LLPS-Hos-2223
SIRT6
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6 |
| Gene Name: | SIRT6, SIR2L6 |
| Ensembl Gene: | ENSG00000077463.14 |
| Ensembl Protein: | ENSP00000305310.5 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Stress granule | "...Deacetylase activity of SIRT6 influences stress granule assembly and the level of G3BP phosphorylation." | MEFs | 24013546 |
| Nucleolus, Others | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000305232.10 | ENSP00000305310.5 |
| Ensembl | ENST00000600938.5 | ENSP00000471123.1 |
| Ensembl | ENST00000594279.5 | ENSP00000472023.1 |
| Ensembl | ENST00000597896.5 | ENSP00000470215.1 |
| Ensembl | ENST00000599365.5 | ENSP00000473085.1 |
| Ensembl | ENST00000337491.6 | ENSP00000337332.1 |
| Ensembl | ENST00000601488.5 | ENSP00000469001.1 |
| Ensembl | ENST00000601571.1 | ENSP00000471837.1 |
| UniProt | Q8N6T7, SIR6_HUMAN, B2RCD0, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1 | |
| GeneBank | AC005620, AC006930, BC004218, CH471139, BC005026, BC028220, AK315048, AK074810, CR457200, AF233396 | CAG33481.1, AAH28220.1, AAD15478.1, BAG37527.1, AAC34468.1, EAW69252.1, AAH05026.1, AAH04218.1, BAC11222.1, AAF43432.1 |
| RefSeq | NM_001193285.2, NM_001321058.1, NM_001321059.1, NM_001321060.1, NM_001321061.1, NM_001321062.1, NM_001321063.1, NM_001321064.1, NM_016539.3 | NP_001180214.1, NP_001307987.1, NP_001307988.1, NP_001307989.1, NP_001307990.1, NP_001307991.1, NP_001307992.1, NP_001307993.1, NP_057623.2 |
| Entrez | 51548 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG 60 61 IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV 120 121 RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE 180 181 LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN 240 241 LQPTKHDRHA DLRIHGYVDE VMTRLMKHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK 300 301 EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS 355 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGGTGA ATTACGCGGC GGGGCTGTCG CCGTACGCGG ACAAGGGCAA GTGCGGCCTC 60 61 CCGGAGATCT TCGACCCCCC GGAGGAGCTG GAGCGGAAGG TGTGGGAACT GGCGAGGCTG 120 121 GTCTGGCAGT CTTCCAGTGT GGTGTTCCAC ACGGGTGCCG GCATCAGCAC TGCCTCTGGC 180 181 ATCCCCGACT TCAGGGGTCC CCACGGAGTC TGGACCATGG AGGAGCGAGG TCTGGCCCCC 240 241 AAGTTCGACA CCACCTTTGA GAGCGCGCGG CCCACGCAGA CCCACATGGC GCTGGTGCAG 300 301 CTGGAGCGCG TGGGCCTCCT CCGCTTCCTG GTCAGCCAGA ACGTGGACGG GCTCCATGTG 360 361 CGCTCAGGCT TCCCCAGGGA CAAACTGGCA GAGCTCCACG GGAACATGTT TGTGGAAGAA 420 421 TGTGCCAAGT GTAAGACGCA GTACGTCCGA GACACAGTCG TGGGCACCAT GGGCCTGAAG 480 481 GCCACGGGCC GGCTCTGCAC CGTGGCTAAG GCAAGGGGGC TGCGAGCCTG CAGGAACGCC 540 541 GACCTGTCCA TCACGCTGGG TACATCGCTG CAGATCCGGC CCAGCGGGAA CCTGCCGCTG 600 601 GCTACCAAGC GCCGGGGAGG CCGCCTGGTC ATCGTCAACC TGCAGCCCAC CAAGCACGAC 660 661 CGCCATGCTG ACCTCCGCAT CCATGGCTAC GTTGACGAGG TCATGACCCG GCTCATGAAG 720 721 CACCTGGGGC TGGAGATCCC CGCCTGGGAC GGCCCCCGTG TGCTGGAGAG GGCGCTGCCA 780 781 CCCCTGCCCC GCCCGCCCAC CCCCAAGCTG GAGCCCAAGG AGGAATCTCC CACCCGGATC 840 841 AACGGCTCTA TCCCCGCCGG CCCCAAGCAG GAGCCCTGCG CCCAGCACAA CGGCTCAGAG 900 901 CCCGCCAGCC CCAAACGGGA GCGGCCCACC AGCCCTGCCC CCCACAGACC CCCCAAAAGG 960 961 GTGAAGGCCA AGGCGGTCCC CAGCTGA 987 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nuclear telomeric heterochromatin | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Molecular Function | Chromatin binding | |
Molecular Function | NAD(P)+-protein-arginine ADP-ribosyltransferase activity | |
Molecular Function | NAD+ ADP-ribosyltransferase activity | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent histone deacetylase activity | |
Molecular Function | NAD-dependent histone deacetylase activity (H3-K9 specific) | |
Molecular Function | NAD-dependent protein deacetylase activity | |
Molecular Function | Transcription corepressor activity | |
Molecular Function | Zinc ion binding | |
Biological Process | Base-excision repair | |
Biological Process | Glucose homeostasis | |
Biological Process | Negative regulation of cell population proliferation | |
Biological Process | Negative regulation of glucose import | |
Biological Process | Negative regulation of glycolytic process | |
Biological Process | Negative regulation of transcription, DNA-templated | |
Biological Process | Positive regulation blood vessel branching | |
Biological Process | Positive regulation of chondrocyte proliferation | |
Biological Process | Positive regulation of chromatin silencing at telomere | |
Biological Process | Positive regulation of cold-induced thermogenesis | |
Biological Process | Positive regulation of fibroblast proliferation | |
Biological Process | Positive regulation of stem cell proliferation | |
Biological Process | Positive regulation of telomere maintenance | |
Biological Process | Positive regulation of telomeric heterochromatin assembly | |
Biological Process | Positive regulation of vascular endothelial cell proliferation | |
Biological Process | Post-embryonic cardiac muscle cell growth involved in heart morphogenesis | |
Biological Process | Protein ADP-ribosylation | |
Biological Process | Protein destabilization | |
Biological Process | Regulation of double-strand break repair via homologous recombination | |
Biological Process | Response to nutrient levels |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | ||||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-2074 | Pan paniscus | 99.44 | 0.0 | 664 |
| LLPS-Pat-1412 | Pan troglodytes | 99.44 | 0.0 | 664 |
| LLPS-Gog-0497 | Gorilla gorilla | 99.44 | 0.0 | 664 |
| LLPS-Paa-0746 | Papio anubis | 99.15 | 0.0 | 662 |
| LLPS-Mam-0053 | Macaca mulatta | 98.87 | 0.0 | 660 |
| LLPS-Mal-0940 | Mandrillus leucophaeus | 98.87 | 0.0 | 657 |
| LLPS-Chs-0195 | Chlorocebus sabaeus | 98.87 | 0.0 | 660 |
| LLPS-Maf-1377 | Macaca fascicularis | 98.87 | 0.0 | 660 |
| LLPS-Poa-1581 | Pongo abelii | 98.59 | 0.0 | 660 |
| LLPS-Rhb-2802 | Rhinopithecus bieti | 98.03 | 0.0 | 656 |
| LLPS-Cea-0265 | Cercocebus atys | 98.03 | 0.0 | 652 |
| LLPS-Caj-0043 | Callithrix jacchus | 97.46 | 0.0 | 657 |
| LLPS-Nol-1922 | Nomascus leucogenys | 96.33 | 6e-44 | 157 |
| LLPS-Man-0325 | Macaca nemestrina | 95.79 | 0.0 | 634 |
| LLPS-Tut-0732 | Tursiops truncatus | 94.31 | 3e-169 | 479 |
| LLPS-Aon-0107 | Aotus nancymaae | 93.52 | 0.0 | 649 |
| LLPS-Aim-0255 | Ailuropoda melanoleuca | 92.24 | 0.0 | 618 |
| LLPS-Mup-0290 | Mustela putorius furo | 92.2 | 0.0 | 620 |
| LLPS-Fec-1802 | Felis catus | 91.36 | 0.0 | 613 |
| LLPS-Sus-0960 | Sus scrofa | 89.69 | 0.0 | 604 |
| LLPS-Otg-2073 | Otolemur garnettii | 89.14 | 0.0 | 600 |
| LLPS-Bot-1265 | Bos taurus | 88.58 | 0.0 | 613 |
| LLPS-Eqc-2395 | Equus caballus | 87.72 | 0.0 | 547 |
| LLPS-Caf-2183 | Canis familiaris | 87.53 | 0.0 | 616 |
| LLPS-Dio-1773 | Dipodomys ordii | 86.76 | 0.0 | 575 |
| LLPS-Ict-0164 | Ictidomys tridecemlineatus | 86.63 | 0.0 | 569 |
| LLPS-Myl-0783 | Myotis lucifugus | 86.43 | 0.0 | 534 |
| LLPS-Urm-0133 | Ursus maritimus | 85.35 | 0.0 | 557 |
| LLPS-Loa-1403 | Loxodonta africana | 85.07 | 0.0 | 567 |
| LLPS-Fia-0330 | Ficedula albicollis | 84.38 | 7e-159 | 457 |
| LLPS-Gaga-0400 | Gallus gallus | 84.17 | 1e-174 | 498 |
| LLPS-Ova-2686 | Ovis aries | 83.15 | 0.0 | 597 |
| LLPS-Lac-2879 | Latimeria chalumnae | 82.37 | 3e-171 | 489 |
| LLPS-Ran-0709 | Rattus norvegicus | 82.25 | 0.0 | 556 |
| LLPS-Mea-1101 | Mesocricetus auratus | 82.25 | 0.0 | 545 |
| LLPS-Xet-0536 | Xenopus tropicalis | 80.94 | 8e-167 | 476 |
| LLPS-Mum-0871 | Mus musculus | 80.28 | 0.0 | 565 |
| LLPS-Tag-1084 | Taeniopygia guttata | 78.99 | 4e-149 | 429 |
| LLPS-Anc-0730 | Anolis carolinensis | 78.63 | 4e-64 | 208 |
| LLPS-Mod-0283 | Monodelphis domestica | 78.31 | 0.0 | 533 |
| LLPS-Dar-0214 | Danio rerio | 73.74 | 4e-151 | 437 |
| LLPS-Orl-0879 | Oryzias latipes | 73.74 | 1e-153 | 443 |
| LLPS-Asm-1651 | Astyanax mexicanus | 73.74 | 8e-151 | 438 |
| LLPS-Meg-2198 | Meleagris gallopavo | 73.72 | 3e-175 | 498 |
| LLPS-Scf-0219 | Scleropages formosus | 72.66 | 1e-149 | 434 |
| LLPS-Icp-2311 | Ictalurus punctatus | 72.66 | 4e-150 | 436 |
| LLPS-Orn-1686 | Oreochromis niloticus | 72.3 | 1e-149 | 431 |
| LLPS-Pof-0810 | Poecilia formosa | 71.94 | 5e-149 | 433 |
| LLPS-Ora-0905 | Ornithorhynchus anatinus | 71.73 | 7e-132 | 385 |
| LLPS-Tar-1079 | Takifugu rubripes | 71.58 | 3e-149 | 432 |
| LLPS-Xim-0773 | Xiphophorus maculatus | 71.58 | 7e-148 | 430 |
| LLPS-Gaa-2167 | Gasterosteus aculeatus | 71.58 | 8e-149 | 431 |
| LLPS-Pes-1629 | Pelodiscus sinensis | 71.56 | 4e-161 | 462 |
| LLPS-Fud-1866 | Fukomys damarensis | 71.27 | 5e-163 | 464 |
| LLPS-Scm-3043 | Scophthalmus maximus | 70.86 | 4e-147 | 427 |
| LLPS-Ten-0533 | Tetraodon nigroviridis | 64.87 | 2e-130 | 382 |
| LLPS-Cis-0613 | Ciona savignyi | 62.09 | 2e-121 | 359 |
| LLPS-Vir-1531 | Vigna radiata | 59.09 | 2e-35 | 140 |
| LLPS-Cii-1572 | Ciona intestinalis | 55.71 | 6e-21 | 90.5 |
| LLPS-Via-0367 | Vigna angularis | 54.48 | 1e-47 | 164 |
| LLPS-Tra-3034 | Triticum aestivum | 53.88 | 3e-81 | 261 |
| LLPS-Hov-1968 | Hordeum vulgare | 53.43 | 5e-89 | 289 |
| LLPS-Prp-0457 | Prunus persica | 53.07 | 6e-95 | 297 |
| LLPS-Sob-1082 | Sorghum bicolor | 53.07 | 1e-92 | 291 |
| LLPS-Lep-0830 | Leersia perrieri | 53.05 | 2e-87 | 276 |
| LLPS-Glm-1488 | Glycine max | 52.77 | 7e-80 | 257 |
| LLPS-Sei-0261 | Setaria italica | 52.53 | 9e-62 | 209 |
| LLPS-Org-0591 | Oryza glaberrima | 52.35 | 9e-91 | 287 |
| LLPS-Ors-1975 | Oryza sativa | 52.35 | 4e-90 | 285 |
| LLPS-Orbr-0402 | Oryza brachyantha | 52.35 | 3e-92 | 291 |
| LLPS-Drm-1373 | Drosophila melanogaster | 52.35 | 5e-101 | 308 |
| LLPS-Mua-2526 | Musa acuminata | 52.35 | 4e-92 | 292 |
| LLPS-Ori-1015 | Oryza indica | 52.16 | 1e-89 | 284 |
| LLPS-Amt-1408 | Amborella trichopoda | 51.99 | 1e-91 | 289 |
| LLPS-Brd-1747 | Brachypodium distachyon | 51.99 | 4e-90 | 285 |
| LLPS-Mae-1141 | Manihot esculenta | 51.62 | 2e-91 | 288 |
| LLPS-Phv-1567 | Phaseolus vulgaris | 51.62 | 4e-92 | 290 |
| LLPS-Php-0586 | Physcomitrella patens | 51.45 | 3e-90 | 286 |
| LLPS-Coc-0785 | Corchorus capsularis | 51.3 | 1e-88 | 286 |
| LLPS-Bro-2146 | Brassica oleracea | 51.26 | 1e-92 | 291 |
| LLPS-Arl-0198 | Arabidopsis lyrata | 51.26 | 4e-92 | 290 |
| LLPS-Brn-0377 | Brassica napus | 51.26 | 1e-92 | 291 |
| LLPS-Brr-2645 | Brassica rapa | 50.9 | 1e-91 | 289 |
| LLPS-Art-2554 | Arabidopsis thaliana | 50.9 | 6e-92 | 290 |
| LLPS-Gor-1707 | Gossypium raimondii | 50.9 | 7e-91 | 287 |
| LLPS-Met-0973 | Medicago truncatula | 50.9 | 9e-91 | 286 |
| LLPS-Sem-0925 | Selaginella moellendorffii | 50.9 | 2e-89 | 278 |
| LLPS-Dac-2228 | Daucus carota | 50.6 | 1e-75 | 247 |
| LLPS-Viv-1259 | Vitis vinifera | 50.54 | 2e-86 | 275 |
| LLPS-Sot-1324 | Solanum tuberosum | 50.42 | 6e-78 | 252 |
| LLPS-Hea-2521 | Helianthus annuus | 50.18 | 3e-87 | 280 |
| LLPS-Pot-1158 | Populus trichocarpa | 49.82 | 1e-88 | 281 |
| LLPS-Sol-1168 | Solanum lycopersicum | 49.82 | 2e-89 | 283 |
| LLPS-Cus-0830 | Cucumis sativus | 49.4 | 4e-19 | 86.7 |
| LLPS-Zem-1172 | Zea mays | 48.84 | 5e-87 | 278 |
| LLPS-Thc-1737 | Theobroma cacao | 48.84 | 8e-77 | 253 |
| LLPS-Tru-1038 | Triticum urartu | 47.64 | 2e-56 | 199 |
| LLPS-Orgl-1483 | Oryza glumaepatula | 47.13 | 2e-66 | 221 |
| LLPS-Orb-1539 | Oryza barthii | 47.13 | 4e-67 | 223 |
| LLPS-Orni-1650 | Oryza nivara | 47.13 | 2e-66 | 221 |
| LLPS-Orr-0483 | Oryza rufipogon | 46.36 | 2e-65 | 219 |
| LLPS-Chc-1070 | Chondrus crispus | 44.8 | 2e-66 | 223 |
| LLPS-Chr-0553 | Chlamydomonas reinhardtii | 44.6 | 1e-67 | 230 |
| LLPS-Nia-1662 | Nicotiana attenuata | 44.4 | 3e-73 | 240 |
| LLPS-Orp-0035 | Oryza punctata | 43.27 | 1e-61 | 209 |
| LLPS-Cym-0590 | Cyanidioschyzon merolae | 42.81 | 3e-61 | 211 |
| LLPS-Cas-1076 | Carlito syrichta | 42.55 | 4e-51 | 180 |
| LLPS-Cap-1993 | Cavia porcellus | 42.39 | 2e-51 | 182 |
| LLPS-Cog-0149 | Colletotrichum gloeosporioides | 41.92 | 1e-50 | 180 |
| LLPS-Anp-3200 | Anas platyrhynchos | 41.91 | 1e-53 | 183 |
| LLPS-Ved-0204 | Verticillium dahliae | 41.73 | 2e-50 | 179 |
| LLPS-Leo-1504 | Lepisosteus oculatus | 41.57 | 1e-46 | 169 |
| LLPS-Gas-0341 | Galdieria sulphuraria | 40.0 | 6e-52 | 183 |
| LLPS-Fus-1223 | Fusarium solani | 39.02 | 6e-55 | 191 |
| LLPS-Fuo-0497 | Fusarium oxysporum | 37.31 | 2e-43 | 159 |
| LLPS-Cae-0167 | Caenorhabditis elegans | 37.01 | 4e-56 | 191 |
| LLPS-Nec-0232 | Neurospora crassa | 34.7 | 6e-28 | 116 |
| LLPS-Sah-3249 | Sarcophilus harrisii | 34.05 | 2e-18 | 89.7 |
| LLPS-Crn-0340 | Cryptococcus neoformans | 32.37 | 2e-19 | 92.4 |
| LLPS-Asni-0922 | Aspergillus niger | 32.23 | 4e-21 | 96.7 |
| LLPS-Asfu-1369 | Aspergillus fumigatus | 32.16 | 5e-22 | 99.8 |
| LLPS-Asc-1426 | Aspergillus clavatus | 32.16 | 5e-18 | 87.4 |
| LLPS-Ast-0632 | Aspergillus terreus | 31.15 | 3e-23 | 102 |
| LLPS-Scs-0276 | Sclerotinia sclerotiorum | 31.0 | 1e-19 | 93.6 |
| LLPS-Nef-0401 | Neosartorya fischeri | 30.98 | 1e-21 | 97.8 |
| LLPS-Pyt-0305 | Pyrenophora teres | 29.83 | 5e-21 | 97.4 |
| LLPS-Scj-0147 | Schizosaccharomyces japonicus | 29.48 | 4e-22 | 99.8 |
| LLPS-Zyt-0654 | Zymoseptoria tritici | 29.41 | 9e-19 | 89.0 |
| LLPS-Miv-1436 | Microbotryum violaceum | 29.29 | 4e-17 | 85.9 |
| LLPS-Blg-1279 | Blumeria graminis | 29.25 | 7e-20 | 93.6 |
| LLPS-Aso-0178 | Aspergillus oryzae | 29.2 | 9e-18 | 87.0 |
| LLPS-Asf-0437 | Aspergillus flavus | 29.2 | 9e-18 | 87.0 |
| LLPS-Fuv-0504 | Fusarium verticillioides | 29.14 | 2e-18 | 90.1 |
| LLPS-Beb-0901 | Beauveria bassiana | 29.04 | 2e-21 | 97.8 |
| LLPS-Asg-0022 | Ashbya gossypii | 28.79 | 5e-17 | 84.7 |
| LLPS-Dos-0200 | Dothistroma septosporum | 28.68 | 6e-19 | 90.9 |
| LLPS-Scp-0985 | Schizosaccharomyces pombe | 28.57 | 6e-21 | 95.9 |
| LLPS-Mao-0429 | Magnaporthe oryzae | 28.52 | 1e-18 | 90.5 |
| LLPS-Trr-0565 | Trichoderma reesei | 28.11 | 4e-20 | 93.2 |
| LLPS-Trv-0640 | Trichoderma virens | 27.94 | 2e-19 | 91.7 |
| LLPS-Asn-0786 | Aspergillus nidulans | 27.84 | 4e-17 | 87.4 |