• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ast-0562
sar1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Small COPII coat GTPase sar1
Gene Name: sar1, ATEG_02597
Ensembl Gene: ATEG_02597
Ensembl Protein: EAU37559
Organism: Aspergillus terreus
Taxa ID: 341663
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. Sar1 controls the coat assembly in a stepwise manner. Activated Sar1-GTP binds to membranes first and recruits the sec23/24 complex. These sec23/24-sar1 prebudding intermediates are then collected by the Sec13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to sar1-GDP triggers coat release and recycles COPII subunits (By similarity).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEAU37559EAU37559
UniProtQ0CUN7, SAR1_ASPTN
GeneBankCH476596EAU37559.1
RefSeqXM_001211775.1XP_001211775.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MWIINWFYDI  LASLGLLNKH  AKLLFLGLDN  AGKTTLLHML  KNDRVAILQP  TAHPTSEELA  60
61    IGNNRFTTFD  LGGHQQARRL  WKDYFPEVSG  IVFLVDAKDY  ERFPESKAEL  DALLAMEELA  120
121   KVPFLILGNK  IDHPDAVSED  ELRHQLGLYQ  TTGKGKVPLE  GIRPIEVFMC  SVVMRQGYGE  180
181   GIRWLSQYV  189

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
ER-Golgi transport
Golgi apparatus
GTP-binding
Hydrolase
Membrane
Nucleotide-binding
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
ER to Golgi transport vesicle membrane
Cellular Component
Golgi membrane
Molecular Function
GTP binding
Molecular Function
Hydrolase activity
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process
Intracellular protein transport
Biological Process
Nuclear envelope organization

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asfu-1499Aspergillus fumigatus98.948e-126 359
LLPS-Asni-0798Aspergillus niger98.411e-125 359
LLPS-Asf-0948Aspergillus flavus98.414e-126 360
LLPS-Aso-0072Aspergillus oryzae98.414e-126 360
LLPS-Nef-0278Neosartorya fischeri98.411e-125 359
LLPS-Asc-1488Aspergillus clavatus97.881e-125 359
LLPS-Asn-0728Aspergillus nidulans97.357e-125 357
LLPS-Mao-0120Magnaporthe oryzae93.124e-120 345
LLPS-Map-0351Magnaporthe poae92.594e-119 342
LLPS-Gag-0213Gaeumannomyces graminis92.594e-119 342
LLPS-Coo-1320Colletotrichum orbiculare91.537e-119 342
LLPS-Cog-0535Colletotrichum gloeosporioides91.532e-118 340
LLPS-Scs-0148Sclerotinia sclerotiorum91.011e-117 338
LLPS-Cogr-0918Colletotrichum graminicola91.011e-117 338
LLPS-Fuv-1281Fusarium verticillioides90.489e-119 342
LLPS-Fus-0323Fusarium solani90.481e-118 341
LLPS-Fuo-1305Fusarium oxysporum90.489e-119 342
LLPS-Blg-0365Blumeria graminis89.952e-116 335
LLPS-Dos-1065Dothistroma septosporum89.952e-115 333
LLPS-Ved-1088Verticillium dahliae89.955e-116 335
LLPS-Tum-1503Tuber melanosporum89.422e-116 335
LLPS-Beb-0811Beauveria bassiana89.422e-114 331
LLPS-Trv-1037Trichoderma virens89.421e-116 336
LLPS-Phn-1393Phaeosphaeria nodorum89.021e-101 298
LLPS-Trr-0036Trichoderma reesei88.893e-116 335
LLPS-Pyt-0934Pyrenophora teres88.442e-102 299
LLPS-Zyt-0144Zymoseptoria tritici88.367e-113 327
LLPS-Lem-1426Leptosphaeria maculans87.861e-101 298
LLPS-Nec-0019Neurospora crassa86.773e-112 325
LLPS-Pytr-1270Pyrenophora triticirepentis86.063e-93 276
LLPS-Abg-1964Absidia glauca83.072e-106 310
LLPS-Put-1023Puccinia triticina82.866e-95 281
LLPS-Scj-1405Schizosaccharomyces japonicus82.296e-103 301
LLPS-Scp-0815Schizosaccharomyces pombe82.111e-102 301
LLPS-Crn-1031Cryptococcus neoformans82.011e-104 306
LLPS-Scc-1600Schizosaccharomyces cryophilus81.584e-102 299
LLPS-Yal-1532Yarrowia lipolytica81.587e-103 301
LLPS-Pug-0685Puccinia graminis81.485e-104 304
LLPS-Spr-1059Sporisorium reilianum80.954e-103 302
LLPS-Mel-0894Melampsora laricipopulina80.424e-104 305
LLPS-Miv-0007Microbotryum violaceum80.422e-99 293
LLPS-Usm-1112Ustilago maydis80.422e-102 300
LLPS-Kop-1371Komagataella pastoris77.891e-96 286
LLPS-Sac-0152Saccharomyces cerevisiae74.874e-89 266
LLPS-Asg-1040Ashbya gossypii72.734e-87 261
LLPS-Brn-2964Brassica napus68.951e-82 250
LLPS-Met-2538Medicago truncatula68.758e-81 245
LLPS-Art-2011Arabidopsis thaliana68.751e-81 247
LLPS-Drm-0684Drosophila melanogaster68.232e-79 242
LLPS-Bro-1553Brassica oleracea68.232e-81 247
LLPS-Osl-0748Ostreococcus lucimarinus68.233e-81 246
LLPS-Brr-1869Brassica rapa67.981e-66 221
LLPS-Thc-1106Theobroma cacao67.712e-80 244
LLPS-Mua-1797Musa acuminata67.715e-81 246
LLPS-Php-0942Physcomitrella patens67.713e-82 249
LLPS-Arl-0887Arabidopsis lyrata67.716e-81 246
LLPS-Gor-0097Gossypium raimondii67.717e-80 243
LLPS-Vir-1362Vigna radiata67.67e-70 223
LLPS-Hea-1316Helianthus annuus67.191e-79 243
LLPS-Glm-1106Glycine max67.191e-79 242
LLPS-Cus-0929Cucumis sativus67.194e-80 244
LLPS-Via-1947Vigna angularis67.192e-79 241
LLPS-Mae-2040Manihot esculenta67.194e-80 243
LLPS-Viv-1161Vitis vinifera67.199e-80 243
LLPS-Prp-1848Prunus persica67.191e-80 245
LLPS-Orbr-0510Oryza brachyantha66.851e-71 221
LLPS-Dac-1135Daucus carota66.677e-79 240
LLPS-Nia-1086Nicotiana attenuata66.678e-80 243
LLPS-Phv-1304Phaseolus vulgaris66.678e-79 240
LLPS-Pot-2367Populus trichocarpa66.671e-79 243
LLPS-Chr-0988Chlamydomonas reinhardtii66.491e-81 247
LLPS-Coc-0795Corchorus capsularis66.471e-64 209
LLPS-Orni-2308Oryza nivara66.152e-78 240
LLPS-Ori-0572Oryza indica66.151e-78 239
LLPS-Orb-1658Oryza barthii66.151e-78 239
LLPS-Sol-0794Solanum lycopersicum66.152e-78 239
LLPS-Brd-0199Brachypodium distachyon66.153e-78 239
LLPS-Tra-1877Triticum aestivum66.152e-78 239
LLPS-Sei-1851Setaria italica66.153e-78 239
LLPS-Sot-1849Solanum tuberosum66.157e-81 245
LLPS-Sob-0197Sorghum bicolor66.153e-78 239
LLPS-Orp-1260Oryza punctata66.151e-78 239
LLPS-Ors-0483Oryza sativa66.151e-78 240
LLPS-Zem-1037Zea mays66.153e-78 239
LLPS-Orr-0407Oryza rufipogon66.151e-78 239
LLPS-Orm-0257Oryza meridionalis66.151e-78 239
LLPS-Sem-1019Selaginella moellendorffii65.971e-79 242
LLPS-Scf-2290Scleropages formosus65.975e-78 238
LLPS-Lep-0030Leersia perrieri65.623e-78 239
LLPS-Orgl-1341Oryza glumaepatula65.622e-78 239
LLPS-Amt-1630Amborella trichopoda65.622e-79 241
LLPS-Anc-2313Anolis carolinensis65.458e-79 240
LLPS-Gog-3514Gorilla gorilla65.351e-48 160
LLPS-Tru-1016Triticum urartu65.226e-73 227
LLPS-Otg-1499Otolemur garnettii65.173e-72 223
LLPS-Org-1402Oryza glaberrima65.15e-79 241
LLPS-Icp-2945Ictalurus punctatus64.924e-74 228
LLPS-Sah-3276Sarcophilus harrisii64.925e-77 236
LLPS-Leo-2136Lepisosteus oculatus64.923e-77 236
LLPS-Ora-1180Ornithorhynchus anatinus64.926e-78 238
LLPS-Xim-4096Xiphophorus maculatus64.922e-76 234
LLPS-Orn-2274Oreochromis niloticus64.924e-76 233
LLPS-Pes-2577Pelodiscus sinensis64.923e-78 239
LLPS-Pof-3947Poecilia formosa64.922e-76 234
LLPS-Xet-2360Xenopus tropicalis64.921e-77 238
LLPS-Gaga-1935Gallus gallus64.922e-78 239
LLPS-Hov-0133Hordeum vulgare64.589e-79 240
LLPS-Anp-0145Anas platyrhynchos64.552e-76 234
LLPS-Caj-3885Callithrix jacchus64.46e-77 236
LLPS-Aon-2656Aotus nancymaae64.47e-77 235
LLPS-Cea-4557Cercocebus atys64.46e-77 236
LLPS-Sus-3921Sus scrofa64.42e-76 234
LLPS-Orl-1573Oryzias latipes64.44e-76 234
LLPS-Chs-2757Chlorocebus sabaeus64.46e-77 236
LLPS-Mea-3546Mesocricetus auratus64.47e-77 235
LLPS-Maf-4687Macaca fascicularis64.46e-77 236
LLPS-Mum-3975Mus musculus64.47e-77 235
LLPS-Aim-3213Ailuropoda melanoleuca64.42e-76 234
LLPS-Mup-3979Mustela putorius furo64.42e-76 234
LLPS-Myl-3330Myotis lucifugus64.42e-76 234
LLPS-Mal-2545Mandrillus leucophaeus64.46e-77 236
LLPS-Paa-3150Papio anubis64.46e-77 236
LLPS-Bot-3514Bos taurus64.42e-76 234
LLPS-Dio-1780Dipodomys ordii64.47e-77 235
LLPS-Rhb-4191Rhinopithecus bieti64.46e-77 236
LLPS-Fia-1441Ficedula albicollis64.47e-78 238
LLPS-Orc-3189Oryctolagus cuniculus64.47e-77 235
LLPS-Loa-3330Loxodonta africana64.47e-77 235
LLPS-Man-4607Macaca nemestrina64.46e-77 236
LLPS-Fec-2290Felis catus64.42e-76 234
LLPS-Pat-0050Pan troglodytes64.46e-77 236
LLPS-Pap-4086Pan paniscus64.46e-77 236
LLPS-Urm-2668Ursus maritimus64.42e-76 234
LLPS-Hos-1165Homo sapiens64.46e-77 236
LLPS-Tag-1261Taeniopygia guttata64.47e-78 238
LLPS-Ict-3893Ictidomys tridecemlineatus64.47e-77 235
LLPS-Nol-1072Nomascus leucogenys64.46e-77 236
LLPS-Cas-0132Carlito syrichta64.47e-77 235
LLPS-Mam-3464Macaca mulatta64.46e-77 236
LLPS-Eqc-1079Equus caballus64.42e-76 234
LLPS-Poa-2703Pongo abelii64.46e-77 236
LLPS-Asm-2667Astyanax mexicanus64.154e-40 139
LLPS-Fud-1598Fukomys damarensis63.871e-76 235
LLPS-Ova-3773Ovis aries63.879e-76 233
LLPS-Ran-4286Rattus norvegicus63.877e-76 233
LLPS-Gaa-0320Gasterosteus aculeatus63.876e-76 233
LLPS-Tut-0061Tursiops truncatus63.875e-76 233
LLPS-Cap-0322Cavia porcellus63.871e-75 232
LLPS-Caf-3006Canis familiaris63.879e-76 233
LLPS-Scm-0096Scophthalmus maximus63.354e-73 227
LLPS-Meg-1796Meleagris gallopavo63.352e-76 234
LLPS-Dar-3119Danio rerio63.354e-75 231
LLPS-Ten-2364Tetraodon nigroviridis63.087e-76 233
LLPS-Lac-2550Latimeria chalumnae62.31e-74 229
LLPS-Cae-0676Caenorhabditis elegans62.235e-73 225
LLPS-Cii-1394Ciona intestinalis62.119e-74 227
LLPS-Tar-1278Takifugu rubripes62.052e-74 229
LLPS-Gas-0277Galdieria sulphuraria61.176e-72 223
LLPS-Chc-1009Chondrus crispus60.116e-70 217
LLPS-Cym-0691Cyanidioschyzon merolae58.977e-69 215
LLPS-Mod-3022Monodelphis domestica57.592e-62 198