LLPS-Drm-0619
Elp2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Probable elongator complex protein 2
Gene Name: Elp2, StIP, CG11887
Ensembl Gene: FBgn0033540
Ensembl Protein: FBpp0087307
Organism: Drosophila melanogaster
Taxa ID: 7227
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (By similarity). Involved in the regulation of the STAT pathway.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblFBtr0088212FBpp0087307
UniProtQ7K4B3, ELP2_DROME
GeneBankAE013599, AY052019AAK93443.1, AAF58765.2
RefSeqNM_136756.4NP_610600.1
Entrez36123

▼ SEQUENCE

Protein Sequence (FASTA)
1     MQVENLHTSV  ACNRCTECAD  WGPNGWIAYG  ACNAIAIMDP  KFQGNSAKVL  FTLVEHTKRV  60
61    NTVRWLDCDK  LLSGGDDAIA  ILWELDETGT  TKSFTLKGHT  SGVNTVDGIR  QQDGSWLLAT  120
121   AAADTTIKLW  TFQDNNYVCF  QTISLSDGFC  FCLRLQLLPK  SNQVLLAFSG  DDETVSLWSE  180
181   QVETAGEGDS  LGRQFQRKHK  LTGHEDWVRG  LDFVVDGEDL  LLASGSQDNF  IRLWRIAPRS  240
241   KEQMQENRVD  LHQLSHNDDE  IKVEEKILQL  GKEAWYAVSL  ESVLYGHEGW  IYGVHWHKTP  300
301   DQELRLLSAS  IDKTVIIWAP  TEEGIWLEEV  RVGEVGGNSV  GFYGGKFSGD  GHSIMAHSYQ  360
361   GGFHIWSQDP  DRPQLWTPGV  IVGGHYGEVR  DLAWEHSGAY  LMTASADQTT  RLHAPWLQDG  420
421   ANPTWHELAR  PQIHGYDMQA  LALLSRYKFA  SGAEEKIVRT  FQAPANFIEN  FRHISGIEND  480
481   DAGDVLLDSL  PKGASVPSLG  LSNKAVYKVD  SEVESTSKTS  KDEYPDNYFV  PIALETPPQE  540
541   ETLMQNTLWP  ELQKLYGHGY  EIFALAATAD  GSLLASTCKA  SNAEHAQIIL  WNPSNWKQIQ  600
601   KLSGHQLTVT  QLSFSPDSRY  LLSVSRDRRW  CLYERQDSSV  SYQLVASTDK  SNGVHTRIIW  660
661   SCDWSHDGQF  FVTSSRDGKV  VVWKKEEDCK  ESSLNGWQAN  GVLELKNESI  TAVAFSNSYL  720
721   SGTDDTYILA  LGTETGLIKI  YQFVRGAWKL  LSDLNKSQAH  HLTVRRLQFR  PGKQLQLASC  780
781   GEDHLVRIYD  IKLT  794
Nucleotide CDS Sequence (FASTA)
1     ATGCAAGTGG  AGAATCTGCA  TACTTCAGTG  GCCTGCAACC  GCTGCACGGA  ATGCGCGGAT  60
61    TGGGGTCCAA  ATGGTTGGAT  TGCCTATGGG  GCATGTAACG  CCATAGCCAT  TATGGATCCA  120
121   AAGTTTCAAG  GCAACTCAGC  CAAGGTCCTG  TTCACGCTGG  TGGAGCACAC  AAAGCGAGTA  180
181   AACACTGTGA  GGTGGTTGGA  TTGCGACAAA  CTTCTTTCCG  GCGGAGATGA  TGCAATTGCT  240
241   ATTCTCTGGG  AACTGGATGA  AACGGGAACG  ACTAAGAGCT  TCACTCTCAA  AGGACACACA  300
301   AGTGGCGTAA  ATACTGTGGA  TGGAATTCGC  CAACAGGATG  GCTCCTGGCT  TTTGGCGACC  360
361   GCAGCAGCAG  ATACCACCAT  CAAGTTGTGG  ACTTTCCAGG  ATAATAATTA  TGTGTGCTTT  420
421   CAAACCATAT  CTTTATCCGA  CGGATTCTGC  TTCTGTCTTC  GACTGCAGCT  GCTGCCCAAG  480
481   AGCAACCAGG  TTCTGCTCGC  CTTCAGTGGC  GATGACGAGA  CTGTTTCCCT  GTGGTCGGAA  540
541   CAGGTAGAAA  CCGCAGGTGA  AGGAGATTCA  CTAGGTCGGC  AGTTCCAACG  CAAACACAAG  600
601   CTCACTGGCC  ACGAAGACTG  GGTTCGAGGT  CTGGATTTCG  TTGTCGATGG  CGAGGATTTG  660
661   CTGCTGGCCA  GTGGCTCTCA  GGATAACTTT  ATTCGTCTCT  GGCGGATTGC  GCCGCGCAGC  720
721   AAAGAGCAAA  TGCAAGAGAA  TCGGGTTGAT  CTGCATCAAT  TGAGCCACAA  CGACGATGAG  780
781   ATAAAGGTGG  AGGAGAAGAT  ACTACAACTG  GGGAAAGAAG  CCTGGTATGC  AGTGAGCTTG  840
841   GAATCGGTTC  TATATGGACA  TGAGGGATGG  ATTTATGGGG  TCCACTGGCA  CAAAACACCC  900
901   GATCAAGAGC  TCCGCCTTCT  ATCCGCTTCT  ATTGACAAGA  CCGTCATAAT  TTGGGCACCT  960
961   ACGGAAGAAG  GCATTTGGTT  GGAAGAAGTT  CGCGTGGGTG  AAGTGGGTGG  AAACTCCGTG  1020
1021  GGCTTCTATG  GTGGAAAGTT  CTCCGGCGAT  GGACACTCGA  TCATGGCCCA  CAGCTACCAA  1080
1081  GGTGGCTTTC  ATATTTGGAG  CCAAGATCCA  GATCGGCCAC  AGCTCTGGAC  CCCAGGTGTC  1140
1141  ATCGTTGGTG  GTCATTATGG  CGAAGTGAGG  GATCTGGCTT  GGGAACATAG  CGGCGCCTAT  1200
1201  TTGATGACCG  CGTCTGCAGA  CCAAACAACT  CGACTGCACG  CTCCGTGGCT  ACAGGATGGA  1260
1261  GCTAATCCCA  CGTGGCACGA  GCTGGCTCGT  CCACAAATTC  ATGGATATGA  TATGCAGGCG  1320
1321  TTGGCTTTGC  TTTCACGTTA  TAAATTTGCC  AGCGGAGCTG  AGGAAAAGAT  TGTGCGCACT  1380
1381  TTTCAAGCGC  CAGCCAACTT  CATTGAAAAC  TTTCGTCACA  TCAGTGGGAT  AGAAAATGAC  1440
1441  GATGCGGGAG  ACGTTCTGCT  GGATTCTCTT  CCCAAAGGAG  CTTCCGTGCC  TTCTTTGGGA  1500
1501  TTATCCAACA  AGGCTGTCTA  CAAGGTAGAT  TCTGAAGTGG  AGTCGACCAG  CAAGACCAGT  1560
1561  AAAGACGAAT  ACCCTGACAA  TTACTTTGTG  CCTATTGCTC  TGGAAACACC  ACCGCAGGAA  1620
1621  GAGACTTTAA  TGCAGAATAC  ACTTTGGCCC  GAGCTGCAGA  AGCTTTATGG  CCATGGCTAC  1680
1681  GAAATCTTTG  CACTAGCTGC  CACTGCAGAT  GGTTCCCTCT  TGGCCTCCAC  TTGCAAAGCC  1740
1741  AGCAATGCCG  AGCATGCTCA  GATTATATTA  TGGAACCCTT  CAAACTGGAA  GCAAATACAG  1800
1801  AAGCTGAGTG  GACACCAGTT  GACAGTGACC  CAACTTAGTT  TCTCCCCCGA  TTCGCGATAT  1860
1861  CTGCTATCAG  TGTCCCGGGA  TCGTCGCTGG  TGTCTCTACG  AGAGGCAGGA  TTCCTCAGTA  1920
1921  AGCTATCAAC  TGGTGGCCAG  CACTGACAAA  TCCAATGGAG  TTCATACACG  CATCATTTGG  1980
1981  TCGTGTGATT  GGTCGCATGA  TGGTCAGTTC  TTTGTGACGA  GCTCAAGGGA  TGGAAAAGTA  2040
2041  GTGGTTTGGA  AAAAGGAAGA  AGACTGCAAG  GAGTCTTCGC  TAAATGGCTG  GCAGGCGAAT  2100
2101  GGAGTTTTAG  AACTTAAAAA  TGAGTCAATC  ACAGCCGTGG  CTTTTTCCAA  TTCTTATCTT  2160
2161  AGTGGTACAG  ATGACACATA  CATTCTTGCT  TTGGGCACGG  AAACCGGACT  GATAAAAATA  2220
2221  TATCAGTTTG  TTCGAGGAGC  ATGGAAGTTA  CTAAGCGATT  TGAATAAGAG  CCAAGCTCAT  2280
2281  CATCTCACCG  TTCGACGTCT  GCAGTTCCGC  CCGGGAAAAC  AACTCCAGCT  TGCGAGTTGT  2340
2341  GGTGAGGATC  ATCTGGTACG  CATCTACGAC  ATTAAGCTCA  CA  2382

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Elongator holoenzyme complex
Cellular Component
Proteasome complex
Cellular Component
Transcription elongation factor complex
Molecular Function
Endopeptidase activator activity
Biological Process
Proteasome assembly
Biological Process
Transcription elongation from RNA polymerase II promoter
Biological Process
TRNA wobble uridine modification

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Physicochemical
AAindex
Function
iEKPD
Localization
COMPARTMENTS
Element
RAID

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Lac-3046Latimeria chalumnae44.250.0 576
LLPS-Pes-1190Pelodiscus sinensis44.070.0 576
LLPS-Tar-1247Takifugu rubripes43.820.0 675
LLPS-Cap-4496Cavia porcellus43.510.0 587
LLPS-Orn-0325Oreochromis niloticus43.230.0 658
LLPS-Scf-1712Scleropages formosus42.960.0 668
LLPS-Leo-1188Lepisosteus oculatus42.860.0 663
LLPS-Icp-3918Ictalurus punctatus42.810.0 655
LLPS-Asm-0078Astyanax mexicanus42.540.0 628
LLPS-Orl-2817Oryzias latipes42.490.0 640
LLPS-Scm-2947Scophthalmus maximus42.310.0 650
LLPS-Gaga-3458Gallus gallus42.250.0 663
LLPS-Xim-1082Xiphophorus maculatus42.210.0 660
LLPS-Dar-3413Danio rerio41.830.0 654
LLPS-Tag-1672Taeniopygia guttata41.690.0 638
LLPS-Anc-1577Anolis carolinensis41.631e-170 523
LLPS-Myl-0576Myotis lucifugus41.580.0 625
LLPS-Mod-0953Monodelphis domestica41.490.0 648
LLPS-Ran-1557Rattus norvegicus41.410.0 605
LLPS-Gaa-3716Gasterosteus aculeatus41.370.0 630
LLPS-Mum-3050Mus musculus41.30.0 610
LLPS-Bot-3087Bos taurus41.290.0 627
LLPS-Mup-0633Mustela putorius furo41.20.0 620
LLPS-Tut-2329Tursiops truncatus41.180.0 621
LLPS-Fud-3745Fukomys damarensis41.110.0 621
LLPS-Ova-3232Ovis aries41.070.0 620
LLPS-Pof-4142Poecilia formosa41.060.0 629
LLPS-Caf-1537Canis familiaris41.020.0 623
LLPS-Urm-2787Ursus maritimus40.90.0 620
LLPS-Mea-3127Mesocricetus auratus40.90.0 604
LLPS-Eqc-4394Equus caballus40.870.0 620
LLPS-Orc-3114Oryctolagus cuniculus40.780.0 625
LLPS-Poa-2330Pongo abelii40.730.0 627
LLPS-Sus-1046Sus scrofa40.730.0 611
LLPS-Fia-3007Ficedula albicollis40.70.0 608
LLPS-Pap-2092Pan paniscus40.450.0 621
LLPS-Loa-3786Loxodonta africana40.310.0 616
LLPS-Aim-3889Ailuropoda melanoleuca40.260.0 558
LLPS-Chs-3580Chlorocebus sabaeus40.240.0 619
LLPS-Ora-2173Ornithorhynchus anatinus39.670.0 588
LLPS-Xet-1198Xenopus tropicalis39.580.0 593
LLPS-Nol-1162Nomascus leucogenys39.50.0 588
LLPS-Fec-4017Felis catus39.310.0 592
LLPS-Cii-1977Ciona intestinalis38.941e-177 536
LLPS-Pat-3560Pan troglodytes38.870.0 600
LLPS-Hos-0374Homo sapiens38.760.0 598
LLPS-Cas-4065Carlito syrichta38.570.0 595
LLPS-Man-3999Macaca nemestrina38.50.0 593
LLPS-Maf-1032Macaca fascicularis38.50.0 592
LLPS-Gog-2733Gorilla gorilla38.320.0 599
LLPS-Caj-3256Callithrix jacchus38.210.0 595
LLPS-Rhb-0884Rhinopithecus bieti38.180.0 596
LLPS-Cea-3869Cercocebus atys38.180.0 591
LLPS-Cis-1869Ciona savignyi38.170.0 551
LLPS-Aon-4543Aotus nancymaae38.130.0 601
LLPS-Paa-2110Papio anubis38.080.0 592
LLPS-Mam-2209Macaca mulatta38.010.0 580
LLPS-Mal-3948Mandrillus leucophaeus37.740.0 590
LLPS-Otg-0776Otolemur garnettii36.80.0 561
LLPS-Coo-1458Colletotrichum orbiculare35.577e-132 419
LLPS-Amt-0442Amborella trichopoda35.512e-148 463
LLPS-Cogr-1633Colletotrichum graminicola35.414e-131 417
LLPS-Mae-1821Manihot esculenta35.352e-149 466
LLPS-Fus-1381Fusarium solani35.315e-128 408
LLPS-Hea-2532Helianthus annuus35.224e-147 459
LLPS-Mua-2370Musa acuminata35.23e-147 460
LLPS-Cog-0993Colletotrichum gloeosporioides35.131e-119 385
LLPS-Asfu-0195Aspergillus fumigatus35.023e-133 422
LLPS-Viv-1089Vitis vinifera34.983e-141 444
LLPS-Trv-0204Trichoderma virens34.942e-127 406
LLPS-Trr-1029Trichoderma reesei34.873e-127 405
LLPS-Nef-1469Neosartorya fischeri34.834e-131 417
LLPS-Yal-1587Yarrowia lipolytica34.832e-110 360
LLPS-Vir-1752Vigna radiata34.782e-118 382
LLPS-Sot-0045Solanum tuberosum34.655e-147 459
LLPS-Sol-1409Solanum lycopersicum34.611e-141 445
LLPS-Blg-1526Blumeria graminis34.614e-125 402
LLPS-Brn-3169Brassica napus34.513e-147 460
LLPS-Brr-2655Brassica rapa34.393e-146 457
LLPS-Phv-2331Phaseolus vulgaris34.371e-141 445
LLPS-Glm-1926Glycine max34.373e-141 444
LLPS-Crn-1022Cryptococcus neoformans34.372e-124 399
LLPS-Bro-1409Brassica oleracea34.357e-146 457
LLPS-Sah-3579Sarcophilus harrisii34.226e-145 456
LLPS-Nia-2222Nicotiana attenuata34.196e-146 456
LLPS-Via-2152Vigna angularis34.142e-138 437
LLPS-Met-2570Medicago truncatula34.141e-141 445
LLPS-Asc-0851Aspergillus clavatus34.123e-125 401
LLPS-Aso-1107Aspergillus oryzae34.081e-122 395
LLPS-Org-1539Oryza glaberrima34.044e-144 452
LLPS-Prp-0265Prunus persica34.034e-142 447
LLPS-Osl-1286Ostreococcus lucimarinus33.945e-98 325
LLPS-Ors-0431Oryza sativa33.922e-144 453
LLPS-Orr-1355Oryza rufipogon33.922e-144 453
LLPS-Ori-2396Oryza indica33.922e-144 453
LLPS-Abg-1992Absidia glauca33.98e-149 465
LLPS-Gor-1967Gossypium raimondii33.881e-140 442
LLPS-Asni-1220Aspergillus niger33.851e-126 405
LLPS-Pot-0014Populus trichocarpa33.843e-145 454
LLPS-Orb-0795Oryza barthii33.84e-144 452
LLPS-Orgl-1030Oryza glumaepatula33.84e-144 452
LLPS-Orni-0897Oryza nivara33.644e-142 447
LLPS-Art-2055Arabidopsis thaliana33.63e-139 439
LLPS-Thc-2425Theobroma cacao33.66e-141 444
LLPS-Mel-1329Melampsora laricipopulina33.581e-92 316
LLPS-Asg-0166Ashbya gossypii33.581e-116 379
LLPS-Zyt-0758Zymoseptoria tritici33.496e-126 403
LLPS-Sem-0613Selaginella moellendorffii33.456e-135 427
LLPS-Dac-0573Daucus carota33.454e-132 421
LLPS-Orbr-2364Oryza brachyantha33.419e-144 451
LLPS-Cus-1197Cucumis sativus33.413e-134 426
LLPS-Fuv-1078Fusarium verticillioides33.336e-127 406
LLPS-Arl-1086Arabidopsis lyrata33.337e-141 443
LLPS-Sei-1044Setaria italica33.221e-138 438
LLPS-Lep-0970Leersia perrieri33.149e-138 435
LLPS-Beb-0766Beauveria bassiana33.138e-65 230
LLPS-Usm-1541Ustilago maydis33.038e-37 154
LLPS-Zem-1443Zea mays32.985e-136 431
LLPS-Mao-1148Magnaporthe oryzae32.953e-125 403
LLPS-Ved-1351Verticillium dahliae32.944e-119 385
LLPS-Spr-0469Sporisorium reilianum32.861e-38 159
LLPS-Asn-1344Aspergillus nidulans32.862e-116 380
LLPS-Fuo-1313Fusarium oxysporum32.854e-126 404
LLPS-Ast-1403Aspergillus terreus32.827e-128 409
LLPS-Sob-0658Sorghum bicolor32.766e-135 428
LLPS-Kop-1502Komagataella pastoris32.765e-111 363
LLPS-Orp-0887Oryza punctata32.755e-139 438
LLPS-Tra-2680Triticum aestivum32.757e-134 425
LLPS-Brd-0832Brachypodium distachyon32.683e-130 416
LLPS-Dos-1414Dothistroma septosporum32.619e-122 393
LLPS-Pytr-0276Pyrenophora triticirepentis32.534e-110 362
LLPS-Tum-1612Tuber melanosporum32.481e-111 366
LLPS-Tru-0843Triticum urartu32.413e-132 421
LLPS-Pyt-1249Pyrenophora teres32.412e-107 354
LLPS-Phn-1548Phaeosphaeria nodorum32.41e-85 293
LLPS-Cae-0708Caenorhabditis elegans32.362e-117 380
LLPS-Lem-1430Leptosphaeria maculans32.361e-112 368
LLPS-Gag-1243Gaeumannomyces graminis32.065e-110 364
LLPS-Put-1345Puccinia triticina32.021e-84 291
LLPS-Scj-1027Schizosaccharomyces japonicus31.92e-101 337
LLPS-Orm-1012Oryza meridionalis31.786e-127 406
LLPS-Miv-0575Microbotryum violaceum31.762e-119 388
LLPS-Sac-1255Saccharomyces cerevisiae31.77e-111 363
LLPS-Scp-0379Schizosaccharomyces pombe31.674e-110 360
LLPS-Nec-1034Neurospora crassa31.446e-104 347
LLPS-Hov-1902Hordeum vulgare31.432e-127 409
LLPS-Asf-1486Aspergillus flavus31.05e-1583.2
LLPS-Scc-1417Schizosaccharomyces cryophilus30.668e-106 348
LLPS-Map-0812Magnaporthe poae30.653e-111 367
LLPS-Pug-1372Puccinia graminis30.573e-102 341
LLPS-Chc-1144Chondrus crispus29.991e-70 251
LLPS-Chr-1692Chlamydomonas reinhardtii29.771e-44 178
LLPS-Ten-1411Tetraodon nigroviridis29.593e-84 292
LLPS-Cym-0534Cyanidioschyzon merolae29.253e-46 181
LLPS-Gas-0733Galdieria sulphuraria29.135e-76 269
LLPS-Ict-1481Ictidomys tridecemlineatus26.979e-0962.4
LLPS-Dio-1970Dipodomys ordii26.978e-0962.4
LLPS-Meg-0761Meleagris gallopavo26.241e-1068.6
LLPS-Anp-1577Anas platyrhynchos26.248e-1168.9