LLPS-Cea-2331
P2RX2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | P2X purinoceptor |
| Gene Name: | P2RX2 |
| Ensembl Gene: | ENSCATG00000037785.1 |
| Ensembl Protein: | ENSCATP00000029052.1 |
| Organism: | Cercocebus atys |
| Taxa ID: | 9531 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Receptor for ATP that acts as a ligand-gated ion channel. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCATT00000053307.1 | ENSCATP00000029052.1 |
| Ensembl | ENSCATT00000053309.1 | ENSCATP00000029054.1 |
| Ensembl | ENSCATT00000053300.1 | ENSCATP00000029045.1 |
| Ensembl | ENSCATT00000053305.1 | ENSCATP00000029050.1 |
| Ensembl | ENSCATT00000053303.1 | ENSCATP00000029048.1 |
| Ensembl | ENSCATT00000053295.1 | ENSCATP00000029040.1 |
| Ensembl | ENSCATT00000053310.1 | ENSCATP00000029055.1 |
| UniProt | A0A2K5MVE5, A0A2K5MVE5_CERAT | |
| RefSeq | XM_012092142.1 | XP_011947532.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAAQPKPPA GATARRLARG CWSALWDYET PKVIVVRNRR LGVLYRAVQL LILLYFVWYV 60 61 FIVQKSYQES ETGPESSIIT KVKGITTSEH KVWDVEEYVK PPEGGSVFSI ITRVEATHSQ 120 121 TQGTCPESIK VHNATCLSDA DCVTGELDML GNGLRTGRCV PYYQGPSKTC EVFGWCPVED 180 181 GASVSQFLGT MAPNFTILIK NSIHYPKFHF SKGNIADRTD GYLKRCTFHE ASDLYCPIFK 240 241 LGFIVEKAGE SFAELAYKGG VIGVIINWDC DLDLPASECN PKYSFRRLDP KHVPASSGYN 300 301 FRFAKYYKIN GTTTRTLIKA YGIRIDVIVH GQAGKFSLIP TIINLATALT SVGVVRSPLW 360 361 GLGGYGVSTG PLHAGLCWPQ GSFLCDWILL TFMNKNKVYS HKKFDKVCTP SRPSGSWPVT 420 421 LARVLGQAPP QPGHCSEDQH PSPPSGQEGQ QGAECGPAFP PLRPCPISAP SEQITPASEP 480 481 APQASTPTDP KGLAQL 496 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGCCG CCCAGCCCAA GCCCCCCGCG GGGGCGACCG CCCGGCGCCT GGCCCGGGGC 60 61 TGCTGGTCCG CCCTCTGGGA CTACGAGACG CCCAAGGTGA TCGTGAGCAT AAAGGTCCAC 120 121 AATGCCACCT GCCTCTCCGA CGCCGACTGT GTGACTGGGG AGCTGGACAT GCTGGGAAAC 180 181 GGCCTGCGGA CCGGGCGCTG TGTGCCCTAT TACCAGGGGC CCTCCAAGAC CTGCGAGGTG 240 241 TTCGGCTGGT GCCCGGTGGA AGATGGGGCC TCCGTCAGCC AATTTCTGGG TACCATGGCC 300 301 CCAAATTTCA CCATCCTCAT CAAGAACAGC ATCCACTACC CCAAATTCCA CTTCTCCAAG 360 361 GGCAACATCG CGGACCGCAC AGACGGGTAC CTGAAGCGCT GCACGTTCCA CGAGGCCTCC 420 421 GACCTCTACT GCCCCATCTT CAAGCTGGGC TTTATTGTCG AAAAGGCTGG GGAGAGCTTC 480 481 GCGGAGCTCG CATACAAGGG TGGTGTCATC GGGGTCATTA TCAACTGGGA CTGTGACCTG 540 541 GACCTGCCCG CGTCGGAGTG TAACCCCAAG TACTCCTTCC GGAGGCTTGA CCCCAAGCAC 600 601 GTGCCTGCCT CGTCAGGCTA CAACTTCAGG TTTGCCAAGT ACTACAAGAT CAATGGTACC 660 661 ACCACCCGCA CGCTCATCAA GGCCTACGGG ATCCGCATTG ACGTCATCGT GCATGGACAG 720 721 GCCGGGAAAT TCAGCCTGAT TCCCACCATT ATTAATCTGG CCACAGCTCT AACTTCCGTC 780 781 GGGGTGGGCT CCTTCCTGTG CGACTGGATC TTGCTAACAT TCATGAACAA AAACAAGGTC 840 841 TACAGCCATA AGAAATTTGA CAAGGTGTGT ACGCCGAGCC GCCCCTCAGG TAGCTGGCCT 900 901 GTGACCCTTG CCCGTGTTTT GGGCCAGGCC CCACCCCAAC CCGGCCACTG CTCCGAGGAC 960 961 CAGCACCCCA GCCCTCCATC AGGCCAGGAG GGCCAACAAG GGGCAGAGTG TGGCCCAGCC 1020 1021 TTCCCACCCC TGCGGCCTTG CCCCATCTCT GCCCCATCTG AGCAGATCAC TCCTGCCTCC 1080 1081 GAGCCTGCCC CACAAGCCTC CACACCCACA GACCCCAAAG GTTTGGCCCA ACTCTGA 1137 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Apical plasma membrane | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | Postsynapse | |
Cellular Component | Receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | Extracellularly ATP-gated cation channel activity | |
Molecular Function | Identical protein binding | |
Molecular Function | Purinergic nucleotide receptor activity | |
Biological Process | Behavioral response to pain | |
Biological Process | Detection of hypoxic conditions in blood by carotid body chemoreceptor signaling | |
Biological Process | Neuromuscular junction development | |
Biological Process | Neuromuscular synaptic transmission | |
Biological Process | Peristalsis | |
Biological Process | Protein homooligomerization | |
Biological Process | Response to ATP | |
Biological Process | Response to carbohydrate | |
Biological Process | Response to hypoxia | |
Biological Process | Sensory perception of sound | |
Biological Process | Sensory perception of taste | |
Biological Process | Skeletal muscle fiber development | |
Biological Process | Urinary bladder smooth muscle contraction |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Paa-2862 | Papio anubis | 98.99 | 0.0 | 1015 |
| LLPS-Mam-0719 | Macaca mulatta | 98.39 | 0.0 | 1010 |
| LLPS-Maf-2449 | Macaca fascicularis | 98.19 | 0.0 | 1008 |
| LLPS-Man-4625 | Macaca nemestrina | 98.19 | 0.0 | 1009 |
| LLPS-Pat-0806 | Pan troglodytes | 96.18 | 0.0 | 981 |
| LLPS-Hos-2611 | Homo sapiens | 96.18 | 0.0 | 978 |
| LLPS-Gog-2636 | Gorilla gorilla | 95.15 | 0.0 | 807 |
| LLPS-Chs-0287 | Chlorocebus sabaeus | 93.55 | 0.0 | 945 |
| LLPS-Mal-3989 | Mandrillus leucophaeus | 92.14 | 0.0 | 691 |
| LLPS-Poa-2720 | Pongo abelii | 91.77 | 0.0 | 924 |
| LLPS-Caj-1636 | Callithrix jacchus | 91.6 | 0.0 | 928 |
| LLPS-Rhb-4307 | Rhinopithecus bieti | 90.73 | 0.0 | 658 |
| LLPS-Pap-2744 | Pan paniscus | 90.54 | 0.0 | 645 |
| LLPS-Eqc-3222 | Equus caballus | 88.33 | 8e-25 | 110 |
| LLPS-Aon-4733 | Aotus nancymaae | 87.73 | 0.0 | 755 |
| LLPS-Urm-2106 | Ursus maritimus | 83.45 | 4e-173 | 501 |
| LLPS-Aim-1125 | Ailuropoda melanoleuca | 81.47 | 0.0 | 602 |
| LLPS-Bot-1447 | Bos taurus | 80.58 | 0.0 | 687 |
| LLPS-Tut-1764 | Tursiops truncatus | 79.69 | 3e-138 | 406 |
| LLPS-Ict-3867 | Ictidomys tridecemlineatus | 79.21 | 0.0 | 764 |
| LLPS-Orc-2270 | Oryctolagus cuniculus | 78.52 | 0.0 | 708 |
| LLPS-Ova-3704 | Ovis aries | 78.34 | 2e-174 | 500 |
| LLPS-Otg-1463 | Otolemur garnettii | 77.45 | 0.0 | 776 |
| LLPS-Cas-0445 | Carlito syrichta | 75.91 | 0.0 | 527 |
| LLPS-Mup-1491 | Mustela putorius furo | 75.35 | 0.0 | 743 |
| LLPS-Cap-4334 | Cavia porcellus | 75.11 | 0.0 | 672 |
| LLPS-Caf-3566 | Canis familiaris | 75.0 | 0.0 | 729 |
| LLPS-Mea-0842 | Mesocricetus auratus | 73.21 | 0.0 | 645 |
| LLPS-Myl-2569 | Myotis lucifugus | 72.68 | 4e-168 | 485 |
| LLPS-Fud-3268 | Fukomys damarensis | 72.6 | 0.0 | 719 |
| LLPS-Fec-1752 | Felis catus | 72.18 | 0.0 | 663 |
| LLPS-Ran-2549 | Rattus norvegicus | 71.71 | 0.0 | 698 |
| LLPS-Mum-3194 | Mus musculus | 71.51 | 0.0 | 723 |
| LLPS-Sus-1930 | Sus scrofa | 69.92 | 0.0 | 691 |
| LLPS-Anc-2422 | Anolis carolinensis | 69.1 | 0.0 | 559 |
| LLPS-Mod-0647 | Monodelphis domestica | 68.22 | 0.0 | 624 |
| LLPS-Loa-3807 | Loxodonta africana | 67.76 | 6e-146 | 427 |
| LLPS-Sah-3946 | Sarcophilus harrisii | 66.82 | 0.0 | 574 |
| LLPS-Anp-0544 | Anas platyrhynchos | 61.63 | 2e-172 | 498 |
| LLPS-Gaga-3643 | Gallus gallus | 59.3 | 1e-159 | 471 |
| LLPS-Lac-2911 | Latimeria chalumnae | 57.95 | 2e-159 | 465 |
| LLPS-Xet-3759 | Xenopus tropicalis | 57.73 | 1e-137 | 409 |
| LLPS-Leo-3013 | Lepisosteus oculatus | 54.19 | 1e-153 | 451 |
| LLPS-Dar-1928 | Danio rerio | 52.82 | 1e-142 | 423 |
| LLPS-Orl-3869 | Oryzias latipes | 52.78 | 8e-145 | 429 |
| LLPS-Scf-2451 | Scleropages formosus | 52.7 | 4e-148 | 437 |
| LLPS-Icp-1151 | Ictalurus punctatus | 52.51 | 6e-142 | 423 |
| LLPS-Pof-2284 | Poecilia formosa | 51.89 | 7e-142 | 421 |
| LLPS-Xim-3191 | Xiphophorus maculatus | 51.26 | 2e-140 | 419 |
| LLPS-Gaa-2722 | Gasterosteus aculeatus | 51.01 | 1e-133 | 400 |
| LLPS-Orn-2756 | Oreochromis niloticus | 50.99 | 2e-139 | 415 |
| LLPS-Tar-2382 | Takifugu rubripes | 50.86 | 5e-141 | 419 |
| LLPS-Asm-1197 | Astyanax mexicanus | 50.72 | 7e-126 | 380 |
| LLPS-Scm-1731 | Scophthalmus maximus | 50.25 | 6e-140 | 416 |
| LLPS-Fia-0496 | Ficedula albicollis | 43.95 | 1e-95 | 301 |
| LLPS-Tag-2511 | Taeniopygia guttata | 42.86 | 1e-95 | 301 |
| LLPS-Pes-1463 | Pelodiscus sinensis | 40.73 | 3e-98 | 309 |
| LLPS-Nol-4327 | Nomascus leucogenys | 40.3 | 2e-82 | 267 |
| LLPS-Meg-0567 | Meleagris gallopavo | 40.25 | 2e-96 | 304 |
| LLPS-Dio-4030 | Dipodomys ordii | 39.77 | 5e-87 | 280 |
| LLPS-Ten-0386 | Tetraodon nigroviridis | 37.17 | 4e-82 | 266 |
| LLPS-Ora-0654 | Ornithorhynchus anatinus | 35.71 | 4e-50 | 181 |