LLPS-Gaga-a190
CHMP4B
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Charged multivesicular body protein 4b; Chromatin-modifying protein 4b; CHMP4b |
| Gene Name: | CHMP4B, RCJMB04_34n7 |
| Ensembl Gene: | ENSGALG00000002095.3 |
| Ensembl Protein: | ENSGALP00000003263.2 |
| Organism: | Gallus gallus |
| Taxa ID: | 9031 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSGALT00000003268.3 | ENSGALP00000003263.2 |
| UniProt | Q5ZHP5, CHM4B_CHICK | |
| GeneBank | AJ721089 | CAG32748.1 |
| RefSeq | NM_001006286.1 | NP_001006286.1 |
| Entrez | 419150 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSGILGKLFG AGAGGKGAGK GPSPQEAIQR LRDTEEMLSK KQEFLEKKIE QELAAARKHG 60 61 TKNKRAALQA LKRKKRYEKQ LAQIDGTLST IEFQREALEN ANTNTEVLKN MGFAAKAMKA 120 121 AHDNMDIDKV DELMQDIAEQ QELADEISTA ISKPVGFGEE FDEDELMAEL EELEQEELDK 180 181 NLLEISGPET VPLPNVPSIS IPSKPAKKKE EEEDDDMKEL EAWAGNM 227 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGGGGA TCCTGGGGAA GCTGTTCGGG GCCGGCGCCG GCGGGAAGGG CGCCGGGAAG 60 61 GGCCCGTCCC CTCAGGAGGC CATCCAGCGG CTGCGGGACA CGGAGGAGAT GCTGAGCAAG 120 121 AAGCAGGAGT TCCTGGAGAA GAAGATCGAG CAGGAGCTGG CGGCCGCCCG CAAACACGGC 180 181 ACCAAGAACA AGCGCGCTGC TCTTCAGGCC CTAAAGCGTA AGAAGAGGTA TGAGAAGCAG 240 241 CTTGCACAGA TAGATGGCAC GTTGTCCACA ATCGAATTTC AGAGGGAAGC CCTGGAGAAT 300 301 GCCAACACCA ACACTGAAGT GCTTAAGAAT ATGGGTTTTG CTGCTAAAGC TATGAAAGCT 360 361 GCTCATGACA ACATGGATAT TGATAAAGTA GATGAATTAA TGCAGGACAT TGCGGAGCAG 420 421 CAAGAGCTGG CAGATGAGAT TTCAACAGCG ATCTCAAAGC CAGTAGGATT TGGGGAGGAA 480 481 TTTGATGAGG ATGAACTCAT GGCAGAACTA GAGGAACTAG AACAAGAAGA ATTAGACAAA 540 541 AACTTGCTGG AAATAAGTGG TCCCGAAACA GTACCACTAC CAAATGTGCC CTCAATATCA 600 601 ATACCATCAA AGCCAGCCAA GAAGAAAGAG GAAGAGGAGG ATGATGACAT GAAAGAGCTG 660 661 GAAGCTTGGG CAGGAAACAT GTAA 684 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasmic side of plasma membrane | |
Cellular Component | Cytosol | |
Cellular Component | ESCRT III complex | |
Cellular Component | Late endosome membrane | |
Cellular Component | Membrane coat | |
Cellular Component | Midbody | |
Cellular Component | Nuclear envelope | |
Molecular Function | Protein homodimerization activity | |
Biological Process | Autophagy | |
Biological Process | Exit from mitosis | |
Biological Process | Maintenance of lens transparency | |
Biological Process | Membrane fission | |
Biological Process | Midbody abscission | |
Biological Process | Mitotic cytokinesis | |
Biological Process | Mitotic metaphase plate congression | |
Biological Process | Negative regulation of autophagosome assembly | |
Biological Process | Negative regulation of neuron death | |
Biological Process | Nuclear envelope reassembly | |
Biological Process | Positive regulation of viral release from host cell | |
Biological Process | Posttranslational protein targeting to endoplasmic reticulum membrane | |
Biological Process | Protein homooligomerization | |
Biological Process | Regulation of centrosome duplication | |
Biological Process | Regulation of mitotic spindle assembly | |
Biological Process | Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway | |
Biological Process | Vacuolar transport | |
Biological Process | Viral budding via host ESCRT complex |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-a202 | Mus musculus | 3e-110 | 325 | undefined |
| LLPS-Hos-a206 | Homo sapiens | 2e-110 | 325 | undefined |