LLPS-Bot-2435
EIF5A
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Eukaryotic translation initiation factor 5A-1 |
| Gene Name: | EIF5A |
| Ensembl Gene: | ENSBTAG00000002018.4 |
| Ensembl Protein: | ENSBTAP00000069104.1 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000084447.1 | ENSBTAP00000069104.1 |
| Ensembl | ENSBTAT00000002616.4 | ENSBTAP00000002616.3 |
| UniProt | Q6EWQ7, IF5A1_BOVIN, Q32PF5 | |
| GeneBank | BC108135, AJ577609, AJ577608 | CAE12194.1, CAE12193.1, AAI08136.1 |
| RefSeq | NM_001003658.2, XM_015458612.1 | NP_001003658.1, XP_015314098.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG 60 61 IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS LLQDSGEVRE DLRLPEGDLG 120 121 KEIEQKYDCG EEILITVLSA MTEEAAVAIK AMAK 154 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCAGATG ATTTGGACTT CGAGACAGGA GATGCAGGGG CCTCAGCCAC CTTCCCGATG 60 61 CAGTGCTCAG CATTACGTAA GAATGGCTTC GTGGTGCTCA AAGGCCGGCC ATGTAAGATT 120 121 GTGGAGATGT CAACTTCTAA GACCGGCAAG CACGGCCATG CCAAGGTCCA TCTGGTTGGT 180 181 ATTGACATCT TCACTGGGAA GAAATACGAA GATATCTGCC CATCAACTCA TAATATGGAT 240 241 GTCCCCAACA TCAAAAGGAA CGATTTTCAG CTGATTGGCA TCCAGGATGG ATACCTATCA 300 301 CTCCTCCAAG ACAGCGGGGA GGTGCGAGAG GACCTCCGTC TGCCTGAGGG AGACCTTGGC 360 361 AAGGAGATTG AGCAGAAATA CGACTGTGGA GAAGAGATTC TGATCACGGT GCTGTCCGCC 420 421 ATGACAGAGG AGGCGGCTGT TGCAATCAAG GCCATGGCAA AATAA 465 |
▼ KEYWORD
ID | Family |
Acetylation | |
Complete proteome | |
Cytoplasm | |
Elongation factor | |
Endoplasmic reticulum | |
Hypusine | |
Membrane | |
mRNA transport | |
Nuclear pore complex | |
Nucleus | |
Protein biosynthesis | |
Protein transport | |
Reference proteome | |
RNA-binding | |
Translocation | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Nuclear pore | |
Molecular Function | Ribosome binding | |
Molecular Function | Translation elongation factor activity | |
Biological Process | MRNA transport | |
Biological Process | Positive regulation of translational elongation | |
Biological Process | Positive regulation of translational termination | |
Biological Process | Protein transport | |
Biological Process | Translational frameshifting |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Maf-3672 | Macaca fascicularis | 100.0 | 4e-110 | 318 |
| LLPS-Mum-1950 | Mus musculus | 100.0 | 7e-111 | 318 |
| LLPS-Chs-1936 | Chlorocebus sabaeus | 100.0 | 2e-109 | 317 |
| LLPS-Cea-1017 | Cercocebus atys | 100.0 | 4e-110 | 318 |
| LLPS-Sah-2855 | Sarcophilus harrisii | 100.0 | 7e-111 | 318 |
| LLPS-Sus-2588 | Sus scrofa | 100.0 | 7e-111 | 318 |
| LLPS-Gog-3153 | Gorilla gorilla | 100.0 | 2e-110 | 318 |
| LLPS-Fud-1385 | Fukomys damarensis | 100.0 | 7e-111 | 318 |
| LLPS-Tut-0064 | Tursiops truncatus | 100.0 | 1e-110 | 318 |
| LLPS-Dio-0243 | Dipodomys ordii | 100.0 | 7e-111 | 318 |
| LLPS-Ran-0649 | Rattus norvegicus | 100.0 | 7e-111 | 318 |
| LLPS-Ere-0409 | Erinaceus europaeus | 100.0 | 1e-110 | 318 |
| LLPS-Mal-4350 | Mandrillus leucophaeus | 100.0 | 4e-110 | 318 |
| LLPS-Aim-0825 | Ailuropoda melanoleuca | 100.0 | 7e-111 | 318 |
| LLPS-Mup-2482 | Mustela putorius furo | 100.0 | 7e-111 | 318 |
| LLPS-Ova-2919 | Ovis aries | 100.0 | 1e-110 | 318 |
| LLPS-Myl-2657 | Myotis lucifugus | 100.0 | 7e-111 | 318 |
| LLPS-Pat-3268 | Pan troglodytes | 100.0 | 2e-110 | 318 |
| LLPS-Pap-3034 | Pan paniscus | 100.0 | 2e-110 | 318 |
| LLPS-Urm-0458 | Ursus maritimus | 100.0 | 6e-110 | 318 |
| LLPS-Fec-1345 | Felis catus | 100.0 | 4e-110 | 318 |
| LLPS-Mod-2131 | Monodelphis domestica | 100.0 | 7e-111 | 319 |
| LLPS-Man-3512 | Macaca nemestrina | 100.0 | 4e-110 | 318 |
| LLPS-Loa-3086 | Loxodonta africana | 100.0 | 7e-111 | 318 |
| LLPS-Otg-1683 | Otolemur garnettii | 100.0 | 7e-111 | 318 |
| LLPS-Rhb-1297 | Rhinopithecus bieti | 100.0 | 3e-110 | 318 |
| LLPS-Caf-1516 | Canis familiaris | 100.0 | 7e-111 | 318 |
| LLPS-Eqc-1452 | Equus caballus | 100.0 | 7e-111 | 318 |
| LLPS-Cap-0288 | Cavia porcellus | 100.0 | 7e-111 | 318 |
| LLPS-Mam-0207 | Macaca mulatta | 100.0 | 4e-110 | 318 |
| LLPS-Cas-1136 | Carlito syrichta | 100.0 | 9e-111 | 320 |
| LLPS-Ict-1770 | Ictidomys tridecemlineatus | 100.0 | 7e-111 | 318 |
| LLPS-Caj-0680 | Callithrix jacchus | 98.7 | 3e-108 | 312 |
| LLPS-Pes-3638 | Pelodiscus sinensis | 98.7 | 1e-109 | 315 |
| LLPS-Hos-2620 | Homo sapiens | 98.05 | 1e-107 | 311 |
| LLPS-Aon-2828 | Aotus nancymaae | 97.83 | 8e-97 | 284 |
| LLPS-Orc-2735 | Oryctolagus cuniculus | 94.94 | 9e-104 | 301 |
| LLPS-Ora-1440 | Ornithorhynchus anatinus | 93.33 | 3e-59 | 185 |
| LLPS-Asm-2450 | Astyanax mexicanus | 91.61 | 2e-100 | 293 |
| LLPS-Scf-1129 | Scleropages formosus | 91.61 | 1e-100 | 293 |
| LLPS-Anc-3323 | Anolis carolinensis | 89.74 | 3e-97 | 284 |
| LLPS-Fia-2742 | Ficedula albicollis | 89.33 | 6e-96 | 281 |
| LLPS-Xim-3721 | Xiphophorus maculatus | 89.03 | 9e-98 | 285 |
| LLPS-Pof-3217 | Poecilia formosa | 89.03 | 9e-98 | 285 |
| LLPS-Orn-0573 | Oreochromis niloticus | 87.74 | 4e-97 | 284 |
| LLPS-Nol-0909 | Nomascus leucogenys | 87.25 | 1e-87 | 259 |
| LLPS-Tag-1423 | Taeniopygia guttata | 86.67 | 6e-94 | 276 |
| LLPS-Leo-3593 | Lepisosteus oculatus | 86.45 | 7e-96 | 281 |
| LLPS-Gaga-1239 | Gallus gallus | 86.0 | 3e-93 | 274 |
| LLPS-Paa-0865 | Papio anubis | 84.0 | 8e-92 | 270 |
| LLPS-Poa-1166 | Pongo abelii | 84.0 | 8e-92 | 270 |
| LLPS-Tar-2824 | Takifugu rubripes | 83.87 | 6e-94 | 276 |
| LLPS-Ten-3233 | Tetraodon nigroviridis | 83.87 | 5e-94 | 276 |
| LLPS-Anp-0413 | Anas platyrhynchos | 82.11 | 4e-51 | 165 |
| LLPS-Dar-0238 | Danio rerio | 81.94 | 2e-91 | 269 |
| LLPS-Icp-1495 | Ictalurus punctatus | 81.29 | 2e-89 | 264 |
| LLPS-Mea-2601 | Mesocricetus auratus | 80.0 | 2e-50 | 163 |
| LLPS-Scm-2462 | Scophthalmus maximus | 75.82 | 4e-82 | 246 |
| LLPS-Orl-0323 | Oryzias latipes | 74.03 | 4e-82 | 248 |
| LLPS-Gaa-1954 | Gasterosteus aculeatus | 70.86 | 5e-77 | 233 |
| LLPS-Drm-1333 | Drosophila melanogaster | 68.46 | 1e-72 | 222 |
| LLPS-Scp-0745 | Schizosaccharomyces pombe | 66.44 | 2e-70 | 216 |
| LLPS-Scj-1201 | Schizosaccharomyces japonicus | 65.52 | 4e-70 | 215 |
| LLPS-Sac-1122 | Saccharomyces cerevisiae | 65.28 | 2e-69 | 214 |
| LLPS-Usm-0206 | Ustilago maydis | 64.58 | 4e-70 | 216 |
| LLPS-Trr-0624 | Trichoderma reesei | 64.29 | 2e-63 | 198 |
| LLPS-Cogr-1645 | Colletotrichum graminicola | 64.29 | 8e-62 | 194 |
| LLPS-Crn-1367 | Cryptococcus neoformans | 63.89 | 2e-67 | 209 |
| LLPS-Trv-0252 | Trichoderma virens | 63.57 | 5e-63 | 197 |
| LLPS-Asg-1178 | Ashbya gossypii | 63.51 | 3e-69 | 213 |
| LLPS-Kop-1313 | Komagataella pastoris | 63.51 | 3e-71 | 218 |
| LLPS-Coo-0772 | Colletotrichum orbiculare | 63.27 | 7e-63 | 197 |
| LLPS-Cog-0781 | Colletotrichum gloeosporioides | 63.27 | 5e-63 | 197 |
| LLPS-Abg-1153 | Absidia glauca | 63.19 | 3e-66 | 206 |
| LLPS-Nec-1080 | Neurospora crassa | 63.19 | 1e-63 | 199 |
| LLPS-Spr-0653 | Sporisorium reilianum | 63.19 | 1e-69 | 214 |
| LLPS-Pug-0613 | Puccinia graminis | 62.84 | 5e-66 | 209 |
| LLPS-Scs-0744 | Sclerotinia sclerotiorum | 62.68 | 4e-63 | 197 |
| LLPS-Scc-1103 | Schizosaccharomyces cryophilus | 62.33 | 3e-68 | 211 |
| LLPS-Fus-1418 | Fusarium solani | 62.33 | 6e-63 | 197 |
| LLPS-Mel-0802 | Melampsora laricipopulina | 62.22 | 4e-60 | 191 |
| LLPS-Yal-1060 | Yarrowia lipolytica | 61.29 | 5e-66 | 205 |
| LLPS-Aso-0752 | Aspergillus oryzae | 60.93 | 3e-61 | 193 |
| LLPS-Blg-1072 | Blumeria graminis | 60.81 | 2e-63 | 198 |
| LLPS-Zyt-0576 | Zymoseptoria tritici | 60.78 | 1e-64 | 202 |
| LLPS-Asf-0917 | Aspergillus flavus | 60.53 | 6e-62 | 194 |
| LLPS-Asc-1211 | Aspergillus clavatus | 60.39 | 1e-63 | 199 |
| LLPS-Map-0512 | Magnaporthe poae | 60.39 | 1e-58 | 186 |
| LLPS-Asni-0317 | Aspergillus niger | 60.0 | 3e-61 | 193 |
| LLPS-Asfu-0414 | Aspergillus fumigatus | 60.0 | 6e-63 | 198 |
| LLPS-Phn-0087 | Phaeosphaeria nodorum | 60.0 | 4e-65 | 202 |
| LLPS-Dos-0421 | Dothistroma septosporum | 59.88 | 3e-62 | 195 |
| LLPS-Gag-1576 | Gaeumannomyces graminis | 59.74 | 4e-58 | 185 |
| LLPS-Beb-0974 | Beauveria bassiana | 59.74 | 2e-62 | 196 |
| LLPS-Fuv-0898 | Fusarium verticillioides | 59.73 | 1e-60 | 191 |
| LLPS-Fuo-0043 | Fusarium oxysporum | 59.73 | 1e-60 | 191 |
| LLPS-Mao-0293 | Magnaporthe oryzae | 59.35 | 4e-58 | 185 |
| LLPS-Pyt-0074 | Pyrenophora teres | 59.33 | 2e-61 | 193 |
| LLPS-Nef-0466 | Neosartorya fischeri | 59.24 | 1e-63 | 199 |
| LLPS-Cus-1123 | Cucumis sativus | 59.18 | 2e-56 | 181 |
| LLPS-Gor-0615 | Gossypium raimondii | 59.18 | 3e-56 | 180 |
| LLPS-Asn-0109 | Aspergillus nidulans | 59.12 | 7e-65 | 202 |
| LLPS-Ast-1100 | Aspergillus terreus | 59.09 | 1e-60 | 191 |
| LLPS-Ved-0001 | Verticillium dahliae | 58.97 | 3e-62 | 195 |
| LLPS-Pytr-0456 | Pyrenophora triticirepentis | 58.67 | 5e-61 | 192 |
| LLPS-Viv-1710 | Vitis vinifera | 58.5 | 9e-55 | 176 |
| LLPS-Arl-1770 | Arabidopsis lyrata | 58.22 | 2e-57 | 183 |
| LLPS-Zem-0168 | Zea mays | 58.0 | 6e-57 | 182 |
| LLPS-Via-0148 | Vigna angularis | 57.82 | 4e-55 | 177 |
| LLPS-Vir-0458 | Vigna radiata | 57.82 | 4e-54 | 174 |
| LLPS-Cae-0655 | Caenorhabditis elegans | 57.79 | 8e-58 | 185 |
| LLPS-Art-2089 | Arabidopsis thaliana | 57.53 | 7e-57 | 181 |
| LLPS-Thc-0151 | Theobroma cacao | 57.34 | 7e-54 | 174 |
| LLPS-Sol-0489 | Solanum lycopersicum | 57.14 | 4e-55 | 177 |
| LLPS-Hea-1366 | Helianthus annuus | 57.14 | 5e-53 | 172 |
| LLPS-Sot-0583 | Solanum tuberosum | 57.14 | 2e-54 | 176 |
| LLPS-Phv-0612 | Phaseolus vulgaris | 57.14 | 8e-54 | 174 |
| LLPS-Prp-1401 | Prunus persica | 57.14 | 5e-54 | 174 |
| LLPS-Amt-1372 | Amborella trichopoda | 57.04 | 1e-52 | 171 |
| LLPS-Sem-1121 | Selaginella moellendorffii | 56.64 | 2e-53 | 172 |
| LLPS-Glm-1820 | Glycine max | 56.46 | 2e-53 | 172 |
| LLPS-Ori-0582 | Oryza indica | 56.46 | 1e-52 | 171 |
| LLPS-Brd-0471 | Brachypodium distachyon | 56.46 | 1e-53 | 173 |
| LLPS-Ors-0490 | Oryza sativa | 56.46 | 4e-52 | 169 |
| LLPS-Pot-1675 | Populus trichocarpa | 56.46 | 8e-53 | 171 |
| LLPS-Orbr-2276 | Oryza brachyantha | 56.46 | 3e-53 | 172 |
| LLPS-Nia-1448 | Nicotiana attenuata | 56.46 | 2e-54 | 175 |
| LLPS-Org-0763 | Oryza glaberrima | 56.46 | 1e-52 | 171 |
| LLPS-Orb-1954 | Oryza barthii | 56.29 | 1e-53 | 174 |
| LLPS-Orni-1315 | Oryza nivara | 56.29 | 1e-53 | 174 |
| LLPS-Dac-0833 | Daucus carota | 56.29 | 4e-55 | 177 |
| LLPS-Orgl-0661 | Oryza glumaepatula | 56.29 | 1e-53 | 174 |
| LLPS-Orm-1330 | Oryza meridionalis | 56.29 | 6e-54 | 174 |
| LLPS-Orr-1071 | Oryza rufipogon | 56.29 | 1e-53 | 174 |
| LLPS-Lem-0297 | Leptosphaeria maculans | 56.25 | 3e-61 | 193 |
| LLPS-Put-0201 | Puccinia triticina | 56.25 | 2e-40 | 139 |
| LLPS-Lep-1463 | Leersia perrieri | 56.16 | 4e-54 | 174 |
| LLPS-Orp-0773 | Oryza punctata | 56.12 | 3e-49 | 164 |
| LLPS-Mua-0858 | Musa acuminata | 55.94 | 2e-51 | 168 |
| LLPS-Met-0683 | Medicago truncatula | 55.78 | 1e-51 | 168 |
| LLPS-Sei-0510 | Setaria italica | 55.48 | 5e-55 | 177 |
| LLPS-Sob-0878 | Sorghum bicolor | 55.48 | 3e-55 | 177 |
| LLPS-Tra-2376 | Triticum aestivum | 55.1 | 1e-51 | 168 |
| LLPS-Mae-1819 | Manihot esculenta | 55.1 | 1e-52 | 171 |
| LLPS-Coc-2064 | Corchorus capsularis | 55.1 | 2e-53 | 173 |
| LLPS-Brn-2221 | Brassica napus | 55.03 | 3e-54 | 174 |
| LLPS-Bro-2498 | Brassica oleracea | 55.03 | 3e-54 | 174 |
| LLPS-Brr-0086 | Brassica rapa | 54.36 | 1e-52 | 171 |
| LLPS-Php-0046 | Physcomitrella patens | 54.3 | 2e-50 | 165 |
| LLPS-Tru-0251 | Triticum urartu | 53.29 | 7e-51 | 169 |
| LLPS-Hov-1153 | Hordeum vulgare | 52.63 | 3e-50 | 166 |
| LLPS-Gas-0388 | Galdieria sulphuraria | 50.97 | 6e-51 | 166 |
| LLPS-Osl-1354 | Ostreococcus lucimarinus | 49.33 | 2e-47 | 157 |
| LLPS-Miv-0104 | Microbotryum violaceum | 49.15 | 3e-58 | 187 |
| LLPS-Cym-0720 | Cyanidioschyzon merolae | 48.73 | 5e-45 | 151 |
| LLPS-Chr-0727 | Chlamydomonas reinhardtii | 48.03 | 7e-48 | 159 |
| LLPS-Cii-0255 | Ciona intestinalis | 40.0 | 3e-13 | 67.0 |