Populus trichocarpa	71.37	7e-125	363
LLPS-Mae-0013	Manihot esculenta	71.37	3e-123	359
LLPS-Osl-0171	Ostreococcus lucimarinus	71.2	6e-118	345
LLPS-Put-0497	Puccinia triticina	71.08	2e-123	359
LLPS-Pug-0287	Puccinia graminis	71.08	2e-123	359
LLPS-Sot-0754	Solanum tuberosum	70.97	2e-123	359
LLPS-Sei-1111	Setaria italica	70.97	2e-124	361
LLPS-Sol-1595	Solanum lycopersicum	70.97	2e-123	359
LLPS-Mua-1272	Musa acuminata	70.97	2e-123	359
LLPS-Sob-0774	Sorghum bicolor	70.97	8e-124	360
LLPS-Nia-0774	Nicotiana attenuata	70.97	6e-124	360
LLPS-Sem-0431	Selaginella moellendorffii	70.56	2e-121	354
LLPS-Hea-0516	Helianthus annuus	70.56	2e-123	359
LLPS-Zem-1003	Zea mays	70.56	6e-123	358
LLPS-Orbr-0426	Oryza brachyantha	70.56	3e-123	358
LLPS-Amt-0630	Amborella trichopoda	70.56	4e-123	358
LLPS-Kop-0437	Komagataella pastoris	70.47	4e-122	355
LLPS-Mel-0812	Melampsora laricipopulina	70.47	7e-127	367
LLPS-Usm-0450	Ustilago maydis	70.28	2e-121	354
LLPS-Brd-1058	Brachypodium distachyon	70.16	1e-123	360
LLPS-Php-0527	Physcomitrella patens	70.16	2e-120	352
LLPS-Spr-0509	Sporisorium reilianum	69.88	1e-120	352
LLPS-Tra-0741	Triticum aestivum	69.76	3e-122	356
LLPS-Met-1062	Medicago truncatula	69.76	6e-123	358
LLPS-Hov-0005	Hordeum vulgare	69.76	2e-122	357
LLPS-Asg-0122	Ashbya gossypii	69.69	2e-127	369
LLPS-Miv-0499	Microbotryum violaceum	69.69	2e-121	354
LLPS-Scj-0525	Schizosaccharomyces japonicus	68.5	1e-118	347
LLPS-Scs-0287	Sclerotinia sclerotiorum	68.5	4e-120	350
LLPS-Gag-0164	Gaeumannomyces graminis	68.11	2e-119	349
LLPS-Mao-0369	Magnaporthe oryzae	68.11	4e-119	348
LLPS-Scp-0362	Schizosaccharomyces pombe	67.72	4e-119	348
LLPS-Cog-0825	Colletotrichum gloeosporioides	67.72	4e-119	348
LLPS-Zyt-0653	Zymoseptoria tritici	67.32	4e-117	343
LLPS-Coo-0002	Colletotrichum orbiculare	67.32	7e-118	345
LLPS-Cym-0214	Cyanidioschyzon merolae	67.32	1e-111	329
LLPS-Dos-0665	Dothistroma septosporum	67.32	1e-116	341
LLPS-Tru-0004	Triticum urartu	67.32	3e-119	348
LLPS-Scc-1318	Schizosaccharomyces cryophilus	67.07	6e-65	214
LLPS-Asni-0037	Aspergillus niger	66.93	4e-115	338
LLPS-Map-0546	Magnaporthe poae	66.93	2e-118	346
LLPS-Asfu-0273	Aspergillus fumigatus	66.93	3e-116	340
LLPS-Nef-0249	Neosartorya fischeri	66.93	3e-116	341
LLPS-Cogr-0116	Colletotrichum graminicola	66.67	2e-115	338
LLPS-Blg-0664	Blumeria graminis	66.54	3e-115	338
LLPS-Nec-0088	Neurospora crassa	66.54	1e-117	344
LLPS-Asf-0186	Aspergillus flavus	66.54	4e-115	338
LLPS-Asc-0833	Aspergillus clavatus	66.54	8e-116	340
LLPS-Trv-1009	Trichoderma virens	66.54	3e-115	338
LLPS-Ved-0552	Verticillium dahliae	66.54	3e-117	343
LLPS-Trr-0447	Trichoderma reesei	66.54	3e-115	338
LLPS-Fuv-0530	Fusarium verticillioides	66.14	5e-116	340
LLPS-Fuo-0433	Fusarium oxysporum	66.14	5e-116	340
LLPS-Beb-0503	Beauveria bassiana	66.14	3e-115	338
LLPS-Ast-0628	Aspergillus terreus	66.14	6e-116	340
LLPS-Fus-0012	Fusarium solani	66.14	6e-116	340
LLPS-Asn-0320	Aspergillus nidulans	65.75	2e-113	333
LLPS-Pyt-0175	Pyrenophora teres	64.96	3e-112	330
LLPS-Pytr-0468	Pyrenophora triticirepentis	64.96	2e-112	332
LLPS-Lem-0703	Leptosphaeria maculans	64.57	1e-111	329
LLPS-Tum-0459	Tuber melanosporum	64.03	4e-106	317
LLPS-Phn-0669	Phaeosphaeria nodorum	59.45	1e-93	282

LLPS-Hos-0259RPL8

Protein Sequence

Nucleotide Sequence

LLPS-Hos-0259
RPL8