LLPS-Cae-0167
sir-2.4
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | NAD-dependent protein deacetylase sir-2.4; Regulatory protein SIR2 homolog 4; SIR2-like protein 4 |
| Gene Name: | sir-2.4, C06A5.11 |
| Ensembl Gene: | WBGene00004803 |
| Ensembl Protein: | C06A5.11 |
| Organism: | Caenorhabditis elegans |
| Taxa ID: | 6239 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P granule | "...The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals." | Caenorhabditis elegans | 24013546 |
| Stress granule, Others | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| NAD-dependent protein deacetylase. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | C06A5.11 | C06A5.11 |
| UniProt | Q95Q89, SIR24_CAEEL | |
| GeneBank | FO080102 | CCD61225.1 |
| RefSeq | NM_059332.2 | NP_491733.2 |
| Entrez | 182284 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MTSVYESLLS DYPDKGVIGK PEIRDTETEI IEKLRTLYNH FVQAKQTGKP IFVLIGAGVS 60 61 TGSKLPDFRG KQGVWTLQAE GKHAEGVDFQ VARPGVSHKS ILALHKAGYI KTIITQNVDG 120 121 LDRKVGIPVE DLIEVHGNLF LEVCQSCFSE YVREEIVMSV GLCPTGRNCE GNKRTGRSCR 180 181 GKLRDATLDW DTEISLNHLD RIRKAWKQTS HLLCIGTSLE IIPMGSLPLD AKSKGIKTTT 240 241 INYQETAHEK IVETAIHADV KLILYSLCNA LGVNVDLGDD LPDEVPIPLK IS 292 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGACATCAG TTTATGAAAG TCTTTTATCA GACTATCCAG ACAAAGGAGT AATTGGAAAA 60 61 CCTGAGATCC GAGACACTGA AACTGAAATA ATTGAGAAAC TCCGCACTTT GTACAACCAT 120 121 TTCGTCCAAG CTAAACAAAC CGGAAAACCA ATTTTTGTTC TTATCGGAGC CGGTGTGAGC 180 181 ACTGGATCGA AACTTCCAGA TTTTCGAGGA AAACAAGGCG TTTGGACATT ACAAGCTGAA 240 241 GGAAAACATG CAGAAGGAGT GGACTTTCAA GTTGCTCGTC CCGGAGTCTC ACACAAATCA 300 301 ATATTGGCAC TTCACAAGGC GGGTTACATC AAAACGATAA TCACACAGAA TGTTGATGGA 360 361 TTGGATCGAA AAGTCGGGAT TCCAGTTGAA GATCTCATTG AAGTACATGG AAATTTATTT 420 421 CTAGAAGTCT GTCAATCATG TTTTAGTGAA TATGTACGAG AGGAAATTGT AATGAGTGTT 480 481 GGCCTGTGTC CAACTGGTCG TAATTGTGAA GGAAACAAAC GAACCGGGCG ATCGTGTCGT 540 541 GGTAAACTTC GTGATGCAAC TCTCGATTGG GATACAGAAA TCAGTTTAAA TCATTTGGAC 600 601 AGAATCCGAA AAGCATGGAA ACAAACATCT CATCTTCTTT GTATTGGAAC ATCACTTGAA 660 661 ATTATTCCAA TGGGATCTCT ACCACTTGAT GCAAAATCAA AAGGAATTAA AACAACTACA 720 721 ATTAATTATC AGGAAACTGC ACATGAAAAA ATCGTGGAAA CTGCAATTCA TGCTGACGTT 780 781 AAACTTATTC TTTACTCATT ATGCAATGCA CTTGGAGTGA ATGTTGATCT TGGAGATGAT 840 841 CTACCGGATG AAGTGCCTAT TCCATTGAAA ATTAGCTAA 879 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasmic stress granule | |
Cellular Component | Nuclear envelope | |
Cellular Component | Nuclear pore | |
Cellular Component | P granule | |
Molecular Function | Metal ion binding | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent protein deacetylase activity | |
Molecular Function | Transcription factor binding | |
Biological Process | P granule assembly | |
Biological Process | Protein deacetylation | |
Biological Process | Response to heat |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Vir-1531 | Vigna radiata | 46.15 | 3e-24 | 107 |
| LLPS-Cus-0830 | Cucumis sativus | 44.74 | 3e-13 | 69.7 |
| LLPS-Scf-0219 | Scleropages formosus | 42.09 | 5e-66 | 217 |
| LLPS-Via-0367 | Vigna angularis | 41.45 | 4e-28 | 111 |
| LLPS-Gaa-2167 | Gasterosteus aculeatus | 41.16 | 1e-63 | 210 |
| LLPS-Orl-0879 | Oryzias latipes | 40.79 | 1e-63 | 210 |
| LLPS-Icp-2311 | Ictalurus punctatus | 40.79 | 7e-64 | 212 |
| LLPS-Tar-1079 | Takifugu rubripes | 40.79 | 3e-63 | 209 |
| LLPS-Xim-0773 | Xiphophorus maculatus | 40.79 | 5e-62 | 207 |
| LLPS-Pof-0810 | Poecilia formosa | 40.79 | 5e-63 | 210 |
| LLPS-Scm-3043 | Scophthalmus maximus | 40.43 | 6e-62 | 206 |
| LLPS-Orn-1686 | Oreochromis niloticus | 40.07 | 2e-62 | 205 |
| LLPS-Ora-0905 | Ornithorhynchus anatinus | 39.89 | 2e-40 | 147 |
| LLPS-Gaga-0400 | Gallus gallus | 39.71 | 9e-60 | 201 |
| LLPS-Meg-2198 | Meleagris gallopavo | 39.35 | 2e-59 | 199 |
| LLPS-Dar-0214 | Danio rerio | 39.35 | 6e-60 | 201 |
| LLPS-Glm-1488 | Glycine max | 39.22 | 2e-48 | 172 |
| LLPS-Asm-1651 | Astyanax mexicanus | 38.99 | 2e-59 | 201 |
| LLPS-Ten-0533 | Tetraodon nigroviridis | 38.85 | 7e-52 | 178 |
| LLPS-Tut-0732 | Tursiops truncatus | 38.8 | 1e-49 | 171 |
| LLPS-Anc-0730 | Anolis carolinensis | 38.73 | 7e-21 | 92.0 |
| LLPS-Otg-2073 | Otolemur garnettii | 38.63 | 6e-58 | 196 |
| LLPS-Fia-0330 | Ficedula albicollis | 38.62 | 6e-53 | 182 |
| LLPS-Met-0973 | Medicago truncatula | 38.61 | 3e-49 | 175 |
| LLPS-Pes-1629 | Pelodiscus sinensis | 38.52 | 1e-52 | 181 |
| LLPS-Cis-0613 | Ciona savignyi | 38.27 | 1e-54 | 185 |
| LLPS-Dac-2228 | Daucus carota | 38.14 | 1e-45 | 166 |
| LLPS-Tra-3034 | Triticum aestivum | 38.05 | 5e-44 | 161 |
| LLPS-Xet-0536 | Xenopus tropicalis | 38.03 | 4e-59 | 198 |
| LLPS-Pot-1158 | Populus trichocarpa | 37.91 | 4e-51 | 180 |
| LLPS-Mae-1141 | Manihot esculenta | 37.91 | 1e-51 | 182 |
| LLPS-Aim-0255 | Ailuropoda melanoleuca | 37.81 | 3e-55 | 189 |
| LLPS-Ict-0164 | Ictidomys tridecemlineatus | 37.72 | 6e-59 | 198 |
| LLPS-Fud-1866 | Fukomys damarensis | 37.6 | 2e-44 | 158 |
| LLPS-Php-0586 | Physcomitrella patens | 37.59 | 3e-51 | 181 |
| LLPS-Bot-1265 | Bos taurus | 37.59 | 3e-56 | 191 |
| LLPS-Lac-2879 | Latimeria chalumnae | 37.55 | 8e-56 | 191 |
| LLPS-Poa-3666 | Pongo abelii | 37.5 | 5e-22 | 95.9 |
| LLPS-Aon-0107 | Aotus nancymaae | 37.37 | 1e-56 | 192 |
| LLPS-Mea-1101 | Mesocricetus auratus | 37.37 | 1e-58 | 197 |
| LLPS-Caj-0043 | Callithrix jacchus | 37.37 | 9e-57 | 192 |
| LLPS-Dio-1773 | Dipodomys ordii | 37.37 | 5e-57 | 192 |
| LLPS-Mup-0290 | Mustela putorius furo | 37.37 | 6e-57 | 193 |
| LLPS-Loa-1403 | Loxodonta africana | 37.37 | 6e-57 | 192 |
| LLPS-Fec-1802 | Felis catus | 37.37 | 5e-56 | 192 |
| LLPS-Caf-2183 | Canis familiaris | 37.37 | 2e-56 | 192 |
| LLPS-Mal-0940 | Mandrillus leucophaeus | 37.18 | 4e-56 | 191 |
| LLPS-Coc-0785 | Corchorus capsularis | 37.17 | 8e-49 | 177 |
| LLPS-Sot-1324 | Solanum tuberosum | 37.07 | 1e-45 | 165 |
| LLPS-Sus-0960 | Sus scrofa | 37.01 | 1e-54 | 187 |
| LLPS-Cea-0265 | Cercocebus atys | 37.01 | 2e-56 | 191 |
| LLPS-Chs-0195 | Chlorocebus sabaeus | 37.01 | 8e-56 | 190 |
| LLPS-Mum-0871 | Mus musculus | 37.01 | 2e-56 | 191 |
| LLPS-Maf-1377 | Macaca fascicularis | 37.01 | 3e-56 | 191 |
| LLPS-Gog-0497 | Gorilla gorilla | 37.01 | 3e-56 | 191 |
| LLPS-Paa-0746 | Papio anubis | 37.01 | 2e-56 | 191 |
| LLPS-Ran-0709 | Rattus norvegicus | 37.01 | 1e-56 | 191 |
| LLPS-Hos-2223 | Homo sapiens | 37.01 | 3e-56 | 191 |
| LLPS-Pap-2074 | Pan paniscus | 37.01 | 3e-56 | 191 |
| LLPS-Pat-1412 | Pan troglodytes | 37.01 | 3e-56 | 191 |
| LLPS-Rhb-2802 | Rhinopithecus bieti | 37.01 | 3e-56 | 191 |
| LLPS-Mam-0053 | Macaca mulatta | 37.01 | 3e-56 | 191 |
| LLPS-Phv-1567 | Phaseolus vulgaris | 36.82 | 4e-49 | 175 |
| LLPS-Man-0325 | Macaca nemestrina | 36.65 | 1e-53 | 184 |
| LLPS-Brn-0377 | Brassica napus | 36.46 | 2e-49 | 176 |
| LLPS-Sem-0925 | Selaginella moellendorffii | 36.46 | 1e-47 | 168 |
| LLPS-Arl-0198 | Arabidopsis lyrata | 36.46 | 4e-49 | 175 |
| LLPS-Brr-2645 | Brassica rapa | 36.46 | 4e-50 | 178 |
| LLPS-Art-2554 | Arabidopsis thaliana | 36.46 | 2e-49 | 176 |
| LLPS-Viv-1259 | Vitis vinifera | 36.46 | 7e-49 | 174 |
| LLPS-Amt-1408 | Amborella trichopoda | 36.46 | 7e-49 | 174 |
| LLPS-Prp-0457 | Prunus persica | 36.46 | 1e-48 | 174 |
| LLPS-Bro-2146 | Brassica oleracea | 36.46 | 2e-49 | 176 |
| LLPS-Mod-0283 | Monodelphis domestica | 36.45 | 1e-56 | 192 |
| LLPS-Drm-1373 | Drosophila melanogaster | 36.33 | 2e-49 | 173 |
| LLPS-Eqc-2395 | Equus caballus | 36.33 | 5e-49 | 174 |
| LLPS-Tag-1084 | Taeniopygia guttata | 36.18 | 5e-47 | 164 |
| LLPS-Urm-0133 | Ursus maritimus | 36.17 | 7e-49 | 171 |
| LLPS-Hea-2521 | Helianthus annuus | 36.1 | 2e-48 | 174 |
| LLPS-Myl-0783 | Myotis lucifugus | 36.02 | 7e-47 | 166 |
| LLPS-Ova-2686 | Ovis aries | 35.86 | 1e-52 | 182 |
| LLPS-Gor-1707 | Gossypium raimondii | 35.74 | 2e-49 | 176 |
| LLPS-Lep-0830 | Leersia perrieri | 35.21 | 7e-48 | 171 |
| LLPS-Brd-1747 | Brachypodium distachyon | 35.06 | 5e-47 | 169 |
| LLPS-Sol-1168 | Solanum lycopersicum | 35.02 | 1e-46 | 169 |
| LLPS-Mua-2526 | Musa acuminata | 35.02 | 7e-46 | 167 |
| LLPS-Orbr-0402 | Oryza brachyantha | 34.66 | 5e-49 | 175 |
| LLPS-Ors-1975 | Oryza sativa | 34.3 | 2e-48 | 173 |
| LLPS-Org-0591 | Oryza glaberrima | 34.3 | 3e-48 | 173 |
| LLPS-Ori-1015 | Oryza indica | 34.17 | 1e-46 | 169 |
| LLPS-Thc-1737 | Theobroma cacao | 33.94 | 6e-43 | 159 |
| LLPS-Hov-1968 | Hordeum vulgare | 33.94 | 3e-44 | 164 |
| LLPS-Chr-0553 | Chlamydomonas reinhardtii | 33.59 | 2e-41 | 155 |
| LLPS-Sob-1082 | Sorghum bicolor | 33.57 | 5e-48 | 172 |
| LLPS-Zem-1172 | Zea mays | 32.32 | 3e-45 | 165 |
| LLPS-Cii-1333 | Ciona intestinalis | 32.11 | 3e-21 | 95.9 |
| LLPS-Tru-1038 | Triticum urartu | 31.93 | 1e-26 | 113 |
| LLPS-Cog-0149 | Colletotrichum gloeosporioides | 31.68 | 1e-24 | 105 |
| LLPS-Nia-1662 | Nicotiana attenuata | 31.41 | 4e-35 | 136 |
| LLPS-Sei-0261 | Setaria italica | 31.05 | 8e-30 | 121 |
| LLPS-Asn-0786 | Aspergillus nidulans | 30.99 | 2e-11 | 68.6 |
| LLPS-Leo-3952 | Lepisosteus oculatus | 30.95 | 2e-15 | 79.3 |
| LLPS-Ved-0204 | Verticillium dahliae | 30.95 | 2e-28 | 117 |
| LLPS-Chc-1070 | Chondrus crispus | 30.6 | 9e-34 | 132 |
| LLPS-Gas-0341 | Galdieria sulphuraria | 30.47 | 2e-23 | 102 |
| LLPS-Nol-1163 | Nomascus leucogenys | 30.2 | 8e-29 | 118 |
| LLPS-Nec-0232 | Neurospora crassa | 30.13 | 7e-14 | 75.1 |
| LLPS-Cap-1993 | Cavia porcellus | 29.81 | 4e-31 | 124 |
| LLPS-Cas-1076 | Carlito syrichta | 29.81 | 2e-30 | 122 |
| LLPS-Orb-1539 | Oryza barthii | 29.43 | 5e-31 | 124 |
| LLPS-Orni-1650 | Oryza nivara | 29.43 | 7e-31 | 124 |
| LLPS-Orgl-1483 | Oryza glumaepatula | 29.43 | 6e-31 | 124 |
| LLPS-Orr-0483 | Oryza rufipogon | 29.43 | 2e-31 | 125 |
| LLPS-Fuo-0497 | Fusarium oxysporum | 29.39 | 2e-20 | 93.6 |
| LLPS-Fuv-0504 | Fusarium verticillioides | 29.27 | 1e-12 | 71.6 |
| LLPS-Anp-3200 | Anas platyrhynchos | 29.02 | 3e-30 | 120 |
| LLPS-Fus-1158 | Fusarium solani | 28.77 | 3e-11 | 67.4 |
| LLPS-Beb-0901 | Beauveria bassiana | 28.44 | 6e-15 | 78.2 |
| LLPS-Blg-1279 | Blumeria graminis | 28.43 | 2e-12 | 70.9 |
| LLPS-Scs-0276 | Sclerotinia sclerotiorum | 28.04 | 5e-12 | 69.7 |
| LLPS-Orp-0035 | Oryza punctata | 27.96 | 1e-25 | 108 |
| LLPS-Scp-0985 | Schizosaccharomyces pombe | 27.95 | 5e-15 | 77.8 |
| LLPS-Trr-0565 | Trichoderma reesei | 27.65 | 3e-14 | 75.1 |
| LLPS-Trv-0640 | Trichoderma virens | 27.27 | 8e-13 | 72.0 |
| LLPS-Kop-0694 | Komagataella pastoris | 26.87 | 2e-14 | 77.4 |
| LLPS-Sah-3855 | Sarcophilus harrisii | 26.64 | 1e-13 | 73.9 |
| LLPS-Zyt-0654 | Zymoseptoria tritici | 26.47 | 3e-12 | 69.3 |
| LLPS-Gag-1218 | Gaeumannomyces graminis | 26.36 | 2e-12 | 71.2 |
| LLPS-Aso-0178 | Aspergillus oryzae | 26.29 | 2e-11 | 68.2 |
| LLPS-Asf-0437 | Aspergillus flavus | 26.29 | 2e-11 | 68.2 |
| LLPS-Cym-0590 | Cyanidioschyzon merolae | 26.25 | 2e-24 | 107 |
| LLPS-Asg-0022 | Ashbya gossypii | 25.65 | 1e-11 | 68.2 |
| LLPS-Asc-0158 | Aspergillus clavatus | 25.55 | 2e-11 | 67.8 |
| LLPS-Pyt-0305 | Pyrenophora teres | 25.37 | 4e-14 | 76.3 |
| LLPS-Nef-0401 | Neosartorya fischeri | 25.11 | 1e-12 | 70.9 |
| LLPS-Dos-0200 | Dothistroma septosporum | 25.11 | 3e-11 | 67.4 |
| LLPS-Scj-0147 | Schizosaccharomyces japonicus | 24.9 | 2e-11 | 68.2 |
| LLPS-Ast-0065 | Aspergillus terreus | 24.77 | 3e-11 | 67.4 |
| LLPS-Asni-0922 | Aspergillus niger | 24.55 | 3e-12 | 70.5 |
| LLPS-Asfu-1369 | Aspergillus fumigatus | 24.05 | 1e-14 | 77.8 |