LLPS-Cae-1875
cit-1.1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Cyclin-T1.1 |
| Gene Name: | cit-1.1, F44B9.4 |
| Ensembl Gene: | WBGene00000507 |
| Ensembl Protein: | F44B9.4c.1 |
| Organism: | Caenorhabditis elegans |
| Taxa ID: | 6239 |
| LLPS Type: | Scaffold |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Droplet, Nuclear speckle | Predicted from orthologs | (View) |
▼ FUNCTION
| Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | F44B9.4c.1 | F44B9.4c.1 |
| Ensembl | F44B9.4c.2 | F44B9.4c.2 |
| Ensembl | F44B9.4a | F44B9.4a |
| Ensembl | F44B9.4b | F44B9.4b |
| UniProt | P34425, CCNT1_CAEEL, Q8IG21, Q8IG22 | |
| GeneBank | FO080400 | CCD63447.1, CCD63446.1, CCD63445.1 |
| RefSeq | NM_066343.4, NM_181927.3, NM_181928.5 | NP_498744.1, NP_871656.1, NP_871657.1 |
| Entrez | 176125 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSVSSRGAAS PAHRTAPTKW LFTKEEMKKT ASIQEGMSRE EELASRQMAA AFIQEMIDGL 60 61 NNVKDPKMKI GHTGLCVAHT HMHRFYYLHS FKKYDYRDVG AACVFLAGKS QECPRKLSHV 120 121 ISVWRERKDR KQLTTETARN EAAQIIVLLE SMILQTIAFD LNVHLPHIYV LDIMKKVDKK 180 181 EHYRPLTSCA YYFATDVIAV TDWSLRYSAA SMSIVIIHLM AAYANVRIER LFADFINEDS 240 241 PWYAKFDETM TNEKLREMEV DFLVTYRNSC QFHHASKFNF REHRPMLENP DVRKLDRTRD 300 301 ARSHSPMVHH VPDSTVNVRP RAYVPRDELT VERLNKERGV EEERRKRERD RMAGKLDSST 360 361 SSEKRARIDP LANNFVSSSS SSNGKLAPPP IPPQLNFPPP PIVSSGYNHK NQINRKNHEN 420 421 NHTNSSVSPA FVPSARTFDV APMLTPPTAP KLQSADNSDM DLEDGELE 468 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGGTGT CGAGTCGAGG CGCGGCTTCC CCAGCACATC GGACCGCGCC AACCAAATGG 60 61 CTCTTCACCA AAGAGGAGAT GAAAAAGACA GCGAGCATTC AAGAAGGAAT GAGCAGAGAA 120 121 GAAGAACTAG CCTCCCGACA AATGGCCGCC GCGTTCATCC AAGAAATGAT AGATGGATTG 180 181 AACAATGTTA AAGATCCAAA AATGAAAATC GGTCACACGG GTCTTTGCGT TGCACATACA 240 241 CATATGCATC GCTTTTATTA TTTGCATAGC TTCAAAAAGT ATGATTATAG AGACGTAGGT 300 301 GCTGCTTGTG TATTTTTAGC GGGTAAAAGT CAGGAGTGTC CAAGAAAATT ATCACATGTG 360 361 ATCAGTGTAT GGCGGGAGCG AAAGGATAGA AAACAATTGA CGACGGAAAC TGCTAGGAAT 420 421 GAAGCAGCCC AAATTATTGT TCTTCTGGAG AGCATGATTC TACAGACAAT CGCATTCGAT 480 481 CTCAACGTTC ATCTTCCTCA TATTTATGTT CTGGATATCA TGAAAAAAGT TGATAAAAAA 540 541 GAGCATTATC GACCTTTGAC ATCTTGCGCC TACTATTTTG CCACAGACGT AATAGCTGTA 600 601 ACAGACTGGT CACTTCGATA TTCTGCAGCG TCAATGTCTA TTGTAATTAT TCATTTAATG 660 661 GCAGCCTATG CCAATGTCCG GATAGAGCGA TTATTTGCCG ATTTCATCAA TGAAGATTCA 720 721 CCGTGGTATG CGAAATTTGA CGAAACAATG ACGAACGAGA AGCTGAGAGA AATGGAAGTA 780 781 GATTTCCTTG TAACATATCG GAATTCCTGT CAATTTCACC ATGCTTCCAA ATTCAACTTC 840 841 CGTGAACATC GTCCTATGCT GGAGAATCCA GACGTACGGA AATTAGATCG TACGAGAGAT 900 901 GCCAGAAGTC ATAGTCCAAT GGTTCATCAT GTACCTGATT CTACAGTAAA TGTACGACCG 960 961 AGAGCATACG TTCCGAGAGA TGAATTGACA GTTGAAAGAT TAAACAAAGA ACGAGGTGTG 1020 1021 GAAGAAGAAC GTCGGAAACG AGAACGAGAT CGAATGGCTG GAAAACTTGA CAGTTCAACG 1080 1081 AGTAGTGAAA AGCGTGCTCG AATAGATCCA CTTGCCAACA ATTTCGTATC TTCATCATCG 1140 1141 TCATCAAATG GAAAATTGGC CCCACCTCCA ATACCTCCAC AGCTTAATTT TCCGCCACCA 1200 1201 CCAATCGTGT CATCTGGATA TAATCACAAA AATCAGATTA ATCGAAAGAA TCATGAGAAT 1260 1261 AATCATACAA ATTCTTCGGT TTCGCCAGCG TTTGTGCCCA GGTACACATT TCATTAG 1317 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cyclin/CDK positive transcription elongation factor complex | |
Cellular Component | Nucleus | |
Molecular Function | Cyclin-dependent protein serine/threonine kinase activator activity | |
Molecular Function | Cyclin-dependent protein serine/threonine kinase regulator activity | |
Molecular Function | Protein kinase binding | |
Biological Process | Positive regulation of DNA-templated transcription, elongation | |
Biological Process | Regulation of transcription by RNA polymerase II |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Interaction | ||||
| iRefIndex | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Element | ||||
| RAID | microRNA.org | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Xim-1445 | Xiphophorus maculatus | 36.81 | 3e-24 | 103 |
| LLPS-Dio-1750 | Dipodomys ordii | 35.93 | 4e-21 | 95.1 |
| LLPS-Gog-3306 | Gorilla gorilla | 35.62 | 1e-16 | 86.7 |
| LLPS-Fia-0435 | Ficedula albicollis | 33.87 | 8e-22 | 102 |
| LLPS-Lac-0775 | Latimeria chalumnae | 33.2 | 7e-31 | 130 |
| LLPS-Loa-2799 | Loxodonta africana | 33.2 | 4e-30 | 128 |
| LLPS-Cis-2064 | Ciona savignyi | 33.02 | 3e-11 | 65.5 |
| LLPS-Leo-0430 | Lepisosteus oculatus | 32.96 | 8e-34 | 139 |
| LLPS-Scf-1118 | Scleropages formosus | 32.93 | 9e-28 | 120 |
| LLPS-Cas-2680 | Carlito syrichta | 32.8 | 2e-31 | 132 |
| LLPS-Aim-0756 | Ailuropoda melanoleuca | 32.8 | 5e-30 | 127 |
| LLPS-Sus-1743 | Sus scrofa | 32.8 | 2e-31 | 132 |
| LLPS-Caj-1428 | Callithrix jacchus | 32.8 | 3e-31 | 131 |
| LLPS-Urm-1018 | Ursus maritimus | 32.67 | 3e-29 | 125 |
| LLPS-Sah-1746 | Sarcophilus harrisii | 32.53 | 4e-30 | 128 |
| LLPS-Gaa-1884 | Gasterosteus aculeatus | 32.42 | 1e-31 | 132 |
| LLPS-Orl-3247 | Oryzias latipes | 32.42 | 2e-30 | 127 |
| LLPS-Cap-0375 | Cavia porcellus | 32.4 | 2e-30 | 129 |
| LLPS-Poa-3443 | Pongo abelii | 32.4 | 4e-30 | 128 |
| LLPS-Xet-1417 | Xenopus tropicalis | 32.4 | 4e-32 | 133 |
| LLPS-Nol-0718 | Nomascus leucogenys | 32.4 | 3e-30 | 128 |
| LLPS-Ict-0532 | Ictidomys tridecemlineatus | 32.4 | 2e-30 | 129 |
| LLPS-Hos-2246 | Homo sapiens | 32.4 | 3e-30 | 128 |
| LLPS-Pat-3683 | Pan troglodytes | 32.4 | 3e-30 | 128 |
| LLPS-Man-3479 | Macaca nemestrina | 32.4 | 3e-30 | 128 |
| LLPS-Pes-1142 | Pelodiscus sinensis | 32.4 | 4e-18 | 91.7 |
| LLPS-Otg-1945 | Otolemur garnettii | 32.4 | 8e-30 | 127 |
| LLPS-Bot-0763 | Bos taurus | 32.4 | 9e-31 | 130 |
| LLPS-Myl-1142 | Myotis lucifugus | 32.4 | 2e-28 | 123 |
| LLPS-Ova-3845 | Ovis aries | 32.4 | 9e-31 | 130 |
| LLPS-Mup-2003 | Mustela putorius furo | 32.4 | 8e-30 | 127 |
| LLPS-Mal-3660 | Mandrillus leucophaeus | 32.4 | 3e-30 | 128 |
| LLPS-Paa-0939 | Papio anubis | 32.4 | 3e-30 | 128 |
| LLPS-Chs-1547 | Chlorocebus sabaeus | 32.4 | 4e-30 | 128 |
| LLPS-Ora-1773 | Ornithorhynchus anatinus | 32.4 | 1e-30 | 129 |
| LLPS-Maf-0914 | Macaca fascicularis | 32.4 | 3e-30 | 128 |
| LLPS-Cea-4023 | Cercocebus atys | 32.4 | 3e-30 | 128 |
| LLPS-Fud-1521 | Fukomys damarensis | 32.4 | 2e-30 | 129 |
| LLPS-Rhb-1256 | Rhinopithecus bieti | 32.27 | 2e-27 | 119 |
| LLPS-Anc-2343 | Anolis carolinensis | 32.18 | 6e-32 | 133 |
| LLPS-Ran-1032 | Rattus norvegicus | 32.18 | 2e-14 | 79.7 |
| LLPS-Scm-2235 | Scophthalmus maximus | 32.16 | 2e-31 | 131 |
| LLPS-Pof-2159 | Poecilia formosa | 32.16 | 3e-32 | 134 |
| LLPS-Asm-4087 | Astyanax mexicanus | 32.13 | 1e-25 | 114 |
| LLPS-Orn-2276 | Oreochromis niloticus | 32.03 | 7e-32 | 132 |
| LLPS-Caf-0561 | Canis familiaris | 32.0 | 4e-30 | 127 |
| LLPS-Mum-1516 | Mus musculus | 32.0 | 1e-29 | 126 |
| LLPS-Mea-2818 | Mesocricetus auratus | 32.0 | 9e-30 | 127 |
| LLPS-Tag-2683 | Taeniopygia guttata | 31.73 | 2e-30 | 129 |
| LLPS-Dar-2552 | Danio rerio | 31.73 | 6e-31 | 130 |
| LLPS-Gaga-1545 | Gallus gallus | 31.72 | 6e-31 | 130 |
| LLPS-Ten-0106 | Tetraodon nigroviridis | 31.64 | 5e-30 | 127 |
| LLPS-Mod-0256 | Monodelphis domestica | 31.62 | 1e-30 | 130 |
| LLPS-Fec-3894 | Felis catus | 31.62 | 3e-29 | 125 |
| LLPS-Orc-0431 | Oryctolagus cuniculus | 31.6 | 2e-29 | 126 |
| LLPS-Tar-2476 | Takifugu rubripes | 31.33 | 4e-26 | 115 |
| LLPS-Eqc-1363 | Equus caballus | 31.23 | 7e-29 | 124 |
| LLPS-Pap-3867 | Pan paniscus | 31.23 | 2e-29 | 125 |
| LLPS-Aon-3157 | Aotus nancymaae | 31.23 | 1e-28 | 123 |
| LLPS-Pyt-1349 | Pyrenophora teres | 28.57 | 3e-13 | 74.7 |
| LLPS-Scc-0369 | Schizosaccharomyces cryophilus | 28.34 | 8e-13 | 73.6 |
| LLPS-Orbr-0914 | Oryza brachyantha | 27.54 | 8e-16 | 84.0 |
| LLPS-Hov-0741 | Hordeum vulgare | 27.41 | 1e-17 | 89.7 |
| LLPS-Php-2125 | Physcomitrella patens | 27.21 | 2e-17 | 89.4 |
| LLPS-Coc-0814 | Corchorus capsularis | 27.06 | 6e-18 | 91.3 |
| LLPS-Cus-0272 | Cucumis sativus | 26.95 | 1e-18 | 92.4 |
| LLPS-Lem-0490 | Leptosphaeria maculans | 26.89 | 2e-12 | 72.8 |
| LLPS-Pot-0122 | Populus trichocarpa | 26.77 | 3e-16 | 85.5 |
| LLPS-Gor-0088 | Gossypium raimondii | 26.67 | 2e-17 | 89.4 |
| LLPS-Drm-1039 | Drosophila melanogaster | 26.67 | 2e-20 | 96.7 |
| LLPS-Yal-0113 | Yarrowia lipolytica | 26.67 | 2e-11 | 70.1 |
| LLPS-Thc-0816 | Theobroma cacao | 26.67 | 8e-18 | 90.1 |
| LLPS-Tra-0185 | Triticum aestivum | 26.56 | 1e-18 | 92.8 |
| LLPS-Mae-2383 | Manihot esculenta | 26.52 | 1e-17 | 89.7 |
| LLPS-Mel-0463 | Melampsora laricipopulina | 26.46 | 2e-13 | 73.6 |
| LLPS-Prp-0902 | Prunus persica | 26.38 | 7e-17 | 87.4 |
| LLPS-Ori-1311 | Oryza indica | 26.38 | 2e-17 | 88.6 |
| LLPS-Zyt-1561 | Zymoseptoria tritici | 26.34 | 2e-11 | 68.6 |
| LLPS-Bro-1500 | Brassica oleracea | 26.27 | 6e-17 | 87.4 |
| LLPS-Brr-0936 | Brassica rapa | 26.27 | 8e-17 | 87.0 |
| LLPS-Brn-0158 | Brassica napus | 26.27 | 5e-17 | 87.8 |
| LLPS-Brd-2059 | Brachypodium distachyon | 26.2 | 5e-17 | 87.8 |
| LLPS-Orgl-2268 | Oryza glumaepatula | 25.98 | 5e-17 | 87.8 |
| LLPS-Orr-1174 | Oryza rufipogon | 25.96 | 9e-16 | 84.0 |
| LLPS-Orp-1500 | Oryza punctata | 25.96 | 4e-15 | 82.0 |
| LLPS-Orb-1418 | Oryza barthii | 25.96 | 1e-15 | 83.2 |
| LLPS-Orni-0885 | Oryza nivara | 25.96 | 2e-15 | 83.2 |
| LLPS-Phv-2217 | Phaseolus vulgaris | 25.88 | 2e-16 | 85.9 |
| LLPS-Glm-0667 | Glycine max | 25.78 | 5e-17 | 87.8 |
| LLPS-Dac-0791 | Daucus carota | 25.76 | 6e-16 | 84.3 |
| LLPS-Sot-2268 | Solanum tuberosum | 25.73 | 2e-10 | 64.7 |
| LLPS-Hea-1483 | Helianthus annuus | 25.59 | 4e-16 | 84.7 |
| LLPS-Viv-1623 | Vitis vinifera | 25.57 | 6e-16 | 84.3 |
| LLPS-Met-2624 | Medicago truncatula | 25.56 | 6e-17 | 87.4 |
| LLPS-Sob-0592 | Sorghum bicolor | 25.38 | 6e-18 | 90.5 |
| LLPS-Mam-1827 | Macaca mulatta | 24.9 | 3e-18 | 91.3 |
| LLPS-Meg-0787 | Meleagris gallopavo | 24.9 | 6e-18 | 90.9 |
| LLPS-Tut-2183 | Tursiops truncatus | 24.9 | 7e-18 | 90.5 |
| LLPS-Art-2711 | Arabidopsis thaliana | 24.81 | 1e-13 | 77.0 |
| LLPS-Fus-1234 | Fusarium solani | 24.81 | 3e-11 | 69.3 |
| LLPS-Sol-1309 | Solanum lycopersicum | 24.73 | 2e-13 | 76.3 |
| LLPS-Arl-2451 | Arabidopsis lyrata | 24.72 | 7e-14 | 77.8 |
| LLPS-Aso-1429 | Aspergillus oryzae | 23.23 | 1e-09 | 63.9 |
| LLPS-Asf-0094 | Aspergillus flavus | 23.12 | 2e-11 | 70.1 |
| LLPS-Anp-2881 | Anas platyrhynchos | 23.08 | 9e-19 | 92.0 |
| LLPS-Org-2026 | Oryza glaberrima | 22.9 | 4e-10 | 65.9 |
| LLPS-Ors-2291 | Oryza sativa | 22.9 | 3e-10 | 66.2 |
| LLPS-Orm-1960 | Oryza meridionalis | 22.85 | 1e-10 | 67.4 |
| LLPS-Icp-1971 | Ictalurus punctatus | 22.22 | 8e-10 | 65.1 |