LLPS-Caf-4413
RAPGEF1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Rap guanine nucleotide exchange factor 1 |
| Gene Name: | RAPGEF1 |
| Ensembl Gene: | ENSCAFG00000019902.4 |
| Ensembl Protein: | ENSCAFP00000041460.1 |
| Organism: | Canis familiaris |
| Taxa ID: | 9615 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nuclear speckle | Predicted from orthologs | (View) |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCAFT00000045043.2 | ENSCAFP00000041460.1 |
| Ensembl | ENSCAFT00000031664.3 | ENSCAFP00000029478.3 |
| UniProt | J9P726, J9P726_CANLF | |
| GeneBank | AAEX03006825 | |
| RefSeq | XM_005625211.2 | XP_005625268.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGNAAEKQKP RKRSRLCPWK QDSQRSHLSS FTMKLKDKFH SPKIKRTPSK KGKPAEVSVK 60 61 NPEKPVSKEA TDRFLPEGYP LPLDLEQQAV EFMSTSAVAS RSQRQKNLSW LEEKEKEVVS 120 121 ALRYFKTIVD KMAIDKKVLE MLPGSASKVL EAILPLVQSD PRIQHSSALS SCYSRVYQSL 180 181 ANLIRWSDQV MLEGVNSEDK ETVTTVKGVI KAVLDGVKEL VRLTIEKQGH PSPTSPVKPS 240 241 SPACKPDGQS ELPLTDREVE ILNKTTGMSQ SAELLPDSTD EEVAPPKPPL PGIRVVDNSP 300 301 PPALPPKKRQ SAPSPTRVAV VAPMSRATSG SSLPVGINRQ DFDVDCYTQR RLSGGSHSYG 360 361 GESPRLSPCS SIGKLSKSDE QLSSLDRDSG QCSRNTSCET LDHYDPDYEF LQQDLSNADQ 420 421 IPQQVACNLS PLPESLGESG SPFLGHPFQL PPAPGSCPQP EGPLAPGQQI DMPPALPEKK 480 481 RRSAASQTTD SSGCRMSYER HPSQYDNISE DDLQNPASVP SIPFTPFAAI LPFQQGGSSA 540 541 SVEFVGDFTV SESTTGDPEK PPPLPEKKNK HMLAYMQLLE DYSEPQPSMF YQTPQNEHIY 600 601 QQKNKLLMEV YGFNDSFSTE APQELAPPPA LPPKQRQLAS YAASSFSSVS YCVQQTKVAF 660 661 TPEDGSATQG ISVSVSNSFL SRHGNLPVPS YKSVFRSYSQ DFVPHNHASV QPFLPPTSSA 720 721 SPHFPTVHQS QSSDLTVPTV ASLPPSTVDG PLSSSQESSF HGNTVCLPSE TSFTDSPQTP 780 781 LSESTSEEAG EGEYVNLYSS GQSSRELAHC GGESPAMKDG HPRDPSSVSS TPGKESRDSD 840 841 RASRSPDGSE LARLEEEVDE LSLIDHNEIM ARLTLKQEGD DGPDVRGGSG DILLVHATET 900 901 DRKDLVLYCE AFLTTYRTFI TPEELIKKLQ YRYEKFSPFA DTFKKRVSKN TFFVLVRVVD 960 961 ELCLVELTEE ILKLLMELVF RLVCNGELSL ARVLRKNILD KVDQKKLLRC ANSDQPLAAR 1020 1021 GVAARPGTLH DFHSHEIAEQ LTLLDAELFY KIEIPEVLLW AKEQNEEKSP NLTQFTEHFN 1080 1081 NMSYWVRSII MLQEKAQDRE RLLLKFIKIM KHLRKLNNFN SYLAILSALD SAPIRRLEWQ 1140 1141 KQTSEGLAEY CTLIDSSSSF RAYRAALSEV EPPCIPYLGL ILQDLTFVHL GNPDYIDGKV 1200 1201 NFSKRWQQFN ILDSMRCFQQ AHYDIRRNDD IINFFNDFSD HLAEEALWEL SLKIKPRNIT 1260 1261 RRKTDREEKT 1270 |
| Nucleotide CDS Sequence (FASTA) |
1 TCAGATTCTC AGCGTTCTCA CCTCTCTTCC TTCACCATGA AGCTGAAGGA CAAATTCCAC 60 61 TCACCCAAAA TCAAGAGAAC GCCATCAAAG AAGGGAAAAC CAGCTGAAGT TTCTGTGAAA 120 121 AATCCGGAGA AGCCTGTGAG CAAAGAGGCA ACAGACAGAT TTCTACCAGA GGGCTACCCT 180 181 CTCCCCTTGG ATCTGGAGCA GCAGGCAGTA GAATTTATGT CCACCAGTGC TGTGGCTTCC 240 241 AGGTCTCAGA GGCAGAAGAA CCTGAGCTGG CTGGAAGAGA AGGAGAAGGA AGTTGTTAGT 300 301 GCCTTGCGCT ACTTTAAGAC TATCGTGGAC AAGATGGCTA TTGATAAGAA GGTACTGGAG 360 361 ATGCTGCCAG GGTCAGCCAG CAAGGTGCTG GAGGCCATCT TACCCCTGGT GCAGAGCGAT 420 421 CCTCGAATTC AACACAGCTC AGCCCTCTCC TCCTGCTATA GCCGAGTGTA CCAAAGTCTT 480 481 GCCAACCTCA TCCGTTGGTC TGACCAAGTG ATGCTGGAAG GTGTGAACTC AGAAGATAAA 540 541 GAGACGGTGA CAACGGTGAA GGGGGTCATC AAGGCGGTAC TGGATGGAGT GAAGGAGCTG 600 601 GTCAGACTTA CCATCGAGAA ACAGGGGCAT CCATCTCCAA CCAGCCCAGT GAAACCCAGT 660 661 TCCCCAGCCT GCAAACCGGA CGGCCAGTCT GAGCTCCCCC TGACAGATCG CGAGGTGGAG 720 721 ATTCTCAACA AGACAACTGG CATGTCCCAG TCGGCCGAGC TACTCCCAGA CTCAACAGAT 780 781 GAGGAGGTTG CGCCCCCTAA GCCCCCCTTA CCTGGCATTC GGGTGGTTGA TAACAGTCCT 840 841 CCCCCAGCAT TGCCACCGAA GAAAAGACAG TCAGCTCCAT CCCCGACCCG AGTGGCTGTT 900 901 GTTGCCCCCA TGAGTCGAGC CACCAGTGGC TCCAGTTTGC CTGTTGGAAT TAATAGGCAG 960 961 GAGGATTTTG ATGTGGACTG TTACACACAG AGGCGACTCT CAGGAGGCAG CCACTCATAC 1020 1021 GGCGGAGAGT CGCCCCGTCT GTCCCCCTGC AGCAGCATAG GCAAGCTCAG CAAGTCAGAT 1080 1081 GAGCAGCTGT CCTCTCTGGA CAGGGACAGC GGCCAGTGCT CCCGGAACAC AAGCTGTGAA 1140 1141 ACACTAGTGA ACACAGATCA TTATGATCCT GACTACGAAT TCCTTCAGCA AGACCTCTCT 1200 1201 AATGCAGACC AGATACCTCA GCAAGTGGCC TGTAACCTTA GCCCATTGCC AGAGTCTTTG 1260 1261 GGAGAGTCTG GGTCTCCATT TCTTGGCCAT CCTTTCCAGT TGCCTCCAGC GCCTGGCAGC 1320 1321 TGTCCCCAGC CAGAGGGGCC CTTGGCCCCA GGACAGCAGA TAGACATGCC ACCTGCTCTC 1380 1381 CCTGAGAAGA AGCGCAGGAG TGCGGCCTCC CAGACCACGG ACAGCTCTGG CTGCAGGATG 1440 1441 TCCTACGAGC GGCACCCCTC ACAATATGAC AATATCTCGG AAGATGACCT GCAGAACCCA 1500 1501 GCCTCGGTCC CGTCCATCCC CTTCACGCCC TTTGCTGCTA TTCTCCCCTT TCAGCAAGGA 1560 1561 GGGTCCTCAG CCTCTGTCGA ATTTGTGGGT GATTTCACTG TTTCTGAATC AACAACGGGT 1620 1621 GACCCAGAAA AACCACCTCC TCTACCAGAG AAGAAAAACA AACACATGCT GGCCTACATG 1680 1681 CAGCTGCTGG AGGACTACTC GGAGCCACAG CCGTCCATGT TCTACCAGAC GCCACAGAAC 1740 1741 GAGCACATCT ACCAGCAGAA GAACAAGCTC CTCATGGAGG TGTACGGCTT CAACGACTCA 1800 1801 TTCAGCACCG AAGCCCCGCA GGAGCTGGCA CCGCCCCCCG CCCTGCCTCC CAAGCAGCGG 1860 1861 CAGCTGCAGG CCTCCTATGC TGCTTCTTCC TTCTCCTCTG TCTCCTACTG TGTCCAGCAA 1920 1921 ACTAAAGTGG CCTTCACCCC CGAGGACGGC AGTGCCACTC AGGGCATCAG TGTGTCCGTC 1980 1981 TCTAACTCCT TTCTCAGCCG GCATGGCAAC TTGCCTGTGC CCTCGTATAA ATCTGTGTTT 2040 2041 AGGTCCTACT CCCAGGATTT CGTGCCTCAC AACCACGCTT CCGTTCAGCC TTTCCTTCCG 2100 2101 CCTACCTCCT CTGCCTCTCC ACACTTCCCA ACTGTCCACC AGTCTCAGAG CTCTGACTTA 2160 2161 ACGGTGCCAA CCGTAGCCAG TCTGCCTCCC AGCACCGTGG ACGGGCCTCT CTCGTCTTCT 2220 2221 CAGGAGAGCA GCTTTCACGG GAACACTGTC TGCCTTCCTT CCGAAACCTC TTTCACTGAC 2280 2281 TCGCCCCAGA CGCCTTTGGA GTCACCAGCT ATGAAAGATG GACATCCCAG AGACCCCTCA 2340 2341 TCGGTCAGCA GCACACCTGG GAAGGAGAGC AGAGACAGCG ACAGGGCCTC AAGGTCACCA 2400 2401 GATGGTTCAG AGTTGGCTCG GTTGGAGGAG GAAGTGGATG AGCTGTCCCT CATTGACCAC 2460 2461 AATGAAATTA TGGCAAGGCT GACACTCAAG CAGGAGGGTG ATGATGGGCC AGACGTCCGT 2520 2521 GGAGGGTCTG GAGATATCCT ACTGGTGCAC GCTACTGAGA CAGACAGGAA AGATTTGGTG 2580 2581 TTGTACTGTG AGGCCTTCTT GACCACCTAC AGGACATTCA TCACCCCAGA GGAGCTCATC 2640 2641 AAGAAGCTGC AGTACAGGTA CGAGAAGTTC TCTCCCTTCG CTGACACCTT CAAGAAGCGC 2700 2701 GTCAGCAAGA ACACTTTCTT CGTGCTGGTG CGAGTGGTGG ATGAGCTCTG CCTAGTGGAG 2760 2761 TTGACAGAAG AGATCTTGAA GCTGCTCATG GAACTGGTCT TTCGCTTGGT GTGCAACGGG 2820 2821 GAGCTCAGCC TGGCCCGCGT GCTCCGGAAG AACATCCTGG ACAAGGTGGA CCAGAAGAAG 2880 2881 CTGCTCAGGT GTGCCAACTC CGACCAGCCC CTGGCAGCCA GGGGGGTAGC TGCCAGGCCA 2940 2941 GGGACTTTGC ATGACTTTCA CAGCCATGAA ATAGCCGAGC AGCTGACACT GCTGGATGCT 3000 3001 GAGCTCTTTT ATAAAATAGA GATTCCTGAG GTTTTGCTTT GGGCAAAAGA ACAGAATGAG 3060 3061 GAGAAAAGCC CCAACTTGAC CCAGTTCACG GAGCACTTCA ACAACATGTC GTACTGGGTC 3120 3121 CGGTCAATAA TCATGTTACA AGAAAAAGCC CAGGACAGGG AGCGACTGCT AAGTCTGCTC 3180 3181 CTTCAGGCCC TGCTCAGACA CTTACGGAAG CTGAACAACT TTAACTCCTA CCTGGCCATC 3240 3241 CTCTCGGCAC TGGACTCAGC TCCCATCCGC AGGCTAGAGT GGCAGAAGCA GACCTCGGAG 3300 3301 GGCCTGGCCG AGTACTGTAC ACTGATCGAC AGCTCGTCCT CCTTCCGCGC CTACCGGGCC 3360 3361 GCCCTGTCCG AGGTGGAGCC GCCCTGCATC CCATACCTGG GGCTTATCCT GCAGGACCTC 3420 3421 ACCTTTGTTC ACCTGGGAAA CCCAGACTAT ATTGACGGGA AGGTGAATTT TTCCAAACGG 3480 3481 TGGCAGCAGT TCAACATTCT GGACAGCATG CGGTGCTTCC AACAAGCGCA CTATGATATC 3540 3541 CGAAGAAACG ATGACATCAT AAACTTCTTC AATGACTTCA GTGACCACCT GGCGGAGGAG 3600 3601 GCTCTGTGGG AACTCTCTCT GAAAATCAAA CCTAGGAACA TAACAAGGAG AAAAACAGAC 3660 3661 CGAGAGGAGA AGACCTAG 3678 |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Rhb-1464 | Rhinopithecus bieti | 95.21 | 0.0 | 853 |
| LLPS-Pap-4087 | Pan paniscus | 94.77 | 0.0 | 850 |
| LLPS-Paa-4860 | Papio anubis | 94.77 | 0.0 | 852 |
| LLPS-Hos-0702 | Homo sapiens | 94.55 | 0.0 | 851 |
| LLPS-Fec-0781 | Felis catus | 94.49 | 0.0 | 2228 |
| LLPS-Mup-2602 | Mustela putorius furo | 94.41 | 0.0 | 2239 |
| LLPS-Sus-3878 | Sus scrofa | 93.15 | 0.0 | 836 |
| LLPS-Eqc-3479 | Equus caballus | 93.14 | 0.0 | 2187 |
| LLPS-Gog-2320 | Gorilla gorilla | 93.13 | 0.0 | 1060 |
| LLPS-Pat-0984 | Pan troglodytes | 92.72 | 0.0 | 1093 |
| LLPS-Maf-1468 | Macaca fascicularis | 92.72 | 0.0 | 1098 |
| LLPS-Mal-1856 | Mandrillus leucophaeus | 92.72 | 0.0 | 1098 |
| LLPS-Nol-3040 | Nomascus leucogenys | 92.56 | 0.0 | 1093 |
| LLPS-Chs-0533 | Chlorocebus sabaeus | 91.98 | 0.0 | 2170 |
| LLPS-Bot-4501 | Bos taurus | 91.98 | 0.0 | 2206 |
| LLPS-Ict-2025 | Ictidomys tridecemlineatus | 91.35 | 0.0 | 2130 |
| LLPS-Cea-3514 | Cercocebus atys | 90.91 | 0.0 | 2141 |
| LLPS-Man-4474 | Macaca nemestrina | 90.73 | 0.0 | 2168 |
| LLPS-Myl-1039 | Myotis lucifugus | 90.09 | 0.0 | 2086 |
| LLPS-Ten-0135 | Tetraodon nigroviridis | 89.9 | 0.0 | 753 |
| LLPS-Cap-2551 | Cavia porcellus | 89.47 | 0.0 | 2101 |
| LLPS-Urm-3792 | Ursus maritimus | 89.41 | 0.0 | 2074 |
| LLPS-Loa-2440 | Loxodonta africana | 89.23 | 0.0 | 2081 |
| LLPS-Scm-3592 | Scophthalmus maximus | 89.18 | 0.0 | 741 |
| LLPS-Aim-2076 | Ailuropoda melanoleuca | 89.12 | 0.0 | 2075 |
| LLPS-Mam-2180 | Macaca mulatta | 88.85 | 0.0 | 2129 |
| LLPS-Aon-4119 | Aotus nancymaae | 88.51 | 0.0 | 1867 |
| LLPS-Mum-4136 | Mus musculus | 88.03 | 0.0 | 2025 |
| LLPS-Asm-2752 | Astyanax mexicanus | 87.77 | 0.0 | 732 |
| LLPS-Ran-0089 | Rattus norvegicus | 87.73 | 0.0 | 2079 |
| LLPS-Cas-2510 | Carlito syrichta | 87.62 | 0.0 | 1184 |
| LLPS-Mod-2710 | Monodelphis domestica | 87.28 | 0.0 | 2061 |
| LLPS-Caj-4154 | Callithrix jacchus | 86.54 | 0.0 | 1827 |
| LLPS-Ora-2988 | Ornithorhynchus anatinus | 85.85 | 0.0 | 1989 |
| LLPS-Sah-2817 | Sarcophilus harrisii | 85.57 | 0.0 | 1991 |
| LLPS-Dio-0742 | Dipodomys ordii | 85.44 | 0.0 | 1960 |
| LLPS-Ova-0079 | Ovis aries | 84.53 | 0.0 | 1934 |
| LLPS-Otg-1706 | Otolemur garnettii | 83.0 | 0.0 | 1894 |
| LLPS-Gaga-3606 | Gallus gallus | 82.76 | 0.0 | 1868 |
| LLPS-Tar-2492 | Takifugu rubripes | 82.43 | 0.0 | 765 |
| LLPS-Mea-3335 | Mesocricetus auratus | 81.78 | 0.0 | 1827 |
| LLPS-Scf-1136 | Scleropages formosus | 81.54 | 0.0 | 769 |
| LLPS-Fia-2625 | Ficedula albicollis | 81.43 | 0.0 | 1834 |
| LLPS-Icp-4204 | Ictalurus punctatus | 81.13 | 0.0 | 750 |
| LLPS-Anp-1272 | Anas platyrhynchos | 80.7 | 0.0 | 1859 |
| LLPS-Meg-1366 | Meleagris gallopavo | 79.91 | 0.0 | 1830 |
| LLPS-Pes-2790 | Pelodiscus sinensis | 79.75 | 0.0 | 1797 |
| LLPS-Dar-1776 | Danio rerio | 79.71 | 0.0 | 740 |
| LLPS-Tag-0323 | Taeniopygia guttata | 79.37 | 0.0 | 1808 |
| LLPS-Anc-2914 | Anolis carolinensis | 73.67 | 1e-120 | 384 |
| LLPS-Xet-3870 | Xenopus tropicalis | 72.35 | 0.0 | 1567 |
| LLPS-Cis-2033 | Ciona savignyi | 72.35 | 9e-98 | 317 |
| LLPS-Lac-3061 | Latimeria chalumnae | 70.81 | 0.0 | 1551 |
| LLPS-Leo-3747 | Lepisosteus oculatus | 70.7 | 0.0 | 1525 |
| LLPS-Cii-1612 | Ciona intestinalis | 67.76 | 1e-74 | 252 |
| LLPS-Orn-0062 | Oreochromis niloticus | 64.53 | 0.0 | 1355 |
| LLPS-Gaa-0697 | Gasterosteus aculeatus | 64.03 | 0.0 | 1333 |
| LLPS-Pof-1264 | Poecilia formosa | 62.74 | 0.0 | 1327 |
| LLPS-Xim-2007 | Xiphophorus maculatus | 61.72 | 0.0 | 1312 |
| LLPS-Orl-0061 | Oryzias latipes | 61.45 | 0.0 | 1257 |
| LLPS-Drm-2211 | Drosophila melanogaster | 52.77 | 2e-121 | 418 |
| LLPS-Cae-0531 | Caenorhabditis elegans | 44.31 | 9e-98 | 339 |
| LLPS-Crn-0074 | Cryptococcus neoformans | 34.68 | 2e-19 | 99.8 |
| LLPS-Poa-3643 | Pongo abelii | 34.46 | 3e-20 | 102 |
| LLPS-Ast-1255 | Aspergillus terreus | 30.73 | 1e-23 | 109 |
| LLPS-Mel-1234 | Melampsora laricipopulina | 28.89 | 1e-34 | 145 |
| LLPS-Abg-1546 | Absidia glauca | 27.8 | 1e-31 | 139 |
| LLPS-Phn-1165 | Phaeosphaeria nodorum | 27.75 | 2e-17 | 92.8 |
| LLPS-Fud-3021 | Fukomys damarensis | 25.9 | 2e-26 | 122 |
| LLPS-Fuv-0807 | Fusarium verticillioides | 25.78 | 1e-19 | 99.8 |
| LLPS-Scc-1518 | Schizosaccharomyces cryophilus | 25.74 | 3e-20 | 101 |
| LLPS-Asni-0271 | Aspergillus niger | 25.51 | 2e-21 | 104 |
| LLPS-Lem-0425 | Leptosphaeria maculans | 25.32 | 4e-19 | 98.2 |
| LLPS-Pytr-1321 | Pyrenophora triticirepentis | 24.86 | 6e-20 | 100 |
| LLPS-Scj-0622 | Schizosaccharomyces japonicus | 24.81 | 3e-22 | 108 |
| LLPS-Blg-0225 | Blumeria graminis | 22.66 | 5e-15 | 84.7 |
| LLPS-Pug-1028 | Puccinia graminis | 22.6 | 2e-20 | 102 |