• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caf-3566
P2RX2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: P2X purinoceptor
Gene Name: P2RX2
Ensembl Gene: ENSCAFG00000006270.4
Ensembl Protein: ENSCAFP00000009417.4
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Receptor for ATP that acts as a ligand-gated ion channel.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAAEPKPPA  GADAARRLAG  GCWSALWDYE  TPKVIVVKNR  RLGVVYRAVQ  LLILLYFVWY  60
61    VFIVQKSYQD  SETGPESSVI  TKVKGITYSE  HKVWDVEEYV  KPPEGGSVFS  IITRIEVTAS  120
121   QTLGNCPESV  RVSNATCDLD  EDCVSGQLDM  LGNGLRTGRC  VPYYQGSAKT  CEVSGWCPVE  180
181   DGASVSQFLG  KMAPNFTILI  KNSIHYPKFQ  FSKGNIEHRK  DGYLKHCTFD  EVSDLYCPIF  240
241   KLGFIVEQAG  ENFTELAHTG  GVIGVVINWD  CDLDLPASKC  NPKYSFRRLD  PKHVPASSGY  300
301   NFRFAKYYKT  NNSTTRTLIK  AYGIRIDVIV  HGQAGKFSLI  PTIINLATAL  TSIGVGSFLC  360
361   DWILLTFMNK  NKVYSHKKFD  KVCAPRHSPG  SWPVTLALVL  GQAPPPAPPC  PADPSQACQA  420
421   LAVPPPPKQM  VDTPEQTTGP  QLCASEPPWQ  DSTLADPRGL  AQL  463
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCCG  CGGAGCCCAA  GCCCCCGGCG  GGGGCGGACG  CGGCCCGGCG  CCTGGCCGGG  60
61    GGCTGCTGGT  CGGCTCTCTG  GGACTACGAG  ACGCCCAAGG  TGATCGTGGT  GAAGAACCGG  120
121   CGCCTGGGCG  TCGTGTACCG  CGCGGTACAG  CTGCTCATCC  TGCTCTACTT  CGTGTGGTAC  180
181   GTGTTCATCG  TGCAGAAGAG  CTACCAGGAC  AGCGAGACGG  GCCCCGAGAG  CTCTGTCATC  240
241   ACCAAGGTCA  AGGGCATCAC  CTACTCCGAG  CACAAAGTGT  GGGATGTGGA  GGAGTACGTG  300
301   AAGCCCCCCG  AGGGAGGCAG  CGTGTTCAGC  ATCATCACCA  GGATTGAGGT  CACAGCCTCC  360
361   CAGACCCTCG  GAAACTGCCC  AGAGAGTGTG  AGGGTCAGCA  ACGCCACCTG  TGACTTGGAC  420
421   GAGGACTGTG  TGTCGGGGCA  GCTGGACATG  CTGGGAAACG  GCCTGCGGAC  CGGGCGCTGT  480
481   GTACCCTACT  ACCAAGGCTC  AGCCAAGACC  TGCGAAGTGT  CTGGCTGGTG  CCCAGTGGAA  540
541   GATGGGGCCT  CTGTCAGCCA  ATTTCTCGGC  AAGATGGCCC  CAAATTTCAC  CATCCTCATC  600
601   AAGAACAGCA  TCCACTACCC  TAAATTCCAG  TTCTCCAAGG  GCAACATAGA  GCACCGCAAG  660
661   GACGGCTACC  TGAAACACTG  CACATTCGAT  GAGGTCTCTG  ACCTCTACTG  TCCCATCTTC  720
721   AAGCTGGGCT  TCATTGTGGA  GCAAGCAGGG  GAGAACTTCA  CGGAGCTGGC  ACATACGGGT  780
781   GGCGTCATTG  GAGTCGTCAT  CAACTGGGAC  TGTGACCTGG  ACCTGCCGGC  GTCAAAATGC  840
841   AACCCCAAAT  ACTCCTTCCG  AAGGCTCGAC  CCCAAGCACG  TCCCAGCCTC  GTCTGGCTAC  900
901   AACTTCAGGT  TTGCCAAATA  TTACAAGACA  AACAACAGCA  CAACCCGCAC  ACTCATCAAG  960
961   GCCTATGGGA  TCCGCATTGA  TGTCATTGTG  CATGGACAGG  CAGGGAAGTT  CAGCCTGATT  1020
1021  CCCACCATCA  TTAATCTGGC  CACAGCACTG  ACTTCCATTG  GAGTGGGCTC  CTTCCTGTGT  1080
1081  GACTGGATCT  TGCTGACGTT  CATGAACAAA  AACAAGGTGT  ACAGCCATAA  GAAATTCGAC  1140
1141  AAGGTGTGCG  CGCCCAGACA  CTCCCCTGGT  AGCTGGCCCG  TGACTCTGGC  TCTGGTTTTG  1200
1201  GGCCAGGCCC  CTCCCCCAGC  CCCTCCCTGC  CCTGCAGACC  CCAGCCAGGC  CTGCCAAGCT  1260
1261  CTGGCTGTCC  CGCCCCCACC  CAAGCAGATG  GTGGATACTC  CTGAGCAGAC  CACTGGACCA  1320
1321  CAGCTGTGCG  CCTCCGAGCC  TCCCTGGCAG  GACTCCACAC  TCGCAGATCC  CCGAGGTCTG  1380
1381  GCCCAGCTCT  GA  1392

▼ KEYWORD

ID
Family
Complete proteome
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Receptor
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Apical plasma membrane
Cellular Component
Integral component of membrane
Cellular Component
Integral component of nuclear inner membrane
Cellular Component
Integral component of plasma membrane
Cellular Component
Postsynapse
Cellular Component
Receptor complex
Molecular Function
ATP binding
Molecular Function
ATP-gated ion channel activity
Molecular Function
Extracellularly ATP-gated cation channel activity
Molecular Function
Identical protein binding
Molecular Function
Purinergic nucleotide receptor activity
Biological Process
Behavioral response to pain
Biological Process
Cation transport
Biological Process
Detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
Biological Process
Ion transmembrane transport
Biological Process
Neuromuscular junction development
Biological Process
Neuromuscular synaptic transmission
Biological Process
Peristalsis
Biological Process
Protein homooligomerization
Biological Process
Response to ATP
Biological Process
Response to carbohydrate
Biological Process
Response to hypoxia
Biological Process
Sensory perception of sound
Biological Process
Sensory perception of taste
Biological Process
Skeletal muscle fiber development
Biological Process
Urinary bladder smooth muscle contraction

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-1125Ailuropoda melanoleuca95.60.0 673
LLPS-Urm-2106Ursus maritimus91.550.0 548
LLPS-Eqc-3222Equus caballus90.25e-161 470
LLPS-Mup-1491Mustela putorius furo88.510.0 796
LLPS-Rhb-4307Rhinopithecus bieti84.840.0 603
LLPS-Fec-1752Felis catus81.430.0 708
LLPS-Myl-2569Myotis lucifugus80.82e-179 513
LLPS-Bot-1447Bos taurus80.390.0 731
LLPS-Ict-3867Ictidomys tridecemlineatus79.650.0 717
LLPS-Tut-1764Tursiops truncatus79.372e-135 397
LLPS-Fud-3268Fukomys damarensis79.240.0 732
LLPS-Loa-3807Loxodonta africana79.071e-167 481
LLPS-Mod-0647Monodelphis domestica78.70.0 639
LLPS-Chs-0287Chlorocebus sabaeus78.080.0 718
LLPS-Poa-2720Pongo abelii77.590.0 717
LLPS-Sus-1930Sus scrofa77.550.0 714
LLPS-Otg-1463Otolemur garnettii77.070.0 734
LLPS-Ova-3704Ovis aries76.940.0 560
LLPS-Orc-2270Oryctolagus cuniculus76.670.0 709
LLPS-Aon-4733Aotus nancymaae76.10.0 638
LLPS-Cap-4334Cavia porcellus75.380.0 702
LLPS-Pap-2744Pan paniscus75.250.0 602
LLPS-Mal-3989Mandrillus leucophaeus75.142e-177 508
LLPS-Hos-2611Homo sapiens74.80.0 711
LLPS-Caj-1636Callithrix jacchus74.510.0 713
LLPS-Pat-0806Pan troglodytes74.410.0 706
LLPS-Paa-2862Papio anubis74.40.0 705
LLPS-Cea-2331Cercocebus atys74.40.0 704
LLPS-Mam-0719Macaca mulatta74.20.0 703
LLPS-Maf-2449Macaca fascicularis74.20.0 703
LLPS-Mum-3194Mus musculus74.040.0 700
LLPS-Man-4625Macaca nemestrina74.00.0 701
LLPS-Cas-0445Carlito syrichta73.648e-165 476
LLPS-Ran-2549Rattus norvegicus72.90.0 675
LLPS-Sah-3946Sarcophilus harrisii72.860.0 589
LLPS-Mea-0842Mesocricetus auratus72.630.0 659
LLPS-Anc-2422Anolis carolinensis72.530.0 561
LLPS-Gog-2636Gorilla gorilla72.380.0 576
LLPS-Anp-0544Anas platyrhynchos65.15e-175 503
LLPS-Gaga-3643Gallus gallus62.63e-164 481
LLPS-Xet-3759Xenopus tropicalis62.438e-143 421
LLPS-Lac-2911Latimeria chalumnae61.813e-164 476
LLPS-Leo-3013Lepisosteus oculatus59.722e-158 462
LLPS-Scf-2451Scleropages formosus58.181e-154 453
LLPS-Orl-3869Oryzias latipes56.012e-148 437
LLPS-Orn-2756Oreochromis niloticus55.921e-145 430
LLPS-Xim-3191Xiphophorus maculatus55.771e-142 424
LLPS-Scm-1731Scophthalmus maximus55.656e-145 428
LLPS-Pof-2284Poecilia formosa55.494e-142 421
LLPS-Gaa-2722Gasterosteus aculeatus54.821e-136 406
LLPS-Dar-1928Danio rerio54.428e-146 430
LLPS-Icp-1151Ictalurus punctatus54.428e-143 424
LLPS-Tar-2382Takifugu rubripes53.936e-144 426
LLPS-Asm-1197Astyanax mexicanus52.514e-128 385
LLPS-Fia-0496Ficedula albicollis43.531e-93 295
LLPS-Tag-2511Taeniopygia guttata43.41e-92 292
LLPS-Meg-0567Meleagris gallopavo41.872e-97 305
LLPS-Pes-1463Pelodiscus sinensis41.539e-96 301
LLPS-Ten-0386Tetraodon nigroviridis40.943e-90 287
LLPS-Nol-4327Nomascus leucogenys39.552e-81 263
LLPS-Dio-4030Dipodomys ordii39.343e-84 271
LLPS-Ora-0654Ornithorhynchus anatinus35.921e-49 179