• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Eqc-2743
MRE11

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Double-strand break repair protein
Gene Name: MRE11
Ensembl Gene: ENSECAG00000000295.2
Ensembl Protein: ENSECAP00000000475.2
Organism: Equus caballus
Taxa ID: 9796
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Chromatin, Nucleolus, PML nuclear bodyPredicted from orthologs(View)

▼ FUNCTION


Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MSPADALDDE  NTFKILVATD  IHLGFMEKDA  VRGNDTFVTL  DEILRLAQEN  QVDFILLGGD  60
61    LFHDNKPSRK  TLHNCLELFR  KYCMGDRPVQ  FEIISDQSVN  FGFSKFPWVN  YQDDNLNVSI  120
121   PVFSIHGNHD  DPTGADALCA  LDILSCAGFV  NHFGRSMSVE  KIDISPVLLQ  KGSTKIALYG  180
181   LGSIPDERLY  RMFINKKVTM  FRPKEDENSW  FNLFVIHQNR  SKHGSTNFIP  EQFLDDFIDL  240
241   VIWGHEHECK  IAPAKNEQQL  FYVSQPGSSV  VTSLSPGEAV  KKHVGLLHVK  GRKMNMQKIP  300
301   LCTVRQFFME  DVVLAAHPDI  FNPDNPKVTQ  AIQNFCLEKI  EEMLENAERE  RLGNSRQPEK  360
361   PLIRLRVDYS  GGFEPFSVLR  FSQKFVDRVA  NPKDIIHFFR  HKEQKENTGE  EINFGKLITK  420
421   PAEGTTLRVE  DLVKQYFQTA  EKNVQLSLLT  ERGMGEAVQE  FVDKEEKDAI  EELVKYQLEK  480
481   TQRFLKERHI  DALEDKIDEE  VRRFRESRQK  NTNEEDDEVR  EAMTRARALR  SQAEDLASGF  540
541   SADDLMSIDL  AEQMADDSDD  SVAAAANKGR  GRGRGRRGGR  GQNSASRGGS  QRGRGTSLET  600
601   STRSRTSKAS  MPTSRNMSIL  DVFKPTRQQP  SQDVATKNYS  EVMEVDESDV  EDNIFPTTSK  660
661   TDQRWSSTSS  SSKHMSQSQT  AKGIEFESDE  DDDDDPFMNI  SSMRRNRR  708
Nucleotide CDS Sequence (FASTA)
1     ATGAGTCCTG  CAGATGCCCT  TGATGATGAA  AATACATTTA  AAATCTTAGT  TGCAACGGAT  60
61    ATTCATCTGG  GATTTATGGA  GAAAGATGCA  GTCAGAGGAA  ATGATACCTT  TGTAACACTT  120
121   GATGAAATTT  TAAGACTTGC  CCAGGAAAAT  CAAGTGGATT  TTATTTTGTT  AGGTGGTGAT  180
181   CTTTTTCATG  ATAATAAGCC  CTCAAGAAAA  ACATTACATA  ACTGCCTCGA  GTTATTCAGA  240
241   AAATATTGCA  TGGGTGATCG  TCCCGTGCAG  TTTGAAATTA  TCAGCGATCA  GTCAGTCAAC  300
301   TTTGGTTTTA  GTAAGTTTCC  GTGGGTGAAC  TACCAAGATG  ACAATCTCAA  CGTTTCGATT  360
361   CCAGTGTTTA  GTATTCATGG  CAATCATGAT  GATCCCACTG  GGGCAGACGC  ACTCTGTGCT  420
421   CTGGATATTT  TAAGTTGTGC  TGGATTTGTA  AATCACTTTG  GACGTTCCAT  GTCTGTGGAG  480
481   AAGATAGACA  TTAGTCCAGT  TTTGCTTCAG  AAAGGAAGCA  CAAAAATTGC  TCTATATGGC  540
541   TTAGGATCCA  TTCCAGATGA  AAGGCTCTAC  AGAATGTTCA  TCAATAAAAA  AGTAACAATG  600
601   TTCAGACCAA  AAGAAGACGA  GAACTCTTGG  TTTAACTTAT  TTGTGATTCA  TCAGAACAGG  660
661   AGTAAACATG  GAAGTACTAA  CTTCATTCCA  GAACAATTTT  TGGATGACTT  CATTGATCTT  720
721   GTTATCTGGG  GCCATGAGCA  TGAATGTAAA  ATAGCTCCAG  CCAAAAATGA  ACAACAACTC  780
781   TTCTATGTAT  CACAGCCTGG  AAGTTCAGTG  GTTACTTCTC  TTTCCCCAGG  AGAAGCTGTA  840
841   AAGAAACATG  TTGGTTTGCT  GCATGTTAAA  GGAAGGAAGA  TGAATATGCA  GAAGATTCCT  900
901   CTTTGCACAG  TACGGCAGTT  TTTTATGGAG  GACGTTGTTC  TGGCTGCTCA  TCCAGACATT  960
961   TTTAACCCAG  ATAATCCTAA  AGTAACCCAA  GCCATACAAA  ACTTCTGTTT  GGAGAAGATT  1020
1021  GAAGAAATGC  TAGAAAACGC  TGAACGGGAA  CGTCTGGGAA  ATTCTCGACA  GCCAGAGAAA  1080
1081  CCTCTTATAC  GACTGCGAGT  GGACTATAGT  GGAGGTTTTG  AACCTTTCAG  TGTTCTTCGC  1140
1141  TTTAGTCAGA  AGTTTGTGGA  TCGGGTAGCT  AATCCAAAAG  ATATTATCCA  TTTTTTCAGG  1200
1201  CATAAAGAAC  AAAAGGAAAA  CACAGGAGAA  GAGATCAACT  TTGGGAAGCT  CATCACAAAA  1260
1261  CCTGCAGAAG  GAACAACTCT  AAGGGTAGAA  GACCTTGTGA  AACAGTATTT  CCAAACCGCA  1320
1321  GAGAAGAATG  TACAGCTCTC  ACTTCTAACA  GAAAGGGGAA  TGGGCGAAGC  AGTGCAAGAA  1380
1381  TTTGTTGACA  AGGAAGAGAA  AGATGCCATA  GAGGAATTAG  TGAAATACCA  GTTGGAAAAA  1440
1441  ACACAGCGAT  TTCTTAAAGA  ACGTCATATT  GATGCTCTAG  AAGATAAAAT  CGATGAAGAG  1500
1501  GTGCGTCGCT  TCAGAGAGAG  CAGACAAAAA  AATACTAATG  AAGAAGATGA  TGAAGTTCGA  1560
1561  GAGGCCATGA  CTAGGGCCAG  AGCCCTCAGA  TCTCAGGCAG  AGGACCTTGC  TTCCGGCTTT  1620
1621  AGTGCCGATG  ACCTTATGAG  TATAGATTTG  GCAGAACAGA  TGGCTGATGA  CTCTGATGAT  1680
1681  AGCGTCGCAG  CAGCAGCCAA  CAAAGGAAGA  GGCCGAGGAA  GAGGCCGGAG  AGGAGGAAGA  1740
1741  GGCCAGAATT  CAGCATCGAG  AGGAGGGTCT  CAGAGAGGAA  GAGGCACCAG  TTTAGAGACT  1800
1801  TCTACTCGAA  GCAGAACTTC  AAAGGCCTCT  ATGCCAACAT  CAAGAAATAT  GTCTATTTTA  1860
1861  GATGTCTTTA  AACCTACAAG  ACAGCAGCCC  TCCCAAGATG  TTGCTACTAA  GAATTACTCA  1920
1921  GAGGTGATGG  AGGTGGATGA  GTCAGATGTC  GAAGACAACA  TTTTTCCTAC  CACTTCAAAA  1980
1981  ACAGATCAAA  GGTGGTCAAG  CACATCATCG  TCCAGCAAAC  ACATGTCCCA  GAGCCAAACA  2040
2041  GCTAAAGGGA  TCGAGTTTGA  ATCAGATGAG  GACGATGATG  ACGATCCTTT  TATGAACATT  2100
2101  AGTTCTATGA  GAAGAAACAG  AAGATAA  2127

▼ KEYWORD


ID
Family
Coiled coil
Complete proteome
DNA damage
DNA repair
Endonuclease
Exonuclease
Hydrolase
Manganese
Meiosis
Nuclease
Nucleus
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Mre11 complex
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
PML body
Cellular Component
Site of double-strand break
Molecular Function
3'-5' exonuclease activity
Molecular Function
3'-5'-exodeoxyribonuclease activity
Molecular Function
5'-3' exonuclease activity
Molecular Function
ATP-dependent DNA helicase activity
Molecular Function
DNA binding
Molecular Function
Identical protein binding
Molecular Function
Manganese ion binding
Molecular Function
Protein C-terminus binding
Molecular Function
Single-stranded DNA endodeoxyribonuclease activity
Biological Process
Cell population proliferation
Biological Process
DNA strand resection involved in replication fork processing
Biological Process
Double-strand break repair via homologous recombination
Biological Process
Double-strand break repair via nonhomologous end joining
Biological Process
Intra-S DNA damage checkpoint
Biological Process
Meiotic DNA double-strand break formation
Biological Process
Mitochondrial double-strand break repair via homologous recombination
Biological Process
Mitotic G2 DNA damage checkpoint
Biological Process
Negative regulation of apoptotic process
Biological Process
Negative regulation of DNA endoreduplication
Biological Process
Positive regulation of kinase activity
Biological Process
Positive regulation of protein autophosphorylation
Biological Process
Positive regulation of telomere maintenance
Biological Process
Sister chromatid cohesion
Biological Process
Synapsis
Biological Process
Telomere maintenance
Biological Process
Telomeric 3' overhang formation

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-2363Dipodomys ordii94.094e-136 406
LLPS-Fud-2349Fukomys damarensis93.130.01086
LLPS-Urm-1152Ursus maritimus92.090.01156
LLPS-Cap-3833Cavia porcellus91.880.01065
LLPS-Mea-2031Mesocricetus auratus91.635e-134 400
LLPS-Maf-0225Macaca fascicularis90.40.01154
LLPS-Mup-3030Mustela putorius furo90.250.01125
LLPS-Ova-3613Ovis aries89.830.01152
LLPS-Tut-0615Tursiops truncatus89.560.01142
LLPS-Fec-0903Felis catus89.00.01156
LLPS-Sah-3052Sarcophilus harrisii88.830.01031
LLPS-Sus-3730Sus scrofa88.80.0 974
LLPS-Cas-0078Carlito syrichta88.60.01129
LLPS-Myl-3391Myotis lucifugus88.150.01118
LLPS-Aim-3349Ailuropoda melanoleuca88.030.01138
LLPS-Pap-2534Pan paniscus87.560.01130
LLPS-Loa-1074Loxodonta africana87.040.01115
LLPS-Otg-2991Otolemur garnettii86.940.01140
LLPS-Mam-0489Macaca mulatta86.320.01151
LLPS-Bot-1109Bos taurus86.320.01145
LLPS-Paa-2936Papio anubis86.320.01152
LLPS-Gog-1857Gorilla gorilla86.320.01152
LLPS-Nol-1334Nomascus leucogenys86.180.01151
LLPS-Man-1406Macaca nemestrina86.180.01149
LLPS-Hos-1253Homo sapiens86.180.01139
LLPS-Cea-1631Cercocebus atys86.180.01151
LLPS-Mal-0966Mandrillus leucophaeus86.070.01135
LLPS-Ran-2500Rattus norvegicus86.040.01098
LLPS-Chs-2786Chlorocebus sabaeus86.040.01148
LLPS-Ict-0717Ictidomys tridecemlineatus85.470.01143
LLPS-Pat-3721Pan troglodytes85.450.01128
LLPS-Caj-2242Callithrix jacchus85.070.01135
LLPS-Caf-3770Canis familiaris85.050.01122
LLPS-Orc-3580Oryctolagus cuniculus84.890.01142
LLPS-Mum-0703Mus musculus84.060.01083
LLPS-Tag-0276Taeniopygia guttata80.880.0 944
LLPS-Gaga-2243Gallus gallus80.80.0 929
LLPS-Meg-1413Meleagris gallopavo80.220.0 922
LLPS-Fia-0213Ficedula albicollis79.850.0 943
LLPS-Rhb-2159Rhinopithecus bieti79.830.01025
LLPS-Mod-0826Monodelphis domestica79.690.01058
LLPS-Ora-0564Ornithorhynchus anatinus79.370.0 912
LLPS-Anc-3799Anolis carolinensis76.260.0 961
LLPS-Leo-2813Lepisosteus oculatus75.050.0 872
LLPS-Pes-0377Pelodiscus sinensis74.340.0 970
LLPS-Dar-3628Danio rerio73.830.0 847
LLPS-Asm-3079Astyanax mexicanus73.820.0 858
LLPS-Lac-0337Latimeria chalumnae73.760.0 959
LLPS-Xet-2556Xenopus tropicalis72.850.0 933
LLPS-Scf-1919Scleropages formosus72.840.0 874
LLPS-Icp-1764Ictalurus punctatus72.080.0 812
LLPS-Aon-3967Aotus nancymaae71.130.0 863
LLPS-Xim-0571Xiphophorus maculatus70.820.0 823
LLPS-Gaa-3106Gasterosteus aculeatus70.730.0 816
LLPS-Pof-0084Poecilia formosa70.650.0 826
LLPS-Orl-2658Oryzias latipes69.980.0 795
LLPS-Anp-1696Anas platyrhynchos69.920.0 937
LLPS-Scm-0123Scophthalmus maximus69.870.0 806
LLPS-Orn-0021Oreochromis niloticus69.510.0 803
LLPS-Tar-2976Takifugu rubripes68.380.0 786
LLPS-Ten-1652Tetraodon nigroviridis68.370.0 767
LLPS-Cis-1233Ciona savignyi60.54e-85 274
LLPS-Sot-0903Solanum tuberosum52.131e-53 192
LLPS-Cii-0132Ciona intestinalis50.190.0 556
LLPS-Mua-1765Musa acuminata47.161e-118 369
LLPS-Scj-1169Schizosaccharomyces japonicus46.612e-147 452
LLPS-Scc-0553Schizosaccharomyces cryophilus46.485e-148 453
LLPS-Zem-2234Zea mays45.931e-118 379
LLPS-Drm-1505Drosophila melanogaster45.65e-137 424
LLPS-Tum-0769Tuber melanosporum45.144e-142 442
LLPS-Coc-0972Corchorus capsularis44.945e-128 403
LLPS-Gor-0523Gossypium raimondii44.84e-130 409
LLPS-Abg-0082Absidia glauca44.658e-140 434
LLPS-Glm-0314Glycine max44.633e-128 404
LLPS-Mae-0652Manihot esculenta44.441e-125 398
LLPS-Tra-1983Triticum aestivum44.365e-128 403
LLPS-Pot-0857Populus trichocarpa44.351e-124 396
LLPS-Hov-0165Hordeum vulgare44.271e-126 400
LLPS-Bro-0377Brassica oleracea44.211e-126 400
LLPS-Map-1396Magnaporthe poae44.182e-131 414
LLPS-Sob-0211Sorghum bicolor44.144e-129 406
LLPS-Sei-0865Setaria italica44.142e-130 409
LLPS-Nia-0074Nicotiana attenuata44.083e-130 410
LLPS-Prp-0258Prunus persica44.025e-126 400
LLPS-Via-1064Vigna angularis43.977e-126 397
LLPS-Sem-0624Selaginella moellendorffii43.753e-125 399
LLPS-Trr-0966Trichoderma reesei43.712e-130 410
LLPS-Met-2128Medicago truncatula43.682e-127 402
LLPS-Phv-0475Phaseolus vulgaris43.69e-126 397
LLPS-Dac-0491Daucus carota43.67e-110 355
LLPS-Scp-0354Schizosaccharomyces pombe43.552e-145 446
LLPS-Pyt-0971Pyrenophora teres43.438e-130 409
LLPS-Trv-0512Trichoderma virens43.293e-129 401
LLPS-Vir-0919Vigna radiata43.284e-97 323
LLPS-Brd-0908Brachypodium distachyon43.086e-125 395
LLPS-Arl-1259Arabidopsis lyrata43.062e-125 397
LLPS-Pytr-0646Pyrenophora triticirepentis43.033e-127 402
LLPS-Cog-0031Colletotrichum gloeosporioides42.984e-129 406
LLPS-Crn-0914Cryptococcus neoformans42.973e-133 417
LLPS-Phn-0290Phaeosphaeria nodorum42.865e-130 409
LLPS-Ved-0106Verticillium dahliae42.713e-131 412
LLPS-Gag-1084Gaeumannomyces graminis42.554e-131 414
LLPS-Php-0104Physcomitrella patens42.537e-128 402
LLPS-Amt-1590Amborella trichopoda42.373e-122 391
LLPS-Hea-0853Helianthus annuus42.341e-128 407
LLPS-Put-0717Puccinia triticina42.276e-126 398
LLPS-Beb-0055Beauveria bassiana42.157e-127 400
LLPS-Orbr-0065Oryza brachyantha42.132e-126 399
LLPS-Lem-1272Leptosphaeria maculans42.121e-121 405
LLPS-Mao-0908Magnaporthe oryzae42.123e-126 399
LLPS-Viv-0269Vitis vinifera41.997e-126 398
LLPS-Pug-0950Puccinia graminis41.958e-132 414
LLPS-Scs-0470Sclerotinia sclerotiorum41.92e-127 402
LLPS-Cogr-1201Colletotrichum graminicola41.816e-133 416
LLPS-Fus-0423Fusarium solani41.79e-123 384
LLPS-Thc-1712Theobroma cacao41.652e-120 383
LLPS-Ast-0388Aspergillus terreus41.67e-128 405
LLPS-Aso-0155Aspergillus oryzae41.587e-125 389
LLPS-Asni-0275Aspergillus niger41.459e-129 406
LLPS-Fuv-1249Fusarium verticillioides41.275e-122 388
LLPS-Zyt-0281Zymoseptoria tritici41.251e-123 393
LLPS-Nec-1218Neurospora crassa41.23e-131 414
LLPS-Orgl-1491Oryza glumaepatula41.196e-129 405
LLPS-Asc-0461Aspergillus clavatus41.13e-125 399
LLPS-Orr-0584Oryza rufipogon41.013e-128 403
LLPS-Orb-1225Oryza barthii41.013e-128 403
LLPS-Dos-1197Dothistroma septosporum41.01e-125 399
LLPS-Coo-0457Colletotrichum orbiculare40.993e-130 409
LLPS-Brr-1236Brassica rapa40.983e-127 401
LLPS-Mel-0308Melampsora laricipopulina40.981e-123 384
LLPS-Orp-0416Oryza punctata40.881e-127 401
LLPS-Orni-1252Oryza nivara40.842e-127 400
LLPS-Spr-0397Sporisorium reilianum40.831e-122 394
LLPS-Art-2126Arabidopsis thaliana40.671e-125 397
LLPS-Brn-2476Brassica napus40.493e-119 379
LLPS-Cus-1140Cucumis sativus40.411e-120 384
LLPS-Sac-0974Saccharomyces cerevisiae40.32e-123 390
LLPS-Blg-0295Blumeria graminis40.274e-122 387
LLPS-Yal-1467Yarrowia lipolytica40.251e-118 378
LLPS-Lep-0622Leersia perrieri40.124e-112 359
LLPS-Asfu-1248Aspergillus fumigatus39.965e-127 403
LLPS-Nef-0341Neosartorya fischeri39.961e-126 402
LLPS-Miv-1433Microbotryum violaceum39.926e-115 370
LLPS-Asf-0519Aspergillus flavus39.895e-125 397
LLPS-Org-1050Oryza glaberrima39.83e-128 404
LLPS-Orm-0394Oryza meridionalis39.663e-127 402
LLPS-Ors-0611Oryza sativa39.632e-127 402
LLPS-Cae-1533Caenorhabditis elegans39.542e-112 363
LLPS-Asn-0851Aspergillus nidulans39.433e-128 407
LLPS-Kop-1197Komagataella pastoris39.266e-120 381
LLPS-Usm-0781Ustilago maydis39.212e-116 378
LLPS-Tru-1393Triticum urartu39.25e-113 361
LLPS-Ori-2146Oryza indica39.064e-118 376
LLPS-Asg-1114Ashbya gossypii38.672e-122 387
LLPS-Chr-0252Chlamydomonas reinhardtii38.523e-102 342
LLPS-Gas-0333Galdieria sulphuraria38.111e-106 346
LLPS-Osl-1341Ostreococcus lucimarinus38.09e-111 353
LLPS-Chc-0596Chondrus crispus35.747e-93 313
LLPS-Fuo-0219Fusarium oxysporum34.763e-22 104
LLPS-Cym-0209Cyanidioschyzon merolae34.371e-89 302