LLPS-Cas-0930
EIF3K
Integrated Annotations
▼ OVERVIEW
Status: | Unreviewed |
Protein Name: | Eukaryotic translation initiation factor 3 subunit K |
Gene Name: | EIF3K, EIF3S12 |
Ensembl Gene: | ENSTSYG00000007001.2 |
Ensembl Protein: | ENSTSYP00000020093.1 |
Organism: | Carlito syrichta |
Taxa ID: | 1868482 |
LLPS Type: | Others |
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
Nucleolus, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENSTSYT00000045853.1 | ENSTSYP00000020093.1 |
Ensembl | ENSTSYT00000042892.1 | ENSTSYP00000014709.1 |
Ensembl | ENSTSYT00000006981.2 | ENSTSYP00000006390.2 |
Ensembl | ENSTSYT00000044896.1 | ENSTSYP00000025057.1 |
UniProt | A0A1U7V3E7, A0A1U7V3E7_TARSY | |
RefSeq | , XM_008074031.1, XM_021706987.1 | , XP_008072222.1, XP_021562662.1, XP_008072222.1, XP_021562662.1 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MAMFEQMRAN VGKLLKGIDR YNPENLATLE RYVETQAKEN AYDLEANLAV LKLYQFNPAF 60 61 FQTTVTAQIL LKALTNLPHT DFTLCKCMID QAHQEERPIR QILYLGDLLE TCHFQAFWQA 120 121 LDENMDLLEG ITGFEDSVRK FICHVVGITY QHIDRWLLAE MLGDLTDSQL KVWMSKYGWS 180 181 ADESGQIFVC SQEESIKPKN IVEKIDFDSV SSIMASSQ 218 |
Nucleotide CDS Sequence (FASTA) |
1 ATGGCTATGT TTGAGCAGAT GAGAGCGAAC GTGGGCAAGT TACTCAAGGG TATCGACAGG 60 61 TACAATCCTG AAAACCTGGC CACCTTGGAG CGCTACGTGG AAACACAGGC CAAGGAGAAT 120 121 GCCTATGATC TGGAAGCCAA CCTGGCTGTT TTGAAGCTGT ACCAGTTCAA CCCAGCCTTC 180 181 TTTCAGACCA CGGTCACTGC CCAGATCCTG CTGAAGGCCC TCACCAACCT GCCCCACACT 240 241 GACTTTACCC TGTGCAAGTG CATGATTGAC CAGGCACATC AAGAAGAGCG GCCGATCCGA 300 301 CAGATTTTGT ACCTTGGGGA TCTGTTGGAG ACCTGCCACT TCCAGGCCTT CTGGGTGTGT 360 361 CCAGCATCAT GGCCTCCTCC CAGTAACTAG 390 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Eukaryotic 43S preinitiation complex | |
Cellular Component | Eukaryotic 48S preinitiation complex | |
Cellular Component | Eukaryotic translation initiation factor 3 complex | |
Cellular Component | Nucleus | |
Molecular Function | Ribosome binding | |
Molecular Function | Translation initiation factor activity | |
Biological Process | Formation of cytoplasmic translation initiation complex | |
Biological Process | Regulation of translational initiation |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Ova-0265 | Ovis aries | 99.54 | 2e-163 | 457 |
LLPS-Myl-0524 | Myotis lucifugus | 99.54 | 2e-163 | 457 |
LLPS-Mup-0703 | Mustela putorius furo | 99.54 | 2e-163 | 457 |
LLPS-Bot-1481 | Bos taurus | 99.54 | 2e-163 | 457 |
LLPS-Caf-2846 | Canis familiaris | 99.54 | 2e-163 | 457 |
LLPS-Fec-0627 | Felis catus | 99.54 | 2e-163 | 457 |
LLPS-Eqc-2803 | Equus caballus | 99.52 | 9e-156 | 439 |
LLPS-Poa-0084 | Pongo abelii | 99.4 | 7e-122 | 350 |
LLPS-Urm-1145 | Ursus maritimus | 99.24 | 7e-93 | 275 |
LLPS-Paa-1503 | Papio anubis | 99.08 | 8e-163 | 456 |
LLPS-Aim-1761 | Ailuropoda melanoleuca | 99.08 | 1e-162 | 455 |
LLPS-Gog-3024 | Gorilla gorilla | 99.08 | 8e-163 | 456 |
LLPS-Fud-1864 | Fukomys damarensis | 99.08 | 5e-162 | 454 |
LLPS-Maf-1713 | Macaca fascicularis | 99.08 | 8e-163 | 456 |
LLPS-Chs-1009 | Chlorocebus sabaeus | 99.08 | 8e-163 | 456 |
LLPS-Cea-3679 | Cercocebus atys | 99.08 | 8e-163 | 456 |
LLPS-Ict-1974 | Ictidomys tridecemlineatus | 99.08 | 1e-162 | 455 |
LLPS-Nol-0529 | Nomascus leucogenys | 99.08 | 8e-163 | 456 |
LLPS-Orc-1227 | Oryctolagus cuniculus | 99.08 | 1e-162 | 456 |
LLPS-Rhb-0897 | Rhinopithecus bieti | 99.08 | 8e-163 | 456 |
LLPS-Pap-2413 | Pan paniscus | 99.08 | 8e-163 | 456 |
LLPS-Pat-1534 | Pan troglodytes | 99.08 | 8e-163 | 456 |
LLPS-Hos-0166 | Homo sapiens | 99.08 | 8e-163 | 456 |
LLPS-Man-0292 | Macaca nemestrina | 99.08 | 8e-163 | 456 |
LLPS-Tut-1248 | Tursiops truncatus | 98.99 | 2e-146 | 414 |
LLPS-Ere-0530 | Erinaceus europaeus | 98.62 | 5e-162 | 454 |
LLPS-Caj-0821 | Callithrix jacchus | 98.62 | 3e-162 | 454 |
LLPS-Mum-1156 | Mus musculus | 98.62 | 2e-162 | 455 |
LLPS-Cap-1620 | Cavia porcellus | 98.62 | 3e-162 | 454 |
LLPS-Otg-0600 | Otolemur garnettii | 98.62 | 3e-162 | 454 |
LLPS-Fia-1725 | Ficedula albicollis | 96.77 | 2e-60 | 191 |
LLPS-Loa-0005 | Loxodonta africana | 96.35 | 4e-157 | 441 |
LLPS-Aon-3069 | Aotus nancymaae | 96.33 | 4e-155 | 437 |
LLPS-Sus-3078 | Sus scrofa | 96.31 | 9e-156 | 439 |
LLPS-Mam-0272 | Macaca mulatta | 96.31 | 8e-156 | 438 |
LLPS-Ran-3681 | Rattus norvegicus | 93.84 | 2e-147 | 416 |
LLPS-Ora-2524 | Ornithorhynchus anatinus | 93.5 | 1e-82 | 249 |
LLPS-Pes-1607 | Pelodiscus sinensis | 92.73 | 5e-114 | 331 |
LLPS-Anc-3093 | Anolis carolinensis | 91.74 | 5e-150 | 425 |
LLPS-Gaga-1369 | Gallus gallus | 91.71 | 2e-152 | 429 |
LLPS-Lac-1792 | Latimeria chalumnae | 89.91 | 3e-148 | 419 |
LLPS-Mod-1388 | Monodelphis domestica | 88.78 | 5e-58 | 185 |
LLPS-Scf-1974 | Scleropages formosus | 86.51 | 5e-141 | 400 |
LLPS-Pof-0902 | Poecilia formosa | 84.86 | 7e-139 | 395 |
LLPS-Dar-0714 | Danio rerio | 84.65 | 1e-138 | 394 |
LLPS-Orn-2532 | Oreochromis niloticus | 84.26 | 2e-136 | 389 |
LLPS-Xim-1913 | Xiphophorus maculatus | 83.94 | 1e-137 | 392 |
LLPS-Scm-0760 | Scophthalmus maximus | 83.72 | 1e-133 | 384 |
LLPS-Xet-1409 | Xenopus tropicalis | 83.64 | 6e-131 | 374 |
LLPS-Tar-0393 | Takifugu rubripes | 83.03 | 9e-137 | 390 |
LLPS-Ten-1518 | Tetraodon nigroviridis | 83.03 | 2e-136 | 389 |
LLPS-Icp-0689 | Ictalurus punctatus | 83.01 | 1e-129 | 372 |
LLPS-Orl-2579 | Oryzias latipes | 81.68 | 2e-121 | 352 |
LLPS-Asm-1383 | Astyanax mexicanus | 75.59 | 2e-66 | 212 |
LLPS-Mea-1645 | Mesocricetus auratus | 73.52 | 6e-106 | 311 |
LLPS-Gaa-0865 | Gasterosteus aculeatus | 73.06 | 3e-114 | 333 |
LLPS-Mal-2698 | Mandrillus leucophaeus | 63.3 | 6e-85 | 256 |
LLPS-Leo-1687 | Lepisosteus oculatus | 61.01 | 6e-83 | 252 |
LLPS-Cii-0090 | Ciona intestinalis | 51.21 | 7e-75 | 232 |
LLPS-Cis-0706 | Ciona savignyi | 50.97 | 3e-73 | 228 |
LLPS-Drm-1539 | Drosophila melanogaster | 49.27 | 5e-68 | 215 |
LLPS-Chc-0137 | Chondrus crispus | 37.44 | 9e-34 | 126 |
LLPS-Gas-0310 | Galdieria sulphuraria | 37.2 | 1e-36 | 134 |
LLPS-Brn-0424 | Brassica napus | 36.89 | 6e-36 | 132 |
LLPS-Brr-1836 | Brassica rapa | 36.41 | 1e-32 | 129 |
LLPS-Php-1063 | Physcomitrella patens | 35.75 | 2e-38 | 139 |
LLPS-Cae-1879 | Caenorhabditis elegans | 35.62 | 3e-50 | 170 |
LLPS-Arl-2797 | Arabidopsis lyrata | 35.12 | 8e-37 | 134 |
LLPS-Phv-1644 | Phaseolus vulgaris | 35.1 | 4e-36 | 132 |
LLPS-Zyt-1465 | Zymoseptoria tritici | 34.42 | 2e-21 | 92.4 |
LLPS-Sei-1562 | Setaria italica | 34.3 | 3e-36 | 133 |
LLPS-Sob-1774 | Sorghum bicolor | 34.3 | 3e-36 | 133 |
LLPS-Bro-1988 | Brassica oleracea | 34.15 | 2e-34 | 129 |
LLPS-Art-2460 | Arabidopsis thaliana | 34.15 | 3e-34 | 127 |
LLPS-Met-2293 | Medicago truncatula | 34.13 | 7e-34 | 127 |
LLPS-Via-0570 | Vigna angularis | 34.13 | 4e-35 | 130 |
LLPS-Sot-1504 | Solanum tuberosum | 34.13 | 2e-35 | 131 |
LLPS-Pot-0249 | Populus trichocarpa | 34.13 | 3e-34 | 128 |
LLPS-Cus-0882 | Cucumis sativus | 34.1 | 5e-35 | 130 |
LLPS-Mua-1744 | Musa acuminata | 33.94 | 8e-36 | 132 |
LLPS-Lep-0725 | Leersia perrieri | 33.82 | 5e-35 | 130 |
LLPS-Zem-0057 | Zea mays | 33.82 | 3e-36 | 132 |
LLPS-Viv-1607 | Vitis vinifera | 33.79 | 2e-34 | 128 |
LLPS-Coc-0675 | Corchorus capsularis | 33.7 | 2e-28 | 111 |
LLPS-Dac-0959 | Daucus carota | 33.65 | 1e-31 | 120 |
LLPS-Sol-1579 | Solanum lycopersicum | 33.65 | 2e-34 | 128 |
LLPS-Glm-2291 | Glycine max | 33.65 | 3e-34 | 128 |
LLPS-Sem-0282 | Selaginella moellendorffii | 33.65 | 7e-33 | 124 |
LLPS-Prp-1954 | Prunus persica | 33.65 | 4e-33 | 125 |
LLPS-Gor-1557 | Gossypium raimondii | 33.65 | 5e-34 | 127 |
LLPS-Nia-1338 | Nicotiana attenuata | 33.64 | 1e-34 | 129 |
LLPS-Hea-2034 | Helianthus annuus | 33.51 | 2e-34 | 128 |
LLPS-Brd-1663 | Brachypodium distachyon | 33.33 | 2e-34 | 128 |
LLPS-Orgl-2152 | Oryza glumaepatula | 33.33 | 5e-35 | 129 |
LLPS-Orni-1678 | Oryza nivara | 33.33 | 5e-35 | 129 |
LLPS-Orb-1703 | Oryza barthii | 33.33 | 5e-35 | 129 |
LLPS-Org-0299 | Oryza glaberrima | 33.33 | 5e-35 | 129 |
LLPS-Orr-0601 | Oryza rufipogon | 33.33 | 5e-35 | 129 |
LLPS-Mae-0911 | Manihot esculenta | 33.33 | 2e-34 | 128 |
LLPS-Ors-1206 | Oryza sativa | 33.33 | 5e-35 | 129 |
LLPS-Asfu-1245 | Aspergillus fumigatus | 33.16 | 3e-26 | 108 |
LLPS-Nef-0006 | Neosartorya fischeri | 33.16 | 1e-26 | 108 |
LLPS-Ori-0184 | Oryza indica | 33.01 | 2e-34 | 128 |
LLPS-Orm-1520 | Oryza meridionalis | 33.01 | 6e-35 | 129 |
LLPS-Orp-0665 | Oryza punctata | 33.01 | 6e-35 | 129 |
LLPS-Asc-1094 | Aspergillus clavatus | 33.0 | 1e-26 | 108 |
LLPS-Amt-0178 | Amborella trichopoda | 32.86 | 5e-34 | 127 |
LLPS-Thc-0935 | Theobroma cacao | 32.69 | 5e-33 | 124 |
LLPS-Asf-0489 | Aspergillus flavus | 32.67 | 1e-26 | 108 |
LLPS-Aso-1249 | Aspergillus oryzae | 32.67 | 1e-26 | 108 |
LLPS-Asni-0042 | Aspergillus niger | 32.51 | 9e-27 | 108 |
LLPS-Hov-1707 | Hordeum vulgare | 32.37 | 3e-33 | 125 |
LLPS-Tra-0330 | Triticum aestivum | 32.37 | 1e-33 | 125 |
LLPS-Tru-0883 | Triticum urartu | 32.37 | 1e-33 | 125 |
LLPS-Ast-0148 | Aspergillus terreus | 32.29 | 7e-26 | 106 |
LLPS-Ved-1319 | Verticillium dahliae | 31.9 | 1e-24 | 102 |
LLPS-Chr-0946 | Chlamydomonas reinhardtii | 31.6 | 3e-30 | 117 |
LLPS-Abg-1548 | Absidia glauca | 31.58 | 7e-33 | 124 |
LLPS-Asn-1479 | Aspergillus nidulans | 31.55 | 9e-27 | 108 |
LLPS-Pug-0844 | Puccinia graminis | 31.12 | 2e-15 | 76.6 |
LLPS-Mao-0597 | Magnaporthe oryzae | 31.03 | 1e-20 | 91.3 |
LLPS-Cog-1110 | Colletotrichum gloeosporioides | 30.99 | 8e-26 | 105 |
LLPS-Tum-1017 | Tuber melanosporum | 30.7 | 4e-26 | 106 |
LLPS-Trr-1280 | Trichoderma reesei | 30.66 | 1e-26 | 107 |
LLPS-Beb-1491 | Beauveria bassiana | 30.66 | 2e-23 | 99.0 |
LLPS-Cym-0172 | Cyanidioschyzon merolae | 30.63 | 4e-14 | 72.8 |
LLPS-Trv-1264 | Trichoderma virens | 30.23 | 5e-26 | 106 |
LLPS-Lem-0605 | Leptosphaeria maculans | 30.22 | 1e-25 | 105 |
LLPS-Put-0651 | Puccinia triticina | 30.16 | 9e-14 | 71.6 |
LLPS-Pyt-0006 | Pyrenophora teres | 29.73 | 1e-24 | 102 |
LLPS-Pytr-1433 | Pyrenophora triticirepentis | 29.73 | 4e-24 | 101 |
LLPS-Mel-1063 | Melampsora laricipopulina | 29.7 | 1e-14 | 74.3 |
LLPS-Phn-0448 | Phaeosphaeria nodorum | 29.33 | 1e-23 | 100 |
LLPS-Cogr-0946 | Colletotrichum graminicola | 29.11 | 9e-25 | 102 |
LLPS-Vir-0487 | Vigna radiata | 29.01 | 9e-11 | 62.0 |
LLPS-Fus-0655 | Fusarium solani | 28.84 | 4e-21 | 92.8 |
LLPS-Spr-0862 | Sporisorium reilianum | 28.74 | 4e-22 | 96.3 |
LLPS-Fuv-0994 | Fusarium verticillioides | 28.7 | 1e-22 | 97.1 |
LLPS-Fuo-0759 | Fusarium oxysporum | 28.7 | 5e-23 | 98.2 |
LLPS-Coo-1340 | Colletotrichum orbiculare | 28.64 | 5e-24 | 100 |
LLPS-Crn-1034 | Cryptococcus neoformans | 28.45 | 8e-22 | 94.7 |
LLPS-Dos-0031 | Dothistroma septosporum | 28.32 | 5e-22 | 95.5 |
LLPS-Gag-1104 | Gaeumannomyces graminis | 28.24 | 3e-22 | 95.9 |
LLPS-Usm-1178 | Ustilago maydis | 28.19 | 8e-24 | 100 |
LLPS-Nec-0123 | Neurospora crassa | 28.18 | 3e-22 | 96.3 |
LLPS-Blg-1380 | Blumeria graminis | 28.12 | 4e-21 | 92.8 |
LLPS-Scs-0018 | Sclerotinia sclerotiorum | 27.68 | 6e-23 | 98.2 |
LLPS-Yal-1253 | Yarrowia lipolytica | 27.48 | 3e-17 | 82.0 |
LLPS-Map-0948 | Magnaporthe poae | 27.31 | 2e-21 | 93.2 |
LLPS-Miv-0896 | Microbotryum violaceum | 26.56 | 1e-12 | 68.6 |