LLPS-Cea-0237
RUNX3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Runt-related transcription factor |
| Gene Name: | RUNX3 |
| Ensembl Gene: | ENSCATG00000016885.1 |
| Ensembl Protein: | ENSCATP00000005022.1 |
| Organism: | Cercocebus atys |
| Taxa ID: | 9531 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, PML nuclear body, Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCATT00000019363.1 | ENSCATP00000005022.1 |
| Ensembl | ENSCATT00000019348.1 | ENSCATP00000005015.1 |
| UniProt | A0A2K5KWG4, A0A2K5KWG4_CERAT | |
| RefSeq | XM_012080110.1, XM_012080112.1, XM_012080113.1 | XP_011935500.1, XP_011935502.1, XP_011935503.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MASNSIFDSF PTYSPTFIRD PSTSRRFTPP STAFPCGGGG KMGENSGALS AQAAVGPGGR 60 61 ARPEVRSMVD VLADHAGELV RTDSPNFLCS VLPSHWRCNK TLPVAFKVVA LGDVPDGTVV 120 121 TVMAGNDENY SAELRNASAV MKNQVARFND LRFVGRSGRG KSFTLTITVF TNPTQVATYH 180 181 RAIKVTVDGP REPRRHRQKL EDQTKPFPER FGELERLRMR VTPSTPSPRG SLSTTSHFSS 240 241 QPQTPIQGTS ELNPFSDPRQ FDRSFPTLPA LTESRFPDPR MHYPGAMSAA FPYSATPSGT 300 301 SISSLSVAGM PATSRFHHTY LPPPYPGAPQ NQSGPFQTNP SPYHLYYGTS SGSYQFSMVA 360 361 GSSSGGDRSP TRMLASCTSS AASVAAGNLM NPSLGGQSDG VEADGSHSNS PTALSTPGRM 420 421 DEAVWRPY 428 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCATCGA ACAGCATCTT CGACTCCTTC CCGACCTACT CGCCGACCTT CATCCGCGAC 60 61 CCAAGCACCA GCCGCCGCTT CACACCTCCC TCCACGGCCT TCCCCTGCGG CGGCGGCGGC 120 121 AAGATGGGCG AGAACAGCGG CGCGCTCAGC GCGCAGGCAG CCGTGGGGCC CGGAGGGCGC 180 181 GCCCGGCCCG AGGTGCGCTC GATGGTGGAC GTGCTGGCGG ACCACGCGGG CGAGCTCGTG 240 241 CGCACCGACA GCCCCAACTT CCTCTGCTCG GTGCTGCCCT CGCACTGGCG CTGCAACAAG 300 301 ACACTGCCCG TCGCTTTCAA GGTGGTGGCA CTGGGGGACG TGCCAGATGG CACCGTGGTG 360 361 ACCGTGATGG CAGGCAATGA CGAGAACTAC TCCGCTGAGC TGCGCAACGC CTCGGCCGTC 420 421 ATGAAGAACC AGGTGGCCAG GTTCAACGAC CTTCGCTTTG TGGGCCGCAG TGGGCGAGGG 480 481 AAGAGTTTCA CCCTGACCAT CACTGTGTTC ACCAACCCCA CCCAAGTGGC CACCTACCAC 540 541 CGAGCCATCA AGGTGACCGT GGACGGACCC CGGGAGCCCA GACGGCACCG GCAGAAGCTG 600 601 GAGGACCAGA CCAAGCCGTT CCCTGAACGC TTTGGGGAAC TGGAACGGCT GCGCATGCGG 660 661 GTGACACCGA GCACGCCCAG CCCCCGAGGC TCACTCAGCA CCACAAGCCA CTTCAGCAGC 720 721 CAGCCGCAGA CCCCAATCCA AGGCACCTCG GAACTGAACC CATTCTCTGA CCCCCGCCAG 780 781 TTTGACCGCT CCTTCCCGAC GCTGCCAGCC CTCACGGAGA GCCGCTTCCC AGACCCCAGG 840 841 ATGCACTACC CCGGGGCCAT GTCAGCTGCC TTCCCCTACA GCGCCACGCC CTCGGGCACG 900 901 AGCATCAGCA GCCTCAGCGT GGCGGGCATG CCGGCCACCA GCCGCTTCCA CCATACCTAC 960 961 CTCCCGCCAC CCTACCCGGG GGCCCCGCAG AACCAGAGCG GGCCCTTCCA GACCAACCCG 1020 1021 TCTCCCTACC ACCTCTACTA CGGGACGTCC TCTGGCTCCT ATCAGTTCTC CATGGTGGCC 1080 1081 GGCAGCAGCA GTGGGGGCGA CCGCTCACCC ACCCGCATGC TGGCCTCTTG CACCAGCAGC 1140 1141 GCTGCCTCTG TCGCCGCCGG CAACCTCATG AACCCCAGCC TGGGTGGCCA GAGCGATGGC 1200 1201 GTGGAGGCCG ACGGCAGCCA CAGCAACTCA CCCACAGCCC TGAGCACTCC GGGCCGCATG 1260 1261 GATGAGGCCG TGTGGCGGCC CTACTGA 1287 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleolus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity | |
Biological Process | Positive regulation of transcription, DNA-templated | |
Biological Process | Protein phosphorylation | |
Biological Process | Response to transforming growth factor beta |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Paa-2102 | Papio anubis | 100.0 | 0.0 | 845 |
| LLPS-Chs-3313 | Chlorocebus sabaeus | 100.0 | 0.0 | 845 |
| LLPS-Ora-1144 | Ornithorhynchus anatinus | 100.0 | 5e-43 | 152 |
| LLPS-Maf-2193 | Macaca fascicularis | 99.77 | 0.0 | 843 |
| LLPS-Mam-1689 | Macaca mulatta | 99.77 | 0.0 | 843 |
| LLPS-Man-4212 | Macaca nemestrina | 99.77 | 0.0 | 827 |
| LLPS-Rhb-0759 | Rhinopithecus bieti | 99.07 | 0.0 | 838 |
| LLPS-Poa-2275 | Pongo abelii | 98.89 | 0.0 | 706 |
| LLPS-Pap-3822 | Pan paniscus | 98.83 | 0.0 | 835 |
| LLPS-Pat-2557 | Pan troglodytes | 98.83 | 0.0 | 835 |
| LLPS-Hos-1910 | Homo sapiens | 98.6 | 0.0 | 820 |
| LLPS-Gog-2356 | Gorilla gorilla | 98.36 | 0.0 | 832 |
| LLPS-Nol-3080 | Nomascus leucogenys | 98.15 | 0.0 | 620 |
| LLPS-Aon-4409 | Aotus nancymaae | 97.9 | 0.0 | 816 |
| LLPS-Caj-4206 | Callithrix jacchus | 97.21 | 0.0 | 812 |
| LLPS-Sus-3002 | Sus scrofa | 94.74 | 0.0 | 749 |
| LLPS-Ict-1385 | Ictidomys tridecemlineatus | 94.67 | 1e-149 | 439 |
| LLPS-Tut-1758 | Tursiops truncatus | 94.65 | 0.0 | 790 |
| LLPS-Urm-0270 | Ursus maritimus | 94.44 | 4e-14 | 73.2 |
| LLPS-Eqc-4351 | Equus caballus | 93.78 | 0.0 | 784 |
| LLPS-Loa-2153 | Loxodonta africana | 93.52 | 0.0 | 785 |
| LLPS-Bot-1352 | Bos taurus | 92.2 | 0.0 | 758 |
| LLPS-Fec-0292 | Felis catus | 91.69 | 0.0 | 767 |
| LLPS-Mea-2403 | Mesocricetus auratus | 90.42 | 0.0 | 762 |
| LLPS-Mum-2621 | Mus musculus | 90.23 | 0.0 | 754 |
| LLPS-Cap-3112 | Cavia porcellus | 90.11 | 0.0 | 749 |
| LLPS-Ova-1293 | Ovis aries | 90.06 | 0.0 | 540 |
| LLPS-Mal-2100 | Mandrillus leucophaeus | 89.49 | 0.0 | 734 |
| LLPS-Dio-2412 | Dipodomys ordii | 89.13 | 0.0 | 548 |
| LLPS-Fud-1533 | Fukomys damarensis | 87.95 | 3e-180 | 512 |
| LLPS-Anp-3093 | Anas platyrhynchos | 85.37 | 0.0 | 639 |
| LLPS-Tag-0371 | Taeniopygia guttata | 85.16 | 0.0 | 693 |
| LLPS-Lac-2221 | Latimeria chalumnae | 84.57 | 4e-99 | 301 |
| LLPS-Fia-0635 | Ficedula albicollis | 84.47 | 0.0 | 682 |
| LLPS-Gaga-3092 | Gallus gallus | 84.39 | 0.0 | 587 |
| LLPS-Pes-0398 | Pelodiscus sinensis | 84.18 | 0.0 | 684 |
| LLPS-Mod-2307 | Monodelphis domestica | 84.06 | 2e-159 | 458 |
| LLPS-Myl-2231 | Myotis lucifugus | 81.82 | 0.0 | 587 |
| LLPS-Sah-2304 | Sarcophilus harrisii | 81.31 | 0.0 | 524 |
| LLPS-Meg-0543 | Meleagris gallopavo | 81.18 | 8e-151 | 436 |
| LLPS-Cis-1246 | Ciona savignyi | 76.92 | 1e-67 | 219 |
| LLPS-Cii-1095 | Ciona intestinalis | 76.77 | 9e-39 | 150 |
| LLPS-Orc-1862 | Oryctolagus cuniculus | 69.28 | 4e-60 | 203 |
| LLPS-Drm-0877 | Drosophila melanogaster | 67.32 | 6e-59 | 209 |
| LLPS-Leo-3371 | Lepisosteus oculatus | 66.01 | 0.0 | 548 |
| LLPS-Xet-1334 | Xenopus tropicalis | 65.31 | 0.0 | 552 |
| LLPS-Asm-1534 | Astyanax mexicanus | 65.3 | 3e-178 | 511 |
| LLPS-Tar-0086 | Takifugu rubripes | 64.79 | 9e-171 | 493 |
| LLPS-Xim-0966 | Xiphophorus maculatus | 64.72 | 2e-174 | 502 |
| LLPS-Gaa-2272 | Gasterosteus aculeatus | 64.62 | 9e-166 | 479 |
| LLPS-Ten-3035 | Tetraodon nigroviridis | 64.56 | 7e-175 | 503 |
| LLPS-Scm-2461 | Scophthalmus maximus | 64.56 | 1e-176 | 508 |
| LLPS-Pof-0297 | Poecilia formosa | 64.41 | 4e-174 | 501 |
| LLPS-Dar-2025 | Danio rerio | 64.32 | 3e-174 | 502 |
| LLPS-Icp-0269 | Ictalurus punctatus | 64.1 | 2e-166 | 483 |
| LLPS-Orn-3122 | Oreochromis niloticus | 63.92 | 1e-165 | 479 |
| LLPS-Anc-3556 | Anolis carolinensis | 63.68 | 2e-157 | 457 |
| LLPS-Orl-0455 | Oryzias latipes | 62.75 | 2e-164 | 476 |
| LLPS-Caf-1289 | Canis familiaris | 61.33 | 5e-50 | 177 |
| LLPS-Scf-1396 | Scleropages formosus | 60.86 | 2e-150 | 441 |
| LLPS-Otg-2545 | Otolemur garnettii | 57.78 | 5e-157 | 459 |
| LLPS-Ran-3440 | Rattus norvegicus | 57.72 | 2e-168 | 488 |
| LLPS-Mup-0357 | Mustela putorius furo | 56.63 | 5e-164 | 478 |
| LLPS-Aim-0515 | Ailuropoda melanoleuca | 54.08 | 3e-138 | 410 |
| LLPS-Cae-0781 | Caenorhabditis elegans | 51.54 | 2e-34 | 135 |