• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Anc-0622
MCM4

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA helicase
Gene Name: MCM4
Ensembl Gene: ENSACAG00000012157.3
Ensembl Protein: ENSACAP00000012052.3
Organism: Anolis carolinensis
Taxa ID: 28377
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Chromatin, Nucleolus, Centrosome/Spindle pole body, Stress granule, OthersPredicted from orthologs(View)

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSPASTPSR  RRGSKRQRSD  PTDNGAANPL  SDDVQSPASQ  RRRPDDSTST  GELQPMPTSP  60
61    PINTQSPNVQ  DTLFSSPPQF  QHSVPLDFDI  SSPLTYGTPS  SRVEGTPRSG  ARGTPIRQRA  120
121   DLGSVRKTRQ  VDLHSDVPTG  EDAMASEQSI  GQKLVIWGTD  VNVASCKEKF  QRFLQRFIDP  180
181   TAPEEENIGL  DLNEPLYMQR  LEEINLIGEP  FLNVNCDHLK  SFDENLYRQL  MCYPQEVIPT  240
241   FDMAVNEIFF  DRYPDSVLEH  QIQVRPFNAL  RTRNMRSLNP  EDIDQLITIN  GMVIRSSQLI  300
301   PEMQEAFFKC  QVCGFTTRVE  IDRGRIAEPS  ACKNCNTTHS  MALIHNRSLF  SDKQMIKLQE  360
361   SPDDMPAGQT  PYTIVLFAHN  DLVDKVQPGD  RINVTGIYRA  VPVRVIPRMS  SVRAVYKTHI  420
421   DVIHYCKTDS  KRLHGIEEGT  EQKIFTEQRE  KMLQELSRKP  DIYDRLSSAL  APSIYEHEDI  480
481   KKGILLQLFG  GSRKDFSHTG  RGNFRAEINI  LLCGDPGTSK  SQLLQYVYNL  VPRGQYTSGK  540
541   GSSAVGLTAY  VMKDPETRQL  VLQTGALVLS  DNGICCIDEF  DKMSESTRSV  LHEVMEQQTL  600
601   SIAKAGIICQ  LNARTSILAA  ANPIESQWNP  KKTTIENIQL  PHTLLSRFDL  IFLMLDPRDE  660
661   AYDRRLAHHL  VALYYQTEEQ  LEEEYMDMTV  LRDYIAYART  YVNPRLSEEA  SQALIEAYVD  720
721   MRKIGSGRGM  VSAYPRQLES  LIRLAEAHAK  VRFSAKVETI  DVEEAKRLHR  EALKQSATDP  780
781   RTGIVDISIL  TTGMSATARK  RKEELAQALK  KLIQSKGKTP  ALRYQQLFDD  LRAQSETAVT  840
841   KEMFEEALHA  LADDDFLTVT  GKTVRLL  867
Nucleotide CDS Sequence (FASTA)
1     ATGTCCTCGC  CGGCATCGAC  CCCCAGCCGC  CGCCGCGGCA  GCAAGCGACA  GAGATCCGAC  60
61    CCGACCGACA  ATGGCGCGGC  CAACCCACTT  TCTGATGATG  TACAATCCCC  TGCATCTCAG  120
121   CGACGTCGCC  CAGATGATTC  CACATCCACA  GGAGAGTTGC  AGCCAATGCC  GACTTCTCCT  180
181   CCAATTAACA  CACAAAGTCC  AAATGTTCAA  GATACTTTGT  TTTCCAGTCC  TCCACAATTC  240
241   CAGCATTCAG  TTCCACTGGA  CTTTGATATT  AGTTCACCAC  TGACTTATGG  CACACCCAGC  300
301   TCTAGAGTGG  AGGGAACCCC  AAGGAGTGGT  GCACGTGGGA  CTCCAATTCG  ACAGAGGGCT  360
361   GATCTTGGCT  CTGTACGCAA  AACCAGGCAG  GTGGATCTTC  ATTCTGATGT  GCCTACAGGA  420
421   GAGGATGCAA  TGGCAAGTGA  GCAGTCTATT  GGACAGAAGC  TTGTGATTTG  GGGCACAGAT  480
481   GTCAATGTGG  CTTCGTGCAA  AGAAAAGTTC  CAGAGGTTTC  TTCAGCGTTT  TATTGATCCA  540
541   ACGGCGCCAG  AAGAAGAAAA  TATTGGACTA  GACCTTAATG  AGCCCCTGTA  TATGCAGAGG  600
601   CTAGAAGAGA  TAAACTTAAT  TGGAGAGCCA  TTTCTTAATG  TGAACTGTGA  CCATCTGAAA  660
661   TCATTTGATG  AAAATCTTTA  CAGACAGCTG  ATGTGCTATC  CACAGGAAGT  TATTCCAACG  720
721   TTTGATATGG  CTGTTAATGA  AATCTTCTTT  GACCGTTACC  CTGACTCCGT  ACTGGAACAT  780
781   CAAATTCAAG  TTAGGCCATT  CAATGCATTA  AGGACCAGAA  ACATGAGGAG  CCTAAATCCA  840
841   GAAGATATTG  ACCAGCTTAT  CACTATAAAT  GGTATGGTGA  TCAGAAGCTC  GCAGTTAATT  900
901   CCAGAAATGC  AAGAAGCTTT  TTTCAAATGC  CAGGTCTGTG  GTTTTACAAC  AAGAGTAGAA  960
961   ATTGATCGTG  GCAGAATTGC  TGAACCATCG  GCGTGCAAGA  ATTGTAACAC  CACACATAGT  1020
1021  ATGGCTTTGA  TTCATAATCG  TTCCCTATTC  TCAGATAAAC  AGATGATCAA  ACTGCAGGAG  1080
1081  TCTCCAGATG  ATATGCCAGC  TGGCCAGACA  CCGTACACAA  TTGTCCTTTT  TGCTCACAAT  1140
1141  GATCTAGTGG  ATAAGGTGCA  GCCTGGTGAC  AGAATAAATG  TTACAGGTAT  ATACAGAGCA  1200
1201  GTTCCTGTTC  GTGTCATTCC  AAGAATGAGC  AGTGTAAGAG  CTGTCTATAA  GACTCACATT  1260
1261  GATGTTATTC  ATTACTGCAA  AACTGACTCA  AAGCGTTTGC  ATGGCATCGA  AGAAGGAACA  1320
1321  GAGCAGAAAA  TATTTACAGA  ACAGCGTGAA  AAAATGCTTC  AGGAGCTTTC  TAGAAAGCCT  1380
1381  GATATTTATG  ATAGGCTTTC  TTCAGCACTT  GCTCCAAGTA  TTTATGAGCA  TGAAGATATT  1440
1441  AAAAAGGGCA  TTCTTCTCCA  GCTGTTCGGA  GGCTCAAGGA  AAGATTTCAG  CCACACTGGT  1500
1501  AGAGGTAACT  TTCGTGCTGA  GATCAACATT  TTGCTTTGTG  GAGATCCTGG  CACCAGTAAA  1560
1561  TCACAGTTGC  TTCAGTATGT  CTATAACCTG  GTTCCAAGAG  GCCAATATAC  ATCTGGAAAA  1620
1621  GGTTCTAGTG  CTGTTGGTCT  CACAGCCTAC  GTGATGAAGG  ATCCTGAAAC  AAGGCAGTTA  1680
1681  GTACTGCAGA  CTGGAGCCTT  GGTCCTCAGT  GACAATGGGA  TTTGCTGTAT  TGATGAGTTT  1740
1741  GATAAAATGA  GTGAAAGCAC  AAGATCAGTT  CTTCATGAAG  TCATGGAGCA  ACAAACACTG  1800
1801  TCTATTGCTA  AGGCTGGAAT  AATTTGCCAA  TTGAATGCTC  GTACCTCCAT  TCTAGCAGCT  1860
1861  GCCAATCCGA  TAGAATCCCA  GTGGAATCCA  AAGAAAACAA  CAATTGAAAA  TATTCAGCTT  1920
1921  CCCCACACCT  TGCTATCTAG  ATTTGATCTA  ATTTTCCTTA  TGCTGGATCC  TCGAGATGAA  1980
1981  GCATATGACA  GACGTTTGGC  TCACCACTTG  GTTGCATTAT  ATTATCAAAC  TGAAGAACAG  2040
2041  TTGGAAGAGG  AGTACATGGA  TATGACAGTT  TTAAGAGATT  ATATTGCTTA  TGCTCGTACC  2100
2101  TATGTCAATC  CACGACTAAG  TGAAGAAGCA  AGTCAAGCTC  TTATTGAGGC  ATATGTTGAT  2160
2161  ATGCGAAAGA  TTGGAAGTGG  TAGAGGAATG  GTTTCTGCCT  ATCCTCGGCA  GCTGGAATCA  2220
2221  TTGATTCGTC  TTGCAGAAGC  TCATGCTAAA  GTCCGTTTCT  CTGCCAAGGT  GGAAACAATA  2280
2281  GATGTAGAGG  AAGCAAAACG  TCTTCATCGT  GAGGCTCTAA  AACAGTCTGC  AACTGATCCA  2340
2341  AGAACTGGGA  TTGTGGATAT  ATCTATCCTG  ACTACAGGAA  TGAGTGCCAC  TGCTCGAAAA  2400
2401  CGTAAGGAAG  AGCTGGCTCA  AGCTTTGAAG  AAGCTTATTC  AGTCGAAGGG  TAAAACACCA  2460
2461  GCTCTAAGAT  ATCAACAGCT  CTTTGATGAT  CTTCGTGCAC  AATCTGAAAC  TGCTGTCACT  2520
2521  AAAGAAATGT  TTGAAGAAGC  ACTTCATGCA  CTGGCTGATG  ACGACTTCTT  GACTGTCACA  2580
2581  GGGAAGACTG  TTAGACTGCT  CTAA  2604

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pes-1330Pelodiscus sinensis90.280.01520
LLPS-Fia-0056Ficedula albicollis89.190.01495
LLPS-Gaga-0117Gallus gallus87.560.01546
LLPS-Tag-0343Taeniopygia guttata87.130.01550
LLPS-Mod-0857Monodelphis domestica87.050.01523
LLPS-Sah-1564Sarcophilus harrisii86.740.01154
LLPS-Ora-2843Ornithorhynchus anatinus86.180.01543
LLPS-Pap-2542Pan paniscus85.440.01489
LLPS-Mup-0171Mustela putorius furo85.410.01488
LLPS-Otg-0208Otolemur garnettii84.950.01483
LLPS-Cas-0165Carlito syrichta84.920.01469
LLPS-Dio-0078Dipodomys ordii84.660.01479
LLPS-Mum-1054Mus musculus84.570.01446
LLPS-Ran-0325Rattus norvegicus84.570.01451
LLPS-Chs-3111Chlorocebus sabaeus84.560.01493
LLPS-Nol-0741Nomascus leucogenys84.330.01494
LLPS-Orc-0651Oryctolagus cuniculus84.230.01496
LLPS-Rhb-1865Rhinopithecus bieti84.220.01507
LLPS-Fec-2356Felis catus84.10.01493
LLPS-Urm-2822Ursus maritimus84.10.01495
LLPS-Pat-0473Pan troglodytes83.990.01498
LLPS-Poa-2313Pongo abelii83.870.01496
LLPS-Aim-0629Ailuropoda melanoleuca83.870.01491
LLPS-Ict-4652Ictidomys tridecemlineatus83.810.01489
LLPS-Myl-0462Myotis lucifugus83.680.01490
LLPS-Man-0613Macaca nemestrina83.640.01486
LLPS-Cea-0173Cercocebus atys83.640.01486
LLPS-Mal-1475Mandrillus leucophaeus83.640.01486
LLPS-Paa-0233Papio anubis83.640.01486
LLPS-Loa-0437Loxodonta africana83.540.01479
LLPS-Mam-2743Macaca mulatta83.530.01485
LLPS-Eqc-1082Equus caballus83.530.01474
LLPS-Maf-1726Macaca fascicularis83.530.01485
LLPS-Caj-0320Callithrix jacchus83.530.01495
LLPS-Fud-2613Fukomys damarensis83.530.01489
LLPS-Gog-1858Gorilla gorilla83.510.01489
LLPS-Cap-0400Cavia porcellus83.310.01474
LLPS-Caf-0584Canis familiaris82.950.01485
LLPS-Mea-2431Mesocricetus auratus82.370.01452
LLPS-Asm-0992Astyanax mexicanus82.20.01400
LLPS-Aon-1607Aotus nancymaae82.130.01459
LLPS-Scf-0506Scleropages formosus81.360.01466
LLPS-Bot-1830Bos taurus81.310.01445
LLPS-Lac-2147Latimeria chalumnae80.960.01441
LLPS-Icp-2463Ictalurus punctatus80.830.01399
LLPS-Orl-1296Oryzias latipes80.780.01391
LLPS-Orn-2048Oreochromis niloticus80.710.01437
LLPS-Scm-0500Scophthalmus maximus80.460.01426
LLPS-Ten-1648Tetraodon nigroviridis80.440.01441
LLPS-Hos-1331Homo sapiens80.090.01476
LLPS-Pof-0534Poecilia formosa79.730.01420
LLPS-Xim-1483Xiphophorus maculatus79.450.01421
LLPS-Gaa-1784Gasterosteus aculeatus79.430.01414
LLPS-Dar-1462Danio rerio79.380.01417
LLPS-Sus-1471Sus scrofa79.190.01424
LLPS-Tar-0561Takifugu rubripes75.540.01023
LLPS-Cii-0760Ciona intestinalis63.140.0 986
LLPS-Drm-0928Drosophila melanogaster61.290.01089
LLPS-Cis-0377Ciona savignyi60.590.01007
LLPS-Cae-0115Caenorhabditis elegans53.340.0 829
LLPS-Cog-0375Colletotrichum gloeosporioides50.230.0 622
LLPS-Pot-0948Populus trichocarpa48.290.0 665
LLPS-Tru-1257Triticum urartu48.130.0 645
LLPS-Asn-0398Aspergillus nidulans47.876e-169 509
LLPS-Orbr-1310Oryza brachyantha47.810.0 669
LLPS-Cus-0903Cucumis sativus47.660.0 656
LLPS-Mae-1092Manihot esculenta47.610.0 661
LLPS-Coc-0651Corchorus capsularis47.610.0 659
LLPS-Kop-1067Komagataella pastoris47.60.0 620
LLPS-Ors-0503Oryza sativa47.540.0 666
LLPS-Hea-0546Helianthus annuus47.540.0 640
LLPS-Via-0885Vigna angularis47.540.0 669
LLPS-Brd-1142Brachypodium distachyon47.540.0 668
LLPS-Dac-0700Daucus carota47.510.0 657
LLPS-Viv-0427Vitis vinifera47.270.0 642
LLPS-Gor-0096Gossypium raimondii47.260.0 672
LLPS-Php-0221Physcomitrella patens47.190.0 700
LLPS-Art-2952Arabidopsis thaliana47.140.0 665
LLPS-Thc-0922Theobroma cacao47.130.0 652
LLPS-Vir-0209Vigna radiata47.090.0 664
LLPS-Bro-0271Brassica oleracea47.060.0 665
LLPS-Arl-0898Arabidopsis lyrata47.00.0 662
LLPS-Orr-1640Oryza rufipogon46.990.0 649
LLPS-Orb-0904Oryza barthii46.990.0 640
LLPS-Orgl-1098Oryza glumaepatula46.990.0 639
LLPS-Tra-0796Triticum aestivum46.990.0 663
LLPS-Hov-0941Hordeum vulgare46.990.0 662
LLPS-Amt-1997Amborella trichopoda46.80.0 598
LLPS-Brn-1699Brassica napus46.790.0 651
LLPS-Nef-0430Neosartorya fischeri46.780.0 672
LLPS-Mua-0639Musa acuminata46.710.0 651
LLPS-Sem-0130Selaginella moellendorffii46.680.0 706
LLPS-Asfu-0177Aspergillus fumigatus46.660.0 668
LLPS-Scp-0314Schizosaccharomyces pombe46.620.0 665
LLPS-Sac-0428Saccharomyces cerevisiae46.60.0 659
LLPS-Asg-0076Ashbya gossypii46.530.0 647
LLPS-Lep-0697Leersia perrieri46.510.0 642
LLPS-Asni-0028Aspergillus niger46.450.0 675
LLPS-Ori-0601Oryza indica46.30.0 615
LLPS-Yal-0457Yarrowia lipolytica46.190.0 663
LLPS-Blg-0561Blumeria graminis46.190.0 687
LLPS-Mel-0144Melampsora laricipopulina46.110.0 644
LLPS-Tum-1185Tuber melanosporum45.990.0 654
LLPS-Met-0926Medicago truncatula45.930.0 667
LLPS-Osl-0442Ostreococcus lucimarinus45.720.0 677
LLPS-Glm-0989Glycine max45.720.0 671
LLPS-Zem-0787Zea mays45.360.0 655
LLPS-Orp-0228Oryza punctata45.340.0 606
LLPS-Phv-0155Phaseolus vulgaris45.330.0 670
LLPS-Sei-0418Setaria italica45.290.0 655
LLPS-Chc-0248Chondrus crispus45.140.0 622
LLPS-Ast-0720Aspergillus terreus45.060.0 659
LLPS-Gas-0073Galdieria sulphuraria45.030.0 674
LLPS-Cym-0633Cyanidioschyzon merolae44.920.0 659
LLPS-Pytr-0570Pyrenophora triticirepentis44.680.0 662
LLPS-Pyt-0431Pyrenophora teres44.560.0 664
LLPS-Trv-0249Trichoderma virens44.470.0 650
LLPS-Scc-1028Schizosaccharomyces cryophilus44.380.0 684
LLPS-Sol-0317Solanum lycopersicum44.340.0 671
LLPS-Sot-0474Solanum tuberosum44.340.0 669
LLPS-Fuv-0562Fusarium verticillioides44.250.0 632
LLPS-Mao-0652Magnaporthe oryzae44.190.0 659
LLPS-Prp-0669Prunus persica44.120.0 660
LLPS-Ved-1197Verticillium dahliae44.10.0 667
LLPS-Scs-0959Sclerotinia sclerotiorum44.060.0 652
LLPS-Brr-1105Brassica rapa43.940.0 648
LLPS-Miv-0037Microbotryum violaceum43.80.0 622
LLPS-Crn-0522Cryptococcus neoformans43.790.0 642
LLPS-Scj-0309Schizosaccharomyces japonicus43.770.0 649
LLPS-Nia-0446Nicotiana attenuata43.60.0 662
LLPS-Spr-0118Sporisorium reilianum43.510.0 635
LLPS-Phn-0079Phaeosphaeria nodorum43.430.0 652
LLPS-Trr-0366Trichoderma reesei42.90.0 650
LLPS-Fuo-0068Fusarium oxysporum42.840.0 641
LLPS-Fus-0479Fusarium solani42.760.0 639
LLPS-Sob-1252Sorghum bicolor42.660.0 644
LLPS-Lem-0530Leptosphaeria maculans42.530.0 666
LLPS-Put-1139Puccinia triticina42.210.0 612
LLPS-Pug-0357Puccinia graminis41.860.0 635
LLPS-Zyt-1094Zymoseptoria tritici41.850.0 657
LLPS-Dos-0525Dothistroma septosporum41.720.0 649
LLPS-Cogr-0244Colletotrichum graminicola41.670.0 654
LLPS-Asc-0435Aspergillus clavatus41.410.0 672
LLPS-Beb-0479Beauveria bassiana41.310.0 658
LLPS-Aso-0883Aspergillus oryzae41.280.0 669
LLPS-Asf-0005Aspergillus flavus41.280.0 670
LLPS-Nec-0080Neurospora crassa41.120.0 655
LLPS-Gag-0505Gaeumannomyces graminis40.850.0 655
LLPS-Coo-0441Colletotrichum orbiculare40.640.0 655
LLPS-Usm-0025Ustilago maydis40.120.0 637
LLPS-Chr-0815Chlamydomonas reinhardtii39.764e-175 540
LLPS-Map-0424Magnaporthe poae36.414e-105 348
LLPS-Abg-0835Absidia glauca36.356e-106 350
LLPS-Xet-0434Xenopus tropicalis35.852e-104 346