DrLLPS - Data resource of LLPS

LLPS-Drm-2299
Trx-2

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Thioredoxin-2
Gene Name:	Trx-2, CG31884
Ensembl Gene:	FBgn0040070
Ensembl Protein:	FBpp0079436
Organism:	Drosophila melanogaster
Taxa ID:	7227
LLPS Type:	Others

PDB: 1XWB (A) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Stress granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-1332	P10599	Client	Stress granule	51.96	4e-29	107

▼ FUNCTION

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	FBtr0079839	FBpp0079436
Ensembl	FBtr0079840	FBpp0079437
UniProt		Q9V429, THIO2_DROME, A4V0H9, D3DMZ9, Q95SW4
GeneBank	AF220362, AE014134, AY060458, BT120324	AAN10701.1, ADC54215.1, AAF37263.1, AAL25497.1, AAN10700.1
RefSeq	NM_078802.4, NM_164863.3	NP_523526.1, NP_723475.1
Entrez	34281

▼ SEQUENCE

Protein Sequence (FASTA)
1 MVYQVKDKAD LDGQLTKASG KLVVLDFFAT WCGPCKMISP KLVELSTQFA DNVVVLKVDV 60 61 DECEDIAMEY NISSMPTFVF LKNGVKVEEF AGANAKRLED VIKANI 106
Nucleotide CDS Sequence (FASTA)
1 ATGGTGTACC AGGTGAAAGA TAAGGCCGAT CTCGATGGAC AGCTGACCAA GGCATCCGGC 60 61 AAGCTGGTGG TGCTGGATTT CTTCGCCACT TGGTGCGGAC CCTGCAAGAT GATCTCGCCC 120 121 AAACTGGTTG AGCTTTCCAC GCAGTTCGCC GACAACGTCG TCGTCCTGAA GGTCGATGTG 180 181 GACGAATGCG AAGACATTGC AATGGAATAC AACATCTCCA GCATGCCCAC CTTCGTGTTC 240 241 CTCAAGAACG GCGTCAAGGT CGAAGAGTTC GCCGGAGCCA ACGCCAAGCG TCTGGAGGAT 300 301 GTCATCAAGG CCAATATC 318

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0181	Complete proteome
KW-1015	Disulfide bond
KW-0249	Electron transport
KW-0676	Redox-active center
KW-1185	Reference proteome
KW-0813	Transport

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005634	Cellular Component	Nucleus
GO:0015036	Molecular Function	Disulfide oxidoreductase activity
GO:0015035	Molecular Function	Protein disulfide oxidoreductase activity
GO:0045454	Biological Process	Cell redox homeostasis
GO:0050832	Biological Process	Defense response to fungus
GO:0008340	Biological Process	Determination of adult lifespan
GO:0006662	Biological Process	Glycerol ether metabolic process
GO:0006979	Biological Process	Response to oxidative stress

▼ KEGG

dme:Dmel_CG31884

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	CDD	PROSITE
Gene3D

PTM
PTMcode

Interaction
HINT	RAIN	Mentha	PINA	IID
iRefIndex	MIST

Drug
CTD

Physicochemical
AAindex

Function
CGDB

Structure
PDB	MMDB

Localization
COMPARTMENTS

Expression
ArrayExpress

Element
RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Gaa-0974	Gasterosteus aculeatus	62.07	2e-26	100
LLPS-Xim-3605	Xiphophorus maculatus	59.41	6e-30	109
LLPS-Pof-1270	Poecilia formosa	57.43	1e-29	108
LLPS-Aon-2981	Aotus nancymaae	56.82	6e-27	101
LLPS-Urm-2255	Ursus maritimus	56.82	6e-27	101
LLPS-Lac-1460	Latimeria chalumnae	56.12	1e-32	115
LLPS-Loa-0552	Loxodonta africana	55.79	4e-29	107
LLPS-Ran-3779	Rattus norvegicus	54.55	2e-25	97.8
LLPS-Mao-0650	Magnaporthe oryzae	54.02	4e-28	106
LLPS-Mal-3848	Mandrillus leucophaeus	53.92	4e-29	107
LLPS-Paa-1260	Papio anubis	53.92	4e-30	109
LLPS-Fud-0875	Fukomys damarensis	53.92	2e-30	110
LLPS-Maf-4559	Macaca fascicularis	53.92	4e-30	109
LLPS-Ora-0247	Ornithorhynchus anatinus	53.92	4e-31	112
LLPS-Chs-3037	Chlorocebus sabaeus	53.92	4e-30	109
LLPS-Cea-1995	Cercocebus atys	53.92	4e-30	109
LLPS-Mam-1522	Macaca mulatta	53.92	4e-30	109
LLPS-Orc-3786	Oryctolagus cuniculus	53.92	2e-29	107
LLPS-Rhb-2907	Rhinopithecus bieti	53.92	4e-30	109
LLPS-Man-2660	Macaca nemestrina	53.92	4e-30	109
LLPS-Viv-0566	Vitis vinifera	53.75	4e-22	89.4
LLPS-Caf-3723	Canis familiaris	53.06	2e-27	102
LLPS-Scj-1178	Schizosaccharomyces japonicus	52.94	9e-25	95.9
LLPS-Ova-4247	Ovis aries	52.94	1e-29	108
LLPS-Aim-1122	Ailuropoda melanoleuca	52.94	3e-29	107
LLPS-Mup-3839	Mustela putorius furo	52.94	4e-29	107
LLPS-Tut-1089	Tursiops truncatus	52.94	2e-27	102
LLPS-Bot-4639	Bos taurus	52.94	2e-29	107
LLPS-Caj-4658	Callithrix jacchus	52.94	1e-28	105
LLPS-Sus-2578	Sus scrofa	52.94	2e-29	107
LLPS-Cap-1432	Cavia porcellus	52.94	1e-29	108
LLPS-Otg-3927	Otolemur garnettii	52.94	6e-29	106
LLPS-Fec-4469	Felis catus	52.94	2e-29	107
LLPS-Eqc-3543	Equus caballus	52.83	4e-31	112
LLPS-Leo-1939	Lepisosteus oculatus	52.13	6e-26	99.4
LLPS-Xet-0097	Xenopus tropicalis	52.04	6e-26	99.0
LLPS-Gog-3506	Gorilla gorilla	51.96	4e-29	107
LLPS-Poa-4455	Pongo abelii	51.96	3e-28	107
LLPS-Pap-0630	Pan paniscus	51.96	4e-29	107
LLPS-Pat-1261	Pan troglodytes	51.96	4e-29	107
LLPS-Hos-1332	Homo sapiens	51.96	4e-29	107
LLPS-Dar-3565	Danio rerio	51.89	5e-29	107
LLPS-Tra-2184	Triticum aestivum	51.85	8e-21	85.9
LLPS-Phn-0107	Phaeosphaeria nodorum	51.76	2e-23	93.6
LLPS-Osl-1287	Ostreococcus lucimarinus	51.72	3e-23	92.0
LLPS-Sem-2089	Selaginella moellendorffii	51.16	1e-21	89.0
LLPS-Crn-1050	Cryptococcus neoformans	51.11	2e-19	82.0
LLPS-Cis-1916	Ciona savignyi	51.09	5e-29	107
LLPS-Cas-3485	Carlito syrichta	51.06	1e-23	92.8
LLPS-Dio-3460	Dipodomys ordii	50.98	5e-27	101
LLPS-Ict-3518	Ictidomys tridecemlineatus	50.98	2e-28	105
LLPS-Gaga-1676	Gallus gallus	50.96	8e-30	108
LLPS-Orl-2358	Oryzias latipes	50.48	2e-23	92.0
LLPS-Mea-4442	Mesocricetus auratus	50.0	2e-26	100
LLPS-Mum-3599	Mus musculus	50.0	2e-26	99.8
LLPS-Sah-1395	Sarcophilus harrisii	50.0	4e-28	104
LLPS-Nol-3642	Nomascus leucogenys	50.0	4e-26	99.4
LLPS-Asm-3791	Astyanax mexicanus	49.52	4e-28	104
LLPS-Scm-0838	Scophthalmus maximus	49.44	5e-19	81.3
LLPS-Orb-0375	Oryza barthii	49.25	2e-17	77.4
LLPS-Ori-0335	Oryza indica	49.25	2e-17	77.4
LLPS-Org-1141	Oryza glaberrima	49.25	2e-17	77.4
LLPS-Orm-1197	Oryza meridionalis	49.25	1e-17	77.4
LLPS-Orbr-1322	Oryza brachyantha	49.25	8e-17	75.5
LLPS-Orp-1501	Oryza punctata	49.25	8e-18	78.2
LLPS-Anp-1444	Anas platyrhynchos	48.96	1e-26	100
LLPS-Asc-0950	Aspergillus clavatus	48.89	1e-21	87.8
LLPS-Ved-1435	Verticillium dahliae	48.81	1e-20	85.5
LLPS-Myl-2647	Myotis lucifugus	48.57	3e-27	102
LLPS-Pyt-1455	Pyrenophora teres	48.57	5e-26	100
LLPS-Pytr-1344	Pyrenophora triticirepentis	48.57	5e-27	101
LLPS-Scp-0567	Schizosaccharomyces pombe	48.11	1e-27	103
LLPS-Scc-0107	Schizosaccharomyces cryophilus	48.11	1e-25	98.2
LLPS-Prp-2393	Prunus persica	48.1	2e-15	73.2
LLPS-Orn-1411	Oreochromis niloticus	48.08	8e-27	101
LLPS-Sob-2177	Sorghum bicolor	48.0	1e-25	98.2
LLPS-Anc-3470	Anolis carolinensis	47.92	7e-26	98.6
LLPS-Coc-0134	Corchorus capsularis	47.78	8e-24	93.6
LLPS-Cii-0031	Ciona intestinalis	47.57	1e-25	98.2
LLPS-Fia-0988	Ficedula albicollis	47.47	1e-26	100
LLPS-Phv-2041	Phaseolus vulgaris	47.37	1e-22	90.9
LLPS-Gas-1219	Galdieria sulphuraria	47.22	7e-26	99.0
LLPS-Ere-0649	Erinaceus europaeus	46.84	3e-16	72.8
LLPS-Sac-1436	Saccharomyces cerevisiae	46.73	4e-26	99.4
LLPS-Icp-3026	Ictalurus punctatus	46.6	9e-24	93.2
LLPS-Gag-0745	Gaeumannomyces graminis	46.6	6e-26	100
LLPS-Ten-0929	Tetraodon nigroviridis	46.53	1e-21	87.8
LLPS-Orgl-1613	Oryza glumaepatula	46.25	1e-18	80.5
LLPS-Orni-1624	Oryza nivara	46.25	2e-18	79.7
LLPS-Lem-1578	Leptosphaeria maculans	46.15	1e-23	95.5
LLPS-Tag-2001	Taeniopygia guttata	46.15	1e-27	103
LLPS-Orr-1425	Oryza rufipogon	45.57	1e-19	83.2
LLPS-Tum-0377	Tuber melanosporum	45.45	7e-23	91.3
LLPS-Map-1151	Magnaporthe poae	45.45	4e-20	85.5
LLPS-Vir-1741	Vigna radiata	45.35	6e-22	89.0
LLPS-Sot-0748	Solanum tuberosum	45.35	9e-20	83.2
LLPS-Asni-0062	Aspergillus niger	45.35	8e-18	77.8
LLPS-Sol-1249	Solanum lycopersicum	45.35	1e-19	82.8
LLPS-Nia-2025	Nicotiana attenuata	45.35	1e-19	82.8
LLPS-Thc-1808	Theobroma cacao	45.26	1e-20	85.5
LLPS-Chc-0890	Chondrus crispus	45.24	2e-19	86.3
LLPS-Cym-0467	Cyanidioschyzon merolae	45.24	2e-18	84.0
LLPS-Bro-1858	Brassica oleracea	45.24	5e-19	81.3
LLPS-Miv-0846	Microbotryum violaceum	45.0	1e-15	72.4
LLPS-Art-1667	Arabidopsis thaliana	45.0	3e-17	76.3
LLPS-Sei-2309	Setaria italica	44.94	4e-21	87.0
LLPS-Met-2568	Medicago truncatula	44.32	1e-20	85.5
LLPS-Lep-1888	Leersia perrieri	44.19	4e-18	84.0
LLPS-Php-1980	Physcomitrella patens	44.19	2e-13	67.4
LLPS-Kop-1155	Komagataella pastoris	44.12	3e-22	89.4
LLPS-Arl-1976	Arabidopsis lyrata	43.75	3e-16	73.9
LLPS-Ors-1651	Oryza sativa	43.69	4e-20	84.7
LLPS-Mod-3507	Monodelphis domestica	43.56	5e-19	82.4
LLPS-Scf-4004	Scleropages formosus	43.4	5e-24	94.0
LLPS-Nef-0788	Neosartorya fischeri	43.4	1e-20	85.5
LLPS-Asf-1314	Aspergillus flavus	43.3	2e-19	82.0
LLPS-Tar-2405	Takifugu rubripes	43.3	2e-21	87.8
LLPS-Aso-1398	Aspergillus oryzae	43.3	2e-19	82.0
LLPS-Zem-2275	Zea mays	43.27	2e-21	87.8
LLPS-Brr-0272	Brassica rapa	43.16	1e-19	82.8
LLPS-Brd-2383	Brachypodium distachyon	42.86	8e-23	91.3
LLPS-Via-1727	Vigna angularis	42.86	1e-19	83.2
LLPS-Yal-1103	Yarrowia lipolytica	42.86	9e-23	90.5
LLPS-Ast-1179	Aspergillus terreus	42.86	4e-20	84.0
LLPS-Pot-0988	Populus trichocarpa	42.86	3e-21	87.8
LLPS-Gor-2121	Gossypium raimondii	42.72	4e-22	89.4
LLPS-Asfu-1153	Aspergillus fumigatus	42.45	5e-20	83.6
LLPS-Dac-2106	Daucus carota	42.05	3e-19	82.0
LLPS-Cus-0315	Cucumis sativus	41.9	1e-20	85.9
LLPS-Mae-1423	Manihot esculenta	41.9	1e-20	85.9
LLPS-Mel-0410	Melampsora laricipopulina	41.76	9e-20	84.3
LLPS-Asn-1571	Aspergillus nidulans	41.75	3e-19	83.6
LLPS-Tru-0527	Triticum urartu	41.67	5e-18	78.2
LLPS-Asg-0440	Ashbya gossypii	41.51	2e-23	92.4
LLPS-Scs-0491	Sclerotinia sclerotiorum	41.18	2e-19	83.2
LLPS-Brn-1435	Brassica napus	41.0	3e-20	85.1
LLPS-Hea-0197	Helianthus annuus	40.96	1e-12	65.1
LLPS-Glm-2840	Glycine max	40.43	5e-19	82.4
LLPS-Blg-1258	Blumeria graminis	40.38	1e-18	79.7
LLPS-Fus-1452	Fusarium solani	40.0	2e-15	71.2
LLPS-Meg-2004	Meleagris gallopavo	39.67	1e-22	91.3
LLPS-Amt-2093	Amborella trichopoda	38.98	5e-11	60.5
LLPS-Mua-1984	Musa acuminata	38.83	3e-19	82.4
LLPS-Trv-0995	Trichoderma virens	38.64	6e-14	68.2
LLPS-Zyt-0904	Zymoseptoria tritici	38.36	4e-11	62.8
LLPS-Hov-0621	Hordeum vulgare	38.1	5e-20	84.3
LLPS-Chr-0673	Chlamydomonas reinhardtii	37.96	8e-20	84.0

LLPS-Drm-2299Trx-2

Protein Sequence

Nucleotide Sequence

LLPS-Drm-2299
Trx-2