LLPS-Fec-3314
RUNX1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Runt-related transcription factor |
| Gene Name: | RUNX1 |
| Ensembl Gene: | ENSFCAG00000006761.5 |
| Ensembl Protein: | ENSFCAP00000006283.5 |
| Organism: | Felis catus |
| Taxa ID: | 9685 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| PML nuclear body | Predicted from orthologs | (View) |
▼ FUNCTION
| Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSFCAT00000006763.5 | ENSFCAP00000006283.5 |
| Ensembl | ENSFCAT00000057393.1 | ENSFCAP00000041320.1 |
| Ensembl | ENSFCAT00000043785.2 | ENSFCAP00000026343.2 |
| Ensembl | ENSFCAT00000029996.3 | ENSFCAP00000019526.3 |
| UniProt | A0A2I2U1P9, A0A2I2U1P9_FELCA | |
| GeneBank | AANG04004523 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MASDSIFESF PSYPQCFMRE CVHGMNPSRD VHDASTSRRF TPPSTALSPG KMSEALPLGA 60 61 PDAGAALAGK LRSGDRSMVE VLADHPGELV RTDSPNFLCS VLPTHWRCNK TLPIAFKVVA 120 121 LGDVPDGTLV TVMAGNDENY SAELRNATAA MKNQVARFND LRFVGRSGRG KSFTLTITVF 180 181 TNPPQVATYH RAIKITVDGP REPRRHRQKL DDQTKPGSLS FSERLSELEQ LRRTAMRVSP 240 241 HHPAPTPNPR ASLNHSTAFN PQPQSQMQDT RQIQPSPPWS YDQSYQYLGS IASPSVHPAT 300 301 PISPGRASGM TTLSAEISSR LSTAPDLTAF GDPRQFPALP SISDPRMHYP GAFTYSPTPV 360 361 TSGIGIGMSA MSSATRYHTY LPPPYPGSSQ AQGGPFQASS PSYHLYYGAS AGSYQFSMVG 420 421 GERSPPRILP PCTNASTGSA LLNPSLPNQS DVVEAEGSHS NSPTNMAPAA RLEEAVWRPY 480 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTTCAG ACAGCATATT TGAGTCATTT CCTTCATACC CACAGTGCTT CATGAGAGAT 60 61 GCCAGCACGA GCCGCCGCTT CACGCCGCCT TCCACCGCGC TGAGCCCGGG CAAGATGAGC 120 121 GAGGCGCTGC CGCTGGGCGC CCCGGACGCC GGCGCCGCCC TGGCCGGCAA GCTGAGGAGC 180 181 GGCGACCGCA GCATGGTGGA GGTGCTGGCC GACCACCCCG GCGAGCTGGT GCGCACCGAC 240 241 AGCCCCAACT TCCTCTGCTC CGTGTTGCCC ACGCACTGGC GCTGCAACAA GACCCTGCCC 300 301 ATCGCTTTCA AGGTGGTGGC TCTGGGGGAT GTCCCAGATG GTACTCTGGT CACTGTGATG 360 361 GCAGGCAATG ACGAAAACTA CTCAGCCGAA CTGAGAAATG CCACCGCAGC CATGAAAAAC 420 421 CAAGTTGCAA GATTCAATGA CCTCAGGTTT GTCGGTCGGA GTGGACGAGG GAAGAGCTTC 480 481 ACTTTGACAA TCACGGTCTT CACGAACCCA CCACAAGTTG CCACGTACCA CAGAGCCATC 540 541 AAAATCACAG TGGATGGACC CCGGGAACCT CGAAGACATC GTCAGAAACT AGATGATCAG 600 601 ACCAAGCCCG GGAGCTTGTC CTTTTCCGAG CGGCTCAGTG AGCTGGAGCA GCTGCGGCGA 660 661 ACAGCCATGA GGGTCAGCCC ACACCACCCA GCCCCCACAC CCAACCCTCG GGCCTCCTTG 720 721 AACCACTCCA CTGCCTTTAA CCCTCAGCCT CAGAGTCAGA TGCAGGACAC AAGGCAGATC 780 781 CAGCCGTCCC CACCGTGGTC CTATGACCAG TCCTACCAGT ACCTGGGATC AATCGCCTCG 840 841 CCTTCCGTAC ACCCAGCAAC GCCCATCTCG CCTGGACGGG CCAGCGGCAT GACAACCCTC 900 901 TCCGCAGAGA TTTCCAGTCG ACTCTCAACG GCGCCCGACC TGACGGCCTT CGGCGACCCG 960 961 CGCCAGTTCC CCGCGCTGCC CTCCATCTCA GACCCTCGCA TGCACTACCC CGGCGCCTTC 1020 1021 ACCTACTCCC CGACGCCCGT CACGTCGGGC ATCGGCATCG GCATGTCGGC CATGAGCTCG 1080 1081 GCCACGCGCT ACCACACGTA CCTGCCGCCG CCCTACCCCG GCTCGTCGCA GGCGCAGGGC 1140 1141 GGCCCCTTCC AGGCCAGCTC GCCCTCCTAC CACCTGTACT ACGGCGCCTC GGCCGGCTCC 1200 1201 TACCAGTTCT CCATGGTGGG CGGCGAGCGC TCGCCGCCGC GCATCCTGCC GCCCTGCACC 1260 1261 AACGCGTCCA CGGGCTCGGC GCTGCTCAAC CCCAGCCTCC CGAACCAGAG CGACGTGGTG 1320 1321 GAGGCCGAGG GCAGCCACAG CAACTCGCCC ACCAACATGG CGCCCGCCGC GCGCCTCGAG 1380 1381 GAGGCCGTGT GGCGGCCCTA CTGA 1404 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleoplasm | |
Molecular Function | ATP binding | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II proximal promoter sequence-specific DNA binding | |
Biological Process | Hemopoiesis | |
Biological Process | Positive regulation of granulocyte differentiation | |
Biological Process | Positive regulation of interleukin-2 production |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Urm-0270 | Ursus maritimus | 100.0 | 2e-15 | 77.0 |
| LLPS-Mup-0357 | Mustela putorius furo | 99.38 | 0.0 | 875 |
| LLPS-Chs-2761 | Chlorocebus sabaeus | 99.12 | 0.0 | 821 |
| LLPS-Poa-1507 | Pongo abelii | 98.96 | 0.0 | 874 |
| LLPS-Bot-3621 | Bos taurus | 98.96 | 0.0 | 873 |
| LLPS-Nol-0185 | Nomascus leucogenys | 98.82 | 0.0 | 753 |
| LLPS-Pat-1471 | Pan troglodytes | 98.75 | 0.0 | 871 |
| LLPS-Pap-0517 | Pan paniscus | 98.75 | 0.0 | 871 |
| LLPS-Hos-2389 | Homo sapiens | 98.75 | 0.0 | 871 |
| LLPS-Man-2048 | Macaca nemestrina | 98.75 | 0.0 | 871 |
| LLPS-Paa-2605 | Papio anubis | 98.75 | 0.0 | 871 |
| LLPS-Mal-1275 | Mandrillus leucophaeus | 98.75 | 0.0 | 871 |
| LLPS-Gog-2139 | Gorilla gorilla | 98.75 | 0.0 | 871 |
| LLPS-Caj-3610 | Callithrix jacchus | 98.75 | 0.0 | 869 |
| LLPS-Maf-2025 | Macaca fascicularis | 98.75 | 0.0 | 871 |
| LLPS-Cea-0601 | Cercocebus atys | 98.75 | 0.0 | 871 |
| LLPS-Sus-1500 | Sus scrofa | 98.75 | 0.0 | 871 |
| LLPS-Caf-1628 | Canis familiaris | 98.7 | 0.0 | 838 |
| LLPS-Mam-0258 | Macaca mulatta | 98.27 | 0.0 | 832 |
| LLPS-Eqc-2861 | Equus caballus | 98.01 | 0.0 | 800 |
| LLPS-Fud-1710 | Fukomys damarensis | 98.01 | 0.0 | 743 |
| LLPS-Meg-0246 | Meleagris gallopavo | 97.8 | 2e-52 | 185 |
| LLPS-Otg-2545 | Otolemur garnettii | 97.59 | 0.0 | 803 |
| LLPS-Aon-2715 | Aotus nancymaae | 97.19 | 0.0 | 807 |
| LLPS-Rhb-0564 | Rhinopithecus bieti | 97.17 | 7e-143 | 417 |
| LLPS-Ict-3142 | Ictidomys tridecemlineatus | 96.46 | 0.0 | 837 |
| LLPS-Orc-1870 | Oryctolagus cuniculus | 96.25 | 0.0 | 829 |
| LLPS-Cap-0908 | Cavia porcellus | 95.21 | 0.0 | 822 |
| LLPS-Ora-1144 | Ornithorhynchus anatinus | 94.44 | 3e-41 | 148 |
| LLPS-Dio-2089 | Dipodomys ordii | 93.76 | 0.0 | 809 |
| LLPS-Mum-0602 | Mus musculus | 93.54 | 0.0 | 806 |
| LLPS-Ran-3440 | Rattus norvegicus | 92.92 | 0.0 | 798 |
| LLPS-Aim-0515 | Ailuropoda melanoleuca | 92.63 | 0.0 | 725 |
| LLPS-Mod-3621 | Monodelphis domestica | 91.31 | 0.0 | 761 |
| LLPS-Pes-2844 | Pelodiscus sinensis | 89.87 | 0.0 | 751 |
| LLPS-Anp-1743 | Anas platyrhynchos | 89.59 | 2e-177 | 508 |
| LLPS-Sah-0149 | Sarcophilus harrisii | 88.36 | 0.0 | 789 |
| LLPS-Xet-1762 | Xenopus tropicalis | 88.13 | 0.0 | 707 |
| LLPS-Gaga-0014 | Gallus gallus | 86.83 | 0.0 | 763 |
| LLPS-Fia-0456 | Ficedula albicollis | 84.39 | 0.0 | 731 |
| LLPS-Ova-0107 | Ovis aries | 84.16 | 0.0 | 572 |
| LLPS-Cii-1095 | Ciona intestinalis | 82.14 | 2e-37 | 147 |
| LLPS-Leo-1797 | Lepisosteus oculatus | 79.83 | 0.0 | 627 |
| LLPS-Drm-1936 | Drosophila melanogaster | 78.51 | 8e-57 | 207 |
| LLPS-Lac-2655 | Latimeria chalumnae | 78.22 | 1e-102 | 314 |
| LLPS-Cis-1246 | Ciona savignyi | 76.92 | 2e-67 | 220 |
| LLPS-Myl-3393 | Myotis lucifugus | 74.78 | 0.0 | 535 |
| LLPS-Scf-0516 | Scleropages formosus | 73.79 | 0.0 | 617 |
| LLPS-Dar-1127 | Danio rerio | 71.77 | 0.0 | 525 |
| LLPS-Icp-2623 | Ictalurus punctatus | 67.53 | 5e-176 | 510 |
| LLPS-Asm-1441 | Astyanax mexicanus | 65.57 | 3e-168 | 490 |
| LLPS-Orn-1557 | Oreochromis niloticus | 65.15 | 3e-169 | 493 |
| LLPS-Pof-1980 | Poecilia formosa | 64.17 | 5e-169 | 493 |
| LLPS-Xim-0579 | Xiphophorus maculatus | 63.8 | 2e-170 | 496 |
| LLPS-Anc-1536 | Anolis carolinensis | 61.04 | 1e-175 | 509 |
| LLPS-Scm-3650 | Scophthalmus maximus | 60.56 | 1e-171 | 500 |
| LLPS-Orl-1687 | Oryzias latipes | 59.96 | 3e-158 | 468 |
| LLPS-Tar-3407 | Takifugu rubripes | 59.31 | 3e-179 | 518 |
| LLPS-Gaa-3282 | Gasterosteus aculeatus | 59.23 | 3e-176 | 510 |
| LLPS-Ten-3737 | Tetraodon nigroviridis | 59.11 | 2e-178 | 516 |
| LLPS-Tag-2807 | Taeniopygia guttata | 57.97 | 2e-170 | 499 |
| LLPS-Loa-2153 | Loxodonta africana | 56.18 | 2e-156 | 459 |
| LLPS-Tut-1758 | Tursiops truncatus | 55.2 | 3e-153 | 451 |
| LLPS-Mea-2403 | Mesocricetus auratus | 54.86 | 2e-154 | 453 |
| LLPS-Cae-0781 | Caenorhabditis elegans | 54.31 | 9e-33 | 131 |