LLPS-Fec-2141
APP
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Amyloid-beta A4 protein |
| Gene Name: | APP |
| Ensembl Gene: | ENSFCAG00000001556.5 |
| Ensembl Protein: | ENSFCAP00000001445.4 |
| Organism: | Felis catus |
| Taxa ID: | 9685 |
| LLPS Type: | Scaffold |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSFCAT00000001556.5 | ENSFCAP00000001445.4 |
| Ensembl | ENSFCAT00000066716.1 | ENSFCAP00000044319.1 |
| Ensembl | ENSFCAT00000061187.1 | ENSFCAP00000040492.1 |
| Ensembl | ENSFCAT00000065428.1 | ENSFCAP00000043534.1 |
| Ensembl | ENSFCAT00000065435.1 | ENSFCAP00000048494.1 |
| Ensembl | ENSFCAT00000062995.1 | ENSFCAP00000047617.1 |
| Ensembl | ENSFCAT00000060752.1 | ENSFCAP00000043449.1 |
| Ensembl | ENSFCAT00000059369.1 | ENSFCAP00000047530.1 |
| UniProt | A0A0A0MPX8, A0A0A0MPX8_FELCA | |
| GeneBank | AANG04001815 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSQAHGDERR ALSTFLEPER PTTHLSLILH RSSPGPRLSL RLAEAPGGRR PAAGAGRAGE 60 61 EAAAPVGAGG AGPSRPERAQ LPGGSARGSL SGAERGGLDQ LTRRAPSPAA ALQLRQFPRQ 120 121 RLERAAGAAR ARGPSETAAA TAPAEPGRGG SHSHSSALGA PRRVAMLPAL ALVLLAAWTA 180 181 RALEVPTDGN AGLLAEPQVA MFCGKLNMHM NVQNGKWESD PSGTKTCIGT KEDILQYCQE 240 241 VYPELQITNV VEANQPVTIQ NWCKRGHKQC KTHARIVIPY RCLVGEFVSD ALLVPDKCKF 300 301 LHQERMDVCE THLHWHTVAK ETCSEKSTSL HDYGMLLPCG IDKFRGVEFV CCPLAEESDN 360 361 IDSADAEEDD SDVWWGGADA DYADGSEDKV VEVAEEEEGA DVEDEEAEDD EDDEDGDEVE 420 421 EEAEEPYEEA TERTTSIATT TTTTTESVEE VVREVCSEQA ETGPCRAMIS RWYFDVTEGK 480 481 CAPFFYGGCG GNRNNFDTEE YCMAVCGSVM SQSLLKTTQE PLPQDAVKLP TTAASTPDAV 540 541 DKYLETPGDE NEHAHFQKAK ERLEAKHRER MSQVMREWEE AERQAKNLPK ADKKAVIQHF 600 601 QEKVESLEQE AANERQQLVE THMARVEAML NDRRRLALEN YITALQAVPP RPRHVFNMLK 660 661 KYVRAEQKDR QHTLKHFEHV RMVDPKKAAQ IRSQVMTHLR VIYERMNQSL SLLYNVPAVA 720 721 EEIQDEVDEL LQKEQNYSDD VLANMISEPR ISYGNDALMP SLTETKTTVE LLPVNGEFSL 780 781 DDLQPWHPFG VDSVPANTEN EVEPVDARPA ADRGLTTRPG SGLTNIKTEE ISEVKMDAEF 840 841 RHESGYEVHH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV IVITLVMLKK KQYTSIHHGV 900 901 VEVDAAVTPE ERHLSKMQQN GYENPTYKFF EQMQN 935 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGTCAAG CTCACGGGGA CGAGCGGCGA GCGCTCTCGA CTTTTCTGGA GCCCGAACGT 60 61 CCTACGACTC ACCTTTCCCT GATCCTGCAC CGGTCCTCTC CCGGCCCCAG ACTCTCGCTC 120 121 CGGCTCGCGG AGGCCCCCGG GGGCCGGCGG CCGGCGGCCG GGGCGGGGCG CGCAGGAGAG 180 181 GAGGCCGCCG CACCTGTGGG CGCCGGGGGC GCGGGCCCCT CCCGGCCCGA GCGCGCGCAG 240 241 CTCCCCGGCG GCTCCGCTAG GGGGTCCCTC TCGGGTGCCG AACGGGGCGG GCTGGATCAG 300 301 CTGACTCGCC GGGCTCCGAG CCCAGCCGCC GCGCTCCAGC TCCGTCAGTT TCCTCGGCAG 360 361 CGGCTGGAGA GAGCAGCCGG AGCGGCGCGG GCGCGGGGGC CATCGGAGAC GGCGGCGGCG 420 421 ACGGCACCGG CGGAGCCAGG GCGCGGCGGA TCCCACTCGC ACAGCAGCGC GCTCGGTGCC 480 481 CCGCGCAGGG TCGCGATGCT GCCTGCTTTG GCACTGGTCC TACTGGCCGC CTGGACGGCT 540 541 CGGGCGTTGG AGGTGCCCAC TGACGGCAAT GCTGGCTTGC TTGCGGAACC CCAGGTTGCC 600 601 ATGTTCTGTG GCAAGCTGAA CATGCACATG AACGTGCAGA ATGGGAAGTG GGAATCTGAT 660 661 CCATCGGGGA CCAAAACGTG CATCGGCACC AAGGAAGACA TCTTGCAGTA TTGCCAAGAA 720 721 GTCTACCCTG AACTGCAGAT CACCAACGTG GTGGAAGCCA ACCAACCAGT GACCATCCAG 780 781 AACTGGTGCA AGAGGGGCCA CAAGCAATGC AAGACCCACG CCCGCATTGT GATTCCCTAC 840 841 CGCTGCTTAG TTGGCGAGTT TGTAAGTGAT GCCCTCCTTG TTCCCGACAA ATGCAAATTC 900 901 TTACACCAGG AGAGGATGGA TGTTTGTGAA ACCCACCTTC ACTGGCACAC CGTCGCCAAA 960 961 GAGACCTGCA GTGAGAAGAG TACCAGCTTG CATGACTATG GCATGTTGCT GCCCTGTGGA 1020 1021 ATTGACAAGT TCCGAGGAGT GGAATTTGTC TGTTGCCCGC TGGCCGAGGA GAGTGACAAT 1080 1081 ATTGATTCGG CAGATGCAGA GGAGGATGAC TCGGACGTCT GGTGGGGCGG AGCAGATGCA 1140 1141 GACTATGCCG ATGGGAGTGA GGACAAAGTA GTAGAAGTAG CAGAGGAAGA AGAGGGGGCT 1200 1201 GACGTCGAAG ACGAAGAGGC CGAGGATGAC GAGGATGACG AAGATGGTGA TGAGGTGGAG 1260 1261 GAAGAGGCGG AAGAACCCTA TGAAGAGGCC ACCGAGCGAA CCACCAGCAT CGCCACGACC 1320 1321 ACCACCACCA CCACGGAGTC TGTGGAAGAG GTGGTGCGAG AGGTGTGCTC TGAACAAGCC 1380 1381 GAGACGGGGC CATGCCGCGC AATGATCTCC CGCTGGTACT TTGATGTGAC CGAAGGCAAG 1440 1441 TGCGCCCCGT TCTTTTACGG CGGATGTGGC GGGAACCGAA ACAACTTTGA CACAGAGGAG 1500 1501 TACTGCATGG CCGTGTGCGG CAGCGTCATG TCCCAAAGCT TACTCAAGAC TACCCAGGAA 1560 1561 CCTCTTCCCC AAGATGCTGT TAAACTTCCT ACAACAGCAG CCAGCACACC TGATGCCGTC 1620 1621 GACAAATATC TTGAGACACC CGGAGATGAG AATGAACATG CCCATTTCCA GAAAGCCAAA 1680 1681 GAGAGGCTGG AGGCCAAGCA CCGCGAGAGA ATGTCCCAGG TCATGCGAGA ATGGGAAGAG 1740 1741 GCAGAAAGGC AAGCAAAGAA CTTGCCTAAA GCGGACAAGA AGGCAGTCAT CCAGCATTTC 1800 1801 CAGGAGAAAG TGGAGTCCCT GGAGCAGGAA GCAGCCAACG AGAGGCAGCA GCTGGTGGAG 1860 1861 ACGCACATGG CCCGAGTGGA AGCCATGCTC AATGACCGCC GTCGCCTGGC TCTGGAGAAT 1920 1921 TACATCACTG CCCTGCAGGC TGTGCCCCCT CGGCCTCGTC ATGTGTTCAA CATGCTAAAG 1980 1981 AAGTATGTCC GCGCTGAACA GAAGGACAGG CAACACACCC TGAAGCATTT TGAACACGTA 2040 2041 CGCATGGTGG ACCCAAAGAA AGCTGCTCAG ATCCGGTCCC AGGTTATGAC ACATCTGCGT 2100 2101 GTGATTTACG AGCGCATGAA CCAGTCTCTG TCCCTGCTCT ACAATGTGCC TGCCGTCGCC 2160 2161 GAGGAGATTC AGGATGAAGT TGATGAGCTG CTTCAGAAAG AGCAAAACTA CTCCGATGAC 2220 2221 GTCTTGGCCA ACATGATCAG CGAACCAAGA ATCAGTTACG GAAACGATGC CCTCATGCCG 2280 2281 TCTTTGACCG AGACGAAAAC CACCGTGGAG CTTCTTCCCG TGAACGGGGA GTTCAGCCTG 2340 2341 GACGATCTGC AGCCCTGGCA TCCTTTCGGG GTCGACTCGG TGCCGGCCAA TACAGAAAAC 2400 2401 GAAGTTGAGC CTGTCGACGC CCGCCCTGCT GCCGACCGAG GACTGACCAC CCGACCAGGT 2460 2461 TCGGGCTTGA CGAACATCAA GACGGAGGAG ATCTCTGAGG TAAAGATGGA TGCCGAGTTC 2520 2521 CGACATGAGT CAGGATACGA AGTTCATCAT CAAAAACTGG TGTTCTTTGC AGAAGATGTG 2580 2581 GGTTCAAACA AAGGTGCCAT CATTGGACTC ATGGTGGGCG GCGTTGTCAT AGCAACGGTG 2640 2641 ATTGTCATCA CCTTGGTGAT GCTGAAGAAG AAACAGTACA CGTCCATCCA TCATGGTGTC 2700 2701 GTGGAGGTCG ACGCTGCCGT GACCCCAGAG GAGCGCCACC TCTCCAAGAT GCAGCAGAAC 2760 2761 GGATACGAAA ATCCAACTTA CAAGTTCTTT GAGCAGATGC AGAACTAG 2808 |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Caf-1233 | Canis familiaris | 99.79 | 0.0 | 942 |
| LLPS-Mup-1440 | Mustela putorius furo | 99.79 | 0.0 | 946 |
| LLPS-Urm-2455 | Ursus maritimus | 99.78 | 0.0 | 874 |
| LLPS-Aim-0364 | Ailuropoda melanoleuca | 99.37 | 0.0 | 937 |
| LLPS-Sus-1763 | Sus scrofa | 99.37 | 0.0 | 937 |
| LLPS-Orc-0216 | Oryctolagus cuniculus | 99.16 | 0.0 | 937 |
| LLPS-Ova-3063 | Ovis aries | 99.16 | 0.0 | 936 |
| LLPS-Bot-0673 | Bos taurus | 99.16 | 0.0 | 936 |
| LLPS-Nol-2004 | Nomascus leucogenys | 98.74 | 0.0 | 930 |
| LLPS-Cas-1402 | Carlito syrichta | 98.74 | 0.0 | 934 |
| LLPS-Pap-0939 | Pan paniscus | 98.74 | 0.0 | 931 |
| LLPS-Rhb-2390 | Rhinopithecus bieti | 98.53 | 0.0 | 928 |
| LLPS-Hos-2530 | Homo sapiens | 98.53 | 0.0 | 929 |
| LLPS-Paa-2768 | Papio anubis | 98.53 | 0.0 | 928 |
| LLPS-Myl-1807 | Myotis lucifugus | 98.53 | 0.0 | 930 |
| LLPS-Dio-2728 | Dipodomys ordii | 98.53 | 0.0 | 932 |
| LLPS-Caj-0189 | Callithrix jacchus | 98.53 | 0.0 | 929 |
| LLPS-Mam-0552 | Macaca mulatta | 98.32 | 0.0 | 926 |
| LLPS-Man-0549 | Macaca nemestrina | 98.32 | 0.0 | 926 |
| LLPS-Loa-1564 | Loxodonta africana | 98.32 | 0.0 | 930 |
| LLPS-Ran-0691 | Rattus norvegicus | 98.32 | 0.0 | 925 |
| LLPS-Fud-0935 | Fukomys damarensis | 98.32 | 0.0 | 927 |
| LLPS-Cea-2904 | Cercocebus atys | 98.32 | 0.0 | 925 |
| LLPS-Maf-2589 | Macaca fascicularis | 98.32 | 0.0 | 926 |
| LLPS-Chs-0807 | Chlorocebus sabaeus | 98.32 | 0.0 | 926 |
| LLPS-Cap-0068 | Cavia porcellus | 98.11 | 0.0 | 926 |
| LLPS-Mum-0954 | Mus musculus | 97.69 | 0.0 | 919 |
| LLPS-Mod-2930 | Monodelphis domestica | 97.19 | 3e-176 | 534 |
| LLPS-Ict-0588 | Ictidomys tridecemlineatus | 96.55 | 6e-123 | 397 |
| LLPS-Eqc-4276 | Equus caballus | 96.55 | 3e-122 | 398 |
| LLPS-Aon-4600 | Aotus nancymaae | 95.71 | 0.0 | 865 |
| LLPS-Pat-3091 | Pan troglodytes | 95.62 | 0.0 | 897 |
| LLPS-Mal-1573 | Mandrillus leucophaeus | 95.62 | 0.0 | 897 |
| LLPS-Mea-3987 | Mesocricetus auratus | 95.54 | 5e-121 | 393 |
| LLPS-Gog-1731 | Gorilla gorilla | 94.99 | 0.0 | 887 |
| LLPS-Gaga-2756 | Gallus gallus | 94.13 | 0.0 | 882 |
| LLPS-Poa-3126 | Pongo abelii | 94.09 | 9e-120 | 389 |
| LLPS-Meg-2010 | Meleagris gallopavo | 93.71 | 0.0 | 880 |
| LLPS-Fia-1028 | Ficedula albicollis | 93.32 | 0.0 | 876 |
| LLPS-Tag-2371 | Taeniopygia guttata | 93.08 | 0.0 | 877 |
| LLPS-Sah-2307 | Sarcophilus harrisii | 92.45 | 0.0 | 871 |
| LLPS-Anc-0267 | Anolis carolinensis | 91.09 | 9e-116 | 379 |
| LLPS-Lac-2015 | Latimeria chalumnae | 88.26 | 0.0 | 827 |
| LLPS-Xet-2588 | Xenopus tropicalis | 87.42 | 0.0 | 828 |
| LLPS-Ora-1908 | Ornithorhynchus anatinus | 84.76 | 6e-113 | 360 |
| LLPS-Leo-2697 | Lepisosteus oculatus | 82.27 | 4e-108 | 358 |
| LLPS-Scf-0034 | Scleropages formosus | 79.31 | 1e-104 | 349 |
| LLPS-Dar-3358 | Danio rerio | 77.34 | 1e-103 | 346 |
| LLPS-Icp-0734 | Ictalurus punctatus | 76.85 | 3e-101 | 340 |
| LLPS-Scm-0263 | Scophthalmus maximus | 76.35 | 1e-100 | 338 |
| LLPS-Pof-2036 | Poecilia formosa | 76.24 | 7e-99 | 333 |
| LLPS-Asm-0352 | Astyanax mexicanus | 72.73 | 1e-80 | 284 |
| LLPS-Gaa-0777 | Gasterosteus aculeatus | 72.12 | 1e-81 | 286 |
| LLPS-Xim-1656 | Xiphophorus maculatus | 70.83 | 4e-78 | 276 |
| LLPS-Tar-2185 | Takifugu rubripes | 70.3 | 2e-77 | 276 |
| LLPS-Orl-4026 | Oryzias latipes | 70.3 | 4e-79 | 279 |
| LLPS-Orn-4105 | Oreochromis niloticus | 70.06 | 8e-79 | 278 |
| LLPS-Ten-0790 | Tetraodon nigroviridis | 66.06 | 1e-70 | 254 |
| LLPS-Ere-0575 | Erinaceus europaeus | 59.09 | 2e-12 | 68.9 |
| LLPS-Cae-1115 | Caenorhabditis elegans | 41.46 | 4e-33 | 141 |
| LLPS-Drm-1324 | Drosophila melanogaster | 39.52 | 4e-31 | 135 |
| LLPS-Cii-0997 | Ciona intestinalis | 36.96 | 6e-08 | 57.4 |