LLPS-Dar-3368
ddx46

▼ OVERVIEW

Status: Unreviewed
Protein Name: Probable ATP-dependent RNA helicase DDX46; DEAD box protein 46
Gene Name: ddx46
Ensembl Gene: ENSDARG00000099458.2
Ensembl Protein: ENSDARP00000135125.1
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Plays an essential role in splicing, either prior to, or during A complex formation.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGRESRHYRK  RSSSRGRSGS  RSKSRSPDSK  RSKKDDRTAS  RTHSRRERSR  SRERRRSRER  60
61    KRQRRSSRDR  RRSRSRERRR  SKSRSRGRSK  EKPENGDQTA  DKKKIKEEKE  EEKPEDQDFD  120
121   QNTLEEEMRK  RKERVEKWRE  EQRKKAMENI  GEIKKELEEM  KQGKKWSLED  DDEEQDKAAE  180
181   AEESERMEEE  EVGEEVDPLD  AYMEEVKEEV  KKFNMGTMKG  ANDKKGGMSV  TKVVTVVKTK  240
241   KMPHATKKKG  ELMENDQDAM  EYSSEEEEVD  LQTALTGFQT  KQRKVLEPVD  HQKIQYEPFR  300
301   KNFYVEVPEL  ARMSPEEVSE  YRLELEGISV  KGKGCPKPIK  TWVQCGISMK  VLNALKKHNY  360
361   EKPTPIQAQA  IPAIMSGRDL  IGIAKTGSGK  TIAFLLPMFR  HILDQRPVGE  AEGPLAVIMT  420
421   PTRELALQIT  KECKKFSKSL  ALRVVCVYGG  TGISEQIAEL  KRGAEIIVCT  PGRMIDMLGA  480
481   NNGRVTNLRR  VTYVVIDEAD  RMFDMGFEPQ  VMRIVDNVRP  DRQTVMFSAT  FPRTMEALAR  540
541   RILSKPVEVQ  VGGRSVVCSD  VEQHVIVIEE  EKKFLKLLEI  LGHYQEKGSV  IIFVDKQEHA  600
601   DGLLKDLMKA  SYPCMSLHGG  IDQYDRDSII  NDFKNGACRL  LVATSVAARG  LDVKQLILVV  660
661   NYSCPNHYED  YVHRAGRTGR  AGNKGYAYTF  ITEGQARYSG  DILKALELSG  SSVPAELEQL  720
721   WTNFKEQQKA  EGKIIKSSSG  FSGKGFKFDE  TEHALANERK  KLQKAALGLH  DSDDEDTALD  780
781   IDEQIESMFN  SKKRVKDFSA  PGSVSAGSAG  GVSGSVSAVS  GLGSLSTPSA  GNIQKLEIAK  840
841   KLALRIQAQK  NLGAEAQDVM  QQATNAILRG  GTIIAPSVSA  KTIAEQQAEK  INAKLNYTPV  900
901   EKLEEERQAA  EAAETVKRYE  EELEINDFPQ  TARWKVTSKE  ALQRIGEYSE  AAITIRGTYF  960
961   PPGKEPKEGE  RKIYLAIESA  NELAVQKAKA  EITRLIKEEL  IRLQNSYQPT  SKGRYKVL  1018
Nucleotide CDS Sequence (FASTA)
1     ATGGGCCGAG  AGTCACGGCA  CTACAGGAAG  CGCTCCAGCT  CCAGGGGCAG  GTCGGGCAGC  60
61    CGGTCTAAGA  GCCGCTCTCC  AGACTCGAAG  CGCTCTAAGA  AAGACGACCG  CACCGCTTCC  120
121   AGAACACACA  GCAGACGAGA  GAGATCCCGC  AGCAGAGAGA  GACGCAGATC  CAGAGAACGC  180
181   AAGAGACAGA  GGCGGTCCAG  TCGAGACCGG  AGACGCTCAC  GCAGTCGAGA  ACGCAGGAGG  240
241   AGTAAGAGCA  GGAGCAGAGG  CAGGAGCAAG  GAGAAGCCGG  AGAATGGAGA  TCAGACGGCT  300
301   GACAAGAAGA  AGATCAAGGA  GGAGAAGGAG  GAGGAGAAGC  CTGAAGATCA  GGACTTTGAT  360
361   CAGAACACGC  TGGAGGAGGA  GATGAGGAAG  AGGAAGGAGC  GTGTGGAGAA  GTGGAGAGAG  420
421   GAGCAGAGGA  AGAAGGCCAT  GGAGAACATC  GGGGAGATCA  AGAAGGAGCT  GGAGGAGATG  480
481   AAGCAGGGCA  AGAAGTGGAG  TCTGGAGGAC  GATGACGAGG  AGCAGGATAA  AGCAGCAGAA  540
541   GCAGAAGAGT  CCGAGCGTAT  GGAGGAGGAG  GAGGTCGGAG  AGGAGGTGGA  CCCGCTGGAC  600
601   GCCTACATGG  AGGAGGTCAA  GGAGGAGGTC  AAGAAGTTCA  ACATGGGCAC  TATGAAGGGA  660
661   GCAAACGACA  AGAAAGGAGG  GATGTCTGTG  ACCAAAGTGG  TGACGGTGGT  GAAGACCAAG  720
721   AAGATGCCGC  ACGCCACCAA  GAAGAAGGGG  GAGCTGATGG  AGAACGACCA  GGACGCCATG  780
781   GAGTATTCGT  CAGAGGAAGA  GGAAGTGGAC  CTCCAGACGG  CGCTCACAGG  CTTCCAGACG  840
841   AAGCAGAGGA  AGGTTCTGGA  GCCGGTGGAT  CACCAGAAGA  TCCAGTACGA  GCCCTTCAGG  900
901   AAAAACTTCT  ATGTGGAGGT  GCCGGAGCTG  GCCCGCATGA  GCCCTGAAGA  GGTGAGCGAG  960
961   TACCGTCTGG  AGCTGGAGGG  AATCAGTGTT  AAAGGAAAAG  GCTGTCCGAA  GCCCATCAAG  1020
1021  ACCTGGGTGC  AGTGTGGGAT  ATCCATGAAA  GTGCTGAACG  CGCTGAAGAA  ACACAACTAC  1080
1081  GAGAAGCCGA  CGCCGATCCA  AGCGCAGGCC  ATACCGGCCA  TCATGTCAGG  ACGAGACCTC  1140
1141  ATCGGCATCG  CCAAAACAGG  AAGCGGAAAG  ACCATCGCCT  TCCTGTTGCC  CATGTTTCGG  1200
1201  CACATATTAG  ACCAGCGGCC  GGTGGGAGAG  GCTGAAGGAC  CCCTCGCGGT  GATCATGACC  1260
1261  CCGACGCGAG  AGCTCGCTCT  GCAGATCACT  AAAGAGTGTA  AGAAGTTCTC  CAAGAGTCTG  1320
1321  GCTCTGCGGG  TGGTCTGTGT  GTACGGCGGC  ACCGGCATCA  GTGAGCAGAT  TGCAGAGCTG  1380
1381  AAGCGTGGAG  CGGAGATCAT  CGTCTGCACT  CCCGGCCGGA  TGATTGACAT  GCTGGGAGCC  1440
1441  AACAATGGTC  GGGTCACTAA  TCTGCGCAGG  GTTACATATG  TGGTGATCGA  CGAGGCTGAC  1500
1501  CGAATGTTCG  ACATGGGCTT  CGAGCCGCAG  GTGATGCGTA  TCGTGGATAA  CGTGCGACCC  1560
1561  GACCGTCAGA  CCGTCATGTT  CTCCGCCACG  TTCCCCCGCA  CCATGGAGGC  TCTGGCCCGC  1620
1621  AGGATCCTGT  CCAAACCTGT  GGAGGTGCAG  GTGGGCGGAC  GGAGCGTGGT  GTGTTCAGAT  1680
1681  GTGGAGCAGC  ATGTGATTGT  GATCGAGGAG  GAGAAGAAGT  TCCTGAAGCT  GCTGGAGATT  1740
1741  CTGGGCCACT  ATCAGGAGAA  GGGCTCCGTC  ATCATCTTCG  TGGACAAGCA  GGAGCACGCG  1800
1801  GACGGCCTGC  TGAAAGACCT  GATGAAGGCC  TCGTACCCCT  GCATGTCTCT  GCATGGAGGC  1860
1861  ATTGACCAGT  ATGACAGAGA  CAGCATCATC  AATGACTTTA  AGAACGGGGC  CTGTCGGCTG  1920
1921  CTGGTGGCCA  CGTCGGTGGC  GGCGCGAGGT  CTTGACGTCA  AGCAGCTGAT  CCTGGTGGTG  1980
1981  AACTACAGCT  GCCCCAACCA  CTATGAGGAC  TACGTGCACC  GCGCAGGACG  CACCGGGCGA  2040
2041  GCCGGAAACA  AGGGTTATGC  CTACACCTTC  ATCACAGAGG  GCCAGGCCCG  ATACTCTGGA  2100
2101  GATATCCTGA  AGGCTCTGGA  GCTGTCGGGA  TCGTCCGTCC  CCGCGGAGCT  CGAGCAGCTC  2160
2161  TGGACAAACT  TTAAAGAGCA  GCAGAAAGCA  GAGGGGAAGA  TCATCAAGAG  CAGCAGTGGC  2220
2221  TTCTCTGGGA  AAGGCTTTAA  GTTTGATGAG  ACTGAGCATG  CTCTGGCCAA  CGAGAGGAAG  2280
2281  AAGCTGCAGA  AGGCGGCGCT  CGGCCTGCAC  GACTCTGATG  ATGAGGACAC  CGCGCTCGAC  2340
2341  ATCGATGAGC  AGATCGAGAG  CATGTTTAAC  TCTAAGAAGC  GGGTGAAGGA  TTTCTCGGCT  2400
2401  CCGGGCTCCG  TGTCTGCGGG  GTCTGCAGGT  GGTGTGAGCG  GCTCCGTGTC  TGCAGTGTCC  2460
2461  GGCCTGGGCA  GTCTGAGCAC  TCCGTCTGCC  GGAAACATCC  AGAAGCTGGA  GATCGCCAAG  2520
2521  AAGCTGGCGC  TCAGGATACA  GGCGCAGAAG  AACCTCGGTG  CAGAGGCGCA  GGATGTGATG  2580
2581  CAGCAGGCCA  CGAATGCCAT  TCTGCGCGGC  GGTACGATAA  TCGCACCTTC  AGTTTCGGCT  2640
2641  AAAACCATCG  CGGAGCAGCA  GGCGGAGAAA  ATCAACGCCA  AACTGAACTA  CACACCGGTG  2700
2701  GAGAAGCTGG  AGGAGGAGAG  ACAGGCGGCG  GAGGCTGCAG  AGACCGTCAA  GAGATACGAA  2760
2761  GAGGAGCTGG  AGATCAACGA  CTTCCCACAG  ACGGCGAGGT  GGAAGGTCAC  GTCTAAAGAA  2820
2821  GCTCTGCAGC  GAATCGGCGA  GTATTCAGAG  GCCGCTATCA  CTATACGAGG  AACATACTTC  2880
2881  CCTCCAGGAA  AAGAGCCCAA  AGAGGGAGAA  CGCAAGATTT  ATCTGGCCAT  CGAGAGTGCG  2940
2941  AATGAATTGG  CTGTTCAGAA  GGCGAAGGCA  GAAATCACAC  GGCTCATCAA  AGAGGAGCTC  3000
3001  ATCCGCCTGC  AAAACTCTTA  CCAGCCGACC  AGCAAAGGCC  GATACAAGGT  CCTGTAG  3057

▼ KEYWORD

ID
Family
ATP-binding
Coiled coil
Complete proteome
Helicase
Hydrolase
mRNA processing
mRNA splicing
Nucleotide-binding
Nucleus
Reference proteome
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cajal body
Cellular Component
Nuclear speck
Molecular Function
ATP binding
Molecular Function
Helicase activity
Molecular Function
RNA binding
Biological Process
Brain development
Biological Process
Definitive hemopoiesis
Biological Process
Digestive tract morphogenesis
Biological Process
Exocrine pancreas development
Biological Process
Liver morphogenesis
Biological Process
MRNA splicing, via spliceosome
Biological Process
Positive regulation of erythrocyte differentiation
Biological Process
Positive regulation of hematopoietic stem cell differentiation
Biological Process
Positive regulation of lymphocyte differentiation

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
Interaction
MIST
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orn-0658Oreochromis niloticus96.235e-0758.5
LLPS-Scm-0521Scophthalmus maximus96.152e-0656.2
LLPS-Xim-1686Xiphophorus maculatus96.152e-0656.2
LLPS-Tar-0120Takifugu rubripes96.152e-0656.6
LLPS-Asm-2297Astyanax mexicanus89.040.01433
LLPS-Pof-1782Poecilia formosa88.580.01346
LLPS-Orl-0778Oryzias latipes88.470.01347
LLPS-Leo-0364Lepisosteus oculatus88.460.01403
LLPS-Icp-0892Ictalurus punctatus87.920.01422
LLPS-Scf-3370Scleropages formosus87.230.01412
LLPS-Rhb-1137Rhinopithecus bieti86.710.01084
LLPS-Ten-2001Tetraodon nigroviridis86.310.01371
LLPS-Gaa-1752Gasterosteus aculeatus86.090.01385
LLPS-Orc-1272Oryctolagus cuniculus83.870.01350
LLPS-Mea-1425Mesocricetus auratus83.850.01354
LLPS-Myl-0743Myotis lucifugus83.760.01348
LLPS-Mum-2615Mus musculus83.760.01350
LLPS-Eqc-1843Equus caballus83.740.01353
LLPS-Nol-0789Nomascus leucogenys83.740.01352
LLPS-Man-1485Macaca nemestrina83.740.01352
LLPS-Pat-2515Pan troglodytes83.740.01352
LLPS-Pap-0183Pan paniscus83.740.01352
LLPS-Fec-3288Felis catus83.740.01353
LLPS-Mal-3892Mandrillus leucophaeus83.740.01352
LLPS-Caj-1508Callithrix jacchus83.740.01352
LLPS-Gog-1706Gorilla gorilla83.740.01352
LLPS-Lac-0463Latimeria chalumnae83.70.01365
LLPS-Caf-2351Canis familiaris83.650.01348
LLPS-Cap-0233Cavia porcellus83.650.01346
LLPS-Hos-0438Homo sapiens83.650.01348
LLPS-Aim-0891Ailuropoda melanoleuca83.650.01348
LLPS-Mup-0831Mustela putorius furo83.650.01348
LLPS-Ova-1531Ovis aries83.650.01348
LLPS-Aon-2770Aotus nancymaae83.650.01348
LLPS-Sus-1247Sus scrofa83.650.01348
LLPS-Maf-1346Macaca fascicularis83.650.01348
LLPS-Fud-0588Fukomys damarensis83.650.01347
LLPS-Ran-2695Rattus norvegicus83.540.01345
LLPS-Bot-2215Bos taurus83.480.01318
LLPS-Cea-1343Cercocebus atys83.450.01348
LLPS-Anp-1613Anas platyrhynchos83.20.01354
LLPS-Mod-0116Monodelphis domestica83.20.01342
LLPS-Sah-0310Sarcophilus harrisii83.20.01337
LLPS-Ict-0244Ictidomys tridecemlineatus83.160.01044
LLPS-Mam-1751Macaca mulatta83.120.01274
LLPS-Meg-0542Meleagris gallopavo83.110.01349
LLPS-Tag-1621Taeniopygia guttata83.080.01352
LLPS-Xet-0012Xenopus tropicalis82.960.01351
LLPS-Fia-0312Ficedula albicollis82.690.01350
LLPS-Pes-1469Pelodiscus sinensis82.680.01335
LLPS-Gaga-1272Gallus gallus82.480.01346
LLPS-Otg-0283Otolemur garnettii82.430.01328
LLPS-Ora-1195Ornithorhynchus anatinus82.430.01334
LLPS-Cas-0408Carlito syrichta82.090.01278
LLPS-Anc-1834Anolis carolinensis81.090.01332
LLPS-Urm-0929Ursus maritimus80.860.01275
LLPS-Loa-1114Loxodonta africana80.730.01286
LLPS-Paa-3186Papio anubis78.810.01245
LLPS-Dio-1579Dipodomys ordii78.480.01263
LLPS-Poa-1409Pongo abelii73.450.01119
LLPS-Drm-1047Drosophila melanogaster68.490.0 793
LLPS-Cii-0672Ciona intestinalis66.590.0 999
LLPS-Abg-0143Absidia glauca66.230.0 615
LLPS-Aso-1308Aspergillus oryzae65.770.0 600
LLPS-Asf-0976Aspergillus flavus65.770.0 599
LLPS-Cis-1679Ciona savignyi65.610.01001
LLPS-Asfu-0977Aspergillus fumigatus65.550.0 597
LLPS-Nef-0317Neosartorya fischeri65.320.0 596
LLPS-Tum-0195Tuber melanosporum65.081e-149 464
LLPS-Asc-0815Aspergillus clavatus64.650.0 596
LLPS-Coc-1183Corchorus capsularis64.570.0 591
LLPS-Sem-0301Selaginella moellendorffii64.382e-125 399
LLPS-Sot-1560Solanum tuberosum63.780.0 582
LLPS-Viv-0106Vitis vinifera63.330.0 587
LLPS-Thc-0661Theobroma cacao63.230.0 586
LLPS-Pot-1621Populus trichocarpa63.10.0 582
LLPS-Orbr-2071Oryza brachyantha63.070.0 578
LLPS-Lep-0198Leersia perrieri63.072e-179 557
LLPS-Dac-0636Daucus carota62.640.0 577
LLPS-Sob-0107Sorghum bicolor62.560.0 583
LLPS-Spr-1189Sporisorium reilianum62.530.0 572
LLPS-Orp-1677Oryza punctata62.330.0 577
LLPS-Php-0581Physcomitrella patens62.160.0 578
LLPS-Orr-1764Oryza rufipogon62.110.0 577
LLPS-Org-0400Oryza glaberrima62.110.0 577
LLPS-Ors-0253Oryza sativa62.110.0 577
LLPS-Blg-1253Blumeria graminis62.110.0 583
LLPS-Orgl-0742Oryza glumaepatula62.110.0 577
LLPS-Orb-1279Oryza barthii62.110.0 576
LLPS-Ori-1084Oryza indica62.110.0 577
LLPS-Prp-0417Prunus persica62.080.0 600
LLPS-Chr-0764Chlamydomonas reinhardtii61.990.0 588
LLPS-Orni-0133Oryza nivara61.880.0 575
LLPS-Tra-0077Triticum aestivum61.470.0 563
LLPS-Hea-0573Helianthus annuus61.280.0 565
LLPS-Scc-0319Schizosaccharomyces cryophilus60.850.0 593
LLPS-Brd-0796Brachypodium distachyon60.780.0 565
LLPS-Amt-1059Amborella trichopoda60.550.0 583
LLPS-Scp-1352Schizosaccharomyces pombe60.040.0 593
LLPS-Miv-1452Microbotryum violaceum60.00.0 569
LLPS-Chc-1118Chondrus crispus60.00.0 576
LLPS-Zyt-0034Zymoseptoria tritici59.914e-177 554
LLPS-Crn-1369Cryptococcus neoformans59.912e-177 553
LLPS-Mae-0493Manihot esculenta59.660.0 584
LLPS-Tru-0412Triticum urartu59.420.0 561
LLPS-Ved-0011Verticillium dahliae59.381e-178 560
LLPS-Coo-0247Colletotrichum orbiculare59.20.0 578
LLPS-Beb-0406Beauveria bassiana58.610.0 569
LLPS-Cog-1304Colletotrichum gloeosporioides58.560.0 576
LLPS-Mao-1454Magnaporthe oryzae58.391e-180 560
LLPS-Nec-0920Neurospora crassa58.144e-170 537
LLPS-Sol-0098Solanum lycopersicum57.437e-23 110
LLPS-Vir-0218Vigna radiata57.321e-20 102
LLPS-Phv-0700Phaseolus vulgaris56.80.0 594
LLPS-Nia-0562Nicotiana attenuata56.720.0 590
LLPS-Glm-2267Glycine max56.420.0 592
LLPS-Gor-2213Gossypium raimondii56.315e-24 113
LLPS-Orm-0129Oryza meridionalis55.870.0 584
LLPS-Fus-0273Fusarium solani55.841e-163 520
LLPS-Cus-0813Cucumis sativus55.840.0 585
LLPS-Art-0985Arabidopsis thaliana55.680.0 588
LLPS-Brr-1063Brassica rapa55.410.0 591
LLPS-Met-0682Medicago truncatula55.310.0 588
LLPS-Bro-2150Brassica oleracea55.220.0 588
LLPS-Arl-2966Arabidopsis lyrata55.120.0 581
LLPS-Osl-0551Ostreococcus lucimarinus54.954e-164 507
LLPS-Pug-1283Puccinia graminis54.860.0 572
LLPS-Sei-0974Setaria italica54.70.0 581
LLPS-Scj-1360Schizosaccharomyces japonicus54.560.0 597
LLPS-Gas-1051Galdieria sulphuraria54.510.0 598
LLPS-Usm-0919Ustilago maydis54.264e-177 555
LLPS-Put-0910Puccinia triticina54.160.0 568
LLPS-Trv-0633Trichoderma virens54.05e-180 565
LLPS-Mel-0262Melampsora laricipopulina53.820.0 560
LLPS-Trr-0682Trichoderma reesei53.581e-180 566
LLPS-Gag-0317Gaeumannomyces graminis53.538e-177 556
LLPS-Map-0271Magnaporthe poae53.532e-178 553
LLPS-Mua-1642Musa acuminata52.949e-23 109
LLPS-Hov-0740Hordeum vulgare52.630.0 563
LLPS-Yal-1500Yarrowia lipolytica52.472e-156 495
LLPS-Kop-0681Komagataella pastoris52.093e-154 483
LLPS-Phn-0795Phaeosphaeria nodorum52.06e-151 486
LLPS-Brn-2559Brassica napus51.683e-169 533
LLPS-Lem-1273Leptosphaeria maculans49.086e-153 492
LLPS-Cae-0874Caenorhabditis elegans48.450.0 719
LLPS-Pytr-0311Pyrenophora triticirepentis47.331e-152 490
LLPS-Pyt-0613Pyrenophora teres46.592e-152 490
LLPS-Cym-1015Cyanidioschyzon merolae45.032e-117 382
LLPS-Via-0588Vigna angularis44.683e-117 376
LLPS-Zem-1169Zea mays40.47e-118 387