LLPS-Cae-0549
sams-3

▼ OVERVIEW

Status: Unreviewed
Protein Name: Probable S-adenosylmethionine synthase 3
Gene Name: sams-3, C06E7.1
Ensembl Gene: WBGene00015538
Ensembl Protein: C06E7.1a
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblC06E7.1aC06E7.1a
UniProtP50305, METK3_CAEEL
GeneBankFO080387CCD63366.1
RefSeqNM_068471.5NP_500872.1
Entrez177355

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSQHKFLFTS  ESVSEGHPDK  MCDQISDAVL  DAHLAQDPHA  KVACETVTKT  GMIMLCGEIT  60
61    SKAVVDYQVL  VRNVIKKIGY  DDSSKGFDYK  TCNVLVALEQ  QSPEIAAGVH  VDKDSDDVGA  120
121   GDQGIMFGYA  TDETEEAMPL  TLLLSHKLNR  KLHELRRSGE  LEWVRPDSKT  QVTIEYASEG  180
181   GACVPLRVHT  VVISTQHSPD  ISLDDLRKEL  IEKVIKAVIP  ANLIDDKTIY  HLNPCGSFII  240
241   GGPMGDAGLT  GRKIIVDTYG  GWGAHGGGAF  SGKDPTKVDR  SAAYAARWVA  KSLVKSGLCR  300
301   RCLVQVSYAI  GVAKPLSVMV  FSFGTSALNE  GELLKIVNDN  FDLRPGMIIK  DLDLKKPIYE  360
361   PTAENGHFGH  NEFPWEQPRH  LQIDVELLKK  IGGKTISNGN  GIAH  404
Nucleotide CDS Sequence (FASTA)
1     Sequence u  navailable  20

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Magnesium
Metal-binding
Nucleotide-binding
One-carbon metabolism
Potassium
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Molecular Function
Methionine adenosyltransferase activity
Biological Process
One-carbon metabolic process
Biological Process
S-adenosylmethionine biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dar-0069Danio rerio75.360.0 517
LLPS-Bot-3022Bos taurus75.00.0 551
LLPS-Sus-4034Sus scrofa75.00.0 551
LLPS-Orn-1635Oreochromis niloticus75.00.0 563
LLPS-Meg-1498Meleagris gallopavo75.00.0 573
LLPS-Lac-0321Latimeria chalumnae75.00.0 575
LLPS-Xet-0456Xenopus tropicalis74.780.0 519
LLPS-Myl-2273Myotis lucifugus74.730.0 576
LLPS-Caj-0295Callithrix jacchus74.730.0 551
LLPS-Pes-0133Pelodiscus sinensis74.730.0 566
LLPS-Man-3151Macaca nemestrina74.730.0 551
LLPS-Mup-0096Mustela putorius furo74.540.0 567
LLPS-Aim-0592Ailuropoda melanoleuca74.540.0 567
LLPS-Gaa-1397Gasterosteus aculeatus74.540.0 557
LLPS-Fud-2583Fukomys damarensis74.540.0 568
LLPS-Icp-0087Ictalurus punctatus74.540.0 561
LLPS-Caf-1423Canis familiaris74.540.0 567
LLPS-Cap-1493Cavia porcellus74.540.0 566
LLPS-Otg-1686Otolemur garnettii74.540.0 567
LLPS-Fia-1380Ficedula albicollis74.540.0 567
LLPS-Fec-4399Felis catus74.540.0 567
LLPS-Mod-1707Monodelphis domestica74.540.0 568
LLPS-Loa-1113Loxodonta africana74.540.0 567
LLPS-Gaga-0823Gallus gallus74.470.0 572
LLPS-Anc-1589Anolis carolinensis74.470.0 565
LLPS-Eqc-0767Equus caballus74.460.0 546
LLPS-Ran-3799Rattus norvegicus74.270.0 568
LLPS-Paa-2923Papio anubis74.270.0 566
LLPS-Ova-3481Ovis aries74.270.0 563
LLPS-Dio-1975Dipodomys ordii74.270.0 566
LLPS-Gog-1123Gorilla gorilla74.270.0 566
LLPS-Mea-0384Mesocricetus auratus74.270.0 566
LLPS-Maf-1148Macaca fascicularis74.270.0 566
LLPS-Mum-3166Mus musculus74.270.0 566
LLPS-Chs-3280Chlorocebus sabaeus74.270.0 566
LLPS-Cea-1338Cercocebus atys74.270.0 566
LLPS-Aon-3122Aotus nancymaae74.270.0 566
LLPS-Poa-1460Pongo abelii74.270.0 566
LLPS-Mam-2050Macaca mulatta74.270.0 566
LLPS-Rhb-2929Rhinopithecus bieti74.270.0 566
LLPS-Pat-1352Pan troglodytes74.270.0 566
LLPS-Pap-1644Pan paniscus74.270.0 566
LLPS-Hos-1410Homo sapiens74.270.0 566
LLPS-Ict-1511Ictidomys tridecemlineatus74.010.0 564
LLPS-Pof-2477Poecilia formosa74.010.0 554
LLPS-Anp-0170Anas platyrhynchos73.940.0 569
LLPS-Cas-3062Carlito syrichta73.830.0 539
LLPS-Xim-1770Xiphophorus maculatus73.740.0 553
LLPS-Asm-3207Astyanax mexicanus73.740.0 542
LLPS-Orl-1999Oryzias latipes73.470.0 553
LLPS-Leo-3580Lepisosteus oculatus73.470.0 561
LLPS-Tag-1753Taeniopygia guttata73.470.0 558
LLPS-Urm-3561Ursus maritimus73.40.0 567
LLPS-Ten-3561Tetraodon nigroviridis73.210.0 558
LLPS-Drm-1266Drosophila melanogaster73.090.0 540
LLPS-Tar-2950Takifugu rubripes73.020.0 553
LLPS-Mal-2151Mandrillus leucophaeus72.870.0 563
LLPS-Nol-0149Nomascus leucogenys72.870.0 564
LLPS-Ora-3195Ornithorhynchus anatinus72.811e-169 485
LLPS-Scf-0619Scleropages formosus72.770.0 562
LLPS-Orc-1026Oryctolagus cuniculus72.560.0 561
LLPS-Sah-2557Sarcophilus harrisii71.960.0 562
LLPS-Yal-1099Yarrowia lipolytica70.870.0 539
LLPS-Spr-0242Sporisorium reilianum70.450.0 526
LLPS-Usm-0593Ustilago maydis69.660.0 521
LLPS-Fus-0472Fusarium solani69.130.0 524
LLPS-Fuv-0294Fusarium verticillioides68.874e-177 507
LLPS-Fuo-1211Fusarium oxysporum68.874e-177 507
LLPS-Scm-1553Scophthalmus maximus68.79e-177 506
LLPS-Mao-1555Magnaporthe oryzae68.60.0 524
LLPS-Trr-1346Trichoderma reesei68.60.0 524
LLPS-Lem-1484Leptosphaeria maculans68.590.0 517
LLPS-Asf-0281Aspergillus flavus68.520.0 522
LLPS-Aso-0972Aspergillus oryzae68.520.0 522
LLPS-Tum-0534Tuber melanosporum68.350.0 523
LLPS-Pyt-1142Pyrenophora teres68.354e-176 504
LLPS-Ved-1434Verticillium dahliae68.340.0 524
LLPS-Map-0958Magnaporthe poae68.256e-175 502
LLPS-Asfu-1142Aspergillus fumigatus68.161e-169 488
LLPS-Trv-0078Trichoderma virens68.072e-174 500
LLPS-Gag-0692Gaeumannomyces graminis67.993e-180 515
LLPS-Nef-1047Neosartorya fischeri67.891e-174 500
LLPS-Blg-1155Blumeria graminis67.550.0 517
LLPS-Beb-1295Beauveria bassiana67.362e-174 500
LLPS-Zyt-1323Zymoseptoria tritici66.931e-178 511
LLPS-Asni-0550Aspergillus niger66.930.0 521
LLPS-Coo-1398Colletotrichum orbiculare66.931e-172 499
LLPS-Phn-0147Phaeosphaeria nodorum66.855e-158 458
LLPS-Asc-1638Aspergillus clavatus66.840.0 521
LLPS-Dos-1282Dothistroma septosporum66.752e-171 492
LLPS-Cog-1285Colletotrichum gloeosporioides66.752e-177 508
LLPS-Asn-1459Aspergillus nidulans66.675e-174 499
LLPS-Cogr-1222Colletotrichum graminicola66.588e-179 511
LLPS-Miv-1180Microbotryum violaceum66.582e-163 472
LLPS-Gas-0809Galdieria sulphuraria66.415e-174 499
LLPS-Kop-0411Komagataella pastoris66.413e-175 502
LLPS-Scp-1449Schizosaccharomyces pombe65.790.0 519
LLPS-Pytr-1152Pyrenophora triticirepentis65.661e-158 459
LLPS-Scj-1316Schizosaccharomyces japonicus65.611e-179 513
LLPS-Sac-0627Saccharomyces cerevisiae64.818e-180 513
LLPS-Scc-1206Schizosaccharomyces cryophilus64.021e-175 503
LLPS-Asg-0492Ashbya gossypii62.88e-173 495
LLPS-Zem-2529Zea mays62.633e-157 457
LLPS-Met-1039Medicago truncatula62.52e-152 444
LLPS-Orgl-1775Oryza glumaepatula62.54e-154 448
LLPS-Orni-1417Oryza nivara62.56e-154 448
LLPS-Sem-2050Selaginella moellendorffii62.56e-155 450
LLPS-Orb-0310Oryza barthii62.54e-154 448
LLPS-Orr-0057Oryza rufipogon62.54e-154 448
LLPS-Orm-2003Oryza meridionalis62.54e-154 448
LLPS-Coc-0264Corchorus capsularis62.53e-153 446
LLPS-Sob-1371Sorghum bicolor62.56e-154 448
LLPS-Ors-1298Oryza sativa62.56e-154 448
LLPS-Hov-0471Hordeum vulgare62.312e-157 457
LLPS-Brd-0192Brachypodium distachyon62.245e-153 446
LLPS-Orbr-1919Oryza brachyantha62.242e-153 446
LLPS-Orp-1145Oryza punctata62.243e-153 446
LLPS-Prp-1969Prunus persica62.29e-154 447
LLPS-Viv-1749Vitis vinifera62.178e-151 441
LLPS-Tra-1071Triticum aestivum62.054e-157 456
LLPS-Tru-0896Triticum urartu62.051e-157 457
LLPS-Sei-0614Setaria italica61.981e-152 447
LLPS-Arl-1236Arabidopsis lyrata61.983e-151 441
LLPS-Lep-1398Leersia perrieri61.985e-153 447
LLPS-Art-1556Arabidopsis thaliana61.983e-151 441
LLPS-Brr-1228Brassica rapa61.824e-153 446
LLPS-Php-2391Physcomitrella patens61.721e-154 450
LLPS-Brn-1898Brassica napus61.723e-152 444
LLPS-Bro-0817Brassica oleracea61.725e-152 443
LLPS-Gor-1480Gossypium raimondii61.665e-153 446
LLPS-Chr-1223Chlamydomonas reinhardtii61.462e-156 454
LLPS-Hea-0846Helianthus annuus61.463e-151 443
LLPS-Org-2200Oryza glaberrima61.461e-151 442
LLPS-Pot-0114Populus trichocarpa61.41e-152 444
LLPS-Glm-2331Glycine max61.341e-152 444
LLPS-Mae-0443Manihot esculenta61.31e-151 442
LLPS-Sol-0656Solanum lycopersicum61.21e-152 444
LLPS-Amt-1643Amborella trichopoda61.24e-151 441
LLPS-Phv-0916Phaseolus vulgaris61.081e-151 442
LLPS-Via-1976Vigna angularis61.033e-152 443
LLPS-Mua-0437Musa acuminata60.575e-151 441
LLPS-Nia-2442Nicotiana attenuata60.161e-150 439
LLPS-Cym-0405Cyanidioschyzon merolae60.14e-160 464