LLPS-Caj-4658
TXN
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Thioredoxin |
| Gene Name: | TXN, TRX |
| Ensembl Gene: | ENSCJAG00000017321.3 |
| Ensembl Protein: | ENSCJAP00000058713.1 |
| Organism: | Callithrix jacchus |
| Taxa ID: | 9483 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCJAT00000073870.1 | ENSCJAP00000058713.1 |
| Ensembl | ENSCJAT00000033707.3 | ENSCJAP00000031890.2 |
| UniProt | Q9BDJ3, THIO_CALJA | |
| GeneBank | AF353204 | AAK30295.1 |
| RefSeq | XM_002743191.4 | XP_002743237.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVKQIDSKDA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVVFLEVDVD 60 61 DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INEFV 105 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTCAAGC AGATCGACAG CAAGGATGCT TTTCAGGAAG CCTTGGATGC GGCAGGTGAT 60 61 AAACTTGTAG TAGTTGACTT CTCAGCCACG TGGTGTGGGC CTTGCAAAAT GATCAAGCCT 120 121 TTTTTCCATT CCCTCTCTGA AAAGTATTCC AATGTGGTAT TCCTTGAAGT AGACGTGGAT 180 181 GACTGTCAGG ATGTTGCTTC AGAGTGTGAA GTCAAATGCA TGCCAACATT CCAGTTTTTT 240 241 AAGAAGGGAC AAAAGGTGGG TGAATTTTCT GGAGCCAATA AGGAAAAGCT TGAAGCCACC 300 301 ATTAATGAAT TCGTCTAA 318 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Extracellular region | |
Cellular Component | Nucleus | |
Molecular Function | Protein disulfide oxidoreductase activity | |
Biological Process | Cell redox homeostasis | |
Biological Process | Glycerol ether metabolic process | |
Biological Process | Oxidation-reduction process | |
Biological Process | Positive regulation of DNA binding | |
Biological Process | Response to radiation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aon-2981 | Aotus nancymaae | 98.96 | 1e-63 | 194 |
| LLPS-Hos-1332 | Homo sapiens | 96.19 | 1e-68 | 207 |
| LLPS-Pat-1261 | Pan troglodytes | 96.19 | 1e-68 | 207 |
| LLPS-Pap-0630 | Pan paniscus | 96.19 | 1e-68 | 207 |
| LLPS-Poa-4455 | Pongo abelii | 96.19 | 9e-70 | 214 |
| LLPS-Gog-3506 | Gorilla gorilla | 96.19 | 1e-68 | 207 |
| LLPS-Otg-3927 | Otolemur garnettii | 95.24 | 3e-67 | 204 |
| LLPS-Rhb-2907 | Rhinopithecus bieti | 95.24 | 1e-67 | 205 |
| LLPS-Man-2660 | Macaca nemestrina | 95.24 | 1e-67 | 205 |
| LLPS-Mam-1522 | Macaca mulatta | 95.24 | 1e-67 | 205 |
| LLPS-Chs-3037 | Chlorocebus sabaeus | 95.24 | 1e-67 | 205 |
| LLPS-Maf-4559 | Macaca fascicularis | 95.24 | 1e-67 | 205 |
| LLPS-Cea-1995 | Cercocebus atys | 95.24 | 1e-67 | 205 |
| LLPS-Paa-1260 | Papio anubis | 95.24 | 1e-67 | 205 |
| LLPS-Urm-2255 | Ursus maritimus | 94.79 | 3e-62 | 191 |
| LLPS-Mup-3839 | Mustela putorius furo | 94.29 | 2e-66 | 202 |
| LLPS-Fec-4469 | Felis catus | 93.33 | 7e-67 | 203 |
| LLPS-Ict-3518 | Ictidomys tridecemlineatus | 93.33 | 3e-67 | 204 |
| LLPS-Sus-2578 | Sus scrofa | 93.33 | 7e-67 | 203 |
| LLPS-Aim-1122 | Ailuropoda melanoleuca | 93.33 | 9e-67 | 202 |
| LLPS-Mal-3848 | Mandrillus leucophaeus | 93.33 | 5e-65 | 198 |
| LLPS-Dio-3460 | Dipodomys ordii | 93.33 | 6e-67 | 203 |
| LLPS-Caf-3723 | Canis familiaris | 93.07 | 7e-63 | 193 |
| LLPS-Cas-3485 | Carlito syrichta | 92.63 | 3e-58 | 181 |
| LLPS-Bot-4639 | Bos taurus | 92.38 | 2e-66 | 202 |
| LLPS-Nol-3642 | Nomascus leucogenys | 91.43 | 7e-64 | 195 |
| LLPS-Cap-1432 | Cavia porcellus | 91.43 | 4e-65 | 199 |
| LLPS-Ova-4247 | Ovis aries | 91.43 | 1e-65 | 200 |
| LLPS-Tut-1089 | Tursiops truncatus | 91.43 | 1e-63 | 195 |
| LLPS-Loa-0552 | Loxodonta africana | 90.82 | 1e-59 | 184 |
| LLPS-Mea-4442 | Mesocricetus auratus | 90.38 | 8e-64 | 195 |
| LLPS-Eqc-3543 | Equus caballus | 89.52 | 2e-63 | 194 |
| LLPS-Orc-3786 | Oryctolagus cuniculus | 88.57 | 1e-64 | 197 |
| LLPS-Mum-3599 | Mus musculus | 88.46 | 2e-62 | 192 |
| LLPS-Ran-3779 | Rattus norvegicus | 88.0 | 4e-59 | 183 |
| LLPS-Fud-0875 | Fukomys damarensis | 87.62 | 9e-63 | 192 |
| LLPS-Myl-2647 | Myotis lucifugus | 85.58 | 5e-63 | 193 |
| LLPS-Ora-0247 | Ornithorhynchus anatinus | 81.73 | 8e-56 | 175 |
| LLPS-Sah-1395 | Sarcophilus harrisii | 81.73 | 2e-58 | 182 |
| LLPS-Ere-0649 | Erinaceus europaeus | 77.92 | 2e-35 | 122 |
| LLPS-Fia-0988 | Ficedula albicollis | 76.84 | 2e-48 | 156 |
| LLPS-Anp-1444 | Anas platyrhynchos | 75.79 | 2e-47 | 153 |
| LLPS-Anc-3470 | Anolis carolinensis | 75.53 | 5e-47 | 152 |
| LLPS-Tag-2001 | Taeniopygia guttata | 72.38 | 2e-50 | 161 |
| LLPS-Pes-2631 | Pelodiscus sinensis | 71.43 | 5e-26 | 107 |
| LLPS-Gaga-1676 | Gallus gallus | 70.48 | 2e-48 | 156 |
| LLPS-Xet-0097 | Xenopus tropicalis | 65.98 | 3e-41 | 138 |
| LLPS-Dar-3565 | Danio rerio | 64.42 | 4e-40 | 135 |
| LLPS-Mod-3507 | Monodelphis domestica | 63.92 | 4e-35 | 124 |
| LLPS-Leo-1939 | Lepisosteus oculatus | 63.64 | 1e-40 | 137 |
| LLPS-Icp-3026 | Ictalurus punctatus | 61.9 | 2e-41 | 138 |
| LLPS-Scm-0838 | Scophthalmus maximus | 61.8 | 6e-31 | 112 |
| LLPS-Gaa-0974 | Gasterosteus aculeatus | 61.8 | 1e-32 | 116 |
| LLPS-Asm-3791 | Astyanax mexicanus | 61.54 | 4e-41 | 137 |
| LLPS-Scf-4004 | Scleropages formosus | 59.05 | 4e-38 | 130 |
| LLPS-Tar-2405 | Takifugu rubripes | 57.84 | 5e-34 | 119 |
| LLPS-Lac-1460 | Latimeria chalumnae | 56.73 | 3e-34 | 120 |
| LLPS-Ten-0929 | Tetraodon nigroviridis | 56.73 | 2e-31 | 112 |
| LLPS-Meg-2004 | Meleagris gallopavo | 55.47 | 4e-41 | 138 |
| LLPS-Orl-2358 | Oryzias latipes | 55.34 | 1e-31 | 113 |
| LLPS-Pof-1270 | Poecilia formosa | 54.72 | 6e-33 | 117 |
| LLPS-Xim-3605 | Xiphophorus maculatus | 54.72 | 1e-34 | 120 |
| LLPS-Osl-1287 | Ostreococcus lucimarinus | 54.37 | 1e-31 | 113 |
| LLPS-Pyt-1455 | Pyrenophora teres | 53.66 | 5e-23 | 92.8 |
| LLPS-Scc-0107 | Schizosaccharomyces cryophilus | 53.4 | 2e-29 | 107 |
| LLPS-Drm-2299 | Drosophila melanogaster | 52.94 | 1e-28 | 105 |
| LLPS-Orn-1411 | Oreochromis niloticus | 52.83 | 6e-36 | 124 |
| LLPS-Sem-2089 | Selaginella moellendorffii | 52.58 | 1e-27 | 104 |
| LLPS-Scj-1178 | Schizosaccharomyces japonicus | 52.43 | 1e-30 | 110 |
| LLPS-Cii-0031 | Ciona intestinalis | 52.0 | 8e-29 | 106 |
| LLPS-Thc-1808 | Theobroma cacao | 51.85 | 2e-24 | 95.1 |
| LLPS-Chc-0890 | Chondrus crispus | 51.49 | 2e-29 | 114 |
| LLPS-Vir-1741 | Vigna radiata | 51.16 | 8e-27 | 101 |
| LLPS-Viv-0566 | Vitis vinifera | 51.11 | 7e-26 | 99.0 |
| LLPS-Lem-1578 | Leptosphaeria maculans | 51.0 | 4e-26 | 102 |
| LLPS-Sob-1368 | Sorghum bicolor | 50.0 | 2e-22 | 90.5 |
| LLPS-Asfu-1153 | Aspergillus fumigatus | 50.0 | 6e-26 | 99.0 |
| LLPS-Pytr-1344 | Pyrenophora triticirepentis | 50.0 | 2e-24 | 94.7 |
| LLPS-Orni-1624 | Oryza nivara | 50.0 | 2e-24 | 95.5 |
| LLPS-Glm-2840 | Glycine max | 50.0 | 1e-28 | 107 |
| LLPS-Cis-1916 | Ciona savignyi | 50.0 | 4e-27 | 102 |
| LLPS-Gag-0745 | Gaeumannomyces graminis | 49.5 | 3e-28 | 106 |
| LLPS-Sac-1436 | Saccharomyces cerevisiae | 49.5 | 4e-28 | 104 |
| LLPS-Scp-0567 | Schizosaccharomyces pombe | 49.5 | 1e-26 | 100 |
| LLPS-Phv-2041 | Phaseolus vulgaris | 49.49 | 3e-27 | 102 |
| LLPS-Asf-1314 | Aspergillus flavus | 49.04 | 3e-24 | 94.7 |
| LLPS-Aso-1398 | Aspergillus oryzae | 49.04 | 3e-24 | 94.7 |
| LLPS-Cym-0467 | Cyanidioschyzon merolae | 49.02 | 1e-26 | 105 |
| LLPS-Orgl-1613 | Oryza glumaepatula | 48.78 | 6e-25 | 96.7 |
| LLPS-Orbr-1515 | Oryza brachyantha | 48.57 | 2e-28 | 106 |
| LLPS-Brr-0272 | Brassica rapa | 48.42 | 5e-26 | 99.4 |
| LLPS-Nef-0788 | Neosartorya fischeri | 48.11 | 1e-24 | 95.5 |
| LLPS-Asni-0062 | Aspergillus niger | 48.08 | 2e-23 | 92.4 |
| LLPS-Yal-1103 | Yarrowia lipolytica | 48.08 | 4e-26 | 99.4 |
| LLPS-Mae-1423 | Manihot esculenta | 47.17 | 9e-27 | 102 |
| LLPS-Asc-0950 | Aspergillus clavatus | 47.17 | 2e-24 | 95.1 |
| LLPS-Miv-0846 | Microbotryum violaceum | 47.06 | 3e-27 | 102 |
| LLPS-Via-1727 | Vigna angularis | 47.06 | 3e-26 | 100 |
| LLPS-Tru-0527 | Triticum urartu | 46.74 | 2e-22 | 89.7 |
| LLPS-Gas-1219 | Galdieria sulphuraria | 46.73 | 1e-25 | 98.2 |
| LLPS-Asn-1571 | Aspergillus nidulans | 46.67 | 4e-23 | 94.0 |
| LLPS-Php-1894 | Physcomitrella patens | 46.67 | 7e-28 | 105 |
| LLPS-Nia-2025 | Nicotiana attenuata | 46.6 | 5e-26 | 99.4 |
| LLPS-Ors-1651 | Oryza sativa | 46.6 | 1e-26 | 101 |
| LLPS-Orp-1673 | Oryza punctata | 46.6 | 1e-25 | 100 |
| LLPS-Org-1732 | Oryza glaberrima | 46.6 | 1e-26 | 101 |
| LLPS-Ori-2112 | Oryza indica | 46.6 | 1e-26 | 101 |
| LLPS-Orb-1865 | Oryza barthii | 46.6 | 1e-26 | 101 |
| LLPS-Prp-1009 | Prunus persica | 46.46 | 2e-25 | 98.2 |
| LLPS-Coc-0134 | Corchorus capsularis | 46.39 | 3e-25 | 97.4 |
| LLPS-Gor-2121 | Gossypium raimondii | 46.32 | 8e-26 | 99.0 |
| LLPS-Sot-0748 | Solanum tuberosum | 46.32 | 5e-24 | 94.4 |
| LLPS-Zem-2198 | Zea mays | 46.25 | 3e-20 | 84.7 |
| LLPS-Art-1667 | Arabidopsis thaliana | 46.24 | 8e-21 | 85.9 |
| LLPS-Phn-0107 | Phaeosphaeria nodorum | 46.08 | 1e-25 | 99.4 |
| LLPS-Bro-1858 | Brassica oleracea | 45.78 | 1e-20 | 85.9 |
| LLPS-Cus-0315 | Cucumis sativus | 45.63 | 3e-26 | 100 |
| LLPS-Mao-0650 | Magnaporthe oryzae | 45.54 | 2e-23 | 94.0 |
| LLPS-Tum-0377 | Tuber melanosporum | 45.54 | 1e-23 | 93.2 |
| LLPS-Sei-2309 | Setaria italica | 45.45 | 3e-24 | 95.1 |
| LLPS-Hea-2417 | Helianthus annuus | 45.28 | 1e-25 | 99.0 |
| LLPS-Brn-1435 | Brassica napus | 45.28 | 2e-27 | 103 |
| LLPS-Arl-2465 | Arabidopsis lyrata | 45.28 | 2e-27 | 103 |
| LLPS-Dac-2106 | Daucus carota | 45.26 | 3e-24 | 95.1 |
| LLPS-Orm-1197 | Oryza meridionalis | 45.24 | 9e-22 | 88.6 |
| LLPS-Brd-2383 | Brachypodium distachyon | 45.24 | 5e-23 | 91.7 |
| LLPS-Ast-1179 | Aspergillus terreus | 45.19 | 4e-22 | 89.0 |
| LLPS-Map-1151 | Magnaporthe poae | 45.1 | 1e-23 | 94.7 |
| LLPS-Scs-0491 | Sclerotinia sclerotiorum | 45.1 | 8e-22 | 89.4 |
| LLPS-Amt-2125 | Amborella trichopoda | 44.94 | 2e-25 | 98.6 |
| LLPS-Tra-2184 | Triticum aestivum | 44.9 | 4e-23 | 92.0 |
| LLPS-Kop-1155 | Komagataella pastoris | 44.76 | 2e-25 | 97.1 |
| LLPS-Lep-1888 | Leersia perrieri | 44.76 | 1e-23 | 99.8 |
| LLPS-Orr-1425 | Oryza rufipogon | 44.19 | 1e-23 | 93.6 |
| LLPS-Mua-1984 | Musa acuminata | 44.12 | 2e-24 | 95.9 |
| LLPS-Crn-1050 | Cryptococcus neoformans | 43.69 | 1e-23 | 92.8 |
| LLPS-Sol-1249 | Solanum lycopersicum | 43.69 | 7e-24 | 94.0 |
| LLPS-Met-2568 | Medicago truncatula | 43.69 | 3e-26 | 100 |
| LLPS-Fus-1452 | Fusarium solani | 43.43 | 1e-21 | 87.4 |
| LLPS-Pot-0988 | Populus trichocarpa | 42.72 | 9e-25 | 96.7 |
| LLPS-Asg-0440 | Ashbya gossypii | 42.72 | 2e-22 | 89.7 |
| LLPS-Ved-1435 | Verticillium dahliae | 41.23 | 2e-23 | 92.8 |
| LLPS-Cog-0558 | Colletotrichum gloeosporioides | 40.86 | 3e-10 | 60.5 |
| LLPS-Blg-1258 | Blumeria graminis | 40.21 | 9e-22 | 88.2 |
| LLPS-Chr-0673 | Chlamydomonas reinhardtii | 39.62 | 3e-21 | 88.2 |
| LLPS-Hov-0621 | Hordeum vulgare | 39.22 | 3e-22 | 90.5 |
| LLPS-Beb-1656 | Beauveria bassiana | 39.13 | 1e-09 | 58.5 |
| LLPS-Trv-0995 | Trichoderma virens | 36.04 | 2e-16 | 74.3 |
| LLPS-Mel-0410 | Melampsora laricipopulina | 35.92 | 8e-22 | 90.1 |
| LLPS-Pug-0763 | Puccinia graminis | 30.39 | 2e-11 | 62.4 |
| LLPS-Put-1220 | Puccinia triticina | 30.39 | 2e-11 | 62.0 |