• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Cas-1922
AURKA

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: aurora kinase A isoform X2
Gene Name: AURKA
Ensembl Gene: ENSTSYG00000036090.1
Ensembl Protein: ENSTSYP00000031337.1
Organism: Carlito syrichta
Taxa ID: 1868482
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Droplet, Nucleolus, PML nuclear body, Centrosome/Spindle pole body, Spindle apparatus, OthersPredicted from orthologs(View)

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDGSKENCIS  EPVKATVPLG  GPKRVPVTQQ  LPCQNPLPAS  SGQAQRVLCP  SNSSQRVPSQ  60
61    AQKLTSSQKL  DQKQKQLQAT  GVPHPVSKPQ  SNTQKSKQPQ  PSAPGNNPKE  ELTSKQKNEE  120
121   SKKRQWALED  FEIGRPLGKG  RFGNVYLARE  RQSKFILALK  VLFKVQLEKA  GVEHQLRREV  180
181   EIQSHLRHPN  ILRLYGYFHD  ATRVYLILEY  APLGTVYREL  QKLSKFDEQR  TATYITELAN  240
241   ALSYCHSKRV  IHRDIKPENL  LLGSAGELKI  ADFGWSVHAP  SSRRTTLCGT  LDYLPPEMIE  300
301   GRMHDEKVDL  WSLGVLCYEF  LVGNPPFEAS  TNQETYRRIS  RIEFTFPDFV  TEGARDLISR  360
361   LLKHTPSQRL  TLREVLEHPW  ITANSSKPSN  CQNKESTSKQ  S  401
Nucleotide CDS Sequence (FASTA)
1     ATGGACGGAT  CTAAAGAAAA  CTGCATTTCA  GAGCCTGTTA  AGGCTACGGT  TCCACTTGGA  60
61    GGTCCAAAAC  GTGTTCCTGT  GACTCAGCAA  CTTCCTTGTC  AGAATCCGTT  ACCTGCAAGC  120
121   AGTGGTCAGG  CTCAGCGGGT  CTTGTGTCCT  TCAAATTCTT  CCCAGCGTGT  TCCTTCGCAA  180
181   GCACAAAAGC  TCACGTCCAG  TCAGAAGCTA  GACCAGAAGC  AGAAGCAATT  GCAGGCAACT  240
241   GGTGTACCTC  ATCCTGTCTC  CAAGCCACAG  AGCAATACCC  AAAAGAGCAA  GCAACCCCAG  300
301   CCATCAGCAC  CTGGAAATAA  TCCTAAGGAG  GAACTGACGT  CAAAACAGAA  AAATGAAGAA  360
361   TCAAAAAAGA  GACAATGGGC  TTTGGAGGAT  TTTGAAATTG  GTCGCCCGCT  GGGTAAAGGA  420
421   AGGTTTGGTA  ATGTTTACTT  GGCAAGAGAA  AGGCAAAGCA  AGTTTATCCT  GGCTCTTAAA  480
481   GTGCTGTTTA  AAGTTCAGCT  GGAGAAAGCT  GGAGTGGAAC  ATCAGCTCAG  AAGAGAAGTA  540
541   GAAATACAGT  CCCACCTTCG  GCATCCTAAT  ATTCTCAGAC  TGTATGGTTA  TTTCCATGAT  600
601   GCCACCAGAG  TTTACCTAAT  TTTAGAATAT  GCGCCGCTTG  GAACAGTCTA  TAGAGAGCTT  660
661   CAGAAACTTT  CAAAATTTGA  TGAACAGAGA  ACTGCTACTT  ATATCACAGA  ATTGGCAAAT  720
721   GCCCTATCCT  ACTGTCATTC  AAAGAGAGTC  ATCCACAGAG  ACATTAAGCC  AGAGAACCTG  780
781   CTTCTTGGAT  CAGCTGGAGA  GCTGAAGATT  GCAGATTTTG  GGTGGTCAGT  ACATGCTCCA  840
841   TCCTCAAGGA  GAACCACTCT  CTGTGGTACC  CTGGACTACC  TGCCCCCCGA  GATGATTGAA  900
901   GGTCGGATGC  ATGATGAGAA  AGTAGATCTC  TGGAGCCTTG  GTGTTCTCTG  CTATGAGTTT  960
961   TTAGTTGGGA  ATCCTCCCTT  TGAGGCAAGC  ACAAACCAAG  AAACCTATAG  AAGAATATCA  1020
1021  CGGATTGAAT  TCACATTCCC  TGACTTTGTA  ACAGAGGGAG  CCAGGGACCT  CATTTCAAGA  1080
1081  CTGCTGAAGC  ACACTCCAAG  CCAGAGGCTA  ACATTAAGGG  AAGTACTTGA  ACATCCCTGG  1140
1141  ATCACAGCCA  ATTCATCAAA  ACCATCAAAC  TGCCAAAACA  AAGAATCAAC  CAGCAAACAG  1200
1201  TCTTAG  1206

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aon-1662Aotus nancymaae91.520.0 733
LLPS-Pat-0269Pan troglodytes91.320.0 729
LLPS-Pap-0394Pan paniscus91.320.0 729
LLPS-Cea-0958Cercocebus atys91.320.0 724
LLPS-Hos-0651Homo sapiens91.070.0 728
LLPS-Man-0266Macaca nemestrina91.070.0 723
LLPS-Maf-2786Macaca fascicularis91.070.0 723
LLPS-Paa-0614Papio anubis91.070.0 722
LLPS-Gog-1941Gorilla gorilla90.820.0 728
LLPS-Caj-0149Callithrix jacchus90.770.0 724
LLPS-Mam-1921Macaca mulatta90.660.0 710
LLPS-Poa-0098Pongo abelii90.590.0 726
LLPS-Rhb-0371Rhinopithecus bieti90.360.0 646
LLPS-Chs-3639Chlorocebus sabaeus90.320.0 719
LLPS-Nol-1379Nomascus leucogenys89.330.0 724
LLPS-Otg-0306Otolemur garnettii89.080.0 711
LLPS-Eqc-2662Equus caballus87.766e-163 472
LLPS-Aim-0753Ailuropoda melanoleuca87.60.0 667
LLPS-Ora-0821Ornithorhynchus anatinus87.460.0 529
LLPS-Mal-0254Mandrillus leucophaeus87.340.0 683
LLPS-Fec-0403Felis catus86.910.0 686
LLPS-Mup-0241Mustela putorius furo86.820.0 666
LLPS-Bot-1417Bos taurus86.630.0 685
LLPS-Myl-1799Myotis lucifugus86.560.0 656
LLPS-Urm-1992Ursus maritimus86.420.0 689
LLPS-Ova-0278Ovis aries86.390.0 682
LLPS-Orc-1617Oryctolagus cuniculus85.570.0 686
LLPS-Caf-0453Canis familiaris84.690.0 687
LLPS-Loa-0807Loxodonta africana84.650.0 669
LLPS-Sus-2126Sus scrofa84.40.0 656
LLPS-Dio-1397Dipodomys ordii84.130.0 653
LLPS-Fud-3321Fukomys damarensis83.720.0 647
LLPS-Ran-0231Rattus norvegicus83.580.0 651
LLPS-Mea-0868Mesocricetus auratus82.460.0 616
LLPS-Mum-0427Mus musculus82.090.0 632
LLPS-Ict-2231Ictidomys tridecemlineatus81.820.0 615
LLPS-Cap-0539Cavia porcellus80.490.0 625
LLPS-Mod-0263Monodelphis domestica78.090.0 598
LLPS-Sah-1436Sarcophilus harrisii76.960.0 615
LLPS-Tag-0143Taeniopygia guttata74.390.0 525
LLPS-Lac-2389Latimeria chalumnae73.115e-151 436
LLPS-Cym-0237Cyanidioschyzon merolae72.359e-143 421
LLPS-Cii-1318Ciona intestinalis71.972e-142 414
LLPS-Scf-1259Scleropages formosus71.917e-148 430
LLPS-Pes-0017Pelodiscus sinensis71.430.0 555
LLPS-Dar-0431Danio rerio71.271e-146 426
LLPS-Ere-0509Erinaceus europaeus70.832e-136 401
LLPS-Gas-0604Galdieria sulphuraria70.729e-140 414
LLPS-Anp-1760Anas platyrhynchos70.450.0 541
LLPS-Gaga-1598Gallus gallus70.050.0 531
LLPS-Leo-0042Lepisosteus oculatus69.578e-147 427
LLPS-Xet-0174Xenopus tropicalis69.431e-143 417
LLPS-Icp-2077Ictalurus punctatus68.572e-145 424
LLPS-Osl-0960Ostreococcus lucimarinus68.441e-134 396
LLPS-Anc-0085Anolis carolinensis68.281e-148 433
LLPS-Pof-1359Poecilia formosa67.151e-141 412
LLPS-Scm-1017Scophthalmus maximus67.053e-138 405
LLPS-Orn-0681Oreochromis niloticus67.047e-137 402
LLPS-Fia-0465Ficedula albicollis66.990.0 522
LLPS-Tar-1644Takifugu rubripes66.912e-138 407
LLPS-Chr-0161Chlamydomonas reinhardtii66.543e-129 381
LLPS-Asm-2145Astyanax mexicanus66.33e-139 407
LLPS-Sem-1439Selaginella moellendorffii66.291e-129 382
LLPS-Mua-0879Musa acuminata66.173e-126 373
LLPS-Cis-1210Ciona savignyi65.884e-144 419
LLPS-Orl-1796Oryzias latipes65.691e-138 406
LLPS-Ors-0006Oryza sativa65.663e-125 370
LLPS-Orr-0517Oryza rufipogon65.663e-125 370
LLPS-Org-0901Oryza glaberrima65.663e-124 368
LLPS-Ori-0419Oryza indica65.665e-125 370
LLPS-Orni-0287Oryza nivara65.665e-125 370
LLPS-Orgl-0338Oryza glumaepatula65.667e-125 370
LLPS-Ten-0906Tetraodon nigroviridis65.347e-137 400
LLPS-Gor-0973Gossypium raimondii65.36e-127 375
LLPS-Php-0231Physcomitrella patens64.842e-129 382
LLPS-Orbr-0354Oryza brachyantha64.792e-124 369
LLPS-Hea-0080Helianthus annuus64.552e-126 374
LLPS-Bro-0803Brassica oleracea64.532e-123 367
LLPS-Sol-0010Solanum lycopersicum64.494e-128 378
LLPS-Dac-0042Daucus carota64.412e-126 374
LLPS-Brn-2903Brassica napus64.299e-124 367
LLPS-Tra-0508Triticum aestivum64.296e-123 365
LLPS-Sob-1500Sorghum bicolor64.163e-126 373
LLPS-Lep-0151Leersia perrieri64.164e-126 373
LLPS-Sot-1738Solanum tuberosum64.135e-128 378
LLPS-Glm-2276Glycine max64.01e-126 375
LLPS-Amt-0593Amborella trichopoda63.991e-128 379
LLPS-Orp-0380Oryza punctata63.934e-125 370
LLPS-Brr-0053Brassica rapa63.914e-123 365
LLPS-Chc-0164Chondrus crispus63.882e-127 376
LLPS-Sei-1392Setaria italica63.83e-125 371
LLPS-Coc-1508Corchorus capsularis63.576e-127 375
LLPS-Prp-0381Prunus persica63.162e-127 376
LLPS-Tru-0796Triticum urartu63.086e-123 365
LLPS-Art-1212Arabidopsis thaliana62.911e-124 371
LLPS-Arl-0499Arabidopsis lyrata62.591e-124 369
LLPS-Phv-1445Phaseolus vulgaris62.244e-127 375
LLPS-Mae-0322Manihot esculenta62.242e-125 371
LLPS-Brd-0258Brachypodium distachyon62.242e-125 371
LLPS-Viv-0559Vitis vinifera62.23e-127 376
LLPS-Via-0913Vigna angularis62.117e-127 375
LLPS-Vir-1007Vigna radiata62.118e-127 375
LLPS-Met-0370Medicago truncatula62.072e-128 379
LLPS-Nia-1373Nicotiana attenuata61.941e-128 380
LLPS-Scp-0044Schizosaccharomyces pombe61.923e-119 358
LLPS-Pot-1957Populus trichocarpa61.894e-127 375
LLPS-Thc-1505Theobroma cacao61.846e-126 372
LLPS-Xim-0226Xiphophorus maculatus60.83e-159 462
LLPS-Hov-0048Hordeum vulgare60.272e-124 369
LLPS-Gaa-0192Gasterosteus aculeatus60.137e-138 404
LLPS-Scj-0231Schizosaccharomyces japonicus59.933e-118 355
LLPS-Mel-0704Melampsora laricipopulina59.224e-117 356
LLPS-Pug-0774Puccinia graminis59.016e-117 353
LLPS-Meg-0376Meleagris gallopavo58.549e-144 422
LLPS-Cae-0311Caenorhabditis elegans57.752e-119 357
LLPS-Cus-0605Cucumis sativus56.582e-116 348
LLPS-Zem-0561Zea mays56.251e-119 357
LLPS-Scc-0017Schizosaccharomyces cryophilus53.536e-118 354
LLPS-Drm-0012Drosophila melanogaster49.325e-121 364