LLPS-Dar-0845
ssrp1a

▼ OVERVIEW

Status: Unreviewed
Protein Name: FACT complex subunit SSRP1
Gene Name: ssrp1a
Ensembl Gene: ENSDARG00000037397.6
Ensembl Protein: ENSDARP00000114529.1
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGDTLEFNDI  HQEVKGSWND  GRLRFSKQTV  VYKSHKTGKV  DSIPAPDLSE  AQWRRVCLGH  60
61    GLKLATSTGH  IYKYDGFKET  DYEKISAFFK  ANYKVELEEK  DMCVKGWNWG  TAKFAGSLLS  120
121   FDVSDSPVFE  IPLSSVSQCA  TGKNEVTVEF  HQNDDAEVSL  MEVRFYVPPN  TGDDGSDPVE  180
181   AFAQNILSKA  DVIQATGDAV  CIFKELQCLT  PRGRYDIRIY  PTFLHLHGKT  FDYKIPYTTV  240
241   LRLFLLPHKD  QRQMFFVISL  DPPIKQGQTR  YHFLILLFSK  DEDISLALNM  SEDEVEKRYE  300
301   GKLSKNMSGP  LYEIVSRVMK  ALVNRKITVP  GNFQGHSGSQ  CITCAYKASS  GLLYPLERGF  360
361   IYVHKPPVHL  RFEEISCVNF  ARGTTTTRSF  DFEIETKQNN  QFTFSNIERE  EYGKLFDFVN  420
421   AKKLTIKNRG  FKEGMKGAED  YSDSDEDQHD  AYLERMKEEG  KIREEGDGSD  DSEGDSDESF  480
481   NPGEEDDDVP  EEYDSNASVS  DSEGDDGDSE  DEGKKKKVEK  KPKKVVKEKK  ERKPRKEKKV  540
541   KDAAAPKRPM  SAYMLWLNGN  RERIKSENPG  ISITEISKKA  GEMWKQLGKD  KKEEWDKKAE  600
601   EAKRQYEKAM  KEYKESGGGA  AAATKEKKKK  GGKVEAKKKS  GGEKEKKKEG  GNDSFKSKEF  660
661   ISSEESSSES  DHDRGSKRKA  SDDDDEEEEA  AASTPASSEE  ESGSD  705
Nucleotide CDS Sequence (FASTA)
1     ATGGGAGACA  CTCTGGAGTT  TAACGACATT  CATCAGGAGG  TGAAGGGATC  TTGGAATGAT  60
61    GGGCGTCTGA  GGTTCAGCAA  GCAGACTGTG  GTCTATAAAA  GCCATAAAAC  AGGGAAGGTG  120
121   GACAGTATCC  CCGCTCCCGA  CCTCTCCGAG  GCCCAGTGGC  GTCGAGTCTG  TCTGGGTCAT  180
181   GGGCTCAAAC  TGGCCACCAG  CACTGGACAC  ATCTACAAAT  ATGACGGCTT  CAAAGAAACA  240
241   GATTATGAGA  AAATCTCAGC  GTTTTTCAAA  GCGAACTACA  AAGTGGAGTT  GGAGGAGAAG  300
301   GACATGTGTG  TGAAGGGCTG  GAATTGGGGA  ACTGCCAAAT  TTGCAGGGTC  TCTGCTGTCT  360
361   TTTGATGTAA  GCGACAGTCC  TGTCTTTGAG  ATCCCACTGT  CCAGTGTATC  CCAGTGTGCA  420
421   ACCGGCAAGA  ACGAGGTGAC  TGTGGAGTTT  CATCAGAATG  ATGATGCTGA  GGTTTCACTC  480
481   ATGGAGGTCC  GCTTTTATGT  CCCGCCAAAC  ACTGGAGACG  ACGGCTCAGA  CCCTGTGGAG  540
541   GCATTTGCGC  AGAATATTCT  GTCAAAAGCA  GATGTCATTC  AAGCTACTGG  AGACGCTGTG  600
601   TGTATCTTCA  AAGAGCTTCA  GTGCCTTACG  CCGAGAGGAA  GGTATGATAT  CCGTATCTAC  660
661   CCGACCTTTC  TGCACCTCCA  CGGTAAGACT  TTTGACTATA  AGATCCCCTA  CACCACTGTA  720
721   CTGCGTCTCT  TCCTGCTCCC  ACACAAGGAC  CAGAGGCAGA  TGTTTTTTGT  GATCAGCCTC  780
781   GATCCACCTA  TTAAACAGGG  TCAGACTCGA  TACCATTTCC  TCATCCTCCT  GTTCTCCAAA  840
841   GATGAAGACA  TCAGCCTGGC  TCTCAACATG  AGCGAAGATG  AGGTGGAGAA  GCGTTATGAA  900
901   GGGAAGCTCA  GCAAGAACAT  GTCTGGTCCG  CTCTATGAGA  TCGTCAGCAG  GGTCATGAAG  960
961   GCTCTGGTCA  ACAGGAAGAT  CACAGTGCCT  GGAAACTTCC  AGGGTCACTC  AGGTTCTCAG  1020
1021  TGTATAACGT  GTGCATATAA  GGCGAGCTCA  GGGCTGCTGT  ATCCACTGGA  GAGAGGCTTT  1080
1081  ATTTATGTGC  ACAAGCCACC  AGTTCACCTG  CGCTTTGAAG  AAATCTCCTG  CGTCAACTTT  1140
1141  GCCAGAGGAA  CCACAACCAC  ACGATCATTT  GACTTCGAGA  TTGAGACCAA  GCAGAACAAT  1200
1201  CAATTCACCT  TCAGCAACAT  TGAGAGGGAA  GAATATGGAA  AACTTTTTGA  CTTTGTCAAC  1260
1261  GCCAAGAAGC  TGACTATCAA  GAACAGAGGA  TTTAAAGAGG  GCATGAAAGG  AGCAGAAGAC  1320
1321  TACAGTGACT  CTGATGAAGA  CCAGCATGAC  GCTTATCTGG  AGAGAATGAA  GGAAGAGGGC  1380
1381  AAGATCAGAG  AAGAGGGAGA  TGGCAGCGAT  GACTCTGAAG  GCGACAGCGA  CGAGTCTTTC  1440
1441  AACCCTGGAG  AAGAGGATGA  TGATGTCCCA  GAAGAGTATG  ACAGTAACGC  TTCAGTGAGT  1500
1501  GATAGTGAAG  GAGATGATGG  AGACAGCGAG  GATGAAGGCA  AGAAGAAAAA  AGTTGAAAAG  1560
1561  AAGCCCAAGA  AAGTGGTGAA  GGAGAAGAAA  GAGCGAAAAC  CACGGAAAGA  GAAAAAGGTG  1620
1621  AAGGACGCAG  CTGCTCCTAA  GAGACCCATG  AGTGCTTACA  TGCTGTGGCT  GAACGGCAAC  1680
1681  AGAGAGCGCA  TCAAGAGTGA  AAATCCTGGA  ATATCAATCA  CTGAAATCTC  CAAGAAGGCC  1740
1741  GGAGAAATGT  GGAAACAGCT  GGGAAAAGAC  AAAAAGGAGG  AGTGGGACAA  AAAAGCAGAA  1800
1801  GAGGCCAAGA  GGCAATATGA  AAAAGCCATG  AAAGAATACA  AAGAGAGTGG  AGGAGGAGCC  1860
1861  GCTGCTGCTA  CTAAAGAAAA  GAAAAAGAAG  GGAGGAAAGG  TGGAGGCCAA  GAAGAAAAGC  1920
1921  GGTGGAGAGA  AGGAGAAAAA  GAAAGAGGGT  GGAAACGACA  GCTTTAAGAG  TAAAGAGTTC  1980
1981  ATCTCCAGCG  AGGAGAGCTC  ATCGGAATCC  GACCACGACA  GAGGCAGCAA  ACGCAAGGCT  2040
2041  TCTGATGATG  ATGACGAGGA  GGAAGAAGCG  GCGGCCTCTA  CTCCAGCAAG  CTCAGAGGAG  2100
2101  GAGTCAGGAT  CTGACTGA  2118

▼ KEYWORD

ID
Family
Chromosome
Coiled coil
Complete proteome
DNA damage
DNA repair
DNA replication
DNA-binding
Nucleus
Proteomics identification
Reference proteome
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chromosome
Cellular Component
Nucleus
Molecular Function
DNA binding
Biological Process
DNA repair
Biological Process
DNA replication
Biological Process
Regulation of cell cycle

▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
RAINMIST
Drug
CTD
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Icp-1946Ictalurus punctatus86.810.0 996
LLPS-Asm-2389Astyanax mexicanus85.550.01003
LLPS-Scf-0084Scleropages formosus85.340.0 994
LLPS-Scm-2718Scophthalmus maximus84.850.0 966
LLPS-Orl-0287Oryzias latipes84.690.0 971
LLPS-Ten-0235Tetraodon nigroviridis84.380.0 956
LLPS-Tar-1677Takifugu rubripes83.360.0 952
LLPS-Aon-1132Aotus nancymaae83.190.0 828
LLPS-Caf-0718Canis familiaris83.190.0 830
LLPS-Xim-0114Xiphophorus maculatus82.930.0 940
LLPS-Orn-0815Oreochromis niloticus82.740.0 953
LLPS-Pof-0177Poecilia formosa82.60.0 941
LLPS-Gaa-1249Gasterosteus aculeatus82.570.0 973
LLPS-Anc-0353Anolis carolinensis81.940.0 819
LLPS-Leo-1578Lepisosteus oculatus78.070.0 779
LLPS-Sah-0639Sarcophilus harrisii77.920.0 906
LLPS-Mod-0502Monodelphis domestica77.920.0 908
LLPS-Mea-0010Mesocricetus auratus77.760.0 920
LLPS-Meg-1460Meleagris gallopavo77.760.0 919
LLPS-Gaga-2726Gallus gallus77.760.0 919
LLPS-Chs-0716Chlorocebus sabaeus77.60.0 896
LLPS-Maf-2870Macaca fascicularis77.60.0 897
LLPS-Cea-1208Cercocebus atys77.60.0 897
LLPS-Paa-1244Papio anubis77.60.0 892
LLPS-Mal-1910Mandrillus leucophaeus77.60.0 897
LLPS-Fec-0093Felis catus77.60.0 897
LLPS-Man-0186Macaca nemestrina77.60.0 897
LLPS-Cas-0721Carlito syrichta77.60.0 897
LLPS-Mam-0799Macaca mulatta77.60.0 897
LLPS-Gog-0664Gorilla gorilla77.440.0 895
LLPS-Caj-0071Callithrix jacchus77.440.0 896
LLPS-Mum-0192Mus musculus77.440.0 901
LLPS-Sus-1554Sus scrofa77.440.0 896
LLPS-Ran-1768Rattus norvegicus77.440.0 899
LLPS-Mup-0721Mustela putorius furo77.440.0 896
LLPS-Aim-0287Ailuropoda melanoleuca77.440.0 896
LLPS-Bot-0023Bos taurus77.440.0 895
LLPS-Dio-1290Dipodomys ordii77.440.0 898
LLPS-Rhb-0123Rhinopithecus bieti77.440.0 895
LLPS-Urm-1214Ursus maritimus77.440.0 896
LLPS-Pap-0137Pan paniscus77.440.0 890
LLPS-Pat-0005Pan troglodytes77.440.0 895
LLPS-Hos-1608Homo sapiens77.440.0 895
LLPS-Loa-0373Loxodonta africana77.440.0 896
LLPS-Ict-2968Ictidomys tridecemlineatus77.440.0 899
LLPS-Nol-0537Nomascus leucogenys77.440.0 894
LLPS-Cap-1390Cavia porcellus77.440.0 902
LLPS-Eqc-0598Equus caballus77.420.0 865
LLPS-Fia-2029Ficedula albicollis77.270.0 913
LLPS-Fud-0019Fukomys damarensis77.110.0 899
LLPS-Otg-1364Otolemur garnettii77.110.0 894
LLPS-Poa-0279Pongo abelii76.740.0 890
LLPS-Pes-0887Pelodiscus sinensis76.620.0 902
LLPS-Tag-1137Taeniopygia guttata75.650.0 881
LLPS-Myl-0706Myotis lucifugus75.320.0 903
LLPS-Anp-0597Anas platyrhynchos75.170.0 840
LLPS-Orc-0263Oryctolagus cuniculus74.345e-134 410
LLPS-Xet-1628Xenopus tropicalis73.940.0 839
LLPS-Ora-1754Ornithorhynchus anatinus71.522e-74 246
LLPS-Drm-0841Drosophila melanogaster67.52e-0965.1
LLPS-Asf-1549Aspergillus flavus54.353e-0857.4
LLPS-Cis-0111Ciona savignyi53.970.0 616
LLPS-Cii-0136Ciona intestinalis53.940.0 635
LLPS-Ova-0029Ovis aries45.838e-0857.4
LLPS-Tut-1437Tursiops truncatus45.837e-0857.4
LLPS-Chr-0479Chlamydomonas reinhardtii43.066e-0757.0
LLPS-Cae-1331Caenorhabditis elegans41.561e-130 409
LLPS-Scs-0054Sclerotinia sclerotiorum40.935e-49 179
LLPS-Mae-1558Manihot esculenta37.924e-72 249
LLPS-Tum-0749Tuber melanosporum37.583e-91 302
LLPS-Scj-0825Schizosaccharomyces japonicus37.123e-101 327
LLPS-Blg-0096Blumeria graminis37.024e-60 214
LLPS-Brn-0589Brassica napus36.887e-91 303
LLPS-Dac-0659Daucus carota36.651e-95 316
LLPS-Art-0094Arabidopsis thaliana36.651e-91 305
LLPS-Hea-1216Helianthus annuus36.445e-96 317
LLPS-Coc-0041Corchorus capsularis36.449e-94 311
LLPS-Ved-0403Verticillium dahliae36.49e-49 179
LLPS-Nia-1208Nicotiana attenuata36.311e-94 313
LLPS-Arl-0130Arabidopsis lyrata36.23e-91 304
LLPS-Mao-1112Magnaporthe oryzae36.166e-97 317
LLPS-Pot-1132Populus trichocarpa36.157e-93 308
LLPS-Scc-0616Schizosaccharomyces cryophilus36.126e-100 323
LLPS-Scp-0628Schizosaccharomyces pombe36.125e-99 321
LLPS-Viv-0511Vitis vinifera36.054e-89 298
LLPS-Sol-1219Solanum lycopersicum35.676e-92 306
LLPS-Sot-0175Solanum tuberosum35.676e-92 306
LLPS-Abg-0852Absidia glauca35.631e-102 331
LLPS-Php-0679Physcomitrella patens35.377e-93 309
LLPS-Map-0701Magnaporthe poae35.315e-97 317
LLPS-Met-0543Medicago truncatula35.312e-92 308
LLPS-Via-1083Vigna angularis35.312e-92 307
LLPS-Phv-0104Phaseolus vulgaris35.313e-93 310
LLPS-Cus-1138Cucumis sativus35.13e-92 307
LLPS-Vir-0344Vigna radiata35.063e-90 302
LLPS-Thc-1173Theobroma cacao35.03e-101 330
LLPS-Cym-0107Cyanidioschyzon merolae34.931e-80 274
LLPS-Glm-0289Glycine max34.882e-91 304
LLPS-Prp-0060Prunus persica34.772e-99 326
LLPS-Brr-0203Brassica rapa34.751e-90 303
LLPS-Usm-0490Ustilago maydis34.736e-92 304
LLPS-Bro-0151Brassica oleracea34.614e-90 301
LLPS-Coo-0743Colletotrichum orbiculare34.561e-92 306
LLPS-Gag-0650Gaeumannomyces graminis34.512e-95 313
LLPS-Gor-1822Gossypium raimondii34.275e-100 328
LLPS-Brd-0806Brachypodium distachyon34.171e-86 292
LLPS-Put-0439Puccinia triticina33.93e-59 214
LLPS-Spr-0736Sporisorium reilianum33.822e-89 296
LLPS-Sem-1029Selaginella moellendorffii33.77e-90 301
LLPS-Fuv-0001Fusarium verticillioides33.693e-84 283
LLPS-Fus-0201Fusarium solani33.694e-82 278
LLPS-Fuo-0475Fusarium oxysporum33.693e-84 283
LLPS-Tra-1154Triticum aestivum33.682e-84 286
LLPS-Cogr-0447Colletotrichum graminicola33.555e-92 304
LLPS-Trv-1046Trichoderma virens33.552e-83 281
LLPS-Asg-0774Ashbya gossypii33.537e-91 300
LLPS-Lep-0568Leersia perrieri33.262e-87 294
LLPS-Orbr-0551Oryza brachyantha33.267e-88 295
LLPS-Orr-0936Oryza rufipogon33.264e-89 298
LLPS-Sei-0397Setaria italica33.192e-85 288
LLPS-Sob-1066Sorghum bicolor32.983e-83 283
LLPS-Amt-0851Amborella trichopoda32.914e-101 330
LLPS-Beb-0572Beauveria bassiana32.92e-83 281
LLPS-Gas-0857Galdieria sulphuraria32.867e-73 251
LLPS-Sac-0396Saccharomyces cerevisiae32.785e-86 288
LLPS-Yal-0030Yarrowia lipolytica32.728e-82 276
LLPS-Ast-0753Aspergillus terreus32.722e-88 296
LLPS-Crn-0210Cryptococcus neoformans32.697e-74 256
LLPS-Lem-0531Leptosphaeria maculans32.691e-80 279
LLPS-Tru-0033Triticum urartu32.634e-84 285
LLPS-Kop-0086Komagataella pastoris32.616e-77 263
LLPS-Zyt-0069Zymoseptoria tritici32.547e-81 274
LLPS-Nec-0340Neurospora crassa32.471e-92 306
LLPS-Trr-0402Trichoderma reesei32.461e-84 285
LLPS-Phn-0253Phaeosphaeria nodorum32.453e-79 270
LLPS-Miv-0743Microbotryum violaceum32.422e-77 266
LLPS-Nef-0589Neosartorya fischeri32.381e-86 290
LLPS-Hov-0009Hordeum vulgare32.352e-84 286
LLPS-Asn-0014Aspergillus nidulans32.21e-84 285
LLPS-Asfu-0242Aspergillus fumigatus32.123e-87 291
LLPS-Dos-0920Dothistroma septosporum32.121e-83 281
LLPS-Aso-0648Aspergillus oryzae31.917e-85 285
LLPS-Pug-0121Puccinia graminis31.913e-77 265
LLPS-Asc-0739Aspergillus clavatus31.773e-84 284
LLPS-Zem-1907Zea mays31.721e-80 275
LLPS-Chc-0007Chondrus crispus31.524e-67 235
LLPS-Orni-0450Oryza nivara31.484e-90 301
LLPS-Ori-0543Oryza indica31.484e-90 301
LLPS-Orb-0106Oryza barthii31.484e-90 301
LLPS-Orgl-0610Oryza glumaepatula31.484e-90 301
LLPS-Ors-0229Oryza sativa31.484e-90 301
LLPS-Org-0002Oryza glaberrima31.484e-90 301
LLPS-Orm-0977Oryza meridionalis31.484e-90 301
LLPS-Osl-0107Ostreococcus lucimarinus31.412e-63 228
LLPS-Asni-0130Aspergillus niger31.353e-84 283
LLPS-Orp-1228Oryza punctata31.323e-89 299
LLPS-Pyt-0260Pyrenophora teres31.253e-75 259
LLPS-Cog-0209Colletotrichum gloeosporioides31.15e-76 261
LLPS-Pytr-0028Pyrenophora triticirepentis30.983e-76 262
LLPS-Mel-0324Melampsora laricipopulina30.851e-79 270
LLPS-Mua-1412Musa acuminata30.271e-83 284