LLPS-Aim-2076
RAPGEF1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Rap guanine nucleotide exchange factor 1 |
| Gene Name: | RAPGEF1 |
| Ensembl Gene: | ENSAMEG00000016435.1 |
| Ensembl Protein: | ENSAMEP00000017408.1 |
| Organism: | Ailuropoda melanoleuca |
| Taxa ID: | 9646 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nuclear speckle | Predicted from orthologs | (View) |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSAMET00000018119.1 | ENSAMEP00000017408.1 |
| UniProt | G1MDI0, G1MDI0_AILME | |
| GeneBank | ACTA01121208, ACTA01129208 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 SDSQRSHLSS FTMKLKDKFH SPKIKRTPSK KGKPAEVSVK NAEKPVSKNL SWLEEKEKEV 60 61 VSALRYFKTI VDKMAIDKKV LEMLPGSASK VLEAILPLVQ SDPRIQHSSA LSSCYSRVYQ 120 121 SLANLIRWSD QVMLEGVNSE DKETVTTVKG VIKAVLDGVK ELVRLTIEKQ GHPSPTSPVK 180 181 PSSPACKPDS QSELPLTDRE MEILNKTSGL SQSAELLPDS TDEEVAPPKP PLPGIRVVDN 240 241 SPPPALPPKK RQSAPSPTRV AVVAPMSRAT SGSSLPVGIN RQEDFDVDCY TQRRLSGGSH 300 301 SYGGESPRLS PCSSIGKLSK SDEQLSSLDR DSGQCSRNTS CETLVNADHY DPDYEFLQQD 360 361 LSNADQIPQQ VACNLSPLPE SLGESGSPFL GHPFQLPPAP GGCPQPEGTS APGQQMDTPP 420 421 ALPEKKRRSA ASQTTDSSGC RVSYERHPSQ YDNISEDDLQ NPASVPSVPF TPFAAILPFQ 480 481 QGGSSASVEF VGDFTVPEST GDPEKPPPLP EKKNKHMLAY MQLLEDYSEP QPSVFYQTPQ 540 541 NEHIYQQKNK LLMEVYGFFT NQVDCGQVVE SEHLTRPCLP HVQAEQASYA ASSFSSVSYC 600 601 VQQTKVAFTP EDSSATQGIS VSVSNSFLSR HGNLPVPSYK SVFRSYSQDF VPHNQASVQP 660 661 FLPSTSSSSP HFPPVHQSQS SDLAVPTVAS LPPSTVDGPL SSSQESNFHG NTVCLPSETS 720 721 FTDSPQTPSE SPAMKDGHPR DLSSASSAPG KESRDGDRAS RSPDGSELAQ SEEEVDELSL 780 781 IDHSEIMARL TLKQEGDDGP DVRGGSGDIL LVHATETDRK DLVLYCEAFL TTYRTFITPE 840 841 ELIRKLPEPY EKFSPFADTF KKRVSKNTFF VLVRVVDELC LVELTEEILK LLMELVFRLV 900 901 CSGELSLARV LRKNILDKVD QKKLLRCANS DQPLAARGVA ARPGTLHDFH SHEIAEQLTL 960 961 LDAELFYKIE IPEVLLWAKE QNEEKSPNLT QFTEHFNNMS YWVRSIIMLQ EKAQDRERLL 1020 1021 LKFIKIMKHL RKLNNFNSYL AILSALDSAP IRRLEWQKQT SEGLAEYCTL IDSSSSFRAY 1080 1081 RAALSEVEPP CIPYLGLILQ DLTFVHLGNP DYIDGKVNFS KRWQQFNILD SMRCFQQAHY 1140 1141 DIRRNDDIIN FFNDFSDHLA EEALWELSLK IKPRNITRRK TDREEKT 1187 |
| Nucleotide CDS Sequence (FASTA) |
1 TCAGACTCTC AGCGTTCTCA TCTCTCCTCC TTCACCATGA AGCTGAAGGA CAAATTCCAC 60 61 TCACCCAAAA TCAAGAGAAC GCCATCAAAG AAGGGAAAAC CAGCTGAGGT GTCTGTGAAA 120 121 AATGCGGAGA AGCCTGTGAG CAAAAACCTG AGCTGGCTGG AAGAGAAAGA GAAAGAAGTT 180 181 GTTAGTGCCT TGCGCTACTT TAAGACCATT GTGGACAAAA TGGCTATTGA TAAGAAGGTA 240 241 CTGGAGATGC TTCCAGGGTC AGCCAGCAAG GTGCTGGAGG CCATCTTACC CCTGGTGCAG 300 301 AGTGATCCTC GAATTCAACA CAGCTCAGCC CTCTCCTCCT GCTATAGCCG AGTGTACCAA 360 361 AGTCTCGCCA ACCTCATCCG TTGGTCTGAC CAAGTGATGC TAGAAGGTGT GAACTCAGAA 420 421 GATAAAGAGA CAGTGACAAC CGTGAAGGGA GTCATCAAGG CTGTGCTGGA CGGAGTGAAG 480 481 GAGCTGGTCA GACTTACCAT CGAGAAGCAG GGGCATCCGT CTCCAACCAG CCCAGTGAAA 540 541 CCCAGTTCCC CAGCCTGCAA ACCCGACAGC CAGTCTGAGC TCCCCCTGAC AGATCGAGAG 600 601 ATGGAGATTC TAAACAAAAC AAGTGGCCTG TCCCAGTCGG CCGAGCTACT CCCAGACTCT 660 661 ACAGATGAGG AGGTCGCACC CCCAAAGCCT CCCTTACCTG GCATTCGGGT GGTTGATAAC 720 721 AGTCCTCCAC CAGCATTGCC ACCGAAGAAA AGACAGTCAG CTCCATCCCC GACACGAGTG 780 781 GCTGTCGTTG CCCCCATGAG TCGAGCCACC AGTGGCTCCA GTTTGCCTGT TGGAATTAAT 840 841 AGGCAGGAGG ATTTTGACGT GGACTGTTAC ACACAGAGGC GACTCTCAGG AGGCAGCCAT 900 901 TCGTACGGCG GAGAGTCGCC CCGCCTGTCC CCCTGCAGCA GCATAGGCAA GCTCAGCAAG 960 961 TCAGACGAGC AGCTGTCCTC TCTGGACAGG GACAGCGGCC AGTGCTCCCG GAACACAAGC 1020 1021 TGTGAAACAC TAGTGAACGC AGATCACTAT GACCCTGACT ACGAATTCCT TCAGCAAGAC 1080 1081 CTCTCTAACG CCGACCAGAT ACCTCAGCAA GTGGCCTGTA ACCTTAGCCC GTTGCCGGAG 1140 1141 TCCTTGGGAG AGTCTGGCTC TCCATTTCTT GGCCATCCTT TCCAGTTGCC TCCAGCACCT 1200 1201 GGCGGCTGTC CCCAGCCAGA GGGAACGTCG GCCCCAGGAC AGCAGATGGA CACGCCGCCT 1260 1261 GCTCTCCCCG AGAAGAAGCG CAGGAGTGCG GCCTCCCAGA CCACGGACAG CTCTGGCTGC 1320 1321 AGGGTGTCCT ACGAGCGGCA CCCCTCCCAG TACGACAACA TCTCCGAGGA TGACCTGCAG 1380 1381 AACCCAGCCT CGGTCCCGTC CGTCCCCTTC ACGCCCTTTG CTGCTATTCT CCCCTTTCAG 1440 1441 CAAGGAGGGT CCTCCGCCTC TGTCGAATTT GTGGGTGATT TCACTGTTCC TGAATCAACG 1500 1501 GGTGACCCGG AAAAACCGCC TCCTTTACCA GAGAAGAAAA ACAAACACAT GCTGGCCTAC 1560 1561 ATGCAGCTGC TCGAGGACTA CTCGGAACCG CAGCCATCCG TGTTCTACCA GACGCCGCAG 1620 1621 AACGAGCACA TCTACCAGCA GAAGAACAAG CTCCTCATGG AGGTGTACGG CTTCTTTACC 1680 1681 AACCAAGTGG ACTGTGGTCA GGTGGTAGAG TCTGAGCATC TCACCCGGCC GTGCCTTCCG 1740 1741 CATGTCCAAG CAGAGCAGGC CTCCTATGCT GCTTCTTCCT TCTCCTCTGT CTCCTACTGT 1800 1801 GTCCAGCAAA CTAAAGTGGC CTTCACCCCC GAGGACAGCA GTGCCACTCA GGGCATCAGT 1860 1861 GTGTCCGTCT CTAACTCCTT TCTCAGCCGG CACGGCAACT TGCCTGTGCC CTCGTATAAA 1920 1921 TCTGTGTTTA GGTCCTACTC CCAGGATTTC GTGCCTCACA ACCAAGCTTC CGTTCAACCT 1980 1981 TTCCTTCCGT CCACCTCCTC TTCCTCTCCA CATTTCCCAC CCGTCCACCA GTCTCAGAGC 2040 2041 TCTGACTTAG CGGTGCCAAC CGTAGCCAGT CTGCCTCCCA GCACCGTGGA CGGGCCTCTC 2100 2101 TCATCTTCTC AGGAGAGCAA CTTTCATGGG AACACTGTCT GCCTTCCTTC CGAAACCTCT 2160 2161 TTCACTGACT CGCCCCAGAC GCCTTCGGAA TCACCAGCTA TGAAAGACGG ACATCCCAGA 2220 2221 GATCTCTCGT CGGCCAGCAG TGCACCCGGG AAGGAGAGCA GAGACGGCGA CAGGGCCTCA 2280 2281 AGGTCACCAG ATGGTTCAGA GTTGGCTCAG TCGGAGGAGG AAGTGGATGA GCTGTCCCTC 2340 2341 ATCGACCACA GCGAGATTAT GGCGAGGCTG ACCCTCAAGC AGGAGGGTGA CGATGGGCCA 2400 2401 GACGTCCGTG GCGGGTCTGG AGATATCCTA CTGGTGCACG CTACTGAGAC AGACAGGAAA 2460 2461 GATTTGGTGC TGTACTGTGA GGCCTTCCTG ACCACCTACA GGACCTTCAT CACCCCGGAG 2520 2521 GAGCTCATCA GGAAGCTGCC AGAGCCGTAC GAGAAGTTCT CACCCTTTGC TGACACGTTC 2580 2581 AAGAAGCGCG TCAGCAAGAA CACGTTCTTC GTGCTGGTGC GGGTGGTGGA TGAGCTCTGC 2640 2641 CTCGTGGAGT TGACCGAAGA GATCTTGAAG CTGCTGATGG AGCTGGTCTT CCGCTTGGTG 2700 2701 TGCAGTGGGG AGCTCAGCCT GGCCCGTGTG CTCCGGAAGA ACATCCTGGA CAAGGTGGAC 2760 2761 CAGAAGAAAC TGCTCAGGTG TGCCAACTCC GACCAGCCCC TGGCAGCCCG GGGGGTAGCC 2820 2821 GCCAGGCCGG GGACTTTGCA TGACTTTCAC AGCCATGAAA TAGCCGAGCA GCTGACCCTG 2880 2881 CTGGATGCTG AGCTCTTCTA TAAAATAGAG ATTCCTGAGG TTTTGCTTTG GGCAAAAGAG 2940 2941 CAGAATGAGG AGAAAAGCCC CAACTTGACC CAGTTCACAG AGCACTTCAA CAACATGTCA 3000 3001 TACTGGGTGC GCTCAATCAT CATGTTACAG GAGAAAGCCC AGGACAGGGA GCGGCTGCTG 3060 3061 TTGAAGTTCA TCAAGATCAT GAAGCACCTA CGGAAGCTGA ACAACTTTAA CTCCTACCTG 3120 3121 GCCATCCTCT CGGCGCTGGA CTCGGCTCCC ATCCGCAGGC TGGAGTGGCA GAAGCAGACC 3180 3181 TCGGAGGGCC TGGCCGAGTA CTGTACGCTG ATCGACAGCT CGTCCTCCTT CCGCGCCTAC 3240 3241 CGGGCCGCCC TCTCCGAGGT GGAGCCCCCC TGTATCCCGT ACCTGGGCCT CATCCTGCAG 3300 3301 GACCTCACCT TTGTTCACCT GGGAAACCCA GACTATATTG ATGGGAAGGT GAATTTTTCC 3360 3361 AAACGGTGGC AGCAGTTCAA CATTCTGGAC AGCATGCGGT GCTTCCAGCA AGCGCACTAC 3420 3421 GATATCCGAA GAAACGATGA TATCATAAAC TTCTTCAATG ACTTCAGCGA CCACCTGGCG 3480 3481 GAGGAGGCCC TGTGGGAACT TTCTCTGAAA ATCAAACCTA GGAACATAAC AAGGAGAAAA 3540 3541 ACAGACCGGG AGGAGAAGAC CTAG 3564 |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Sus-3878 | Sus scrofa | 95.01 | 0.0 | 857 |
| LLPS-Pap-4087 | Pan paniscus | 94.55 | 0.0 | 857 |
| LLPS-Rhb-1464 | Rhinopithecus bieti | 94.55 | 0.0 | 856 |
| LLPS-Paa-4860 | Papio anubis | 94.55 | 0.0 | 857 |
| LLPS-Hos-0702 | Homo sapiens | 94.34 | 0.0 | 857 |
| LLPS-Gog-2320 | Gorilla gorilla | 92.74 | 0.0 | 849 |
| LLPS-Urm-3792 | Ursus maritimus | 90.2 | 0.0 | 1997 |
| LLPS-Caf-4413 | Canis familiaris | 89.44 | 0.0 | 2045 |
| LLPS-Cas-2510 | Carlito syrichta | 89.13 | 0.0 | 1113 |
| LLPS-Fec-0781 | Felis catus | 88.93 | 0.0 | 2033 |
| LLPS-Mup-2602 | Mustela putorius furo | 88.84 | 0.0 | 2000 |
| LLPS-Scm-3592 | Scophthalmus maximus | 88.7 | 0.0 | 737 |
| LLPS-Nol-3040 | Nomascus leucogenys | 88.0 | 0.0 | 795 |
| LLPS-Myl-1039 | Myotis lucifugus | 87.99 | 0.0 | 1959 |
| LLPS-Bot-4501 | Bos taurus | 87.86 | 0.0 | 1982 |
| LLPS-Eqc-3479 | Equus caballus | 87.75 | 0.0 | 1988 |
| LLPS-Loa-2440 | Loxodonta africana | 87.62 | 0.0 | 1933 |
| LLPS-Asm-2752 | Astyanax mexicanus | 86.99 | 0.0 | 723 |
| LLPS-Mam-2180 | Macaca mulatta | 86.94 | 0.0 | 1933 |
| LLPS-Dar-1776 | Danio rerio | 86.75 | 0.0 | 723 |
| LLPS-Scf-1136 | Scleropages formosus | 86.39 | 0.0 | 756 |
| LLPS-Mal-1856 | Mandrillus leucophaeus | 86.37 | 0.0 | 782 |
| LLPS-Maf-1468 | Macaca fascicularis | 86.34 | 0.0 | 778 |
| LLPS-Mum-4136 | Mus musculus | 85.97 | 0.0 | 1877 |
| LLPS-Chs-0533 | Chlorocebus sabaeus | 85.73 | 0.0 | 1925 |
| LLPS-Tar-2492 | Takifugu rubripes | 85.62 | 0.0 | 750 |
| LLPS-Pat-0984 | Pan troglodytes | 85.55 | 0.0 | 941 |
| LLPS-Caj-4154 | Callithrix jacchus | 85.55 | 0.0 | 1638 |
| LLPS-Ict-2025 | Ictidomys tridecemlineatus | 85.45 | 0.0 | 1894 |
| LLPS-Sah-2817 | Sarcophilus harrisii | 85.4 | 0.0 | 1882 |
| LLPS-Cea-3514 | Cercocebus atys | 85.38 | 0.0 | 1930 |
| LLPS-Man-4474 | Macaca nemestrina | 85.37 | 0.0 | 1931 |
| LLPS-Dio-0742 | Dipodomys ordii | 84.56 | 0.0 | 1820 |
| LLPS-Cap-2551 | Cavia porcellus | 83.77 | 0.0 | 1878 |
| LLPS-Ran-0089 | Rattus norvegicus | 83.55 | 0.0 | 1854 |
| LLPS-Mod-2710 | Monodelphis domestica | 83.52 | 0.0 | 1885 |
| LLPS-Aon-4119 | Aotus nancymaae | 83.42 | 0.0 | 1630 |
| LLPS-Ten-0135 | Tetraodon nigroviridis | 83.08 | 0.0 | 747 |
| LLPS-Icp-4204 | Ictalurus punctatus | 82.93 | 0.0 | 736 |
| LLPS-Gaga-3606 | Gallus gallus | 82.08 | 0.0 | 1812 |
| LLPS-Fia-2625 | Ficedula albicollis | 81.93 | 0.0 | 1787 |
| LLPS-Mea-3335 | Mesocricetus auratus | 81.47 | 0.0 | 1749 |
| LLPS-Anp-1272 | Anas platyrhynchos | 81.28 | 0.0 | 1801 |
| LLPS-Otg-1706 | Otolemur garnettii | 81.26 | 0.0 | 1736 |
| LLPS-Meg-1366 | Meleagris gallopavo | 81.19 | 0.0 | 1795 |
| LLPS-Ora-2988 | Ornithorhynchus anatinus | 80.93 | 0.0 | 1807 |
| LLPS-Tag-0323 | Taeniopygia guttata | 80.08 | 0.0 | 1751 |
| LLPS-Ova-0079 | Ovis aries | 79.81 | 0.0 | 1726 |
| LLPS-Pes-2790 | Pelodiscus sinensis | 79.45 | 0.0 | 1745 |
| LLPS-Xet-3870 | Xenopus tropicalis | 72.68 | 0.0 | 1524 |
| LLPS-Anc-2914 | Anolis carolinensis | 72.38 | 3e-113 | 363 |
| LLPS-Cis-2033 | Ciona savignyi | 72.35 | 4e-98 | 317 |
| LLPS-Leo-3747 | Lepisosteus oculatus | 70.86 | 0.0 | 1467 |
| LLPS-Lac-3061 | Latimeria chalumnae | 69.92 | 0.0 | 1502 |
| LLPS-Cii-1612 | Ciona intestinalis | 67.76 | 6e-75 | 252 |
| LLPS-Orn-0062 | Oreochromis niloticus | 65.38 | 0.0 | 1325 |
| LLPS-Gaa-0697 | Gasterosteus aculeatus | 63.45 | 0.0 | 1307 |
| LLPS-Pof-1264 | Poecilia formosa | 63.16 | 0.0 | 1310 |
| LLPS-Xim-2007 | Xiphophorus maculatus | 62.39 | 0.0 | 1295 |
| LLPS-Orl-0061 | Oryzias latipes | 61.56 | 0.0 | 1248 |
| LLPS-Drm-2211 | Drosophila melanogaster | 52.77 | 4e-121 | 416 |
| LLPS-Cae-0531 | Caenorhabditis elegans | 44.06 | 3e-97 | 337 |
| LLPS-Poa-3643 | Pongo abelii | 34.83 | 3e-20 | 102 |
| LLPS-Crn-0074 | Cryptococcus neoformans | 34.68 | 1e-19 | 99.8 |
| LLPS-Ast-1255 | Aspergillus terreus | 30.73 | 1e-23 | 109 |
| LLPS-Mel-1234 | Melampsora laricipopulina | 28.64 | 3e-34 | 143 |
| LLPS-Abg-1546 | Absidia glauca | 28.33 | 1e-30 | 135 |
| LLPS-Phn-1165 | Phaeosphaeria nodorum | 27.75 | 2e-17 | 92.4 |
| LLPS-Fud-3021 | Fukomys damarensis | 26.45 | 1e-26 | 122 |
| LLPS-Fuv-0807 | Fusarium verticillioides | 26.13 | 8e-20 | 100 |
| LLPS-Asni-0271 | Aspergillus niger | 26.02 | 4e-21 | 103 |
| LLPS-Lem-0425 | Leptosphaeria maculans | 25.33 | 5e-20 | 100 |
| LLPS-Scj-0622 | Schizosaccharomyces japonicus | 25.06 | 3e-23 | 111 |
| LLPS-Scc-1518 | Schizosaccharomyces cryophilus | 24.85 | 9e-21 | 103 |
| LLPS-Pytr-1321 | Pyrenophora triticirepentis | 24.59 | 3e-19 | 98.2 |
| LLPS-Blg-0225 | Blumeria graminis | 23.16 | 3e-15 | 85.5 |
| LLPS-Pug-1028 | Puccinia graminis | 22.83 | 8e-20 | 100 |