• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Cas-0930
EIF3K

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit K
Gene Name: EIF3K, EIF3S12
Ensembl Gene: ENSTSYG00000007001.2
Ensembl Protein: ENSTSYP00000020093.1
Organism: Carlito syrichta
Taxa ID: 1868482
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION


Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MAMFEQMRAN  VGKLLKGIDR  YNPENLATLE  RYVETQAKEN  AYDLEANLAV  LKLYQFNPAF  60
61    FQTTVTAQIL  LKALTNLPHT  DFTLCKCMID  QAHQEERPIR  QILYLGDLLE  TCHFQAFWQA  120
121   LDENMDLLEG  ITGFEDSVRK  FICHVVGITY  QHIDRWLLAE  MLGDLTDSQL  KVWMSKYGWS  180
181   ADESGQIFVC  SQEESIKPKN  IVEKIDFDSV  SSIMASSQ  218
Nucleotide CDS Sequence (FASTA)
1     ATGGCTATGT  TTGAGCAGAT  GAGAGCGAAC  GTGGGCAAGT  TACTCAAGGG  TATCGACAGG  60
61    TACAATCCTG  AAAACCTGGC  CACCTTGGAG  CGCTACGTGG  AAACACAGGC  CAAGGAGAAT  120
121   GCCTATGATC  TGGAAGCCAA  CCTGGCTGTT  TTGAAGCTGT  ACCAGTTCAA  CCCAGCCTTC  180
181   TTTCAGACCA  CGGTCACTGC  CCAGATCCTG  CTGAAGGCCC  TCACCAACCT  GCCCCACACT  240
241   GACTTTACCC  TGTGCAAGTG  CATGATTGAC  CAGGCACATC  AAGAAGAGCG  GCCGATCCGA  300
301   CAGATTTTGT  ACCTTGGGGA  TCTGTTGGAG  ACCTGCCACT  TCCAGGCCTT  CTGGGTGTGT  360
361   CCAGCATCAT  GGCCTCCTCC  CAGTAACTAG  390

▼ KEYWORD


ID
Family
Complete proteome
Cytoplasm
Initiation factor
Nucleus
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Cellular Component
Nucleus
Molecular Function
Ribosome binding
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex
Biological Process
Regulation of translational initiation

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-0265Ovis aries99.542e-163 457
LLPS-Myl-0524Myotis lucifugus99.542e-163 457
LLPS-Mup-0703Mustela putorius furo99.542e-163 457
LLPS-Bot-1481Bos taurus99.542e-163 457
LLPS-Caf-2846Canis familiaris99.542e-163 457
LLPS-Fec-0627Felis catus99.542e-163 457
LLPS-Eqc-2803Equus caballus99.529e-156 439
LLPS-Poa-0084Pongo abelii99.47e-122 350
LLPS-Urm-1145Ursus maritimus99.247e-93 275
LLPS-Paa-1503Papio anubis99.088e-163 456
LLPS-Aim-1761Ailuropoda melanoleuca99.081e-162 455
LLPS-Gog-3024Gorilla gorilla99.088e-163 456
LLPS-Fud-1864Fukomys damarensis99.085e-162 454
LLPS-Maf-1713Macaca fascicularis99.088e-163 456
LLPS-Chs-1009Chlorocebus sabaeus99.088e-163 456
LLPS-Cea-3679Cercocebus atys99.088e-163 456
LLPS-Ict-1974Ictidomys tridecemlineatus99.081e-162 455
LLPS-Nol-0529Nomascus leucogenys99.088e-163 456
LLPS-Orc-1227Oryctolagus cuniculus99.081e-162 456
LLPS-Rhb-0897Rhinopithecus bieti99.088e-163 456
LLPS-Pap-2413Pan paniscus99.088e-163 456
LLPS-Pat-1534Pan troglodytes99.088e-163 456
LLPS-Hos-0166Homo sapiens99.088e-163 456
LLPS-Man-0292Macaca nemestrina99.088e-163 456
LLPS-Tut-1248Tursiops truncatus98.992e-146 414
LLPS-Ere-0530Erinaceus europaeus98.625e-162 454
LLPS-Caj-0821Callithrix jacchus98.623e-162 454
LLPS-Mum-1156Mus musculus98.622e-162 455
LLPS-Cap-1620Cavia porcellus98.623e-162 454
LLPS-Otg-0600Otolemur garnettii98.623e-162 454
LLPS-Fia-1725Ficedula albicollis96.772e-60 191
LLPS-Loa-0005Loxodonta africana96.354e-157 441
LLPS-Aon-3069Aotus nancymaae96.334e-155 437
LLPS-Sus-3078Sus scrofa96.319e-156 439
LLPS-Mam-0272Macaca mulatta96.318e-156 438
LLPS-Ran-3681Rattus norvegicus93.842e-147 416
LLPS-Ora-2524Ornithorhynchus anatinus93.51e-82 249
LLPS-Pes-1607Pelodiscus sinensis92.735e-114 331
LLPS-Anc-3093Anolis carolinensis91.745e-150 425
LLPS-Gaga-1369Gallus gallus91.712e-152 429
LLPS-Lac-1792Latimeria chalumnae89.913e-148 419
LLPS-Mod-1388Monodelphis domestica88.785e-58 185
LLPS-Scf-1974Scleropages formosus86.515e-141 400
LLPS-Pof-0902Poecilia formosa84.867e-139 395
LLPS-Dar-0714Danio rerio84.651e-138 394
LLPS-Orn-2532Oreochromis niloticus84.262e-136 389
LLPS-Xim-1913Xiphophorus maculatus83.941e-137 392
LLPS-Scm-0760Scophthalmus maximus83.721e-133 384
LLPS-Xet-1409Xenopus tropicalis83.646e-131 374
LLPS-Tar-0393Takifugu rubripes83.039e-137 390
LLPS-Ten-1518Tetraodon nigroviridis83.032e-136 389
LLPS-Icp-0689Ictalurus punctatus83.011e-129 372
LLPS-Orl-2579Oryzias latipes81.682e-121 352
LLPS-Asm-1383Astyanax mexicanus75.592e-66 212
LLPS-Mea-1645Mesocricetus auratus73.526e-106 311
LLPS-Gaa-0865Gasterosteus aculeatus73.063e-114 333
LLPS-Mal-2698Mandrillus leucophaeus63.36e-85 256
LLPS-Leo-1687Lepisosteus oculatus61.016e-83 252
LLPS-Cii-0090Ciona intestinalis51.217e-75 232
LLPS-Cis-0706Ciona savignyi50.973e-73 228
LLPS-Drm-1539Drosophila melanogaster49.275e-68 215
LLPS-Chc-0137Chondrus crispus37.449e-34 126
LLPS-Gas-0310Galdieria sulphuraria37.21e-36 134
LLPS-Brn-0424Brassica napus36.896e-36 132
LLPS-Brr-1836Brassica rapa36.411e-32 129
LLPS-Php-1063Physcomitrella patens35.752e-38 139
LLPS-Cae-1879Caenorhabditis elegans35.623e-50 170
LLPS-Arl-2797Arabidopsis lyrata35.128e-37 134
LLPS-Phv-1644Phaseolus vulgaris35.14e-36 132
LLPS-Zyt-1465Zymoseptoria tritici34.422e-2192.4
LLPS-Sei-1562Setaria italica34.33e-36 133
LLPS-Sob-1774Sorghum bicolor34.33e-36 133
LLPS-Bro-1988Brassica oleracea34.152e-34 129
LLPS-Art-2460Arabidopsis thaliana34.153e-34 127
LLPS-Met-2293Medicago truncatula34.137e-34 127
LLPS-Via-0570Vigna angularis34.134e-35 130
LLPS-Sot-1504Solanum tuberosum34.132e-35 131
LLPS-Pot-0249Populus trichocarpa34.133e-34 128
LLPS-Cus-0882Cucumis sativus34.15e-35 130
LLPS-Mua-1744Musa acuminata33.948e-36 132
LLPS-Lep-0725Leersia perrieri33.825e-35 130
LLPS-Zem-0057Zea mays33.823e-36 132
LLPS-Viv-1607Vitis vinifera33.792e-34 128
LLPS-Coc-0675Corchorus capsularis33.72e-28 111
LLPS-Dac-0959Daucus carota33.651e-31 120
LLPS-Sol-1579Solanum lycopersicum33.652e-34 128
LLPS-Glm-2291Glycine max33.653e-34 128
LLPS-Sem-0282Selaginella moellendorffii33.657e-33 124
LLPS-Prp-1954Prunus persica33.654e-33 125
LLPS-Gor-1557Gossypium raimondii33.655e-34 127
LLPS-Nia-1338Nicotiana attenuata33.641e-34 129
LLPS-Hea-2034Helianthus annuus33.512e-34 128
LLPS-Brd-1663Brachypodium distachyon33.332e-34 128
LLPS-Orgl-2152Oryza glumaepatula33.335e-35 129
LLPS-Orni-1678Oryza nivara33.335e-35 129
LLPS-Orb-1703Oryza barthii33.335e-35 129
LLPS-Org-0299Oryza glaberrima33.335e-35 129
LLPS-Orr-0601Oryza rufipogon33.335e-35 129
LLPS-Mae-0911Manihot esculenta33.332e-34 128
LLPS-Ors-1206Oryza sativa33.335e-35 129
LLPS-Asfu-1245Aspergillus fumigatus33.163e-26 108
LLPS-Nef-0006Neosartorya fischeri33.161e-26 108
LLPS-Ori-0184Oryza indica33.012e-34 128
LLPS-Orm-1520Oryza meridionalis33.016e-35 129
LLPS-Orp-0665Oryza punctata33.016e-35 129
LLPS-Asc-1094Aspergillus clavatus33.01e-26 108
LLPS-Amt-0178Amborella trichopoda32.865e-34 127
LLPS-Thc-0935Theobroma cacao32.695e-33 124
LLPS-Asf-0489Aspergillus flavus32.671e-26 108
LLPS-Aso-1249Aspergillus oryzae32.671e-26 108
LLPS-Asni-0042Aspergillus niger32.519e-27 108
LLPS-Hov-1707Hordeum vulgare32.373e-33 125
LLPS-Tra-0330Triticum aestivum32.371e-33 125
LLPS-Tru-0883Triticum urartu32.371e-33 125
LLPS-Ast-0148Aspergillus terreus32.297e-26 106
LLPS-Ved-1319Verticillium dahliae31.91e-24 102
LLPS-Chr-0946Chlamydomonas reinhardtii31.63e-30 117
LLPS-Abg-1548Absidia glauca31.587e-33 124
LLPS-Asn-1479Aspergillus nidulans31.559e-27 108
LLPS-Pug-0844Puccinia graminis31.122e-1576.6
LLPS-Mao-0597Magnaporthe oryzae31.031e-2091.3
LLPS-Cog-1110Colletotrichum gloeosporioides30.998e-26 105
LLPS-Tum-1017Tuber melanosporum30.74e-26 106
LLPS-Trr-1280Trichoderma reesei30.661e-26 107
LLPS-Beb-1491Beauveria bassiana30.662e-2399.0
LLPS-Cym-0172Cyanidioschyzon merolae30.634e-1472.8
LLPS-Trv-1264Trichoderma virens30.235e-26 106
LLPS-Lem-0605Leptosphaeria maculans30.221e-25 105
LLPS-Put-0651Puccinia triticina30.169e-1471.6
LLPS-Pyt-0006Pyrenophora teres29.731e-24 102
LLPS-Pytr-1433Pyrenophora triticirepentis29.734e-24 101
LLPS-Mel-1063Melampsora laricipopulina29.71e-1474.3
LLPS-Phn-0448Phaeosphaeria nodorum29.331e-23 100
LLPS-Cogr-0946Colletotrichum graminicola29.119e-25 102
LLPS-Vir-0487Vigna radiata29.019e-1162.0
LLPS-Fus-0655Fusarium solani28.844e-2192.8
LLPS-Spr-0862Sporisorium reilianum28.744e-2296.3
LLPS-Fuv-0994Fusarium verticillioides28.71e-2297.1
LLPS-Fuo-0759Fusarium oxysporum28.75e-2398.2
LLPS-Coo-1340Colletotrichum orbiculare28.645e-24 100
LLPS-Crn-1034Cryptococcus neoformans28.458e-2294.7
LLPS-Dos-0031Dothistroma septosporum28.325e-2295.5
LLPS-Gag-1104Gaeumannomyces graminis28.243e-2295.9
LLPS-Usm-1178Ustilago maydis28.198e-24 100
LLPS-Nec-0123Neurospora crassa28.183e-2296.3
LLPS-Blg-1380Blumeria graminis28.124e-2192.8
LLPS-Scs-0018Sclerotinia sclerotiorum27.686e-2398.2
LLPS-Yal-1253Yarrowia lipolytica27.483e-1782.0
LLPS-Map-0948Magnaporthe poae27.312e-2193.2
LLPS-Miv-0896Microbotryum violaceum26.561e-1268.6