LLPS-Cae-1723
sym-2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | RNA-binding protein sym-2; Synthetic lethal with mec-8 protein 2 |
| Gene Name: | sym-2, ZK1067.6 |
| Ensembl Gene: | WBGene00006367 |
| Ensembl Protein: | ZK1067.6a |
| Organism: | Caenorhabditis elegans |
| Taxa ID: | 6239 |
| LLPS Type: | Scaffold |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| mRNA splicing factor that regulates alternative splicing of many genes in embryo. Probably plays a role in the formation of embryo-specific isoforms. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ZK1067.6a | ZK1067.6a |
| Ensembl | ZK1067.6b.2 | ZK1067.6b.2 |
| Ensembl | ZK1067.6b.1 | ZK1067.6b.1 |
| UniProt | Q22708, SYM2_CAEEL, Q23391, Q86GJ8 | |
| GeneBank | Z70038, AY220985, Z68319 | CAA93887.2, AAO65265.1 |
| RefSeq | NM_063559.6 | NP_495960.2 |
| Entrez | 174461 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MNRQTSHPEQ RLLLIRVSDG NYDENTKLVV TSFYPRRQED ANNNSTSPSS ASSSGSEIST 60 61 RLVNITPEDV VKFFDEHPTS SYIFTKGPEP IRHVLIPLFA RNELCVPHPL HHYYDIKHLY 120 121 YGNQEEDGME QEEIEDDVAI ARAILDMDDE LLEKTHQFVN IEYQPAPILE DQEVGADGDN 180 181 VVCRARGLPW QASDHHVAQF FAGLDIVPGG IALCLSSEGR RNGEVLVQFS SQESRDLALK 240 241 RHRNFLLSRY IEVYKAGLDE FMHVATGSST EAMEFVSANA IIVRMRGLPY DCTDAQIRTF 300 301 FEPLKLTDKI LFITRTDGRP TGDAFVQFET EEDAQQGLLK HRQVIGQRYI ELFKSTAAEV 360 361 QQVVKRCNLI NSSPAVANAV EAPEEKKKDC VRLRGLPYEA TVQHIVTFLG DFATMVKFQG 420 421 VHMVYNNQGH PSGEAFIQMI NEQAASACAA GVHNNFMSVG KKKRYIEVFQ ASAEELNLHH 480 481 LVGQQHQVPP PAPLGFMGQL PPQAPQPQQF WSSYPSPPIS PIVPGQVTQL IIYGIHMSIG 540 541 VPELVANFTT PEHTVDNVLF TRWPTHLCPG EAILTLRNRG APPPQTSPLS QISQLSAPNF 600 601 AAYSHHPQNF PLQPILME 618 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAATTTG TGAGCGCCAA TGCAATTATT GTTCGGATGA GAGGATTGCC TTATGATTGT 60 61 ACTGATGCTC AGATTAGAAC ATTCTTCGAA CCACTAAAAC TTACGGACAA AATCTTATTC 120 121 ATCACCAGAA CTGATGGACG ACCCACAGGC GACGCATTTG TTCAATTCGA AACCGAAGAG 180 181 GATGCCCAAC AGGGTCTTCT GAAGCATCGC CAAGTCATCG GACAACGCTA CATTGAGCTC 240 241 TTCAAGAGCA CGGCGGCCGA AGTTCAACAA GTTGTGAAAA GATGCAATCT GATTAATAGC 300 301 TCTCCAGCAG TAGCAAATGC TGTTGAAGCA CCGGAAGAGA AAAAGAAGGA TTGTGTACGC 360 361 CTACGTGGAT TGCCTTATGA AGCTACTGTG CAACATATCG TCACATTCCT TGGTGACTTT 420 421 GCAACAATGG TAAAGTTCCA AGGTGTTCAT ATGGTATACA ACAATCAAGG TCATCCATCA 480 481 GGTGAAGCAT TCATTCAAAT GATCAATGAG CAAGCGGCTT CTGCCTGCGC TGCTGGAGTT 540 541 CACAATAACT TTATGTCTGT TGGCAAAAAG AAGAGATACA TCGAAGTATT CCAAGCATCT 600 601 GCTGAGGAGC TTAACCTTCA TCATCTGGTT GGTCAACAAC ATCAGGTTCC ACCACCGGCT 660 661 CCATTGGGTT TCATGGGGCA GCTGCCACCA CAGGCACCAC AACCACAACA GTTCTGGTCA 720 721 AGTTACCCAT CTCCACCAAT TTCACCAATT GTGCCAGGGC AGGTTACCCA ATTGATTATC 780 781 TATGGTATCC ATATGAGCAT CGGAGTTCCT GAGCTGGTGG CTAATTTCAC AACACCGGAA 840 841 CATACTGTTG ATAATGTCCT ATTCACACGT TGGCCAACTC ATTTGTGTCC GGGAGAAGCC 900 901 ATTTTGACGC TCCGCAATCG TGGTGCTCCA CCGCCTCAAA CGAGCCCATT ATCACAAATT 960 961 TCTCAGTTAT CTGCTCCGAA CTTCGCTGCT TATTCTCACC ATCCACAAAA CTTCCCACTT 1020 1021 CAACCGATTT TGATGGAATA G 1041 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | RNA binding | |
Biological Process | Embryo development ending in birth or egg hatching | |
Biological Process | Embryonic body morphogenesis | |
Biological Process | MRNA processing | |
Biological Process | Multicellular organismal movement | |
Biological Process | Regulation of RNA splicing | |
Biological Process | RNA splicing |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Drm-0081 | Drosophila melanogaster | 56.88 | 1e-27 | 123 |
| LLPS-Orn-1328 | Oreochromis niloticus | 51.55 | 1e-91 | 305 |
| LLPS-Scm-1476 | Scophthalmus maximus | 51.24 | 3e-88 | 298 |
| LLPS-Fud-2842 | Fukomys damarensis | 51.1 | 9e-93 | 305 |
| LLPS-Bot-1741 | Bos taurus | 51.1 | 1e-92 | 306 |
| LLPS-Nol-3008 | Nomascus leucogenys | 51.1 | 2e-92 | 306 |
| LLPS-Ran-2730 | Rattus norvegicus | 51.05 | 3e-92 | 305 |
| LLPS-Caf-4314 | Canis familiaris | 50.96 | 2e-92 | 304 |
| LLPS-Tut-1965 | Tursiops truncatus | 50.63 | 4e-92 | 305 |
| LLPS-Aon-1238 | Aotus nancymaae | 50.45 | 1e-93 | 309 |
| LLPS-Gog-1256 | Gorilla gorilla | 50.15 | 1e-93 | 309 |
| LLPS-Icp-0392 | Ictalurus punctatus | 50.15 | 8e-94 | 310 |
| LLPS-Caj-4168 | Callithrix jacchus | 50.15 | 2e-92 | 308 |
| LLPS-Chs-3462 | Chlorocebus sabaeus | 50.15 | 9e-94 | 309 |
| LLPS-Maf-4076 | Macaca fascicularis | 50.15 | 1e-93 | 309 |
| LLPS-Cea-1218 | Cercocebus atys | 50.15 | 1e-93 | 309 |
| LLPS-Ova-3491 | Ovis aries | 50.15 | 6e-93 | 308 |
| LLPS-Mup-3623 | Mustela putorius furo | 50.15 | 6e-92 | 306 |
| LLPS-Paa-1368 | Papio anubis | 50.15 | 1e-93 | 309 |
| LLPS-Mal-0032 | Mandrillus leucophaeus | 50.15 | 1e-93 | 309 |
| LLPS-Dio-1414 | Dipodomys ordii | 50.15 | 1e-93 | 309 |
| LLPS-Orc-1461 | Oryctolagus cuniculus | 50.15 | 2e-93 | 309 |
| LLPS-Pap-2405 | Pan paniscus | 50.15 | 1e-93 | 309 |
| LLPS-Pat-2989 | Pan troglodytes | 50.15 | 1e-93 | 309 |
| LLPS-Hos-4301 | Homo sapiens | 50.15 | 1e-93 | 309 |
| LLPS-Man-2197 | Macaca nemestrina | 50.15 | 1e-93 | 309 |
| LLPS-Poa-4200 | Pongo abelii | 50.15 | 4e-93 | 309 |
| LLPS-Mam-4217 | Macaca mulatta | 50.15 | 1e-93 | 309 |
| LLPS-Pof-3837 | Poecilia formosa | 50.0 | 3e-88 | 296 |
| LLPS-Mea-3289 | Mesocricetus auratus | 49.85 | 3e-93 | 308 |
| LLPS-Sus-2624 | Sus scrofa | 49.85 | 2e-93 | 308 |
| LLPS-Rhb-3906 | Rhinopithecus bieti | 49.85 | 2e-93 | 308 |
| LLPS-Loa-1555 | Loxodonta africana | 49.85 | 2e-93 | 308 |
| LLPS-Eqc-3687 | Equus caballus | 49.85 | 3e-93 | 308 |
| LLPS-Cap-0410 | Cavia porcellus | 49.85 | 3e-93 | 308 |
| LLPS-Myl-2612 | Myotis lucifugus | 49.7 | 4e-93 | 308 |
| LLPS-Scf-2618 | Scleropages formosus | 49.7 | 3e-91 | 303 |
| LLPS-Asm-2895 | Astyanax mexicanus | 49.55 | 1e-90 | 302 |
| LLPS-Ora-2696 | Ornithorhynchus anatinus | 49.55 | 5e-95 | 308 |
| LLPS-Mum-3097 | Mus musculus | 49.55 | 7e-93 | 307 |
| LLPS-Aim-3435 | Ailuropoda melanoleuca | 49.55 | 8e-93 | 307 |
| LLPS-Fec-3562 | Felis catus | 49.55 | 4e-93 | 308 |
| LLPS-Mod-2201 | Monodelphis domestica | 49.55 | 3e-93 | 308 |
| LLPS-Urm-3212 | Ursus maritimus | 49.55 | 4e-93 | 308 |
| LLPS-Cas-1348 | Carlito syrichta | 49.55 | 6e-93 | 307 |
| LLPS-Ict-1247 | Ictidomys tridecemlineatus | 48.95 | 8e-87 | 291 |
| LLPS-Leo-2862 | Lepisosteus oculatus | 48.65 | 8e-91 | 303 |
| LLPS-Tag-3483 | Taeniopygia guttata | 48.2 | 1e-87 | 294 |
| LLPS-Xim-1721 | Xiphophorus maculatus | 47.34 | 9e-90 | 300 |
| LLPS-Gaa-0440 | Gasterosteus aculeatus | 46.99 | 3e-14 | 79.0 |
| LLPS-Anp-0047 | Anas platyrhynchos | 46.88 | 9e-91 | 300 |
| LLPS-Tar-2522 | Takifugu rubripes | 46.73 | 5e-87 | 293 |
| LLPS-Cis-1912 | Ciona savignyi | 46.61 | 2e-81 | 277 |
| LLPS-Pes-3491 | Pelodiscus sinensis | 46.59 | 1e-89 | 299 |
| LLPS-Ten-2665 | Tetraodon nigroviridis | 46.13 | 4e-88 | 295 |
| LLPS-Cii-2238 | Ciona intestinalis | 46.06 | 2e-80 | 275 |
| LLPS-Fia-3675 | Ficedula albicollis | 45.84 | 4e-91 | 303 |
| LLPS-Orl-1847 | Oryzias latipes | 45.76 | 4e-87 | 293 |
| LLPS-Meg-0392 | Meleagris gallopavo | 45.31 | 4e-90 | 301 |
| LLPS-Gaga-2463 | Gallus gallus | 45.04 | 3e-90 | 301 |
| LLPS-Sah-0570 | Sarcophilus harrisii | 45.03 | 3e-65 | 226 |
| LLPS-Lac-0514 | Latimeria chalumnae | 44.9 | 4e-88 | 295 |
| LLPS-Anc-1653 | Anolis carolinensis | 42.53 | 5e-08 | 59.7 |
| LLPS-Otg-2414 | Otolemur garnettii | 41.98 | 1e-07 | 58.5 |
| LLPS-Sem-0075 | Selaginella moellendorffii | 41.24 | 8e-12 | 72.0 |
| LLPS-Xet-2184 | Xenopus tropicalis | 40.27 | 4e-92 | 305 |
| LLPS-Dar-1400 | Danio rerio | 40.0 | 3e-88 | 296 |
| LLPS-Ere-0322 | Erinaceus europaeus | 39.42 | 3e-87 | 291 |
| LLPS-Php-0153 | Physcomitrella patens | 38.28 | 1e-37 | 150 |
| LLPS-Brn-0088 | Brassica napus | 35.29 | 1e-30 | 125 |
| LLPS-Gas-1331 | Galdieria sulphuraria | 33.94 | 3e-25 | 115 |