• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Crn-1031
SAR1

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Small COPII coat GTPase SAR1
Gene Name: SAR1, CNB03430
Ensembl Gene: CNB03430
Ensembl Protein: AAW41610
Organism: Cryptococcus neoformans
Taxa ID: 214684
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity).

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblAAW41610AAW41610
UniProtP0CR30, SAR1_CRYNJ, Q55XY7, Q5KM05
GeneBankAE017342AAW41610.1
RefSeqXM_568917.1XP_568917.1

▼ SEQUENCE


Protein Sequence (FASTA)
1     MFIINWFWDV  LASLGLMNKS  AKLLFLGLDN  AGKTTLLHML  KNDRLATLQP  TLHPTSEELA  60
61    IGNVKFTTYD  LGGHIQARRL  WRDYFPEVDG  IVFLVDSADA  ERFAESKAEL  DSLLSIESLA  120
121   QVPFLILGNK  IDAYGAVSEE  QLRHELGLYQ  TTGKGKIPLR  DIRPIEVFMC  SVVMRQGYGE  180
181   GFRWLSQYI  189
Nucleotide CDS Sequence (FASTA)
1     ATGTTCATCA  TCAACTGGTT  CTGGGACGTC  CTCGCCTCTC  TCGGTCTTAT  GAACAAGAGC  60
61    GCAAAGCTCT  TGTTCCTTGG  TCTCGATAAT  GCGGGAAAGA  CTACCCTTCT  TCACATGCTC  120
121   AAGAACGACC  GTCTCGCTAC  CCTTCAACCC  ACTCTTCACC  CTACCTCTGA  AGAACTCGCC  180
181   ATCGGCAACG  TCAAGTTCAC  TACTTATGAT  CTCGGTGGTC  ACATTCAAGC  TCGACGATTG  240
241   TGGAGAGATT  ACTTCCCAGA  GGTTGACGGG  ATTGTGTTTT  TGGTAGACAG  CGCCGACGCC  300
301   GAGAGGTTCG  CTGAAAGCAA  GGCCGAGTTG  GACTCTTTGT  TGTCCATTGA  ATCCCTCGCT  360
361   CAGGTTCCCT  TCCTCATTCT  CGGTAACAAG  ATTGACGCCT  ACGGTGCTGT  CTCAGAGGAG  420
421   CAGCTCAGAC  ACGAGCTCGG  CCTTTACCAG  ACTACCGGCA  AGGGCAAGAT  TCCTCTCCGT  480
481   GATATCCGAC  CTATTGAAGT  ATTCATGTGC  TCCGTCGTCA  TGCGACAGGG  CTATGGCGAA  540
541   GGTTTCCGAT  GGCTCAGTCA  ATATATCTAA  570

▼ KEYWORD


ID
Family
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
ER-Golgi transport
Golgi apparatus
GTP-binding
Hydrolase
Membrane
Nucleotide-binding
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
COPII vesicle coat
Cellular Component
Endoplasmic reticulum
Cellular Component
Endoplasmic reticulum exit site
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Golgi membrane
Molecular Function
GTP binding
Molecular Function
GTPase activity
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process
Intracellular protein transport
Biological Process
Membrane organization
Biological Process
Positive regulation of protein exit from endoplasmic reticulum
Biological Process
Regulation of COPII vesicle coating
Biological Process
Vesicle organization

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Abg-1964Absidia glauca86.778e-122 349
LLPS-Put-1023Puccinia triticina86.293e-109 317
LLPS-Mel-0894Melampsora laricipopulina86.244e-121 347
LLPS-Pug-0685Puccinia graminis86.243e-120 345
LLPS-Miv-0007Microbotryum violaceum85.713e-119 343
LLPS-Usm-1112Ustilago maydis85.712e-120 346
LLPS-Spr-1059Sporisorium reilianum85.719e-121 347
LLPS-Tum-1503Tuber melanosporum84.133e-116 335
LLPS-Scs-0148Sclerotinia sclerotiorum83.66e-116 335
LLPS-Nef-0278Neosartorya fischeri83.072e-114 330
LLPS-Asc-1488Aspergillus clavatus82.544e-114 330
LLPS-Aso-0072Aspergillus oryzae82.541e-113 328
LLPS-Asf-0948Aspergillus flavus82.541e-113 328
LLPS-Asfu-1499Aspergillus fumigatus82.543e-114 330
LLPS-Phn-1393Phaeosphaeria nodorum82.085e-102 298
LLPS-Mao-0120Magnaporthe oryzae82.012e-114 330
LLPS-Ast-0562Aspergillus terreus82.014e-113 327
LLPS-Dos-1065Dothistroma septosporum82.014e-114 330
LLPS-Asni-0798Aspergillus niger81.481e-112 326
LLPS-Gag-0213Gaeumannomyces graminis80.952e-112 325
LLPS-Map-0351Magnaporthe poae80.952e-112 325
LLPS-Beb-0811Beauveria bassiana80.952e-114 330
LLPS-Pyt-0934Pyrenophora teres80.923e-102 299
LLPS-Lem-1426Leptosphaeria maculans80.358e-101 295
LLPS-Asn-0728Aspergillus nidulans79.894e-111 322
LLPS-Cog-0535Colletotrichum gloeosporioides79.893e-112 325
LLPS-Cogr-0918Colletotrichum graminicola79.891e-112 326
LLPS-Fuv-1281Fusarium verticillioides79.374e-113 327
LLPS-Zyt-0144Zymoseptoria tritici79.371e-110 321
LLPS-Fuo-1305Fusarium oxysporum79.374e-113 327
LLPS-Scp-0815Schizosaccharomyces pombe78.952e-109 318
LLPS-Coo-1320Colletotrichum orbiculare78.844e-112 325
LLPS-Blg-0365Blumeria graminis78.844e-112 325
LLPS-Fus-0323Fusarium solani78.842e-111 323
LLPS-Ved-1088Verticillium dahliae78.842e-110 320
LLPS-Scj-1405Schizosaccharomyces japonicus78.653e-108 315
LLPS-Yal-1532Yarrowia lipolytica78.424e-108 315
LLPS-Pytr-1270Pyrenophora triticirepentis78.186e-94 278
LLPS-Scc-1600Schizosaccharomyces cryophilus77.892e-108 315
LLPS-Trr-0036Trichoderma reesei77.256e-109 317
LLPS-Trv-1037Trichoderma virens77.254e-109 317
LLPS-Sac-0152Saccharomyces cerevisiae75.42e-96 285
LLPS-Kop-1371Komagataella pastoris75.266e-101 296
LLPS-Nec-0019Neurospora crassa75.131e-105 308
LLPS-Asg-1040Ashbya gossypii72.198e-94 278
LLPS-Drm-0684Drosophila melanogaster69.791e-90 270
LLPS-Brn-1098Brassica napus68.751e-90 270
LLPS-Bro-1553Brassica oleracea68.751e-90 270
LLPS-Met-2538Medicago truncatula68.235e-90 269
LLPS-Arl-0887Arabidopsis lyrata68.231e-90 270
LLPS-Art-2532Arabidopsis thaliana68.233e-90 270
LLPS-Prp-1700Prunus persica68.235e-90 269
LLPS-Osl-0748Ostreococcus lucimarinus68.238e-89 266
LLPS-Otg-1499Otolemur garnettii67.982e-83 251
LLPS-Glm-1106Glycine max67.713e-89 267
LLPS-Php-1725Physcomitrella patens67.716e-90 268
LLPS-Mua-1797Musa acuminata67.712e-90 270
LLPS-Thc-1106Theobroma cacao67.712e-89 267
LLPS-Brd-0199Brachypodium distachyon67.712e-88 265
LLPS-Sei-1851Setaria italica67.712e-88 265
LLPS-Sob-0197Sorghum bicolor67.712e-88 265
LLPS-Zem-1037Zea mays67.712e-88 265
LLPS-Orbr-0510Oryza brachyantha67.427e-81 245
LLPS-Ori-0572Oryza indica67.194e-88 264
LLPS-Orb-1658Oryza barthii67.194e-88 264
LLPS-Dac-1135Daucus carota67.194e-88 264
LLPS-Orni-2308Oryza nivara67.197e-88 264
LLPS-Via-1947Vigna angularis67.193e-88 264
LLPS-Tra-1877Triticum aestivum67.197e-88 263
LLPS-Hov-0133Hordeum vulgare67.192e-89 267
LLPS-Cus-0929Cucumis sativus67.196e-89 266
LLPS-Ors-0483Oryza sativa67.194e-88 264
LLPS-Viv-1161Vitis vinifera67.191e-88 265
LLPS-Pot-2367Populus trichocarpa67.194e-89 266
LLPS-Orp-1260Oryza punctata67.194e-88 264
LLPS-Phv-1304Phaseolus vulgaris67.192e-88 265
LLPS-Mae-2040Manihot esculenta67.193e-89 267
LLPS-Orm-0257Oryza meridionalis67.194e-88 264
LLPS-Orr-0407Oryza rufipogon67.194e-88 264
LLPS-Vir-1362Vigna radiata67.041e-78 246
LLPS-Ora-1180Ornithorhynchus anatinus67.027e-86 258
LLPS-Tru-1016Triticum urartu66.853e-82 251
LLPS-Sol-0794Solanum lycopersicum66.678e-88 263
LLPS-Orgl-1341Oryza glumaepatula66.671e-88 265
LLPS-Scf-2290Scleropages formosus66.676e-87 261
LLPS-Sot-1950Solanum tuberosum66.674e-88 264
LLPS-Gor-2295Gossypium raimondii66.671e-88 265
LLPS-Anp-2512Anas platyrhynchos66.671e-86 260
LLPS-Nia-0342Nicotiana attenuata66.674e-89 266
LLPS-Amt-1630Amborella trichopoda66.671e-88 265
LLPS-Coc-1429Corchorus capsularis66.672e-88 265
LLPS-Sem-2291Selaginella moellendorffii66.491e-86 260
LLPS-Sah-3276Sarcophilus harrisii66.493e-85 257
LLPS-Chr-0988Chlamydomonas reinhardtii66.493e-88 264
LLPS-Gaga-1935Gallus gallus66.491e-85 258
LLPS-Hea-1316Helianthus annuus66.153e-88 264
LLPS-Lep-0030Leersia perrieri66.154e-88 264
LLPS-Meg-1796Meleagris gallopavo66.153e-86 259
LLPS-Pes-1119Pelodiscus sinensis66.153e-86 259
LLPS-Orn-2274Oreochromis niloticus66.151e-85 258
LLPS-Xet-2360Xenopus tropicalis65.972e-84 254
LLPS-Fia-3084Ficedula albicollis65.823e-87 261
LLPS-Asm-2667Astyanax mexicanus65.799e-45 151
LLPS-Mum-4008Mus musculus65.644e-86 259
LLPS-Mea-2935Mesocricetus auratus65.647e-86 258
LLPS-Leo-0999Lepisosteus oculatus65.643e-85 257
LLPS-Orl-1573Oryzias latipes65.643e-86 259
LLPS-Xim-4096Xiphophorus maculatus65.644e-86 259
LLPS-Hos-2068Homo sapiens65.647e-86 258
LLPS-Loa-1548Loxodonta africana65.641e-85 258
LLPS-Anc-2313Anolis carolinensis65.646e-87 261
LLPS-Org-1402Oryza glaberrima65.625e-88 263
LLPS-Scm-3517Scophthalmus maximus65.463e-84 256
LLPS-Chs-2757Chlorocebus sabaeus65.453e-84 254
LLPS-Maf-4687Macaca fascicularis65.453e-84 254
LLPS-Sus-3921Sus scrofa65.458e-84 253
LLPS-Cea-4557Cercocebus atys65.453e-84 254
LLPS-Aon-2656Aotus nancymaae65.454e-84 254
LLPS-Gog-2143Gorilla gorilla65.453e-84 254
LLPS-Caj-3885Callithrix jacchus65.453e-84 254
LLPS-Fud-1598Fukomys damarensis65.458e-84 253
LLPS-Bot-3514Bos taurus65.458e-84 253
LLPS-Dio-1780Dipodomys ordii65.454e-84 254
LLPS-Mup-3979Mustela putorius furo65.458e-84 253
LLPS-Aim-3213Ailuropoda melanoleuca65.458e-84 253
LLPS-Myl-3330Myotis lucifugus65.458e-84 253
LLPS-Paa-3150Papio anubis65.453e-84 254
LLPS-Mal-2545Mandrillus leucophaeus65.453e-84 254
LLPS-Fec-2290Felis catus65.458e-84 253
LLPS-Lac-2550Latimeria chalumnae65.451e-85 258
LLPS-Pat-0050Pan troglodytes65.453e-84 254
LLPS-Urm-2668Ursus maritimus65.458e-84 253
LLPS-Pap-4086Pan paniscus65.453e-84 254
LLPS-Man-4607Macaca nemestrina65.453e-84 254
LLPS-Rhb-4191Rhinopithecus bieti65.453e-84 254
LLPS-Orc-3189Oryctolagus cuniculus65.454e-84 254
LLPS-Cap-1422Cavia porcellus65.458e-84 253
LLPS-Eqc-1079Equus caballus65.458e-84 253
LLPS-Poa-2703Pongo abelii65.453e-84 254
LLPS-Mam-3464Macaca mulatta65.453e-84 254
LLPS-Cas-0132Carlito syrichta65.454e-84 254
LLPS-Nol-1072Nomascus leucogenys65.453e-84 254
LLPS-Ict-3893Ictidomys tridecemlineatus65.454e-84 254
LLPS-Brr-1869Brassica rapa65.171e-72 238
LLPS-Icp-0458Ictalurus punctatus65.132e-85 257
LLPS-Tut-0061Tursiops truncatus65.131e-85 258
LLPS-Ran-4286Rattus norvegicus65.132e-85 257
LLPS-Ova-3773Ovis aries65.131e-85 258
LLPS-Pof-3947Poecilia formosa65.131e-85 258
LLPS-Caf-3006Canis familiaris65.131e-85 258
LLPS-Tag-1261Taeniopygia guttata65.132e-85 257
LLPS-Dar-3119Danio rerio64.621e-83 253
LLPS-Gaa-0320Gasterosteus aculeatus64.18e-84 253
LLPS-Cii-1394Ciona intestinalis63.687e-84 253
LLPS-Cae-0676Caenorhabditis elegans63.357e-84 253
LLPS-Ten-2364Tetraodon nigroviridis63.082e-84 255
LLPS-Tar-1278Takifugu rubripes62.561e-82 250
LLPS-Gas-0277Galdieria sulphuraria60.645e-82 248
LLPS-Chc-1009Chondrus crispus60.119e-80 243
LLPS-Mod-3022Monodelphis domestica59.692e-70 219
LLPS-Cym-0691Cyanidioschyzon merolae59.495e-78 238