DrLLPS - Data resource of LLPS

LLPS-Drm-0856
Pfdn4

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Probable prefoldin subunit 4
Gene Name:	Pfdn4, CG10635
Ensembl Gene:	FBgn0035603
Ensembl Protein:	FBpp0076858
Organism:	Drosophila melanogaster
Taxa ID:	7227
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Stress granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-0824	Q9NQP4	Client	Stress granule	39.02	2e-23	94.7

▼ FUNCTION

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	FBtr0077154	FBpp0076858
UniProt		Q9VRL3, PFD4_DROME
GeneBank	AE014296	AAF50782.1
RefSeq	NM_139704.2	NP_647961.1
Entrez	38615

▼ SEQUENCE

Protein Sequence (FASTA)
1 MAAKVASGTN KVFQNHDDVH ISFEDQQRIN RFAKHNARMD DFKAELETKR NELKSLEEAL 60 61 EEIELFDEDE DIPFLVGEVF LSHKLEKTQD MLKETKEQVL KEIAGVEAKA KVIKAEMDEL 120 121 KAHLYQRFGS NISLEAED 138
Nucleotide CDS Sequence (FASTA)
1 ATGGCAGCAA AAGTAGCGAG CGGCACGAAC AAAGTGTTCC AGAACCACGA TGACGTGCAC 60 61 ATCTCCTTCG AGGATCAGCA GCGGATCAAC CGCTTTGCGA AGCACAACGC CCGCATGGAT 120 121 GACTTCAAAG CGGAGCTGGA AACGAAGCGC AATGAGCTGA AGAGCTTGGA GGAGGCGCTG 180 181 GAGGAGATTG AGCTGTTCGA CGAGGACGAG GACATACCGT TCCTGGTTGG CGAGGTGTTC 240 241 CTCTCGCACA AGCTGGAGAA AACACAGGAC ATGCTGAAGG AGACCAAGGA GCAGGTGCTC 300 301 AAGGAGATCG CCGGCGTGGA GGCCAAGGCG AAGGTTATCA AGGCGGAAAT GGACGAGCTG 360 361 AAGGCTCATC TGTACCAGCG GTTCGGCAGC AATATCTCAC TGGAGGCCGA GGAT 414

▼ KEYWORD

ID	Family
KW-0143	Chaperone
KW-0181	Complete proteome
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0016272	Cellular Component	Prefoldin complex
GO:0051082	Molecular Function	Unfolded protein binding
GO:0006457	Biological Process	Protein folding

▼ KEGG

dme:Dmel_CG10635

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
Gene3D

PTM
EPSD	dbPTM

Interaction
HINT	RAIN	Mentha	PINA	IID
iRefIndex	MIST

Physicochemical
AAindex

Function
PIRSF

Localization
COMPARTMENTS

Expression
ArrayExpress

Element
microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Mup-0520	Mustela putorius furo	45.67	2e-25	99.4
LLPS-Aim-1000	Ailuropoda melanoleuca	45.38	2e-24	97.1
LLPS-Scf-3830	Scleropages formosus	44.78	1e-13	68.2
LLPS-Fud-0506	Fukomys damarensis	44.72	7e-24	95.5
LLPS-Eqc-2226	Equus caballus	44.72	3e-23	95.9
LLPS-Tag-1691	Taeniopygia guttata	44.35	4e-25	98.6
LLPS-Urm-1268	Ursus maritimus	44.09	2e-25	99.8
LLPS-Leo-3190	Lepisosteus oculatus	43.9	3e-23	94.0
LLPS-Bot-4393	Bos taurus	43.9	9e-23	93.6
LLPS-Fec-1108	Felis catus	43.9	1e-23	95.9
LLPS-Fia-0345	Ficedula albicollis	43.55	3e-21	88.6
LLPS-Meg-2113	Meleagris gallopavo	43.09	8e-24	95.5
LLPS-Gaga-3000	Gallus gallus	43.09	8e-24	95.5
LLPS-Anp-1715	Anas platyrhynchos	42.74	7e-24	95.5
LLPS-Caf-3436	Canis familiaris	42.42	2e-24	97.1
LLPS-Sus-4851	Sus scrofa	42.28	8e-23	92.8
LLPS-Tut-2280	Tursiops truncatus	42.28	6e-23	93.2
LLPS-Aon-3751	Aotus nancymaae	42.15	8e-23	92.8
LLPS-Mod-1252	Monodelphis domestica	41.86	1e-23	94.7
LLPS-Anc-3769	Anolis carolinensis	41.8	3e-23	94.0
LLPS-Ova-4335	Ovis aries	41.73	7e-23	92.8
LLPS-Cea-4720	Cercocebus atys	41.46	6e-23	93.2
LLPS-Chs-0913	Chlorocebus sabaeus	41.46	6e-23	93.2
LLPS-Maf-0988	Macaca fascicularis	41.46	6e-23	93.2
LLPS-Caj-3413	Callithrix jacchus	41.46	2e-22	91.7
LLPS-Gog-2862	Gorilla gorilla	41.46	6e-23	93.2
LLPS-Myl-3564	Myotis lucifugus	41.46	2e-23	94.0
LLPS-Paa-0511	Papio anubis	41.46	6e-23	93.2
LLPS-Mal-1386	Mandrillus leucophaeus	41.46	6e-23	93.2
LLPS-Ere-0177	Erinaceus europaeus	41.46	5e-22	90.5
LLPS-Loa-4550	Loxodonta africana	41.46	2e-22	91.7
LLPS-Man-3039	Macaca nemestrina	41.46	6e-23	93.2
LLPS-Lac-0419	Latimeria chalumnae	41.46	1e-22	92.4
LLPS-Pap-3202	Pan paniscus	41.46	6e-23	93.2
LLPS-Pat-3075	Pan troglodytes	41.46	6e-23	93.2
LLPS-Hos-0824	Homo sapiens	41.46	6e-23	93.2
LLPS-Rhb-2346	Rhinopithecus bieti	41.46	6e-23	93.2
LLPS-Orc-2826	Oryctolagus cuniculus	41.46	6e-23	93.2
LLPS-Mam-3761	Macaca mulatta	41.46	6e-23	93.2
LLPS-Cap-1942	Cavia porcellus	41.46	7e-23	92.8
LLPS-Poa-0503	Pongo abelii	41.46	6e-23	93.2
LLPS-Ict-1780	Ictidomys tridecemlineatus	41.46	6e-23	93.2
LLPS-Nol-1563	Nomascus leucogenys	41.46	6e-23	93.2
LLPS-Cas-1783	Carlito syrichta	41.46	6e-23	93.2
LLPS-Ora-2341	Ornithorhynchus anatinus	40.98	7e-22	90.9
LLPS-Sah-4077	Sarcophilus harrisii	40.16	1e-22	92.4
LLPS-Trr-1379	Trichoderma reesei	40.0	7e-13	66.2
LLPS-Pes-2069	Pelodiscus sinensis	40.0	3e-22	92.4
LLPS-Otg-3147	Otolemur garnettii	39.85	4e-24	96.3
LLPS-Tar-1119	Takifugu rubripes	39.84	2e-22	92.0
LLPS-Xet-0864	Xenopus tropicalis	39.67	5e-22	90.9
LLPS-Crn-1122	Cryptococcus neoformans	39.34	1e-11	62.8
LLPS-Fuv-0013	Fusarium verticillioides	39.17	2e-09	56.2
LLPS-Sac-1652	Saccharomyces cerevisiae	39.17	2e-10	59.3
LLPS-Fuo-1291	Fusarium oxysporum	39.17	1e-09	56.6
LLPS-Asm-2967	Astyanax mexicanus	39.02	2e-22	92.0
LLPS-Xim-1001	Xiphophorus maculatus	38.97	5e-22	91.3
LLPS-Gas-1013	Galdieria sulphuraria	38.89	6e-07	48.9
LLPS-Asn-1240	Aspergillus nidulans	38.52	9e-13	65.9
LLPS-Aso-1545	Aspergillus oryzae	38.39	3e-11	61.6
LLPS-Asf-1111	Aspergillus flavus	38.39	3e-11	61.6
LLPS-Gag-0599	Gaeumannomyces graminis	38.33	2e-10	59.3
LLPS-Mao-0290	Magnaporthe oryzae	38.33	1e-11	62.8
LLPS-Trv-1616	Trichoderma virens	38.33	2e-10	59.3
LLPS-Icp-3904	Ictalurus punctatus	38.21	3e-19	83.6
LLPS-Gaa-1447	Gasterosteus aculeatus	38.21	2e-22	92.0
LLPS-Ran-3092	Rattus norvegicus	38.21	5e-23	93.6
LLPS-Scm-3292	Scophthalmus maximus	38.21	4e-23	94.7
LLPS-Dar-0532	Danio rerio	38.21	4e-23	93.6
LLPS-Fus-0186	Fusarium solani	38.21	9e-07	48.5
LLPS-Dos-0992	Dothistroma septosporum	38.05	2e-12	64.7
LLPS-Blg-0930	Blumeria graminis	37.5	4e-08	52.8
LLPS-Pof-3059	Poecilia formosa	37.41	6e-22	90.5
LLPS-Orl-3874	Oryzias latipes	37.4	1e-20	87.0
LLPS-Mea-0628	Mesocricetus auratus	37.4	3e-21	89.0
LLPS-Mum-3847	Mus musculus	37.4	4e-22	90.9
LLPS-Beb-0542	Beauveria bassiana	36.92	4e-06	47.4
LLPS-Lem-1166	Leptosphaeria maculans	36.89	3e-11	61.6
LLPS-Scs-0570	Sclerotinia sclerotiorum	36.76	2e-14	70.9
LLPS-Asg-1132	Ashbya gossypii	36.75	1e-07	51.2
LLPS-Map-0361	Magnaporthe poae	36.67	5e-10	58.2
LLPS-Pyt-0665	Pyrenophora teres	36.07	3e-10	58.5
LLPS-Dio-1802	Dipodomys ordii	35.77	5e-16	74.7
LLPS-Orn-3808	Oreochromis niloticus	35.77	1e-20	87.0
LLPS-Yal-1172	Yarrowia lipolytica	35.59	2e-09	56.2
LLPS-Nef-1645	Neosartorya fischeri	35.4	3e-09	55.8
LLPS-Cii-2259	Ciona intestinalis	35.25	5e-16	74.7
LLPS-Coo-0771	Colletotrichum orbiculare	35.0	2e-07	50.4
LLPS-Cog-0459	Colletotrichum gloeosporioides	35.0	2e-07	50.8
LLPS-Cogr-1204	Colletotrichum graminicola	35.0	1e-10	59.7
LLPS-Osl-1460	Ostreococcus lucimarinus	34.75	6e-06	46.2
LLPS-Ved-1224	Verticillium dahliae	34.17	9e-09	54.3
LLPS-Chr-1736	Chlamydomonas reinhardtii	33.61	5e-06	46.2
LLPS-Usm-0362	Ustilago maydis	33.61	2e-07	50.4
LLPS-Dac-1716	Daucus carota	33.6	1e-07	50.8
LLPS-Miv-0200	Microbotryum violaceum	33.33	2e-07	50.8
LLPS-Phn-1100	Phaeosphaeria nodorum	33.33	1e-08	53.9
LLPS-Nec-0465	Neurospora crassa	33.06	3e-08	52.8
LLPS-Asni-1311	Aspergillus niger	32.35	1e-10	60.1
LLPS-Abg-1963	Absidia glauca	32.2	9e-06	45.8
LLPS-Amt-1754	Amborella trichopoda	32.17	6e-06	46.2
LLPS-Mae-2038	Manihot esculenta	31.97	2e-07	50.4
LLPS-Spr-1126	Sporisorium reilianum	31.97	2e-07	50.8
LLPS-Asfu-1120	Aspergillus fumigatus	31.62	8e-10	57.4
LLPS-Cus-0875	Cucumis sativus	31.3	1e-06	48.1
LLPS-Glm-0857	Glycine max	31.15	5e-07	49.3
LLPS-Orbr-0764	Oryza brachyantha	30.33	3e-07	50.1
LLPS-Ast-1155	Aspergillus terreus	30.28	3e-08	52.8
LLPS-Pot-0058	Populus trichocarpa	30.25	4e-06	46.6
LLPS-Asc-1070	Aspergillus clavatus	30.15	2e-09	56.6
LLPS-Phv-1494	Phaseolus vulgaris	29.51	4e-06	46.6
LLPS-Arl-1141	Arabidopsis lyrata	28.81	3e-06	47.4
LLPS-Org-1773	Oryza glaberrima	28.81	1e-07	50.8
LLPS-Ori-0955	Oryza indica	27.97	3e-06	47.0
LLPS-Orb-2051	Oryza barthii	27.97	3e-06	47.0
LLPS-Orni-2159	Oryza nivara	27.97	3e-06	47.0
LLPS-Orgl-1980	Oryza glumaepatula	27.97	3e-06	47.0
LLPS-Ors-0557	Oryza sativa	27.97	3e-06	47.0
LLPS-Orr-1947	Oryza rufipogon	27.97	3e-06	47.0
LLPS-Met-0478	Medicago truncatula	27.12	1e-06	48.1

LLPS-Drm-0856Pfdn4

Protein Sequence

Nucleotide Sequence

LLPS-Drm-0856
Pfdn4