LLPS-Cae-0832
csn-3
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | COP9 signalosome complex subunit 3 |
| Gene Name: | csn-3, Y38C1AA.2 |
| Ensembl Gene: | WBGene00000815 |
| Ensembl Protein: | Y38C1AA.2 |
| Organism: | Caenorhabditis elegans |
| Taxa ID: | 6239 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | Y38C1AA.2 | Y38C1AA.2 |
| UniProt | Q9N425, CSN3_CAEEL | |
| GeneBank | FO081257 | CCD70246.1 |
| RefSeq | NM_067477.5 | NP_499878.3 |
| Entrez | 176834 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MTTFFNKLFT GASSSSSAAA SSGMDLGSME SLCAAINELC SEKHVSENVG ELAAGIVRKN 60 61 KELFEKKSND VEAFLLHCSP NVGSAAMVAA IKGMFDTSAA KNNETGTDRA VELLNHYVDE 120 121 NNFVGGHLKL VPEIIFPLLR DVGLYCLEKK NKPEIGQRII MKALGSMFPR NGSNAPNVLT 180 181 SAHGVLFACA LETKDYASVE PFIDLHVDEI ANENCIQDQE KSDNRERDFG DVFLGRMKKG 240 241 AAFGSQPVAH NPHLHPKYVL DYLYNGACIL IELKRFEDAL FLLEICVGMP AFSVQDQHLD 300 301 SFKKYVLISL ILKGKVDVTE NGDKSAIRHF KTKSPEYKQF SEIRFSRSSN THSAVESLVK 360 361 SAKDRLRKDG NTEIAKYLVV EMKKKTIMSL TRMFTSIRIS EIEELAFLKS RDQVTELIGQ 420 421 LVEEQRITVR IDGDMVFWTE LSPVPSKNDV ENKIRIVDHL NTLLHEKNTT MKAGSGRMRP 480 481 SVMYNEDEGL SMPPTESKFF S 501 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGACAACTT TTTTCAATAA GCTCTTCACG GGAGCCTCAT CATCATCGTC TGCAGCAGCT 60 61 TCTTCTGGAA TGGATCTTGG TAGTATGGAG TCATTGTGTG CTGCGATCAA TGAGCTTTGC 120 121 AGTGAAAAAC ATGTTTCAGA GAATGTTGGT GAACTGGCCG CTGGAATTGT TCGTAAGAAT 180 181 AAAGAGCTTT TCGAAAAGAA ATCGAACGAT GTTGAAGCAT TTTTGCTTCA TTGTAGTCCA 240 241 AATGTTGGTT CAGCTGCAAT GGTTGCTGCA ATTAAAGGAA TGTTTGATAC GTCGGCTGCA 300 301 AAAAATAATG AAACTGGAAC AGATCGAGCT GTTGAGCTTC TCAATCATTA TGTTGATGAG 360 361 AATAATTTTG TTGGAGGACA TTTGAAGCTT GTACCTGAAA TTATTTTCCC ACTGCTCCGC 420 421 GACGTCGGCT TATATTGTTT GGAAAAGAAG AATAAACCAG AAATAGGACA AAGAATTATC 480 481 ATGAAAGCAC TCGGATCAAT GTTCCCAAGA AATGGCTCAA ATGCTCCAAA TGTGCTCACT 540 541 TCTGCACACG GTGTGCTCTT TGCGTGTGCT CTTGAAACAA AGGATTATGC ATCTGTTGAA 600 601 CCATTTATTG ATCTACATGT TGATGAGATT GCAAATGAGA ATTGTATTCA AGATCAGGAA 660 661 AAGAGTGATA ATAGAGAACG AGATTTTGGA GATGTTTTTC TTGGAAGAAT GAAGAAAGGC 720 721 GCCGCATTCG GTTCACAGCC AGTGGCACAT AATCCTCATC TTCATCCAAA ATATGTACTT 780 781 GATTATCTCT ACAATGGAGC ATGTATTCTC ATTGAGCTTA AACGTTTCGA AGATGCTCTT 840 841 TTCCTGCTCG AAATTTGTGT CGGAATGCCA GCGTTCTCGG TTCAGGATCA ACATTTGGAT 900 901 TCGTTCAAAA AATATGTGCT CATTTCGCTA ATTCTGAAAG GAAAAGTGGA CGTGACGGAA 960 961 AACGGTGACA AATCAGCGAT TCGTCACTTC AAAACCAAAA GTCCTGAATA CAAACAATTC 1020 1021 TCAGAGATTC GGTTCTCCCG AAGTTCGAAT ACCCATTCAG CAGTGGAGAG TCTTGTGAAA 1080 1081 TCGGCAAAAG ATCGTTTGAG AAAAGACGGA AATACAGAAA TTGCCAAATA TTTGGTCGTT 1140 1141 GAAATGAAGA AAAAGACAAT TATGTCGCTG ACAAGAATGT TCACATCAAT TCGGATTTCT 1200 1201 GAAATTGAGG AGTTGGCATT TTTGAAGTCA CGGGATCAAG TTACAGAGCT TATTGGTCAA 1260 1261 TTGGTTGAGG AGCAGAGGAT TACTGTACGA ATTGATGGAG ATATGGTCTT TTGGACTGAA 1320 1321 TTGAGCCCTG TTCCATCTAA AAATGATGTT GAGAATAAGA TTAGAATCGT CGATCACCTG 1380 1381 AACACTCTTC TTCACGAGAA AAACACTACT ATGAAAGCCG GTTCAGGACG TATGAGACCA 1440 1441 TCAGTTATGT ACAATGAGGA TGAAGGATTG AGCATGCCAC CAACTGAATC TAAATTTTTC 1500 1501 TCCTAA 1506 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | COP9 signalosome | |
Cellular Component | Cytoplasm | |
Biological Process | Establishment of mitotic spindle localization | |
Biological Process | Mitotic cytokinesis | |
Biological Process | Multicellular organism development | |
Biological Process | Oogenesis | |
Biological Process | Ubiquitin-dependent protein catabolic process |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| AAindex | ||||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Element | ||||
| RAID | microRNA.org | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Man-3556 | Macaca nemestrina | 48.33 | 5e-07 | 55.8 |
| LLPS-Nol-0563 | Nomascus leucogenys | 31.95 | 2e-11 | 69.7 |
| LLPS-Lep-0805 | Leersia perrieri | 28.95 | 2e-12 | 73.2 |
| LLPS-Rhb-0846 | Rhinopithecus bieti | 28.81 | 1e-14 | 79.3 |
| LLPS-Arl-0232 | Arabidopsis lyrata | 27.78 | 5e-11 | 68.6 |
| LLPS-Ast-1085 | Aspergillus terreus | 27.61 | 3e-07 | 56.6 |
| LLPS-Aon-3035 | Aotus nancymaae | 27.6 | 5e-08 | 58.9 |
| LLPS-Met-0485 | Medicago truncatula | 27.47 | 4e-10 | 65.9 |
| LLPS-Dio-1659 | Dipodomys ordii | 27.31 | 1e-13 | 76.6 |
| LLPS-Ten-1869 | Tetraodon nigroviridis | 27.27 | 2e-12 | 71.6 |
| LLPS-Mae-0001 | Manihot esculenta | 27.22 | 3e-13 | 75.5 |
| LLPS-Sei-0712 | Setaria italica | 26.89 | 2e-09 | 63.9 |
| LLPS-Art-0758 | Arabidopsis thaliana | 26.79 | 6e-10 | 65.5 |
| LLPS-Pot-1906 | Populus trichocarpa | 26.76 | 3e-11 | 69.3 |
| LLPS-Chs-1121 | Chlorocebus sabaeus | 26.69 | 2e-13 | 75.5 |
| LLPS-Nia-2449 | Nicotiana attenuata | 26.67 | 6e-10 | 65.5 |
| LLPS-Usm-0073 | Ustilago maydis | 26.63 | 4e-10 | 65.9 |
| LLPS-Zem-0884 | Zea mays | 26.51 | 4e-12 | 72.4 |
| LLPS-Viv-0033 | Vitis vinifera | 26.45 | 2e-10 | 67.0 |
| LLPS-Tru-1960 | Triticum urartu | 26.4 | 6e-09 | 62.0 |
| LLPS-Brn-1875 | Brassica napus | 26.32 | 2e-11 | 70.1 |
| LLPS-Orb-1669 | Oryza barthii | 26.26 | 2e-10 | 67.0 |
| LLPS-Ori-1307 | Oryza indica | 26.26 | 1e-10 | 67.4 |
| LLPS-Orgl-1027 | Oryza glumaepatula | 26.26 | 3e-10 | 66.2 |
| LLPS-Ors-0741 | Oryza sativa | 26.26 | 1e-10 | 67.4 |
| LLPS-Orr-1486 | Oryza rufipogon | 26.26 | 1e-10 | 67.4 |
| LLPS-Org-0553 | Oryza glaberrima | 26.26 | 2e-10 | 67.0 |
| LLPS-Brr-0044 | Brassica rapa | 26.24 | 2e-11 | 70.1 |
| LLPS-Hov-0666 | Hordeum vulgare | 26.2 | 3e-11 | 69.7 |
| LLPS-Gas-1235 | Galdieria sulphuraria | 26.19 | 6e-09 | 62.0 |
| LLPS-Sol-1882 | Solanum lycopersicum | 26.11 | 4e-10 | 65.9 |
| LLPS-Sem-1582 | Selaginella moellendorffii | 26.11 | 3e-08 | 60.1 |
| LLPS-Sot-1148 | Solanum tuberosum | 26.11 | 5e-10 | 65.9 |
| LLPS-Sob-2128 | Sorghum bicolor | 26.05 | 5e-10 | 65.9 |
| LLPS-Mal-1153 | Mandrillus leucophaeus | 25.93 | 2e-13 | 75.9 |
| LLPS-Tra-1016 | Triticum aestivum | 25.91 | 8e-12 | 71.2 |
| LLPS-Orni-0454 | Oryza nivara | 25.7 | 5e-10 | 65.5 |
| LLPS-Amt-0618 | Amborella trichopoda | 25.7 | 6e-08 | 58.9 |
| LLPS-Pap-4095 | Pan paniscus | 25.63 | 8e-14 | 77.4 |
| LLPS-Glm-2040 | Glycine max | 25.56 | 2e-10 | 66.6 |
| LLPS-Hea-1037 | Helianthus annuus | 25.56 | 1e-08 | 61.2 |
| LLPS-Via-2309 | Vigna angularis | 25.56 | 3e-11 | 69.3 |
| LLPS-Phv-1442 | Phaseolus vulgaris | 25.56 | 5e-11 | 68.6 |
| LLPS-Prp-1214 | Prunus persica | 25.56 | 3e-09 | 63.2 |
| LLPS-Dac-2187 | Daucus carota | 25.28 | 5e-08 | 59.3 |
| LLPS-Brd-1188 | Brachypodium distachyon | 25.14 | 3e-10 | 66.2 |
| LLPS-Orbr-2104 | Oryza brachyantha | 25.14 | 4e-09 | 62.8 |
| LLPS-Bro-1382 | Brassica oleracea | 25.12 | 2e-10 | 67.8 |
| LLPS-Meg-1606 | Meleagris gallopavo | 25.08 | 9e-16 | 83.6 |
| LLPS-Thc-0220 | Theobroma cacao | 25.0 | 7e-11 | 67.8 |
| LLPS-Php-0989 | Physcomitrella patens | 25.0 | 1e-07 | 57.8 |
| LLPS-Coc-0142 | Corchorus capsularis | 25.0 | 4e-09 | 62.8 |
| LLPS-Icp-1448 | Ictalurus punctatus | 24.92 | 7e-17 | 87.0 |
| LLPS-Mup-2111 | Mustela putorius furo | 24.68 | 2e-14 | 79.3 |
| LLPS-Dar-2473 | Danio rerio | 24.65 | 7e-11 | 68.2 |
| LLPS-Tar-0460 | Takifugu rubripes | 24.62 | 2e-14 | 79.3 |
| LLPS-Scf-0240 | Scleropages formosus | 24.61 | 5e-16 | 84.3 |
| LLPS-Xim-1264 | Xiphophorus maculatus | 24.61 | 2e-16 | 85.5 |
| LLPS-Pof-0611 | Poecilia formosa | 24.61 | 2e-16 | 85.9 |
| LLPS-Scm-3494 | Scophthalmus maximus | 24.61 | 1e-16 | 86.3 |
| LLPS-Fia-1765 | Ficedula albicollis | 24.61 | 8e-16 | 83.6 |
| LLPS-Tag-1105 | Taeniopygia guttata | 24.61 | 8e-16 | 83.6 |
| LLPS-Gaga-1367 | Gallus gallus | 24.61 | 8e-16 | 83.6 |
| LLPS-Orp-0218 | Oryza punctata | 24.47 | 3e-08 | 60.1 |
| LLPS-Cus-1409 | Cucumis sativus | 24.44 | 2e-08 | 60.5 |
| LLPS-Asm-0957 | Astyanax mexicanus | 24.29 | 7e-16 | 84.0 |
| LLPS-Anc-1401 | Anolis carolinensis | 24.29 | 3e-15 | 82.0 |
| LLPS-Sah-0072 | Sarcophilus harrisii | 24.27 | 1e-15 | 82.8 |
| LLPS-Cea-1569 | Cercocebus atys | 24.27 | 1e-15 | 82.8 |
| LLPS-Mum-3609 | Mus musculus | 24.27 | 1e-15 | 83.2 |
| LLPS-Maf-2050 | Macaca fascicularis | 24.27 | 1e-15 | 82.8 |
| LLPS-Mea-2213 | Mesocricetus auratus | 24.27 | 1e-15 | 83.2 |
| LLPS-Ora-1718 | Ornithorhynchus anatinus | 24.27 | 9e-16 | 83.2 |
| LLPS-Fud-0621 | Fukomys damarensis | 24.27 | 1e-15 | 82.8 |
| LLPS-Caj-2509 | Callithrix jacchus | 24.27 | 1e-15 | 82.8 |
| LLPS-Paa-3635 | Papio anubis | 24.27 | 1e-15 | 82.8 |
| LLPS-Myl-3109 | Myotis lucifugus | 24.27 | 5e-16 | 84.0 |
| LLPS-Ran-4014 | Rattus norvegicus | 24.27 | 1e-15 | 83.2 |
| LLPS-Loa-4153 | Loxodonta africana | 24.27 | 1e-15 | 82.8 |
| LLPS-Hos-0045 | Homo sapiens | 24.27 | 1e-15 | 82.8 |
| LLPS-Urm-2036 | Ursus maritimus | 24.27 | 1e-15 | 83.2 |
| LLPS-Pat-4107 | Pan troglodytes | 24.27 | 1e-15 | 82.8 |
| LLPS-Mod-1207 | Monodelphis domestica | 24.27 | 1e-15 | 82.8 |
| LLPS-Orc-1774 | Oryctolagus cuniculus | 24.27 | 7e-16 | 84.3 |
| LLPS-Otg-0839 | Otolemur garnettii | 24.27 | 1e-15 | 82.8 |
| LLPS-Mam-1129 | Macaca mulatta | 24.27 | 1e-15 | 82.8 |
| LLPS-Caf-2667 | Canis familiaris | 24.27 | 1e-15 | 83.6 |
| LLPS-Poa-3554 | Pongo abelii | 24.27 | 1e-15 | 82.8 |
| LLPS-Eqc-2141 | Equus caballus | 24.27 | 1e-15 | 82.8 |
| LLPS-Ict-3710 | Ictidomys tridecemlineatus | 24.27 | 1e-15 | 82.8 |
| LLPS-Cas-1451 | Carlito syrichta | 24.27 | 1e-15 | 82.8 |
| LLPS-Spr-1078 | Sporisorium reilianum | 24.26 | 1e-11 | 71.2 |
| LLPS-Nec-1380 | Neurospora crassa | 24.04 | 2e-06 | 54.7 |
| LLPS-Gaa-0580 | Gasterosteus aculeatus | 23.97 | 6e-15 | 80.9 |
| LLPS-Orn-1798 | Oreochromis niloticus | 23.97 | 6e-16 | 84.0 |
| LLPS-Xet-1550 | Xenopus tropicalis | 23.97 | 3e-14 | 78.6 |
| LLPS-Bot-1121 | Bos taurus | 23.95 | 2e-15 | 82.4 |
| LLPS-Fec-0670 | Felis catus | 23.95 | 1e-15 | 82.8 |
| LLPS-Cap-1782 | Cavia porcellus | 23.95 | 3e-15 | 82.0 |
| LLPS-Gor-2445 | Gossypium raimondii | 23.89 | 2e-07 | 57.4 |
| LLPS-Pes-2211 | Pelodiscus sinensis | 23.73 | 2e-16 | 85.5 |
| LLPS-Lac-1384 | Latimeria chalumnae | 23.66 | 7e-14 | 77.8 |
| LLPS-Leo-1702 | Lepisosteus oculatus | 23.62 | 9e-15 | 80.5 |
| LLPS-Tut-0215 | Tursiops truncatus | 23.62 | 4e-15 | 81.3 |
| LLPS-Ova-2537 | Ovis aries | 23.62 | 9e-15 | 80.5 |
| LLPS-Mua-0887 | Musa acuminata | 22.91 | 1e-09 | 64.3 |
| LLPS-Lem-0361 | Leptosphaeria maculans | 22.76 | 6e-13 | 75.1 |
| LLPS-Drm-1700 | Drosophila melanogaster | 22.6 | 2e-14 | 79.7 |
| LLPS-Sus-1604 | Sus scrofa | 22.49 | 4e-16 | 84.3 |
| LLPS-Pytr-0935 | Pyrenophora triticirepentis | 21.35 | 1e-06 | 55.1 |
| LLPS-Pyt-0495 | Pyrenophora teres | 20.44 | 4e-09 | 62.8 |