• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caf-0238
RUVBL2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: RuvB-like helicase
Gene Name: RUVBL2
Ensembl Gene: ENSCAFG00000003844.4
Ensembl Protein: ENSCAFP00000032477.2
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Cajal body, Nucleolus, Centrosome/Spindle pole body, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     LYPQTATTKV  PEIRDVTRIE  RIGAHSHIRG  LGLDDALEPR  QASQGMVGQL  AARRAAGVVL  60
61    EMIREGKIAG  RAVLIAGQPG  TGKTAIAMGM  AQALGPDTPF  TAIAGSEIFS  LEMSKTEALT  120
121   QAFRRSIGVR  IKEETEIIEG  EVVEIQIDRP  ATGTGSKVGK  LTLKTTEMET  IYDLGTKMIE  180
181   SLTKDKVQAG  DVITIDKATG  KISKLGRSFT  RARDYDAMGS  QTKFVQCPDG  ELQKRKEVVH  240
241   TVSLHEIDVI  NSRTQGFLAL  FSGDTGEIKS  EVREQINAKV  AEWREEGKAE  IIPGVLFIDE  300
301   VHMLDIESFS  FLNRALESDM  APVLIMATNR  GITRIRGTSY  QSPHGIPIDL  LDRLLIVSTS  360
361   PYSEKDTKQI  LRIRCEEEDV  EMSEDAYTVL  TRIGLETSLR  YAIQLITAAS  LVCRKRKGTE  420
421   VQVDDIKRVY  SLFLDESRST  QYMKEYQDAF  LFNELKGETM  DTS  463
Nucleotide CDS Sequence (FASTA)
1     ATGGCAACCG  TGACGGCCAC  AACCAAGGTC  CCAGAGATCC  GAGATGTGAC  AAGAATTGAG  60
61    CGTATTGGTG  CGCACTCCCA  CATCCGGGGA  CTGGGACTGG  ATGATGCCTT  GGAGCCACGG  120
121   CAGGCTTCCC  AGGGCATGGT  GGGGCAGCTG  GCAGCCCGGC  GGGCAGCTGG  TGTTGTGCTG  180
181   GAGATGATCC  GGGAAGGGAA  GATCGCTGGG  CGGGCTGTGC  TCATCGCTGG  CCAGCCGGGC  240
241   ACTGGGAAGA  CGGCTATCGC  CATGGGCATG  GCACAGGCCC  TGGGCCCTGA  CACCCCGTTC  300
301   ACAGCCATCG  CGGGCAGTGA  GATCTTCTCG  CTGGAGATGA  GTAAGACAGA  GGCACTGACC  360
361   CAGGCCTTCC  GGCGCTCTAT  TGGCGTTCGA  ATCAAGGAGG  AGACTGAGAT  CATTGAAGGG  420
421   GAAGTGGTGG  AGATCCAGAT  TGACCGTCCA  GCCACAGGGA  CGGGCTCTAA  GGTCGGCAAG  480
481   CTGACCCTCA  AGACCACAGA  GATGGAGACT  ATATACGACC  TGGGCACCAA  GATGATTGAG  540
541   TCCCTGACTA  AGGACAAGGT  CCAGGCTGGG  GATGTGATTA  CCATCGACAA  GGCCACAGGC  600
601   AAGATCTCCA  AGCTGGGCCG  CTCCTTCACA  CGCGCTCGCG  ACTATGATGC  CATGGGCTCC  660
661   CAGACCAAGT  TTGTGCAGTG  TCCAGACGGA  GAGCTCCAGA  AACGCAAGGA  GGTCGTACAC  720
721   ACCGTGTCCC  TGCATGAGAT  TGATGTCATC  AACTCCCGCA  CCCAGGGCTT  CCTGGCTCTC  780
781   TTCTCAGGCG  ACACAGGGGA  GATCAAGTCA  GAAGTCCGAG  AGCAGATCAA  TGCCAAGGTG  840
841   GCCGAGTGGC  GTGAGGAGGG  CAAGGCTGAG  ATCATCCCTG  GCGTGCTGTT  TATCGACGAG  900
901   GTCCACATGC  TGGACATTGA  GAGCTTCTCC  TTCCTCAATC  GGGCCCTGGA  GAGTGACATG  960
961   GCGCCCGTCC  TCATCATGGC  CACCAACCGA  GGCATCACCC  GGATCCGGGG  TACCAGCTAC  1020
1021  CAGAGCCCCC  ATGGCATCCC  CATCGACCTA  CTAGACCGAC  TGCTCATTGT  CTCCACCTCT  1080
1081  CCCTACAGTG  AGAAGGACAC  AAAGCAGATC  CTACGCATCC  GGTGTGAAGA  GGAAGACGTA  1140
1141  GAAATGAGTG  AGGACGCCTA  CACGGTGCTG  ACGCGCATCG  GCCTGGAGAC  CTCATTACGC  1200
1201  TACGCCATCC  AGCTTATCAC  AGCTGCCAGC  CTGGTGTGCC  GGAAACGCAA  GGGCACGGAA  1260
1261  GTACAGGTAG  ATGACATCAA  ACGGGTCTAC  TCGCTCTTTC  TGGACGAGTC  ACGCTCCACG  1320
1321  CAGTACATGA  AGGAGTACCA  GGATGCCTTT  CTCTTCAACG  AGCTCAAAGG  TGAAACCATG  1380
1381  GACACC  1386

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
DNA damage
DNA recombination
DNA repair
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Reference proteome
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centrosome
Cellular Component
Cytosol
Cellular Component
Ino80 complex
Cellular Component
MLL1 complex
Cellular Component
NuA4 histone acetyltransferase complex
Cellular Component
Nuclear euchromatin
Cellular Component
R2TP complex
Cellular Component
Ribonucleoprotein complex
Cellular Component
Swr1 complex
Molecular Function
ADP binding
Molecular Function
ATP binding
Molecular Function
ATP-dependent 5'-3' DNA helicase activity
Molecular Function
ATP-dependent DNA helicase activity
Molecular Function
ATPase binding
Molecular Function
Beta-catenin binding
Molecular Function
Chromatin DNA binding
Molecular Function
Protein homodimerization activity
Molecular Function
RNA polymerase II core promoter sequence-specific DNA binding
Molecular Function
RNA polymerase II distal enhancer sequence-specific DNA binding
Molecular Function
TBP-class protein binding
Molecular Function
TFIID-class transcription factor complex binding
Molecular Function
Transcription corepressor activity
Biological Process
Box C/D snoRNP assembly
Biological Process
Cellular response to estradiol stimulus
Biological Process
Cellular response to UV
Biological Process
Chromatin remodeling
Biological Process
DNA recombination
Biological Process
DNA repair
Biological Process
Establishment of protein localization to chromatin
Biological Process
Histone acetylation
Biological Process
Histone H2A acetylation
Biological Process
Histone H4 acetylation
Biological Process
Negative regulation of canonical Wnt signaling pathway
Biological Process
Negative regulation of estrogen receptor binding
Biological Process
Positive regulation of histone acetylation
Biological Process
Regulation of transcription by RNA polymerase II
Biological Process
Transcriptional activation by promoter-enhancer looping

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Bot-1184Bos taurus100.00.0 876
LLPS-Ran-1582Rattus norvegicus100.00.0 890
LLPS-Mum-0554Mus musculus100.00.0 890
LLPS-Sus-0612Sus scrofa100.00.0 892
LLPS-Eqc-0366Equus caballus100.00.0 890
LLPS-Ict-0433Ictidomys tridecemlineatus100.00.0 890
LLPS-Fec-0570Felis catus100.00.0 892
LLPS-Ova-0695Ovis aries99.780.0 897
LLPS-Mup-1435Mustela putorius furo99.780.0 889
LLPS-Chs-0060Chlorocebus sabaeus99.780.0 890
LLPS-Gog-0538Gorilla gorilla99.780.0 890
LLPS-Fud-0389Fukomys damarensis99.780.0 890
LLPS-Cap-0417Cavia porcellus99.780.0 874
LLPS-Mam-1132Macaca mulatta99.780.0 890
LLPS-Cas-1190Carlito syrichta99.780.0 889
LLPS-Hos-2560Homo sapiens99.780.0 890
LLPS-Pap-0791Pan paniscus99.780.0 890
LLPS-Urm-1557Ursus maritimus99.780.0 890
LLPS-Pat-1517Pan troglodytes99.780.0 890
LLPS-Man-2304Macaca nemestrina99.780.0 890
LLPS-Rhb-1238Rhinopithecus bieti99.780.0 890
LLPS-Poa-0285Pongo abelii99.760.0 806
LLPS-Otg-0053Otolemur garnettii99.570.0 885
LLPS-Cea-0329Cercocebus atys99.560.0 882
LLPS-Orc-0729Oryctolagus cuniculus99.560.0 889
LLPS-Aon-2355Aotus nancymaae99.550.0 867
LLPS-Nol-0480Nomascus leucogenys99.350.0 885
LLPS-Mod-0597Monodelphis domestica99.130.0 885
LLPS-Dio-0674Dipodomys ordii98.920.0 892
LLPS-Mea-0285Mesocricetus auratus98.910.0 879
LLPS-Myl-0013Myotis lucifugus98.863e-170 487
LLPS-Aim-0161Ailuropoda melanoleuca98.50.0 887
LLPS-Paa-0398Papio anubis98.270.0 880
LLPS-Mal-1471Mandrillus leucophaeus98.270.0 880
LLPS-Maf-0596Macaca fascicularis98.270.0 880
LLPS-Caj-1248Callithrix jacchus98.250.0 871
LLPS-Tut-0917Tursiops truncatus95.420.0 836
LLPS-Anc-1614Anolis carolinensis94.980.0 859
LLPS-Xet-1640Xenopus tropicalis94.760.0 860
LLPS-Gaga-0073Gallus gallus94.680.0 841
LLPS-Lac-1465Latimeria chalumnae94.530.0 856
LLPS-Loa-1046Loxodonta africana91.30.0 795
LLPS-Gaa-0101Gasterosteus aculeatus89.330.0 783
LLPS-Orl-1845Oryzias latipes89.080.0 799
LLPS-Orn-0380Oreochromis niloticus89.080.0 797
LLPS-Xim-0122Xiphophorus maculatus88.860.0 796
LLPS-Pof-1021Poecilia formosa88.650.0 791
LLPS-Leo-2092Lepisosteus oculatus88.550.0 783
LLPS-Dar-1958Danio rerio87.90.0 798
LLPS-Icp-0800Ictalurus punctatus87.690.0 788
LLPS-Asm-1348Astyanax mexicanus87.690.0 812
LLPS-Scf-2453Scleropages formosus87.260.0 785
LLPS-Ten-0934Tetraodon nigroviridis87.060.0 798
LLPS-Tar-0411Takifugu rubripes85.840.0 548
LLPS-Cii-0237Ciona intestinalis85.330.0 758
LLPS-Cis-1206Ciona savignyi82.890.0 546
LLPS-Abg-0480Absidia glauca79.730.0 694
LLPS-Chr-0555Chlamydomonas reinhardtii78.850.0 719
LLPS-Php-0160Physcomitrella patens78.490.0 710
LLPS-Amt-0063Amborella trichopoda78.410.0 713
LLPS-Gor-1803Gossypium raimondii78.220.0 701
LLPS-Drm-0931Drosophila melanogaster78.150.0 707
LLPS-Coc-1380Corchorus capsularis77.780.0 699
LLPS-Sem-0229Selaginella moellendorffii77.610.0 660
LLPS-Thc-0607Theobroma cacao77.330.0 694
LLPS-Hea-2318Helianthus annuus77.180.0 696
LLPS-Mae-0500Manihot esculenta77.110.0 680
LLPS-Cus-1038Cucumis sativus76.960.0 680
LLPS-Glm-0708Glycine max76.890.0 698
LLPS-Via-0550Vigna angularis76.440.0 692
LLPS-Brr-1137Brassica rapa76.220.0 694
LLPS-Art-0872Arabidopsis thaliana76.220.0 692
LLPS-Met-1702Medicago truncatula76.060.0 692
LLPS-Vir-0171Vigna radiata76.054e-177 509
LLPS-Arl-1326Arabidopsis lyrata76.00.0 691
LLPS-Phv-0108Phaseolus vulgaris76.00.0 693
LLPS-Bro-0549Brassica oleracea75.780.0 692
LLPS-Nia-0210Nicotiana attenuata75.610.0 697
LLPS-Pot-0629Populus trichocarpa75.560.0 686
LLPS-Chc-1105Chondrus crispus75.390.0 656
LLPS-Sot-0320Solanum tuberosum75.220.0 693
LLPS-Prp-0773Prunus persica75.160.0 672
LLPS-Sol-0288Solanum lycopersicum75.00.0 693
LLPS-Dac-0348Daucus carota74.840.0 677
LLPS-Miv-0195Microbotryum violaceum74.710.0 632
LLPS-Usm-0507Ustilago maydis73.210.0 637
LLPS-Spr-0393Sporisorium reilianum72.750.0 635
LLPS-Orb-0517Oryza barthii72.641e-162 469
LLPS-Kop-0259Komagataella pastoris72.510.0 609
LLPS-Mel-0719Melampsora laricipopulina72.360.0 648
LLPS-Sei-1790Setaria italica72.290.0 667
LLPS-Scp-0245Schizosaccharomyces pombe71.850.0 642
LLPS-Orbr-0425Oryza brachyantha71.650.0 664
LLPS-Sob-0378Sorghum bicolor71.610.0 665
LLPS-Orni-0232Oryza nivara71.550.0 669
LLPS-Orgl-0979Oryza glumaepatula71.490.0 662
LLPS-Orm-0527Oryza meridionalis71.490.0 667
LLPS-Brd-0323Brachypodium distachyon71.430.0 664
LLPS-Pug-0378Puccinia graminis71.330.0 640
LLPS-Orr-0418Oryza rufipogon71.240.0 669
LLPS-Org-0712Oryza glaberrima71.240.0 669
LLPS-Ors-0205Oryza sativa71.240.0 669
LLPS-Scj-0039Schizosaccharomyces japonicus71.230.0 632
LLPS-Gas-0621Galdieria sulphuraria71.210.0 668
LLPS-Asg-0078Ashbya gossypii71.160.0 615
LLPS-Lep-0279Leersia perrieri71.150.0 664
LLPS-Orp-1212Oryza punctata71.130.0 541
LLPS-Osl-0422Ostreococcus lucimarinus70.950.0 641
LLPS-Zem-0817Zea mays70.910.0 660
LLPS-Scc-0247Schizosaccharomyces cryophilus70.710.0 629
LLPS-Tra-2053Triticum aestivum70.50.0 656
LLPS-Tru-0179Triticum urartu70.280.0 600
LLPS-Asc-0013Aspergillus clavatus69.210.0 619
LLPS-Nef-0042Neosartorya fischeri69.210.0 618
LLPS-Ast-0791Aspergillus terreus68.990.0 618
LLPS-Tum-0705Tuber melanosporum68.970.0 604
LLPS-Sac-0315Saccharomyces cerevisiae68.760.0 615
LLPS-Pyt-0690Pyrenophora teres68.710.0 607
LLPS-Pytr-0517Pyrenophora triticirepentis68.710.0 607
LLPS-Nec-0162Neurospora crassa68.560.0 603
LLPS-Asfu-0383Aspergillus fumigatus68.530.0 618
LLPS-Asf-0374Aspergillus flavus68.30.0 619
LLPS-Asni-0167Aspergillus niger68.080.0 616
LLPS-Beb-0921Beauveria bassiana68.050.0 595
LLPS-Crn-0032Cryptococcus neoformans67.870.0 603
LLPS-Lem-0150Leptosphaeria maculans67.860.0 602
LLPS-Scs-0579Sclerotinia sclerotiorum67.560.0 618
LLPS-Blg-0499Blumeria graminis67.490.0 603
LLPS-Ori-1018Oryza indica67.460.0 613
LLPS-Fuv-0290Fusarium verticillioides67.420.0 602
LLPS-Fuo-0272Fusarium oxysporum67.420.0 602
LLPS-Cogr-0911Colletotrichum graminicola67.260.0 605
LLPS-Fus-0566Fusarium solani67.190.0 600
LLPS-Trv-0110Trichoderma virens67.120.0 598
LLPS-Trr-0507Trichoderma reesei66.890.0 596
LLPS-Coo-0721Colletotrichum orbiculare66.810.0 617
LLPS-Asn-1091Aspergillus nidulans66.810.0 619
LLPS-Mao-0609Magnaporthe oryzae66.810.0 600
LLPS-Yal-0176Yarrowia lipolytica66.380.0 606
LLPS-Map-0188Magnaporthe poae66.160.0 606
LLPS-Ved-0006Verticillium dahliae66.160.0 603
LLPS-Cog-0220Colletotrichum gloeosporioides66.160.0 602
LLPS-Zyt-0084Zymoseptoria tritici65.840.0 588
LLPS-Put-0238Puccinia triticina65.750.0 538
LLPS-Phn-0024Phaeosphaeria nodorum65.650.0 594
LLPS-Dos-0437Dothistroma septosporum65.170.0 584
LLPS-Mua-0398Musa acuminata65.070.0 565
LLPS-Gag-0334Gaeumannomyces graminis64.680.0 598
LLPS-Brn-0208Brassica napus63.594e-148 433
LLPS-Cym-0086Cyanidioschyzon merolae59.390.0 553
LLPS-Cae-0051Caenorhabditis elegans58.970.0 540
LLPS-Viv-0943Vitis vinifera42.952e-116 357
LLPS-Scm-0883Scophthalmus maximus42.323e-119 364
LLPS-Meg-0758Meleagris gallopavo41.232e-116 357