LLPS-Hos-0111
LYZ

▼ OVERVIEW

Status: Reviewed
Protein Name: Lysozyme C; 1,4-beta-N-acetylmuramidase C
Gene Name: LYZ, LZM
Ensembl Gene: ENSG00000090382.6
Ensembl Protein: ENSP00000449898.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Scaffold
PDB: 1W08 (A, NULL) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...Comparing protein relative abundances between the sorted and pre-sorted fractions, we identified 125 proteins as significantly enriched in P-bodies."
HEK293 cells28965817
DropletPredicted from orthologsIn vitro(View)

▼ FUNCTION

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKALIVLGLV  LLSVTVQGKV  FERCELARTL  KRLGMDGYRG  ISLANWMCLA  KWESGYNTRA  60
61    TNYNAGDRST  DYGIFQINSR  YWCNDGKTPG  AVNACHLSCS  ALLQDNIADA  VACAKRVVRD  120
121   PQGIRAWVAW  RNRCQNRDVR  QYVQGCGV  148
Nucleotide CDS Sequence (FASTA)
1     ATGAAGGCTC  TCATTGTTCT  GGGGCTTGTC  CTCCTTTCTG  TTACGGTCCA  GGGCAAGGTC  60
61    TTTGAAAGGT  GTGAGTTGGC  CAGAACTCTG  AAAAGATTGG  GAATGGATGG  CTACAGGGGA  120
121   ATCAGCCTAG  CAAACTGGAT  GTGTTTGGCC  AAATGGGAGA  GTGGTTACAA  CACACGAGCT  180
181   ACAAACTACA  ATGCTGGAGA  CAGAAGCACT  GATTATGGGA  TATTTCAGAT  CAATAGCCGC  240
241   TACTGGTGTA  ATGATGGCAA  AACCCCAGGA  GCAGTTAATG  CCTGTCATTT  ATCCTGCAGT  300
301   GCTTTGCTGC  AAGATAACAT  CGCTGATGCT  GTAGCTTGTG  CAAAGAGGGT  TGTCCGTGAT  360
361   CCACAAGGCA  TTAGAGCATG  GGTGGCATGG  AGAAATCGTT  GTCAAAACAG  AGATGTCCGT  420
421   CAGTATGTTC  AAGGTTGTGG  AGTGTAA  447

▼ KEYWORD

ID
Family
3D-structure
Amyloid
Amyloidosis
Antimicrobial
Bacteriolytic enzyme
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycosidase
Hydrolase
Polymorphism
Reference proteome
Secreted
Signal

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Azurophil granule lumen
Cellular Component
Extracellular exosome
Cellular Component
Extracellular region
Cellular Component
Extracellular space
Cellular Component
Specific granule lumen
Cellular Component
Tertiary granule lumen
Molecular Function
Identical protein binding
Molecular Function
Lysozyme activity
Biological Process
Antimicrobial humoral response
Biological Process
Cellular protein metabolic process
Biological Process
Cytolysis
Biological Process
Defense response to bacterium
Biological Process
Defense response to Gram-negative bacterium
Biological Process
Defense response to Gram-positive bacterium
Biological Process
Inflammatory response
Biological Process
Killing of cells of other organism
Biological Process
Neutrophil degranulation
Biological Process
Retina homeostasis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-1836Pan troglodytes100.04e-105 303
LLPS-Pap-0434Pan paniscus100.04e-105 303
LLPS-Gog-0589Gorilla gorilla98.651e-103 300
LLPS-Poa-0211Pongo abelii97.971e-103 300
LLPS-Nol-0807Nomascus leucogenys96.625e-103 298
LLPS-Chs-0824Chlorocebus sabaeus89.864e-97 283
LLPS-Cea-0211Cercocebus atys88.512e-95 279
LLPS-Maf-2614Macaca fascicularis88.511e-95 280
LLPS-Mal-0328Mandrillus leucophaeus88.512e-95 279
LLPS-Paa-1025Papio anubis88.512e-95 279
LLPS-Mam-1901Macaca mulatta88.511e-95 280
LLPS-Aon-4398Aotus nancymaae87.844e-94 276
LLPS-Man-0275Macaca nemestrina87.252e-62 194
LLPS-Caj-1787Callithrix jacchus86.491e-85 254
LLPS-Rhb-2121Rhinopithecus bieti86.493e-94 276
LLPS-Ict-3525Ictidomys tridecemlineatus84.463e-85 253
LLPS-Otg-2633Otolemur garnettii83.114e-82 245
LLPS-Cap-3539Cavia porcellus83.111e-84 251
LLPS-Tut-0992Tursiops truncatus82.432e-82 246
LLPS-Loa-1205Loxodonta africana82.436e-82 244
LLPS-Eqc-1535Equus caballus81.765e-81 243
LLPS-Mup-1770Mustela putorius furo81.085e-81 243
LLPS-Bot-4160Bos taurus81.088e-83 247
LLPS-Urm-2187Ursus maritimus81.081e-79 240
LLPS-Aim-3134Ailuropoda melanoleuca80.412e-79 238
LLPS-Caf-3730Canis familiaris80.411e-80 241
LLPS-Dio-2946Dipodomys ordii80.142e-84 251
LLPS-Ova-1860Ovis aries79.733e-86 256
LLPS-Myl-1402Myotis lucifugus79.739e-80 239
LLPS-Orc-0933Oryctolagus cuniculus79.054e-82 245
LLPS-Fec-4248Felis catus79.055e-81 242
LLPS-Fud-3180Fukomys damarensis76.987e-70 214
LLPS-Mum-3821Mus musculus76.352e-74 226
LLPS-Mod-2336Monodelphis domestica76.034e-79 239
LLPS-Cas-0031Carlito syrichta75.01e-73 224
LLPS-Ora-1578Ornithorhynchus anatinus73.654e-77 233
LLPS-Ran-2999Rattus norvegicus71.622e-69 213
LLPS-Ten-3435Tetraodon nigroviridis71.546e-61 192
LLPS-Mea-2800Mesocricetus auratus70.958e-70 214
LLPS-Sus-0797Sus scrofa70.452e-68 210
LLPS-Scf-1311Scleropages formosus69.235e-57 181
LLPS-Tar-0246Takifugu rubripes66.419e-57 181
LLPS-Pof-2168Poecilia formosa65.913e-56 179
LLPS-Pes-0283Pelodiscus sinensis64.862e-61 192
LLPS-Asm-1202Astyanax mexicanus64.622e-52 169
LLPS-Xim-1469Xiphophorus maculatus63.644e-55 177
LLPS-Sah-1437Sarcophilus harrisii61.644e-66 204
LLPS-Orl-2754Oryzias latipes61.493e-57 183
LLPS-Icp-0001Ictalurus punctatus60.772e-45 152
LLPS-Orn-0834Oreochromis niloticus60.282e-52 169
LLPS-Gaa-3546Gasterosteus aculeatus60.277e-57 181
LLPS-Anp-2294Anas platyrhynchos60.271e-58 185
LLPS-Gaga-0000Gallus gallus57.532e-56 179
LLPS-Meg-0574Meleagris gallopavo56.164e-55 176
LLPS-Xet-3425Xenopus tropicalis56.162e-52 169
LLPS-Fia-1407Ficedula albicollis53.447e-49 160
LLPS-Anc-3811Anolis carolinensis52.413e-42 144
LLPS-Lac-0870Latimeria chalumnae50.981e-33 120
LLPS-Drm-0725Drosophila melanogaster40.911e-26 103
LLPS-Dar-3757Danio rerio39.582e-31 116
LLPS-Ere-0001Erinaceus europaeus39.198e-33 119