LLPS-Art-0758
CSN3

▼ OVERVIEW

Status: Reviewed
Protein Name: COP9 signalosome complex subunit 3
Gene Name: CSN3, FUS11, At5g14250, F18O22.40
Ensembl Gene: AT5G14250
Ensembl Protein: AT5G14250.2
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."
Arabidopsis thaliana cells26980300
Centrosome/Spindle pole bodyPredicted from orthologsN/A(View)

▼ FUNCTION

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MIGAVNSVEA  VITSIQGLSG  SPEDLSALHD  LLRGAQDSLR  AEPGVNFSTL  DQLDASKHSL  60
61    GYLYFLEVLT  CGPVSKEKAA  YEIPIIARFI  NSCDAGQIRL  ASYKFVSLCK  ILKDHVIALG  120
121   DPLRGVGPLL  NAVQKLQVSS  KRLTALHPDV  LQLCLQAKSY  KSGFSILSDD  IVEIDQPRDF  180
181   FLYSYYGGMI  CIGLKRFQKA  LELLYNVVTA  PMHQVNAIAL  EAYKKYILVS  LIHNGQFTNT  240
241   LPKCASTAAQ  RSFKNYTGPY  IELGNCYNDG  KIGELEALVV  ARNAEFEEDK  NLGLVKQAVS  300
301   SLYKRNILRL  TQKYLTLSLQ  DIANMVQLGN  AKEAEMHVLQ  MIQDGQIHAL  INQKDGMVRF  360
361   LEDPEQYKSS  EMIEIMDSVI  QRTIGLSKNL  LAMDESLSCD  PLYLGKVGRE  RQRYDFGDDF  420
421   DTVPQKFSM  429
Nucleotide CDS Sequence (FASTA)
1     ATGATCGGAG  CTGTGAACTC  GGTGGAGGCT  GTGATAACGT  CAATCCAAGG  TTTATCGGGG  60
61    AGTCCAGAGG  ATTTATCTGC  ACTTCACGAT  CTTTTGAGAG  GAGCTCAAGA  CTCGCTCCGA  120
121   GCCGAACCAG  GTGTTAATTT  CTCTACTCTT  GACCAGCTCG  ACGCCTCGAA  GCACTCTCTC  180
181   GGTTACCTGT  ATTTCCTTGA  GGTTCTTACC  TGTGGTCCAG  TGTCGAAGGA  GAAAGCTGCT  240
241   TATGAGATAC  CGATAATTGC  ACGGTTCATC  AATTCTTGTG  ATGCTGGGCA  GATTCGTTTG  300
301   GCGAGCTATA  AATTTGTATC  TCTTTGTAAG  ATATTGAAAG  ACCATGTTAT  AGCACTGGGA  360
361   GATCCGTTGC  GAGGAGTAGG  GCCACTGTTA  AACGCTGTTC  AGAAGCTTCA  GGTCTCCTCC  420
421   AAGCGTTTGA  CTGCATTGCA  TCCAGATGTT  CTTCAACTCT  GTTTGCAGGC  GAAATCGTAC  480
481   AAATCTGGTT  TCTCCATTCT  TAGTGATGAT  ATCGTGGAGA  TTGACCAGCC  AAGAGACTTT  540
541   TTTCTCTATA  GCTATTATGG  GGGAATGATT  TGTATTGGAC  TGAAGAGATT  TCAGAAAGCA  600
601   TTAGAGCTTC  TTTACAATGT  TGTGACTGCT  CCTATGCATC  AAGTCAATGC  CATAGCTCTT  660
661   GAGGCGTACA  AAAAGTACAT  ATTGGTGTCT  CTCATTCACA  ATGGGCAGTT  TACTAACACT  720
721   CTCCCCAAGT  GTGCTTCTAC  AGCAGCACAG  AGGAGCTTCA  AGAACTATAC  CGGACCTTAC  780
781   ATTGAACTGG  GTAATTGTTA  CAACGACGGG  AAGATTGGTG  AACTAGAGGC  ATTGGTTGTG  840
841   GCCAGGAATG  CAGAATTTGA  AGAGGATAAG  AACCTTGGAT  TAGTTAAGCA  AGCAGTGTCA  900
901   TCCCTTTACA  AGCGTAACAT  TCTGAGATTG  ACACAGAAGT  ACTTGACCCT  GTCGCTTCAA  960
961   GATATAGCCA  ACATGGTCCA  ACTTGGTAAT  GCTAAGGAGG  CGGAAATGCA  TGTGCTTCAG  1020
1021  ATGGTATTGT  GTCCCACACT  TGATTTTTGG  AAGCTAGCTT  TATTAGTTTA  A  1071

▼ KEYWORD

ID
Family
Alternative splicing
Complete proteome
Cytoplasm
Developmental protein
Nucleus
Phytochrome signaling pathway
Reference proteome
Signalosome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
COP9 signalosome
Cellular Component
Cytosol
Biological Process
Multicellular organism development
Biological Process
Positive regulation of G2/M transition of mitotic cell cycle
Biological Process
Protein deneddylation
Biological Process
Red, far-red light phototransduction
Biological Process
Ubiquitin-dependent protein catabolic process

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
Physicochemical
Compute pI/MwAAindex
Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-0232Arabidopsis lyrata93.240.0 827
LLPS-Brn-1875Brassica napus79.760.0 711
LLPS-Brr-0044Brassica rapa79.060.0 706
LLPS-Bro-1382Brassica oleracea77.880.0 665
LLPS-Mae-0001Manihot esculenta68.00.0 584
LLPS-Thc-0220Theobroma cacao67.48e-177 506
LLPS-Coc-0142Corchorus capsularis66.820.0 583
LLPS-Viv-0033Vitis vinifera66.350.0 565
LLPS-Prp-1214Prunus persica65.410.0 560
LLPS-Gor-2445Gossypium raimondii65.180.0 557
LLPS-Glm-2040Glycine max64.940.0 558
LLPS-Pot-1906Populus trichocarpa63.590.0 541
LLPS-Cus-1409Cucumis sativus63.380.0 544
LLPS-Hea-1037Helianthus annuus63.060.0 554
LLPS-Via-2309Vigna angularis63.060.0 548
LLPS-Nia-2449Nicotiana attenuata62.50.0 545
LLPS-Phv-1442Phaseolus vulgaris62.350.0 542
LLPS-Sol-1882Solanum lycopersicum61.650.0 546
LLPS-Dac-1277Daucus carota61.50.0 539
LLPS-Sot-1148Solanum tuberosum61.410.0 545
LLPS-Met-0485Medicago truncatula61.120.0 521
LLPS-Amt-0618Amborella trichopoda59.129e-146 427
LLPS-Mua-0887Musa acuminata58.392e-171 494
LLPS-Sob-2128Sorghum bicolor57.112e-161 469
LLPS-Tru-1960Triticum urartu57.052e-123 373
LLPS-Brd-1188Brachypodium distachyon56.886e-170 491
LLPS-Orni-0454Oryza nivara55.974e-161 468
LLPS-Orgl-1027Oryza glumaepatula55.742e-160 467
LLPS-Org-0553Oryza glaberrima55.746e-161 468
LLPS-Sei-0712Setaria italica55.587e-153 447
LLPS-Ori-1307Oryza indica55.58e-160 465
LLPS-Orbr-2104Oryza brachyantha55.51e-158 462
LLPS-Ors-0741Oryza sativa55.58e-160 465
LLPS-Orb-1669Oryza barthii55.041e-154 452
LLPS-Tra-1016Triticum aestivum54.912e-160 466
LLPS-Orr-1486Oryza rufipogon54.86e-154 450
LLPS-Zem-0884Zea mays54.447e-156 455
LLPS-Hov-0666Hordeum vulgare54.191e-155 456
LLPS-Lep-0805Leersia perrieri54.11e-150 441
LLPS-Orp-0218Oryza punctata53.442e-150 441
LLPS-Sem-1582Selaginella moellendorffii51.883e-138 410
LLPS-Vir-1202Vigna radiata51.717e-108 329
LLPS-Php-0989Physcomitrella patens48.131e-134 401
LLPS-Tut-0215Tursiops truncatus41.782e-83 268
LLPS-Sus-1604Sus scrofa40.715e-83 267
LLPS-Fia-1765Ficedula albicollis40.716e-82 264
LLPS-Ora-1718Ornithorhynchus anatinus40.468e-83 267
LLPS-Orc-1774Oryctolagus cuniculus40.462e-81 265
LLPS-Pes-2211Pelodiscus sinensis40.466e-82 265
LLPS-Meg-1606Meleagris gallopavo40.461e-78 256
LLPS-Anc-1401Anolis carolinensis40.43e-82 267
LLPS-Myl-3109Myotis lucifugus40.22e-81 263
LLPS-Xim-1264Xiphophorus maculatus39.175e-82 265
LLPS-Scf-0240Scleropages formosus39.071e-82 266
LLPS-Xet-1550Xenopus tropicalis38.843e-82 266
LLPS-Icp-1448Ictalurus punctatus38.821e-82 267
LLPS-Leo-1702Lepisosteus oculatus38.823e-82 266
LLPS-Lac-1384Latimeria chalumnae38.823e-80 261
LLPS-Pof-0611Poecilia formosa38.825e-82 265
LLPS-Orn-1798Oreochromis niloticus38.574e-81 263
LLPS-Tag-1105Taeniopygia guttata38.572e-82 266
LLPS-Gaga-1367Gallus gallus38.572e-82 266
LLPS-Cap-1782Cavia porcellus38.118e-82 265
LLPS-Asm-0957Astyanax mexicanus38.083e-81 263
LLPS-Gaa-0580Gasterosteus aculeatus38.084e-79 258
LLPS-Scm-3494Scophthalmus maximus38.081e-79 259
LLPS-Tar-0460Takifugu rubripes38.075e-78 255
LLPS-Fud-0621Fukomys damarensis38.04e-82 265
LLPS-Caf-2667Canis familiaris37.884e-81 263
LLPS-Caj-2509Callithrix jacchus37.763e-82 266
LLPS-Cea-1569Cercocebus atys37.763e-82 266
LLPS-Mea-2213Mesocricetus auratus37.765e-82 265
LLPS-Maf-2050Macaca fascicularis37.763e-82 266
LLPS-Mum-3609Mus musculus37.764e-82 266
LLPS-Paa-3635Papio anubis37.763e-82 266
LLPS-Ran-4014Rattus norvegicus37.765e-82 265
LLPS-Bot-1121Bos taurus37.768e-83 267
LLPS-Otg-0839Otolemur garnettii37.763e-82 266
LLPS-Loa-4153Loxodonta africana37.763e-82 266
LLPS-Fec-0670Felis catus37.763e-82 266
LLPS-Pat-4107Pan troglodytes37.763e-82 266
LLPS-Urm-2036Ursus maritimus37.765e-82 265
LLPS-Hos-0045Homo sapiens37.763e-82 266
LLPS-Ict-3710Ictidomys tridecemlineatus37.763e-82 266
LLPS-Cas-1451Carlito syrichta37.763e-82 266
LLPS-Mam-1129Macaca mulatta37.763e-82 266
LLPS-Eqc-2141Equus caballus37.763e-82 266
LLPS-Poa-3554Pongo abelii37.763e-82 266
LLPS-Sah-0072Sarcophilus harrisii37.412e-82 266
LLPS-Mod-1207Monodelphis domestica37.412e-82 266
LLPS-Ova-2537Ovis aries37.35e-81 263
LLPS-Dio-1659Dipodomys ordii37.195e-56 196
LLPS-Chr-0406Chlamydomonas reinhardtii36.984e-71 238
LLPS-Nol-0563Nomascus leucogenys36.591e-47 175
LLPS-Chs-1121Chlorocebus sabaeus36.511e-50 180
LLPS-Mup-2111Mustela putorius furo35.833e-75 248
LLPS-Ten-1869Tetraodon nigroviridis35.314e-44 162
LLPS-Rhb-0846Rhinopithecus bieti35.16e-65 219
LLPS-Pap-4095Pan paniscus35.032e-69 232
LLPS-Drm-1700Drosophila melanogaster33.856e-61 211
LLPS-Mal-1153Mandrillus leucophaeus33.88e-65 219
LLPS-Aon-3035Aotus nancymaae33.51e-52 186
LLPS-Gas-1235Galdieria sulphuraria32.585e-30 124
LLPS-Dar-2473Danio rerio32.113e-57 200
LLPS-Spr-1078Sporisorium reilianum31.92e-30 126
LLPS-Abg-1179Absidia glauca30.821e-33 135
LLPS-Man-3556Macaca nemestrina30.384e-33 132
LLPS-Osl-0663Ostreococcus lucimarinus30.133e-1888.6
LLPS-Usm-0073Ustilago maydis30.13e-26 114
LLPS-Cii-0382Ciona intestinalis29.059e-0858.2
LLPS-Miv-0378Microbotryum violaceum28.614e-32 131
LLPS-Lem-0361Leptosphaeria maculans28.572e-27 117
LLPS-Scs-0822Sclerotinia sclerotiorum28.48e-1992.0
LLPS-Cis-0065Ciona savignyi27.966e-0858.9
LLPS-Tum-0330Tuber melanosporum27.911e-29 124
LLPS-Blg-0080Blumeria graminis27.173e-1684.7
LLPS-Cae-0832Caenorhabditis elegans26.795e-1065.5
LLPS-Gog-2284Gorilla gorilla26.264e-0756.2
LLPS-Chc-0556Chondrus crispus26.112e-0860.5
LLPS-Pug-0091Puccinia graminis25.92e-1994.7
LLPS-Mel-0137Melampsora laricipopulina25.851e-1995.1
LLPS-Pytr-0935Pyrenophora triticirepentis25.71e-2098.2
LLPS-Orl-3390Oryzias latipes25.51e-0654.7
LLPS-Asc-1026Aspergillus clavatus25.076e-23 104
LLPS-Mao-0263Magnaporthe oryzae24.771e-0860.8
LLPS-Pyt-0495Pyrenophora teres24.741e-22 103
LLPS-Ast-1085Aspergillus terreus24.676e-1992.0
LLPS-Crn-1183Cryptococcus neoformans24.234e-1272.0
LLPS-Asfu-0032Aspergillus fumigatus24.136e-1992.8
LLPS-Nef-0786Neosartorya fischeri23.975e-1993.2
LLPS-Dos-1130Dothistroma septosporum23.953e-1890.9
LLPS-Cogr-1249Colletotrichum graminicola23.846e-1374.7
LLPS-Gag-1209Gaeumannomyces graminis23.743e-1168.9
LLPS-Asn-0494Aspergillus nidulans23.548e-1992.4
LLPS-Trr-0824Trichoderma reesei22.791e-1273.6
LLPS-Fuv-1303Fusarium verticillioides22.762e-0963.5
LLPS-Ved-1125Verticillium dahliae22.148e-1270.9
LLPS-Trv-1197Trichoderma virens21.814e-0962.4
LLPS-Fuo-1079Fusarium oxysporum21.141e-0757.8