• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caf-3461
DYRK2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Dual specificity tyrosine phosphorylation regulated kinase 2
Gene Name: DYRK2
Ensembl Gene: ENSCAFG00000000407.2
Ensembl Protein: ENSCAFP00000000587.2
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granule, OthersPredicted from orthologs(View)

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLTRKPSAAA  PAAYPTGRGG  DSAVRQLQAS  PGLGAGAPRS  GVGTGPPSPI  ALPPLRAGNA  60
61    AAAAHTLGGS  KHTMNDHLHV  GSHSHGQIQV  QQLFEDNSNK  RTVLTTQPNG  LTTVGKAGLP  120
121   VVPERQLESI  HRRQGSSTSL  KSMEGMGKVK  ATPMTPEQAM  KQYMQKLTTF  EHHEIFSYPE  180
181   IYFLGPNAKK  RQGMTGGPNN  GGYDDDQGSY  VQVPHDHVAY  RYEVLKVIGK  GSFGQVVKAY  240
241   DHKVHQHVAL  KMVRNEKRFH  RQAAEEIRIL  EHLRKQDKDN  TMNVIHMLEN  FTFRNHICMT  300
301   FELLSMNLYE  LIKKNKFQGF  SLPLVRKFAH  SILQCLDALH  KNRIIHCDLK  PENILLKQQG  360
361   RSGIKVIDFG  SSCYEHQRVY  TYIQSRFYRA  PEVILGARYG  MPIDMWSLGC  ILAELLTGYP  420
421   LLPGEDEGDQ  LACMIELLGM  PSQKLLDASK  RAKNFVSSKG  YPRYCTVTTL  SDGSVVLNGG  480
481   RSRRGKLRGP  PESREWGNAL  KGCDDPLFLD  FLKQCLEWDP  AVRMTPGQAL  RHPWLRRRLP  540
541   KPPTGEKTSV  KRITESTGAI  TSISKLPPPS  SSASKLRTNL  AQMTDANGNI  QQRTVLPKLV  600
601   S  601
Nucleotide CDS Sequence (FASTA)
1     ATGTTGACCA  GGAAACCTTC  GGCCGCCGCT  CCCGCCGCCT  ACCCGACCGG  CCGAGGAGGG  60
61    GACAGCGCCG  TGCGACAGCT  GCAGGCCTCC  CCGGGGCTCG  GTGCGGGGGC  CCCCCGGAGC  120
121   GGAGTGGGGA  CCGGCCCGCC  CTCCCCGATC  GCCCTGCCGC  CTCTCCGGGC  CGGCAACGCT  180
181   GCGGCCGCGG  CGCACACGCT  TGGCGGCAGT  AAGCACACAA  TGAATGATCA  CTTACACGTC  240
241   GGCAGCCACA  GCCACGGACA  GATCCAGGTT  CAGCAGCTGT  TTGAGGATAA  TAGTAACAAG  300
301   CGGACAGTGC  TCACGACACA  ACCAAATGGG  CTTACAACAG  TGGGTAAAGC  GGGATTGCCG  360
361   GTGGTGCCCG  AGCGGCAGCT  GGAGAGCATC  CACAGACGGC  AGGGGAGCTC  CACGTCTCTG  420
421   AAGTCTATGG  AAGGCATGGG  GAAGGTGAAA  GCCACCCCCA  TGACACCCGA  ACAAGCAATG  480
481   AAGCAATACA  TGCAAAAACT  AACCACCTTT  GAACACCACG  AGATTTTCAG  CTACCCTGAA  540
541   ATATATTTCT  TGGGTCCAAA  TGCAAAGAAG  CGCCAGGGCA  TGACAGGTGG  GCCCAACAAC  600
601   GGGGGCTACG  ACGATGACCA  GGGATCCTAC  GTGCAGGTGC  CCCACGATCA  CGTGGCTTAC  660
661   AGGTACGAGG  TCCTCAAGGT  CATTGGGAAG  GGCAGCTTTG  GGCAGGTGGT  CAAGGCCTAC  720
721   GACCACAAAG  TCCACCAGCA  CGTGGCCCTG  AAGATGGTGC  GGAATGAGAA  GCGGTTCCAC  780
781   CGGCAGGCAG  CGGAGGAGAT  CCGGATCCTG  GAGCACCTGC  GGAAGCAGGA  CAAGGACAAC  840
841   ACCATGAACG  TCATCCACAT  GCTGGAGAAC  TTCACCTTCC  GGAACCACAT  CTGCATGACG  900
901   TTCGAGCTGC  TGAGCATGAA  CCTCTACGAG  CTCATCAAGA  AGAATAAGTT  CCAGGGCTTC  960
961   AGCCTGCCTT  TGGTTCGCAA  GTTTGCCCAC  TCCATTCTGC  AGTGCTTGGA  TGCTTTGCAC  1020
1021  AAGAACAGAA  TAATTCACTG  TGACCTTAAG  CCCGAGAACA  TTTTATTAAA  GCAGCAGGGT  1080
1081  AGAAGTGGTA  TTAAAGTGAT  CGATTTTGGC  TCCAGTTGTT  ACGAGCATCA  GCGCGTCTAC  1140
1141  ACGTACATTC  AGTCCCGTTT  CTACCGGGCT  CCGGAAGTGA  TCCTGGGCGC  CAGGTACGGC  1200
1201  ATGCCCATCG  ATATGTGGAG  CCTGGGTTGC  ATTTTAGCCG  AGCTCCTGAC  TGGTTACCCG  1260
1261  CTCTTGCCTG  GGGAAGACGA  AGGGGACCAG  CTGGCTTGTA  TGATTGAACT  ATTGGGCATG  1320
1321  CCCTCCCAGA  AACTGCTGGA  TGCATCCAAA  CGAGCCAAAA  ATTTTGTGAG  CTCCAAGGGT  1380
1381  TATCCCCGTT  ACTGCACTGT  CACGACACTC  TCAGACGGCT  CTGTGGTTCT  CAACGGAGGC  1440
1441  CGTTCCCGGA  GGGGGAAACT  GAGGGGCCCA  CCAGAGAGCC  GGGAGTGGGG  GAATGCACTG  1500
1501  AAGGGGTGTG  ACGATCCCCT  TTTCCTGGAC  TTCTTAAAAC  AGTGTTTAGA  ATGGGATCCT  1560
1561  GCGGTTCGCA  TGACCCCTGG  CCAGGCTTTA  CGGCATCCCT  GGCTGCGGAG  GCGGCTGCCA  1620
1621  AAGCCTCCGA  CAGGGGAGAA  GACGTCCGTG  AAAAGGATAA  CCGAGAGCAC  TGGTGCTATC  1680
1681  ACATCCATTT  CCAAGTTACC  TCCACCTTCC  AGCTCAGCTT  CCAAACTGAG  GACTAATTTG  1740
1741  GCACAGATGA  CAGATGCCAA  TGGGAATATT  CAGCAGAGGA  CAGTGTTGCC  AAAACTTGTC  1800
1801  AGCTGA  1806

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fec-0633Felis catus99.50.01158
LLPS-Urm-1226Ursus maritimus99.40.01013
LLPS-Sus-2804Sus scrofa99.170.01155
LLPS-Ova-0486Ovis aries98.880.01069
LLPS-Ere-0389Erinaceus europaeus98.880.01078
LLPS-Aon-3731Aotus nancymaae98.840.01151
LLPS-Hos-2629Homo sapiens98.670.01147
LLPS-Pat-0305Pan troglodytes98.670.01147
LLPS-Cap-0534Cavia porcellus98.670.01150
LLPS-Caj-0523Callithrix jacchus98.670.01149
LLPS-Mam-1556Macaca mulatta98.50.01145
LLPS-Poa-2121Pongo abelii98.50.01146
LLPS-Cea-1312Cercocebus atys98.50.01145
LLPS-Chs-0189Chlorocebus sabaeus98.50.01145
LLPS-Paa-3011Papio anubis98.50.01145
LLPS-Bot-2434Bos taurus98.50.01147
LLPS-Mup-0961Mustela putorius furo98.480.01061
LLPS-Rhb-2437Rhinopithecus bieti98.460.01131
LLPS-Pap-2407Pan paniscus98.460.01140
LLPS-Ict-3388Ictidomys tridecemlineatus98.340.01145
LLPS-Ran-1502Rattus norvegicus98.30.01056
LLPS-Tut-0276Tursiops truncatus98.290.01141
LLPS-Fud-1806Fukomys damarensis98.130.01073
LLPS-Nol-0148Nomascus leucogenys97.810.01144
LLPS-Loa-0726Loxodonta africana97.780.01129
LLPS-Man-1077Macaca nemestrina97.670.01154
LLPS-Eqc-2445Equus caballus97.670.01140
LLPS-Maf-0068Macaca fascicularis97.640.01139
LLPS-Mea-2115Mesocricetus auratus97.340.01145
LLPS-Mum-1391Mus musculus97.00.01136
LLPS-Myl-1426Myotis lucifugus96.980.01141
LLPS-Dio-2073Dipodomys ordii96.670.01124
LLPS-Orc-1622Oryctolagus cuniculus96.640.01144
LLPS-Mal-0936Mandrillus leucophaeus96.520.01143
LLPS-Otg-2122Otolemur garnettii96.340.01128
LLPS-Gog-2687Gorilla gorilla94.70.01122
LLPS-Anp-0109Anas platyrhynchos94.010.01027
LLPS-Meg-0113Meleagris gallopavo93.070.01018
LLPS-Fia-1716Ficedula albicollis92.610.01001
LLPS-Tag-1868Taeniopygia guttata92.520.01013
LLPS-Anc-2477Anolis carolinensis91.670.0 990
LLPS-Sah-1047Sarcophilus harrisii90.960.01046
LLPS-Gaga-1243Gallus gallus88.420.01049
LLPS-Pes-0123Pelodiscus sinensis87.310.01050
LLPS-Xet-0641Xenopus tropicalis87.030.01007
LLPS-Lac-3208Latimeria chalumnae87.020.01015
LLPS-Leo-0174Lepisosteus oculatus86.860.01005
LLPS-Ora-0824Ornithorhynchus anatinus85.690.0 915
LLPS-Cii-0752Ciona intestinalis84.180.0 723
LLPS-Dar-0752Danio rerio84.10.0 942
LLPS-Asm-0173Astyanax mexicanus83.190.0 966
LLPS-Icp-1692Ictalurus punctatus82.860.0 954
LLPS-Scf-2506Scleropages formosus80.870.0 944
LLPS-Cis-1522Ciona savignyi79.040.0 698
LLPS-Ten-1018Tetraodon nigroviridis77.840.0 835
LLPS-Gaa-1777Gasterosteus aculeatus77.090.0 854
LLPS-Cae-0280Caenorhabditis elegans73.450.0 635
LLPS-Drm-1365Drosophila melanogaster72.730.0 623
LLPS-Orl-1145Oryzias latipes72.180.0 853
LLPS-Scm-1591Scophthalmus maximus71.410.0 839
LLPS-Orn-1519Oreochromis niloticus71.10.0 858
LLPS-Pof-0864Poecilia formosa70.850.0 857
LLPS-Xim-0298Xiphophorus maculatus69.980.0 845
LLPS-Tar-0404Takifugu rubripes68.750.0 829
LLPS-Aim-2313Ailuropoda melanoleuca65.760.0 688
LLPS-Mod-0609Monodelphis domestica64.630.0 657
LLPS-Cas-0797Carlito syrichta64.480.0 674
LLPS-Chr-1349Chlamydomonas reinhardtii53.832e-141 449
LLPS-Phn-0409Phaeosphaeria nodorum53.392e-126 412
LLPS-Ast-0965Aspergillus terreus52.094e-126 410
LLPS-Miv-1213Microbotryum violaceum52.083e-133 437
LLPS-Pyt-1521Pyrenophora teres52.082e-125 410
LLPS-Spr-0318Sporisorium reilianum52.076e-134 438
LLPS-Usm-1120Ustilago maydis51.561e-130 428
LLPS-Abg-1599Absidia glauca51.491e-130 418
LLPS-Put-0441Puccinia triticina50.785e-128 418
LLPS-Nef-0145Neosartorya fischeri50.725e-129 416
LLPS-Asfu-1169Aspergillus fumigatus50.725e-129 416
LLPS-Lem-1457Leptosphaeria maculans50.613e-121 399
LLPS-Asn-0089Aspergillus nidulans50.54e-125 408
LLPS-Pytr-0816Pyrenophora triticirepentis50.492e-131 403
LLPS-Mel-0064Melampsora laricipopulina50.385e-135 410
LLPS-Mao-0939Magnaporthe oryzae50.372e-127 414
LLPS-Sem-0330Selaginella moellendorffii50.135e-126 383
LLPS-Asf-0556Aspergillus flavus50.123e-127 410
LLPS-Aso-1071Aspergillus oryzae50.128e-131 401
LLPS-Asni-0586Aspergillus niger50.02e-128 417
LLPS-Asc-0491Aspergillus clavatus50.01e-125 408
LLPS-Trr-0672Trichoderma reesei49.875e-126 385
LLPS-Tum-1414Tuber melanosporum49.752e-123 404
LLPS-Gag-1059Gaeumannomyces graminis49.076e-127 412
LLPS-Crn-0948Cryptococcus neoformans48.632e-122 402
LLPS-Fus-1035Fusarium solani48.483e-127 412
LLPS-Map-0739Magnaporthe poae48.382e-127 414
LLPS-Fuo-1027Fusarium oxysporum48.371e-127 414
LLPS-Scs-0866Sclerotinia sclerotiorum48.058e-118 387
LLPS-Scj-0077Schizosaccharomyces japonicus47.913e-115 374
LLPS-Blg-0482Blumeria graminis47.791e-124 405
LLPS-Dos-0950Dothistroma septosporum47.622e-123 380
LLPS-Cog-0036Colletotrichum gloeosporioides47.532e-126 410
LLPS-Beb-0688Beauveria bassiana46.989e-125 406
LLPS-Cogr-0519Colletotrichum graminicola46.972e-126 410
LLPS-Ved-1416Verticillium dahliae46.875e-125 402
LLPS-Coo-0223Colletotrichum orbiculare46.671e-125 408
LLPS-Zyt-1151Zymoseptoria tritici46.679e-126 384
LLPS-Trv-1476Trichoderma virens46.287e-124 403
LLPS-Scc-1067Schizosaccharomyces cryophilus45.997e-105 347
LLPS-Scp-0086Schizosaccharomyces pombe45.523e-111 365
LLPS-Pug-0248Puccinia graminis45.055e-104 352
LLPS-Nec-0524Neurospora crassa44.897e-124 404
LLPS-Yal-0220Yarrowia lipolytica42.727e-103 344