• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caf-0584
MCM4

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA helicase
Gene Name: MCM4
Ensembl Gene: ENSCAFG00000006598.3
Ensembl Protein: ENSCAFP00000009885.3
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Chromatin, Nucleolus, Centrosome/Spindle pole body, Stress granule, OthersPredicted from orthologs(View)

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSPASTPSR  RGSRRGRTTP  AQTPRSEDAR  SSPHQRRRGD  DSTSTGELQP  MPTSPGADLH  60
61    SPAAHDALFS  SPAQIQPSTI  PLDFDVSSPL  TYGTPSSRVD  GTPRSGVRGT  PVRQRPDLGS  120
121   ARKGLQVDLQ  TEVPATEDIV  ASEQALGQKL  VIWGTDVNVA  TCKENFQRFL  QHFIDPLAKE  180
181   EETIGIDITE  PLYMQRLGEI  NVIGEPFLNV  NCEHIQSFDK  NLYRQLICYP  QEVIPTFDMA  240
241   VNEIFFDRYP  DSILEHQIQV  RPFNALKTKN  MRNLNPDDID  QLIAISGMVI  RTSQLIPEMQ  300
301   EAFFQCQVCA  HTARVEIDRG  RIAEPSVCEH  CHTTHSMALI  HNRSVFSDKQ  MIKLQESPED  360
361   MPAGQTPHTV  ILFAHNDLVD  KVQPGDRVNI  TGIYRAVPIR  VSSRVSNVKS  VYKTHIDVIH  420
421   YRKTDAKRLH  GLDEEAEQKL  FSEKRVELLK  ELSRKPDIYE  RLASALAPSI  YEHEDIKKGI  480
481   LLQLFGGTRK  DFSHTGRGKF  RAEINILLCG  DPGTSKSQLL  QYVYNLVPRG  QYTSGKGSSA  540
541   VGLTAYVMKD  PETRQLVLQT  GALVLSDNGI  CCIDEFDKMN  ESTRSVLHEV  MEQQTLSIAK  600
601   AGIICQLNAR  TSILAAANPV  ESQWNPKKTT  IENIQLPHTL  LSRFDLIFLM  LDPQDEAYDR  660
661   RLAHHLVALY  YRSEEQMEEE  FMDMAVLKDY  IAYAHSMVMP  RLSQEASQAL  IEAYVDMRKI  720
721   GSSRGMVSAY  PRQLESLIRL  AEAHAKVRFS  SKVEAVDVEE  AKRLHREALK  QSATDPRTGI  780
781   VDISILTTGM  SATSRKRKEE  LAEALKKLIL  SKGKTPALKY  QQLFEDIRGQ  SDIAITKDMF  840
841   EEALRALADD  DFLTVTGKTV  RLL  863
Nucleotide CDS Sequence (FASTA)
1     ATGTCGTCCC  CGGCGTCCAC  CCCGAGCCGC  CGCGGCAGCC  GGCGCGGGCG  GACCACCCCT  60
61    GCGCAGACGC  CTCGAAGTGA  GGATGCCAGG  TCATCACCAC  ATCAAAGACG  GAGGGGCGAC  120
121   GATTCTACCT  CCACCGGAGA  GTTGCAGCCT  ATGCCCACCT  CACCTGGAGC  TGACCTACAC  180
181   AGCCCTGCCG  CGCACGACGC  CTTATTCTCC  AGCCCTGCTC  AGATACAGCC  CTCAACAATT  240
241   CCCCTTGATT  TTGACGTTAG  TTCACCACTG  ACATATGGCA  CTCCCAGCTC  TCGGGTGGAC  300
301   GGAACCCCAA  GGAGTGGCGT  TAGAGGCACA  CCTGTGAGGC  AGAGGCCTGA  CCTGGGGTCT  360
361   GCTCGGAAAG  GCCTGCAGGT  GGATTTGCAG  ACCGAAGTGC  CAGCAACAGA  AGATATAGTG  420
421   GCAAGTGAGC  AGGCTCTAGG  CCAAAAACTT  GTGATCTGGG  GAACAGATGT  AAATGTGGCA  480
481   ACTTGCAAAG  AAAATTTTCA  GAGATTCCTT  CAGCATTTTA  TTGACCCTCT  GGCCAAAGAA  540
541   GAAGAAACTA  TTGGCATAGA  TATTACTGAG  CCTCTGTACA  TGCAACGACT  TGGAGAGATT  600
601   AATGTAATTG  GGGAGCCATT  TTTAAATGTA  AACTGTGAAC  ATATACAATC  ATTTGACAAA  660
661   AATCTCTACA  GACAGCTCAT  CTGCTACCCA  CAGGAAGTTA  TCCCAACCTT  TGACATGGCT  720
721   GTCAATGAGA  TCTTCTTTGA  CCGTTACCCT  GACTCAATCT  TAGAACATCA  GATTCAAGTA  780
781   AGACCCTTCA  ATGCTTTAAA  GACGAAGAAT  ATGAGAAACC  TGAATCCAGA  CGATATTGAC  840
841   CAGCTCATTG  CCATCAGTGG  CATGGTAATC  AGGACATCCC  AGCTGATTCC  AGAGATGCAA  900
901   GAGGCCTTCT  TCCAGTGCCA  AGTGTGTGCC  CACACAGCCC  GGGTGGAGAT  TGACCGTGGT  960
961   CGCATTGCTG  AGCCTTCTGT  TTGTGAGCAC  TGCCACACCA  CCCACAGCAT  GGCACTGATC  1020
1021  CACAACCGCT  CTGTGTTCTC  TGACAAGCAG  ATGATCAAAC  TTCAAGAGTC  TCCCGAAGAT  1080
1081  ATGCCTGCAG  GGCAGACACC  TCACACTGTC  ATCCTTTTTG  CTCACAATGA  TCTTGTTGAC  1140
1141  AAGGTTCAGC  CTGGAGACAG  AGTGAACATT  ACAGGCATCT  ATCGAGCTGT  TCCTATTCGA  1200
1201  GTTAGCTCAA  GAGTGAGTAA  TGTGAAGTCT  GTCTACAAAA  CTCACATTGA  TGTCATTCAC  1260
1261  TATCGGAAAA  CTGATGCAAA  ACGTCTGCAT  GGCCTTGATG  AAGAAGCAGA  GCAGAAACTT  1320
1321  TTTTCAGAGA  AGCGTGTGGA  ATTGCTTAAG  GAACTTTCCA  GAAAGCCAGA  CATTTATGAG  1380
1381  AGACTTGCTT  CAGCCTTGGC  TCCAAGCATT  TATGAACACG  AAGATATAAA  GAAGGGAATC  1440
1441  TTGCTTCAGC  TCTTTGGTGG  AACAAGAAAG  GATTTCAGTC  ACACAGGAAG  AGGTAAATTT  1500
1501  CGTGCCGAGA  TCAATATCCT  GTTGTGCGGT  GACCCTGGGA  CCAGCAAGTC  TCAGCTGCTG  1560
1561  CAGTATGTGT  ACAATCTGGT  CCCCAGGGGC  CAGTACACAT  CCGGGAAAGG  CTCCAGTGCA  1620
1621  GTCGGCCTCA  CTGCGTATGT  GATGAAAGAC  CCTGAGACGA  GGCAGCTTGT  CTTGCAGACT  1680
1681  GGTGCCCTTG  TCCTGAGTGA  CAATGGTATC  TGCTGTATTG  ATGAGTTCGA  CAAGATGAAT  1740
1741  GAAAGTACAA  GATCAGTACT  ACATGAAGTC  ATGGAACAGC  AGACTCTTTC  CATTGCAAAG  1800
1801  GCTGGGATTA  TTTGCCAGCT  CAATGCTCGC  ACCTCTATTC  TGGCAGCAGC  AAATCCTGTT  1860
1861  GAGTCTCAAT  GGAATCCTAA  AAAAACCACC  ATTGAAAATA  TCCAGCTGCC  TCACACGTTA  1920
1921  TTATCAAGGT  TTGATTTGAT  ATTCCTCATG  CTGGACCCTC  AGGATGAAGC  CTATGATAGG  1980
1981  CGTCTGGCCC  ACCACCTCGT  CGCTTTGTAC  TACCGGAGCG  AAGAACAAAT  GGAGGAAGAG  2040
2041  TTCATGGACA  TGGCAGTGCT  AAAGGACTAC  ATTGCTTATG  CCCACAGCAT  GGTCATGCCT  2100
2101  CGGCTGAGCC  AGGAAGCCAG  CCAGGCTCTC  ATTGAGGCTT  ATGTAGACAT  GAGGAAGATA  2160
2161  GGTAGCAGCC  GAGGAATGGT  TTCTGCATAC  CCTCGACAGC  TGGAATCATT  AATTCGATTA  2220
2221  GCAGAAGCCC  ATGCTAAAGT  ACGATTCTCA  AGCAAAGTTG  AAGCAGTTGA  TGTTGAAGAA  2280
2281  GCAAAACGCC  TCCATCGGGA  AGCTCTGAAG  CAGTCTGCCA  CTGACCCTCG  GACTGGCATT  2340
2341  GTGGACATAT  CTATTCTGAC  TACAGGAATG  AGTGCTACGT  CTCGTAAACG  GAAAGAAGAG  2400
2401  TTAGCTGAAG  CATTGAAAAA  ACTTATTTTA  TCTAAGGGCA  AGACACCAGC  TCTAAAATAT  2460
2461  CAGCAACTCT  TTGAGGATAT  CCGGGGACAA  TCTGACATAG  CAATTACCAA  AGATATGTTT  2520
2521  GAAGAAGCCC  TGCGTGCCTT  AGCCGATGAT  GACTTCTTAA  CAGTAACTGG  CAAAACTGTC  2580
2581  CGCTTGCTCT  GA  2592

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Urm-2822Ursus maritimus97.030.01642
LLPS-Mup-0171Mustela putorius furo96.790.01636
LLPS-Aim-0629Ailuropoda melanoleuca96.560.01639
LLPS-Fec-2356Felis catus96.080.01634
LLPS-Eqc-1082Equus caballus95.250.01596
LLPS-Ict-4652Ictidomys tridecemlineatus94.50.01596
LLPS-Myl-0462Myotis lucifugus94.430.01601
LLPS-Poa-2313Pongo abelii94.420.01606
LLPS-Rhb-1865Rhinopithecus bieti94.420.01608
LLPS-Dio-0078Dipodomys ordii94.30.01605
LLPS-Pat-0473Pan troglodytes94.30.01604
LLPS-Pap-2542Pan paniscus94.270.01595
LLPS-Gog-1858Gorilla gorilla94.160.01593
LLPS-Orc-0651Oryctolagus cuniculus94.070.01593
LLPS-Paa-0233Papio anubis94.060.01598
LLPS-Mal-1475Mandrillus leucophaeus94.060.01598
LLPS-Chs-3111Chlorocebus sabaeus94.060.01602
LLPS-Cea-0173Cercocebus atys94.060.01598
LLPS-Nol-0741Nomascus leucogenys94.060.01602
LLPS-Man-0613Macaca nemestrina94.060.01598
LLPS-Caj-0320Callithrix jacchus93.940.01604
LLPS-Mam-2743Macaca mulatta93.940.01597
LLPS-Otg-0208Otolemur garnettii93.940.01587
LLPS-Maf-1726Macaca fascicularis93.820.01594
LLPS-Fud-2613Fukomys damarensis93.590.01595
LLPS-Cas-0165Carlito syrichta93.590.01579
LLPS-Cap-0400Cavia porcellus93.00.01578
LLPS-Loa-0437Loxodonta africana92.870.01576
LLPS-Mum-1054Mus musculus92.730.01543
LLPS-Ran-0325Rattus norvegicus92.470.01541
LLPS-Aon-1607Aotus nancymaae92.440.01568
LLPS-Mod-0857Monodelphis domestica92.030.01571
LLPS-Mea-2431Mesocricetus auratus91.810.01551
LLPS-Ora-2843Ornithorhynchus anatinus91.680.01563
LLPS-Sus-1471Sus scrofa91.650.01508
LLPS-Sah-1564Sarcophilus harrisii90.270.01181
LLPS-Bot-1830Bos taurus90.110.01520
LLPS-Hos-1331Homo sapiens90.030.01583
LLPS-Pes-1330Pelodiscus sinensis87.330.01457
LLPS-Fia-0056Ficedula albicollis87.10.01439
LLPS-Tag-0343Taeniopygia guttata86.480.01482
LLPS-Gaga-0117Gallus gallus85.60.01469
LLPS-Lac-2147Latimeria chalumnae84.540.01394
LLPS-Anc-0622Anolis carolinensis84.190.01457
LLPS-Orn-2048Oreochromis niloticus82.560.01421
LLPS-Scf-0506Scleropages formosus82.420.01415
LLPS-Orl-1296Oryzias latipes82.350.01365
LLPS-Ten-1648Tetraodon nigroviridis82.250.01410
LLPS-Asm-0992Astyanax mexicanus82.00.01370
LLPS-Pof-0534Poecilia formosa81.90.01409
LLPS-Xim-1483Xiphophorus maculatus81.790.01411
LLPS-Tar-0561Takifugu rubripes81.611e-30 134
LLPS-Scm-0500Scophthalmus maximus81.610.01401
LLPS-Dar-1462Danio rerio80.980.01388
LLPS-Gaa-1784Gasterosteus aculeatus80.360.01389
LLPS-Icp-2463Ictalurus punctatus80.050.01368
LLPS-Cii-0760Ciona intestinalis63.390.0 962
LLPS-Drm-0928Drosophila melanogaster63.180.01054
LLPS-Cis-0377Ciona savignyi59.780.0 963
LLPS-Cae-0115Caenorhabditis elegans52.230.0 831
LLPS-Cog-0375Colletotrichum gloeosporioides51.10.0 611
LLPS-Via-0885Vigna angularis49.770.0 650
LLPS-Osl-0442Ostreococcus lucimarinus49.420.0 672
LLPS-Prp-0669Prunus persica49.390.0 649
LLPS-Vir-0209Vigna radiata49.10.0 643
LLPS-Kop-1067Komagataella pastoris48.910.0 635
LLPS-Sob-1252Sorghum bicolor48.630.0 642
LLPS-Asn-0398Aspergillus nidulans48.34e-169 509
LLPS-Zem-0787Zea mays48.220.0 638
LLPS-Orm-1057Oryza meridionalis48.150.0 640
LLPS-Ors-0503Oryza sativa48.150.0 651
LLPS-Put-1139Puccinia triticina48.110.0 599
LLPS-Tru-1257Triticum urartu48.050.0 622
LLPS-Sei-0418Setaria italica48.020.0 636
LLPS-Scc-1028Schizosaccharomyces cryophilus48.020.0 669
LLPS-Orbr-1310Oryza brachyantha48.020.0 652
LLPS-Gor-0096Gossypium raimondii48.010.0 664
LLPS-Dac-0700Daucus carota47.780.0 654
LLPS-Coc-0651Corchorus capsularis47.680.0 648
LLPS-Pot-0948Populus trichocarpa47.680.0 645
LLPS-Orgl-1098Oryza glumaepatula47.610.0 623
LLPS-Orni-0336Oryza nivara47.610.0 623
LLPS-Orr-1640Oryza rufipogon47.610.0 634
LLPS-Nia-0446Nicotiana attenuata47.530.0 651
LLPS-Brd-1142Brachypodium distachyon47.470.0 644
LLPS-Hea-0546Helianthus annuus47.470.0 640
LLPS-Lep-0697Leersia perrieri47.40.0 628
LLPS-Viv-0427Vitis vinifera47.40.0 645
LLPS-Orb-0904Oryza barthii47.330.0 622
LLPS-Cus-0903Cucumis sativus47.320.0 649
LLPS-Amt-1997Amborella trichopoda47.240.0 599
LLPS-Asc-0435Aspergillus clavatus47.160.0 670
LLPS-Hov-0941Hordeum vulgare47.060.0 644
LLPS-Tum-1185Tuber melanosporum47.050.0 648
LLPS-Asni-0028Aspergillus niger47.010.0 672
LLPS-Tra-0796Triticum aestivum46.920.0 645
LLPS-Scj-0309Schizosaccharomyces japonicus46.760.0 640
LLPS-Mua-0639Musa acuminata46.680.0 644
LLPS-Ori-0601Oryza indica46.640.0 615
LLPS-Asfu-0177Aspergillus fumigatus46.630.0 670
LLPS-Nef-0430Neosartorya fischeri46.510.0 671
LLPS-Mae-1092Manihot esculenta46.50.0 647
LLPS-Sac-0428Saccharomyces cerevisiae46.460.0 650
LLPS-Ast-0720Aspergillus terreus46.430.0 657
LLPS-Sem-0130Selaginella moellendorffii46.320.0 686
LLPS-Php-0221Physcomitrella patens46.180.0 680
LLPS-Mel-0144Melampsora laricipopulina46.10.0 628
LLPS-Orp-0228Oryza punctata45.880.0 590
LLPS-Met-0926Medicago truncatula45.750.0 667
LLPS-Aso-0883Aspergillus oryzae45.520.0 659
LLPS-Asf-0005Aspergillus flavus45.520.0 659
LLPS-Glm-0989Glycine max45.490.0 659
LLPS-Chc-0248Chondrus crispus45.450.0 603
LLPS-Bro-0271Brassica oleracea45.40.0 650
LLPS-Scp-0314Schizosaccharomyces pombe45.350.0 646
LLPS-Blg-0561Blumeria graminis45.330.0 670
LLPS-Phv-0155Phaseolus vulgaris45.330.0 656
LLPS-Sot-0474Solanum tuberosum45.040.0 667
LLPS-Trv-0249Trichoderma virens44.840.0 637
LLPS-Brn-1699Brassica napus44.770.0 641
LLPS-Nec-0080Neurospora crassa44.670.0 629
LLPS-Mao-0652Magnaporthe oryzae44.570.0 641
LLPS-Zyt-1094Zymoseptoria tritici44.50.0 646
LLPS-Sol-0317Solanum lycopersicum44.50.0 659
LLPS-Beb-0479Beauveria bassiana44.460.0 630
LLPS-Fus-0479Fusarium solani44.420.0 620
LLPS-Pyt-0431Pyrenophora teres44.310.0 641
LLPS-Pytr-0570Pyrenophora triticirepentis44.180.0 637
LLPS-Ved-1197Verticillium dahliae44.170.0 641
LLPS-Gas-0073Galdieria sulphuraria44.110.0 632
LLPS-Scs-0959Sclerotinia sclerotiorum44.060.0 631
LLPS-Thc-0922Theobroma cacao43.930.0 649
LLPS-Gag-0505Gaeumannomyces graminis43.770.0 638
LLPS-Cogr-0244Colletotrichum graminicola43.750.0 629
LLPS-Asg-0076Ashbya gossypii43.690.0 630
LLPS-Phn-0079Phaeosphaeria nodorum43.680.0 634
LLPS-Brr-1105Brassica rapa43.560.0 645
LLPS-Cym-0633Cyanidioschyzon merolae43.410.0 609
LLPS-Crn-0522Cryptococcus neoformans43.350.0 630
LLPS-Coo-0441Colletotrichum orbiculare43.180.0 620
LLPS-Spr-0118Sporisorium reilianum43.170.0 618
LLPS-Usm-0025Ustilago maydis42.940.0 617
LLPS-Lem-0530Leptosphaeria maculans42.760.0 646
LLPS-Yal-0457Yarrowia lipolytica42.680.0 652
LLPS-Arl-0898Arabidopsis lyrata42.620.0 652
LLPS-Art-2952Arabidopsis thaliana42.250.0 651
LLPS-Fuv-0562Fusarium verticillioides42.180.0 619
LLPS-Pug-0357Puccinia graminis41.770.0 615
LLPS-Trr-0366Trichoderma reesei41.660.0 640
LLPS-Dos-0525Dothistroma septosporum41.590.0 627
LLPS-Chr-0815Chlamydomonas reinhardtii41.432e-172 533
LLPS-Fuo-0068Fusarium oxysporum41.330.0 626
LLPS-Miv-0037Microbotryum violaceum40.460.0 609
LLPS-Abg-1663Absidia glauca36.656e-105 347
LLPS-Xet-0434Xenopus tropicalis35.978e-102 339
LLPS-Map-0424Magnaporthe poae35.933e-105 348
LLPS-Org-0164Oryza glaberrima35.442e-101 340