• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Cap-4036
ORC1

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Origin recognition complex subunit 1
Gene Name: ORC1
Ensembl Gene: ENSCPOG00000005075.4
Ensembl Protein: ENSCPOP00000004564.3
Organism: Cavia porcellus
Taxa ID: 10141
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Chromatin, Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION


Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MISHNTRQKT  RKTYSWVGRR  LLDRKLGYQT  YTEVSVKREG  CSIQTHIQVG  QFVLIEGKDE  60
61    NPYVAKLIEL  FEDGEKRARV  QWFIRFCEVA  PCKRHLLGRK  PDPQEIFWYD  YPACDDNISI  120
121   ETIIGPVKVV  ALAPDEVIPV  GLKNEETFFV  KLSWNEKKFK  PLSPELFAVF  DRRQEDRSKY  180
181   QKPSTKNAES  PSCHTADSVV  KRTESRHSAS  KSCHIPSAGK  KLELDSKCFP  RIPASKIAQK  240
241   TSCASLDSPR  KTKRKMTFSE  TTSASKRPQL  EAVKTSFPAL  KTPEKTGNDS  PECHMTLRTP  300
301   GSAVKTMRIS  EEMKLTPIRE  GRRTSGVPYV  GLKPEYISKR  EAKEPEAQNE  AIGTPHHARR  360
361   KSSLLTLNRI  RQQLRYLENN  KSDQEDKEFL  PASEDSNSSS  EDEGASALPL  LRRRPCHTSR  420
421   HLQPVSEPSV  QSPSRTPKKR  RTPRCVTAKI  RSRSLAAQEP  ASMLEEARLR  LHVSAVPDSL  480
481   PCREKEFQDI  YNFVESKLLD  QTGGCMYISG  VPGTGKTATV  HEVIRCLQQA  AQANDVPPFQ  540
541   YIEVNGMKLT  EPYQVYVQIL  QKLTGQKATA  SHAAALLAKQ  FCTRGSPQET  TVLLVDELDL  600
601   LWTHKQDVMY  NLFDWPTHKE  ARLVVLTIAN  TMDLPERIMM  NRVSSRLGLT  RMSFQPYTHS  660
661   QLQQILVSRL  KHLKAFEDDA  IQLVARKVAA  LSGDARRCLD  ICRRATEICE  FSHQKQDSPG  720
721   LVTVAHLMEA  VDEMFSSSYI  TAIKNSSVLE  QGFLRAILAE  FRRSGLEEAT  FQQIYSQHVA  780
781   LCQMEGLPYP  TMSETMAVCS  RLGSCRLLLM  EPSRNDLLLR  VRLNVSRDDV  LYALKEE  837
Nucleotide CDS Sequence (FASTA)
1     ATGATATCCC  ATAATACAAG  GCAGAAGACC  AGGAAGACTT  ACTCATGGGT  TGGCAGGCGT  60
61    TTGCTGGATC  GAAAATTGGG  CTACCAAACC  TATACAGAAG  TGTCTGTGAA  AAGAGAAGGT  120
121   TGTTCAATTC  AGACTCACAT  CCAAGTTGGC  CAGTTTGTGT  TGATTGAAGG  GAAAGATGAA  180
181   AACCCCTATG  TTGCAAAATT  GATCGAATTA  TTTGAAGATG  GTGAGAAACG  TGCACGAGTA  240
241   CAGTGGTTTA  TCCGATTTTG  TGAAGTTGCT  CCCTGCAAAC  GGCATTTATT  AGGCCGAAAG  300
301   CCTGACCCAC  AGGAGATTTT  CTGGTATGAC  TACCCCGCCT  GTGATGACAA  CATTAGTATT  360
361   GAGACCATCA  TTGGCCCTGT  TAAGGTAGTG  GCTTTAGCAC  CAGATGAAGT  GATCCCAGTG  420
421   GGTCTGAAAA  ATGAAGAAAC  ATTCTTTGTG  AAACTGTCCT  GGAATGAAAA  GAAGTTCAAA  480
481   CCACTTTCCC  CAGAACTATT  TGCAGTGTTT  GATAGACGAC  AAGAAGACAG  GTCCAAGTAC  540
541   CAGAAGCCCA  GTACTAAGAA  TGCAGAAAGC  CCTTCTTGTC  ATACAGCAGA  CAGTGTGGTC  600
601   AAAAGGACTG  AATCAAGACA  TTCTGCCTCC  AAATCTTGCC  ACATCCCCTC  TGCAGGAAAA  660
661   AAGCTGGAGC  TTGACAGTAA  GTGTTTCCCT  AGGATACCTG  CTTCTAAGAT  AGCCCAGAAG  720
721   ACTTCATGTG  CTTCCTTGGA  TTCTCCAAGA  AAAACTAAGC  GGAAAATGAC  CTTCTCAGAG  780
781   ACTACCTCAG  CTTCAAAGAG  ACCTCAGCTA  GAGGCAGTCA  AGACCTCATT  TCCAGCTCTG  840
841   AAAACCCCAG  AGAAAACTGG  AAATGACTCA  CCTGAATGCC  ACATGACCCT  GCGAACCCCA  900
901   GGCTCAGCTG  TGAAAACCAT  GAGGATTAGT  GAGGAGATGA  AACTTACCCC  TATCAGGGAA  960
961   GGCCGAAGAA  CTTCAGGGGT  GCCTTATGTG  GGTCTGAAAC  CAGAATACAT  CAGTAAAAGG  1020
1021  GAGGCAAAAG  AGCCAGAAGC  TCAGAATGAA  GCTATTGGTA  CTCCCCATCA  TGCCCGGAGA  1080
1081  AAGAGTTCTC  TCTTGACATT  GAATCGGATT  AGGCAGCAGC  TTCGGTATCT  AGAAAATAAT  1140
1141  AAAAGTGACC  AAGAGGACAA  AGAATTCCTG  CCAGCATCAG  AGGATTCCAA  CTCCAGCAGT  1200
1201  GAGGACGAAG  GGGCTTCTGC  TCTGCCCCTT  CTGAGAAGAC  GCCCCTGCCA  CACATCCAGG  1260
1261  CACTTGCAGC  CTGTCTCAGA  GCCATCTGTC  CAGTCCCCCT  CCAGAACACC  AAAGAAACGT  1320
1321  AGAACACCAC  GTTGTGTCAC  TGCCAAGATC  CGTAGCCGAA  GCCTGGCTGC  ACAGGAACCA  1380
1381  GCCAGCATGC  TGGAGGAGGC  CCGGCTGAGG  CTGCATGTTT  CTGCTGTGCC  TGATTCTCTT  1440
1441  CCTTGTCGAG  AGAAGGAATT  CCAAGACATC  TACAACTTTG  TGGAAAGCAA  ACTCCTTGAC  1500
1501  CAAACTGGGG  GGTGCATGTA  CATCTCTGGG  GTCCCTGGGA  CAGGAAAAAC  TGCCACTGTG  1560
1561  CATGAGGTGA  TTCGCTGTCT  GCAGCAGGCA  GCCCAAGCTA  ACGATGTTCC  GCCCTTCCAG  1620
1621  TATATTGAGG  TTAATGGCAT  GAAGTTGACG  GAGCCCTACC  AGGTCTACGT  GCAGATCTTG  1680
1681  CAGAAGCTGA  CAGGCCAGAA  GGCAACAGCT  AGCCATGCTG  CAGCACTGCT  GGCAAAGCAA  1740
1741  TTCTGCACCC  GAGGGTCTCC  ACAGGAAACC  ACTGTCCTGC  TTGTGGATGA  GCTTGACCTC  1800
1801  CTGTGGACTC  ACAAGCAAGA  TGTCATGTAT  AATCTCTTCG  ACTGGCCAAC  TCACAAAGAG  1860
1861  GCCCGTCTGG  TGGTACTAAC  CATTGCCAAC  ACCATGGATC  TGCCAGAAAG  AATAATGATG  1920
1921  AACCGGGTAT  CGAGCCGATT  GGGCCTCACC  AGGATGTCCT  TCCAGCCCTA  TACTCACAGC  1980
1981  CAACTGCAGC  AGATCCTTGT  GTCTCGGCTT  AAGCATTTGA  AGGCCTTCGA  GGATGATGCC  2040
2041  ATCCAGCTGG  TAGCCAGGAA  GGTGGCAGCC  CTGTCTGGGG  ATGCACGGCG  CTGCCTGGAT  2100
2101  ATTTGCCGGC  GAGCCACAGA  GATCTGTGAG  TTCTCCCATC  AGAAACAGGA  CTCGCCTGGC  2160
2161  CTGGTCACTG  TGGCCCATTT  AATGGAAGCT  GTGGATGAGA  TGTTCTCCTC  ATCGTACATC  2220
2221  ACTGCCATCA  AGAATTCCTC  CGTCTTGGAA  CAGGGCTTCC  TGAGAGCCAT  CCTTGCAGAG  2280
2281  TTCCGTCGAT  CTGGACTAGA  GGAAGCAACA  TTTCAGCAGA  TATACAGTCA  GCATGTGGCC  2340
2341  CTGTGCCAGA  TGGAGGGGCT  GCCTTATCCC  ACCATGTCAG  AGACCATGGC  CGTGTGCTCG  2400
2401  CGCCTGGGCT  CCTGCCGCCT  GCTCCTCATG  GAGCCCAGCA  GAAACGACCT  GCTCCTCCGG  2460
2461  GTGCGGCTCA  ACGTCAGCCG  GGATGACGTG  TTGTATGCGC  TGAAGGAAGA  GTGA  2514

▼ KEYWORD


ID
Family
ATP-binding
Coiled coil
Complete proteome
DNA replication
DNA-binding
Nucleotide-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
Nuclear origin of replication recognition complex
Cellular Component
Nucleolus
Cellular Component
Plasma membrane
Molecular Function
ATP binding
Molecular Function
Chromatin binding
Molecular Function
DNA binding
Biological Process
DNA replication

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-1680Rattus norvegicus90.540.0 652
LLPS-Mum-0772Mus musculus88.750.0 638
LLPS-Fud-2717Fukomys damarensis77.650.01158
LLPS-Poa-1064Pongo abelii75.320.01134
LLPS-Hos-0565Homo sapiens74.940.01139
LLPS-Gog-1089Gorilla gorilla74.940.01137
LLPS-Eqc-1500Equus caballus74.930.0 920
LLPS-Asm-0059Astyanax mexicanus74.741e-172 526
LLPS-Pap-1500Pan paniscus74.710.01127
LLPS-Pat-1130Pan troglodytes74.710.01126
LLPS-Fia-0414Ficedula albicollis74.428e-180 547
LLPS-Ict-2764Ictidomys tridecemlineatus74.250.01103
LLPS-Icp-2540Ictalurus punctatus74.231e-168 523
LLPS-Tag-3270Taeniopygia guttata74.176e-179 545
LLPS-Man-1080Macaca nemestrina74.10.01120
LLPS-Aon-4054Aotus nancymaae73.990.01115
LLPS-Cea-0997Cercocebus atys73.990.01116
LLPS-Cas-0581Carlito syrichta73.930.01110
LLPS-Rhb-0294Rhinopithecus bieti73.870.01117
LLPS-Maf-2365Macaca fascicularis73.870.01112
LLPS-Paa-3353Papio anubis73.760.01110
LLPS-Chs-0635Chlorocebus sabaeus73.670.01111
LLPS-Urm-2248Ursus maritimus73.640.01118
LLPS-Loa-1124Loxodonta africana73.570.01099
LLPS-Mal-0682Mandrillus leucophaeus73.560.01105
LLPS-Aim-3442Ailuropoda melanoleuca73.410.01112
LLPS-Caj-4173Callithrix jacchus73.330.01098
LLPS-Scf-1941Scleropages formosus73.219e-167 514
LLPS-Bot-2681Bos taurus73.210.01117
LLPS-Ten-0992Tetraodon nigroviridis73.032e-161 498
LLPS-Tut-2011Tursiops truncatus73.010.01068
LLPS-Fec-1916Felis catus72.830.01078
LLPS-Ova-2626Ovis aries72.620.01098
LLPS-Mup-0956Mustela putorius furo72.490.01076
LLPS-Orl-0899Oryzias latipes72.453e-168 518
LLPS-Caf-0545Canis familiaris72.250.01073
LLPS-Scm-0472Scophthalmus maximus71.943e-168 520
LLPS-Orc-3043Oryctolagus cuniculus71.890.01080
LLPS-Sus-0629Sus scrofa71.20.01038
LLPS-Pof-2116Poecilia formosa71.129e-163 503
LLPS-Gaa-2182Gasterosteus aculeatus71.073e-154 482
LLPS-Nol-2616Nomascus leucogenys71.050.01043
LLPS-Orn-0983Oreochromis niloticus70.598e-166 513
LLPS-Otg-0315Otolemur garnettii70.530.0 865
LLPS-Xim-0504Xiphophorus maculatus70.35e-159 494
LLPS-Mea-1017Mesocricetus auratus69.470.01002
LLPS-Dio-1568Dipodomys ordii68.750.01001
LLPS-Tar-0629Takifugu rubripes61.042e-162 503
LLPS-Cis-1547Ciona savignyi59.155e-108 342
LLPS-Drm-0446Drosophila melanogaster55.714e-112 371
LLPS-Mod-0782Monodelphis domestica54.410.0 747
LLPS-Sah-1286Sarcophilus harrisii51.670.0 718
LLPS-Asc-0669Aspergillus clavatus51.012e-65 239
LLPS-Xet-1283Xenopus tropicalis50.710.0 691
LLPS-Mao-0251Magnaporthe oryzae50.01e-68 248
LLPS-Aso-0408Aspergillus oryzae49.818e-69 242
LLPS-Asf-0846Aspergillus flavus49.814e-66 241
LLPS-Nef-0498Neosartorya fischeri49.779e-54 203
LLPS-Gag-0304Gaeumannomyces graminis49.612e-67 245
LLPS-Abg-1068Absidia glauca48.751e-90 303
LLPS-Anc-1938Anolis carolinensis48.240.0 619
LLPS-Gaga-3814Gallus gallus48.190.0 638
LLPS-Scj-0317Schizosaccharomyces japonicus47.783e-77 271
LLPS-Leo-1806Lepisosteus oculatus47.480.0 655
LLPS-Scc-0267Schizosaccharomyces cryophilus46.672e-76 268
LLPS-Meg-1628Meleagris gallopavo46.620.0 570
LLPS-Dar-0175Danio rerio46.520.0 642
LLPS-Scp-1081Schizosaccharomyces pombe46.481e-77 272
LLPS-Ved-1425Verticillium dahliae45.792e-25 116
LLPS-Mel-0872Melampsora laricipopulina44.884e-51 184
LLPS-Fus-0840Fusarium solani44.851e-75 267
LLPS-Fuo-0193Fusarium oxysporum44.851e-75 266
LLPS-Fuv-0861Fusarium verticillioides44.852e-75 266
LLPS-Beb-0602Beauveria bassiana44.412e-75 266
LLPS-Map-1152Magnaporthe poae44.348e-44 171
LLPS-Phn-0100Phaeosphaeria nodorum43.735e-71 254
LLPS-Dos-1141Dothistroma septosporum43.431e-72 259
LLPS-Blg-0008Blumeria graminis43.22e-72 258
LLPS-Yal-1327Yarrowia lipolytica43.087e-70 250
LLPS-Sem-0863Selaginella moellendorffii43.063e-75 265
LLPS-Sot-1690Solanum tuberosum42.963e-58 217
LLPS-Nec-0736Neurospora crassa42.861e-68 248
LLPS-Zyt-0392Zymoseptoria tritici42.748e-69 248
LLPS-Cus-1294Cucumis sativus42.154e-75 267
LLPS-Pyt-0429Pyrenophora teres41.993e-73 261
LLPS-Trv-0956Trichoderma virens41.91e-74 264
LLPS-Trr-0200Trichoderma reesei41.341e-73 261
LLPS-Coc-0999Corchorus capsularis41.274e-74 265
LLPS-Amt-0870Amborella trichopoda41.267e-69 251
LLPS-Asfu-0279Aspergillus fumigatus41.266e-66 240
LLPS-Ora-0526Ornithorhynchus anatinus41.211e-112 365
LLPS-Thc-1293Theobroma cacao41.213e-75 268
LLPS-Vir-0405Vigna radiata41.161e-74 266
LLPS-Lem-1200Leptosphaeria maculans41.093e-75 267
LLPS-Sol-1826Solanum lycopersicum41.052e-74 266
LLPS-Prp-1657Prunus persica40.973e-70 254
LLPS-Brr-2677Brassica rapa40.952e-75 268
LLPS-Bro-1515Brassica oleracea40.952e-75 268
LLPS-Brn-1739Brassica napus40.952e-75 268
LLPS-Pytr-0872Pyrenophora triticirepentis40.944e-68 247
LLPS-Arl-1577Arabidopsis lyrata40.93e-74 265
LLPS-Cog-0163Colletotrichum gloeosporioides40.888e-70 251
LLPS-Via-2364Vigna angularis40.886e-74 265
LLPS-Php-1466Physcomitrella patens40.823e-72 261
LLPS-Mua-0694Musa acuminata40.762e-70 254
LLPS-Cogr-0765Colletotrichum graminicola40.754e-67 243
LLPS-Asn-0796Aspergillus nidulans40.693e-69 250
LLPS-Phv-0929Phaseolus vulgaris40.615e-74 265
LLPS-Met-1137Medicago truncatula40.444e-71 257
LLPS-Glm-1164Glycine max40.331e-73 263
LLPS-Art-2425Arabidopsis thaliana40.287e-74 263
LLPS-Viv-1042Vitis vinifera40.214e-72 260
LLPS-Ast-0320Aspergillus terreus40.211e-70 254
LLPS-Usm-1255Ustilago maydis40.119e-63 233
LLPS-Sei-1806Setaria italica39.956e-69 249
LLPS-Pot-0650Populus trichocarpa39.943e-71 257
LLPS-Orp-1340Oryza punctata39.896e-69 250
LLPS-Hea-1378Helianthus annuus39.836e-72 258
LLPS-Miv-0385Microbotryum violaceum39.775e-64 235
LLPS-Coo-0809Colletotrichum orbiculare39.655e-67 243
LLPS-Lep-1226Leersia perrieri39.553e-69 250
LLPS-Gor-1580Gossypium raimondii39.51e-74 268
LLPS-Brd-1009Brachypodium distachyon39.497e-69 249
LLPS-Pug-0467Puccinia graminis39.392e-63 226
LLPS-Orm-0756Oryza meridionalis39.228e-69 249
LLPS-Org-0329Oryza glaberrima39.227e-69 249
LLPS-Orr-0689Oryza rufipogon39.172e-67 248
LLPS-Orb-0874Oryza barthii39.178e-68 248
LLPS-Orgl-0642Oryza glumaepatula39.172e-68 248
LLPS-Zem-0907Zea mays39.032e-65 240
LLPS-Spr-1225Sporisorium reilianum39.024e-61 228
LLPS-Sob-0167Sorghum bicolor38.972e-66 242
LLPS-Crn-0812Cryptococcus neoformans38.942e-54 206
LLPS-Kop-0156Komagataella pastoris38.693e-60 222
LLPS-Tra-0285Triticum aestivum38.692e-68 249
LLPS-Hov-1284Hordeum vulgare38.693e-68 249
LLPS-Put-0683Puccinia triticina38.632e-67 237
LLPS-Dac-1220Daucus carota38.613e-73 262
LLPS-Nia-1157Nicotiana attenuata38.462e-70 254
LLPS-Mae-0404Manihot esculenta38.294e-71 256
LLPS-Osl-0747Ostreococcus lucimarinus36.621e-60 224
LLPS-Tru-0765Triticum urartu36.484e-59 218
LLPS-Orni-1588Oryza nivara36.474e-59 222
LLPS-Cym-0120Cyanidioschyzon merolae35.442e-44 176
LLPS-Cii-1520Ciona intestinalis35.432e-28 124
LLPS-Ori-0015Oryza indica35.433e-64 238
LLPS-Chr-1502Chlamydomonas reinhardtii34.665e-43 173
LLPS-Chc-0589Chondrus crispus34.146e-51 191
LLPS-Asg-0251Ashbya gossypii33.873e-48 189
LLPS-Gas-1190Galdieria sulphuraria31.833e-38 156
LLPS-Cae-2037Caenorhabditis elegans31.393e-40 162
LLPS-Myl-1809Myotis lucifugus31.227e-36 147
LLPS-Mam-2310Macaca mulatta30.686e-37 151
LLPS-Sac-1419Saccharomyces cerevisiae30.09e-47 184
LLPS-Scs-0975Sclerotinia sclerotiorum29.772e-26 119
LLPS-Pes-2476Pelodiscus sinensis29.632e-36 149
LLPS-Asni-1463Aspergillus niger29.141e-34 145
LLPS-Orbr-2208Oryza brachyantha28.452e-29 127
LLPS-Ors-1285Oryza sativa28.372e-29 127