LLPS-Drm-1716
Dhod

▼ OVERVIEW

Status: Unreviewed
Protein Name: Dihydroorotate dehydrogenase (quinone), mitochondrial
Gene Name: Dhod, CG9741
Ensembl Gene: FBgn0000447
Ensembl Protein: FBpp0081376
Organism: Drosophila melanogaster
Taxa ID: 7227
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDQDHLKNAK  NATRRVGRLR  SLGIVTVGGA  ALVAGITAYK  NQDQLFRTFV  MPAVRLLPAE  60
61    ASHQLAVLAC  KYRLCPVSQY  HDDQNLHTSF  FGRMLSNPIG  IAAGFDKNAE  AVDGLQDLGF  120
121   GFIEVGTVTP  AAQEGNPKPR  VFRLTEDKAI  INRYGFNSDG  HQAVLQRLRL  LRKKENFNGV  180
181   VGVNLGRNKT  TMSPIADYVQ  GVRVFGPVAD  YLVINVSSPN  TKGLRDMQSK  EKLRELLEQV  240
241   NDTKSSLDKN  KNVPILLKLS  PDLSLDDMKD  IVWVIKRKKS  RVDGLIVSNT  TVSRENIEKN  300
301   KLAEETGGLS  GPPLKARSTE  MIAQMYQLTD  GKIPIIGVGG  VASGYDAYEK  IEAGASYVQI  360
361   YTALVYEGPA  LVEDIKAELS  ALITRLGHTN  VADVVGTNSK  FYLPK  405
Nucleotide CDS Sequence (FASTA)
1     ATGGATCAGG  ATCACTTAAA  GAATGCTAAA  AACGCCACGC  GGAGAGTTGG  TCGTTTGCGG  60
61    TCGCTGGGAA  TCGTTACAGT  CGGAGGAGCT  GCCTTGGTGG  CGGGCATTAC  GGCATACAAG  120
121   AACCAGGACC  AGTTGTTCCG  GACCTTCGTG  ATGCCAGCGG  TGCGACTTCT  TCCGGCGGAA  180
181   GCCAGCCATC  AACTGGCCGT  GCTGGCGTGC  AAGTACCGCC  TGTGCCCGGT  TTCACAGTAC  240
241   CATGATGACC  AGAACTTGCA  CACGTCGTTC  TTTGGCCGGA  TGCTTAGCAA  TCCCATTGGC  300
301   ATTGCAGCGG  GATTCGATAA  GAACGCGGAG  GCGGTGGACG  GCCTGCAGGA  TCTAGGATTC  360
361   GGATTTATAG  AGGTGGGCAC  AGTTACCCCG  GCGGCTCAGG  AGGGCAATCC  CAAGCCGAGA  420
421   GTATTCCGGT  TGACCGAGGA  CAAGGCCATC  ATTAATCGGT  ACGGATTTAA  TAGCGACGGG  480
481   CATCAGGCCG  TGCTCCAACG  GCTGCGCTTG  CTCCGCAAAA  AGGAGAACTT  CAATGGAGTT  540
541   GTGGGCGTGA  ATCTGGGCCG  GAACAAGACC  ACCATGAGCC  CGATAGCGGA  TTATGTACAG  600
601   GGTGTTCGGG  TTTTCGGGCC  CGTAGCAGAC  TACCTGGTCA  TTAATGTGAG  CAGTCCGAAC  660
661   ACCAAGGGCC  TGCGCGATAT  GCAGAGCAAG  GAGAAGCTAA  GAGAGCTCCT  GGAACAGGTC  720
721   AACGACACGA  AATCCTCCCT  GGATAAGAAC  AAGAATGTGC  CTATACTCTT  GAAACTTTCG  780
781   CCGGATCTAT  CTTTGGACGA  CATGAAGGAC  ATCGTGTGGG  TAATCAAGCG  CAAGAAGAGC  840
841   CGCGTGGATG  GCCTGATCGT  TTCAAACACC  ACGGTGTCGC  GGGAAAACAT  CGAAAAGAAC  900
901   AAGCTGGCCG  AGGAAACTGG  CGGATTAAGT  GGTCCTCCAC  TCAAGGCCCG  CTCCACAGAG  960
961   ATGATCGCCC  AGATGTACCA  GCTCACCGAT  GGAAAGATTC  CCATCATAGG  CGTCGGCGGA  1020
1021  GTGGCTTCCG  GCTATGATGC  ATACGAAAAG  ATCGAAGCTG  GAGCTTCCTA  CGTCCAAATC  1080
1081  TACACGGCTT  TAGTGTACGA  GGGACCCGCT  CTTGTGGAAG  ACATTAAGGC  GGAGCTGTCG  1140
1141  GCGCTGATCA  CACGGCTGGG  TCACACTAAT  GTTGCGGACG  TGGTGGGCAC  CAACAGCAAG  1200
1201  TTCTACTTGC  CCAAA  1215

▼ KEYWORD

ID
Family
Complete proteome
Flavoprotein
FMN
Membrane
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Pyrimidine biosynthesis
Reference proteome
Transit peptide
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Cellular Component
Mitochondrial inner membrane
Cellular Component
Mitochondrial intermembrane space
Cellular Component
Mitochondrion
Cellular Component
Plasma membrane
Molecular Function
Dihydroorotate dehydrogenase activity
Biological Process
'de novo' pyrimidine nucleobase biosynthetic process
Biological Process
'de novo' UMP biosynthetic process
Biological Process
Pyrimidine ribonucleotide biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Anp-2324Anas platyrhynchos54.649e-84 264
LLPS-Ora-0295Ornithorhynchus anatinus54.43e-102 313
LLPS-Cas-0422Carlito syrichta54.099e-63 208
LLPS-Meg-0437Meleagris gallopavo53.828e-100 306
LLPS-Mel-0098Melampsora laricipopulina52.991e-31 131
LLPS-Otg-4249Otolemur garnettii52.071e-114 347
LLPS-Fia-2252Ficedula albicollis51.552e-110 337
LLPS-Asm-0702Astyanax mexicanus51.475e-113 344
LLPS-Icp-0485Ictalurus punctatus51.466e-116 351
LLPS-Gaga-1017Gallus gallus51.382e-104 321
LLPS-Fud-4070Fukomys damarensis50.962e-110 337
LLPS-Mea-2645Mesocricetus auratus50.794e-115 348
LLPS-Dio-4037Dipodomys ordii50.772e-115 349
LLPS-Rhb-1858Rhinopithecus bieti50.692e-108 331
LLPS-Poa-4394Pongo abelii50.692e-109 333
LLPS-Leo-3767Lepisosteus oculatus50.523e-116 353
LLPS-Ict-1948Ictidomys tridecemlineatus50.261e-113 345
LLPS-Mum-4641Mus musculus50.262e-114 347
LLPS-Pof-2999Poecilia formosa50.132e-111 340
LLPS-Xim-2381Xiphophorus maculatus50.138e-111 338
LLPS-Caj-1181Callithrix jacchus50.01e-112 342
LLPS-Ran-4005Rattus norvegicus50.01e-114 347
LLPS-Dar-1219Danio rerio49.871e-113 345
LLPS-Anc-0615Anolis carolinensis49.551e-58 197
LLPS-Aon-1247Aotus nancymaae49.481e-111 340
LLPS-Scf-1571Scleropages formosus49.488e-111 338
LLPS-Eqc-0481Equus caballus49.474e-111 339
LLPS-Fec-4448Felis catus49.353e-114 347
LLPS-Caf-1300Canis familiaris49.354e-101 313
LLPS-Mup-4288Mustela putorius furo49.353e-102 316
LLPS-Myl-2424Myotis lucifugus49.312e-107 329
LLPS-Cap-1538Cavia porcellus49.234e-111 338
LLPS-Hos-3455Homo sapiens49.211e-110 337
LLPS-Pap-4156Pan paniscus49.211e-110 337
LLPS-Mam-1597Macaca mulatta49.217e-111 338
LLPS-Gog-1592Gorilla gorilla49.212e-111 339
LLPS-Cea-4118Cercocebus atys49.217e-111 338
LLPS-Mal-0661Mandrillus leucophaeus49.217e-111 338
LLPS-Tut-1747Tursiops truncatus49.216e-112 340
LLPS-Pat-2619Pan troglodytes49.092e-110 337
LLPS-Gaa-3431Gasterosteus aculeatus49.03e-110 337
LLPS-Man-3025Macaca nemestrina48.973e-111 339
LLPS-Nol-3259Nomascus leucogenys48.953e-109 333
LLPS-Sus-4219Sus scrofa48.953e-112 342
LLPS-Chs-3215Chlorocebus sabaeus48.954e-110 336
LLPS-Paa-3267Papio anubis48.951e-109 335
LLPS-Urm-1649Ursus maritimus48.836e-102 315
LLPS-Aim-3739Ailuropoda melanoleuca48.724e-103 318
LLPS-Maf-3684Macaca fascicularis48.714e-110 336
LLPS-Loa-0486Loxodonta africana48.74e-109 333
LLPS-Orc-0236Oryctolagus cuniculus48.691e-110 337
LLPS-Scm-3048Scophthalmus maximus48.435e-105 323
LLPS-Orl-1197Oryzias latipes48.25e-105 323
LLPS-Ova-3605Ovis aries48.171e-106 327
LLPS-Bot-1435Bos taurus48.175e-109 335
LLPS-Chr-0392Chlamydomonas reinhardtii47.888e-97 302
LLPS-Ten-1659Tetraodon nigroviridis47.765e-108 331
LLPS-Mod-1526Monodelphis domestica47.645e-110 335
LLPS-Gas-0530Galdieria sulphuraria47.316e-103 318
LLPS-Sah-2485Sarcophilus harrisii47.231e-105 325
LLPS-Tar-0425Takifugu rubripes47.015e-105 323
LLPS-Xet-1745Xenopus tropicalis46.915e-104 320
LLPS-Osl-0503Ostreococcus lucimarinus46.241e-95 298
LLPS-Cae-1982Caenorhabditis elegans45.361e-94 297
LLPS-Cis-0581Ciona savignyi45.261e-104 322
LLPS-Cii-0884Ciona intestinalis43.976e-101 312
LLPS-Scc-0750Schizosaccharomyces cryophilus43.236e-84 270
LLPS-Asg-1354Ashbya gossypii40.951e-79 259
LLPS-Yal-1490Yarrowia lipolytica40.949e-77 251
LLPS-Cym-0869Cyanidioschyzon merolae40.936e-86 275
LLPS-Scp-0511Schizosaccharomyces pombe40.144e-83 268
LLPS-Spr-0911Sporisorium reilianum39.671e-77 260
LLPS-Miv-0843Microbotryum violaceum39.422e-79 269
LLPS-Usm-0266Ustilago maydis39.311e-79 265
LLPS-Scj-1496Schizosaccharomyces japonicus37.632e-68 229
LLPS-Abg-1505Absidia glauca28.133e-0652.8
LLPS-Sac-0200Saccharomyces cerevisiae24.924e-0858.5