• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-1807
EIF3I

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit I
Gene Name: EIF3I, EIF3S2
Ensembl Gene: ENSBTAG00000014388.4
Ensembl Protein: ENSBTAP00000057668.1
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKPILLQGHE  RSITQIKYNR  EGDLLFTVAK  DPIVNVWYSV  NGERLGTYMG  HTGAVWCVDA  60
61    DWDTKHVLTG  SADNSCRLWD  CETGKQLALL  KTNSAVRTCG  FDFGGNIIMF  STDKQMGYQC  120
121   FVSFFDLRDP  SQIDSNEPYM  RIPCNDSKIT  SAVWGPLGEC  IIAGHEGGEL  NQYSAKSGEV  180
181   LVNVKEHSRQ  INDIQLSRDM  TMFVTASKDN  TAKLFDSTTL  EHQKTFRTER  PVNSAALSPN  240
241   YDHVVLGGGQ  EAMDVTTTST  RIGKFEARFF  HLAFEEEFGR  VKGHFGPINS  VAFHPDGKSY  300
301   SSGGEDGYVR  IHYFDPQYFE  FEFEA  325
Nucleotide CDS Sequence (FASTA)
1     ATGAAGCCGA  TCTTGCTGCA  GGGCCATGAG  CGGTCCATTA  CTCAGATTAA  GTACAACCGC  60
61    GAGGGAGACC  TCCTCTTCAC  GGTGGCCAAG  GACCCTATTG  TCAATGTATG  GTACTCTGTG  120
121   AATGGTGAGA  GACTGGGCAC  CTACATGGGC  CATACCGGAG  CTGTGTGGTG  TGTGGACGCG  180
181   GACTGGGACA  CCAAGCATGT  CCTCACTGGC  TCAGCTGACA  ACAGCTGTCG  TCTCTGGGAC  240
241   TGTGAAACAG  GGAAGCAGCT  GGCCCTGCTC  AAGACCAATT  CAGCAGTCCG  GACCTGTGGC  300
301   TTTGACTTTG  GGGGCAACAT  CATCATGTTC  TCCACAGACA  AGCAGATGGG  CTACCAGTGC  360
361   TTCGTGAGCT  TCTTTGACCT  GCGGGATCCA  AGCCAGATCG  ACAGCAATGA  GCCCTACATG  420
421   AGGATCCCTT  GCAACGACTC  CAAGATCACC  AGTGCCGTTT  GGGGACCTCT  GGGAGAGTGC  480
481   ATCATCGCAG  GCCACGAAGG  TGGAGAGCTC  AACCAGTATA  GTGCCAAGTC  TGGGGAGGTT  540
541   CTGGTGAATG  TTAAGGAGCA  CTCCCGGCAG  ATCAATGACA  TCCAGTTATC  CAGGGATATG  600
601   ACCATGTTCG  TCACTGCATC  CAAGGACAAC  ACTGCCAAGC  TCTTCGACTC  CACAACCCTT  660
661   GAACACCAGA  AGACTTTCAG  GACAGAACGA  CCTGTCAACT  CAGCTGCCCT  CTCTCCCAAC  720
721   TACGATCATG  TGGTGCTGGG  CGGTGGTCAG  GAAGCCATGG  ATGTAACCAC  CACCTCCACC  780
781   AGGATTGGGA  AGTTCGAGGC  CAGGTTCTTC  CACTTGGCCT  TTGAAGAAGA  GTTTGGAAGA  840
841   GTCAAGGGTC  ACTTCGGACC  TATCAACAGT  GTTGCCTTCC  ATCCTGATGG  CAAGAGCTAC  900
901   AGCAGTGGCG  GCGAAGATGG  TTACGTCCGC  ATCCACTACT  TCGACCCACA  GTACTTTGAA  960
961   TTTGAGTTTG  AAGCTTAA  978

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Cytoplasm
Initiation factor
Isopeptide bond
Phosphoprotein
Protein biosynthesis
Reference proteome
Repeat
Ubl conjugation
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Cellular Component
Eukaryotic translation initiation factor 3 complex, eIF3m
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex
Biological Process
Translational initiation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-3722Ovis aries100.00.0 682
LLPS-Cea-1802Cercocebus atys100.06e-45 154
LLPS-Aim-0158Ailuropoda melanoleuca99.690.0 681
LLPS-Fec-0984Felis catus99.380.0 682
LLPS-Mup-2502Mustela putorius furo99.380.0 680
LLPS-Sus-2722Sus scrofa99.380.0 677
LLPS-Loa-2424Loxodonta africana99.370.0 667
LLPS-Cap-0647Cavia porcellus99.080.0 681
LLPS-Poa-0637Pongo abelii99.080.0 680
LLPS-Pap-4011Pan paniscus99.080.0 680
LLPS-Pat-3590Pan troglodytes99.080.0 680
LLPS-Hos-1103Homo sapiens99.080.0 680
LLPS-Dio-0837Dipodomys ordii99.080.0 680
LLPS-Mal-2773Mandrillus leucophaeus99.080.0 680
LLPS-Aon-4018Aotus nancymaae99.080.0 680
LLPS-Chs-0413Chlorocebus sabaeus99.080.0 680
LLPS-Mum-3511Mus musculus99.080.0 681
LLPS-Maf-0942Macaca fascicularis99.080.0 680
LLPS-Caj-2143Callithrix jacchus99.080.0 680
LLPS-Gog-0440Gorilla gorilla99.080.0 680
LLPS-Caf-0588Canis familiaris99.070.0 679
LLPS-Man-1407Macaca nemestrina99.070.0 676
LLPS-Rhb-2067Rhinopithecus bieti99.070.0 676
LLPS-Orc-0371Oryctolagus cuniculus99.070.0 678
LLPS-Myl-0876Myotis lucifugus99.070.0 677
LLPS-Eqc-2258Equus caballus99.030.0 645
LLPS-Ict-3356Ictidomys tridecemlineatus98.770.0 679
LLPS-Nol-3567Nomascus leucogenys98.770.0 679
LLPS-Cas-2647Carlito syrichta98.770.0 678
LLPS-Urm-2348Ursus maritimus98.770.0 671
LLPS-Otg-0653Otolemur garnettii98.770.0 675
LLPS-Paa-0959Papio anubis98.770.0 678
LLPS-Mea-2231Mesocricetus auratus98.770.0 679
LLPS-Mod-1158Monodelphis domestica97.540.0 666
LLPS-Sah-0038Sarcophilus harrisii97.230.0 665
LLPS-Fud-2816Fukomys damarensis96.920.0 667
LLPS-Ora-2032Ornithorhynchus anatinus95.240.0 590
LLPS-Gaga-1219Gallus gallus93.230.0 644
LLPS-Anp-2981Anas platyrhynchos93.210.0 642
LLPS-Fia-1078Ficedula albicollis92.90.0 640
LLPS-Tag-0503Taeniopygia guttata92.590.0 639
LLPS-Anc-1869Anolis carolinensis91.690.0 634
LLPS-Xet-1236Xenopus tropicalis89.850.0 630
LLPS-Pes-1788Pelodiscus sinensis89.41e-145 417
LLPS-Mam-2108Macaca mulatta87.690.0 575
LLPS-Lac-1430Latimeria chalumnae86.240.0 555
LLPS-Orn-0495Oreochromis niloticus84.620.0 597
LLPS-Tar-3055Takifugu rubripes84.620.0 595
LLPS-Scf-2430Scleropages formosus84.310.0 595
LLPS-Orl-1810Oryzias latipes84.310.0 592
LLPS-Ten-3315Tetraodon nigroviridis84.00.0 594
LLPS-Pof-2657Poecilia formosa84.00.0 592
LLPS-Dar-2298Danio rerio83.690.0 592
LLPS-Gaa-1424Gasterosteus aculeatus83.690.0 588
LLPS-Scm-0699Scophthalmus maximus83.380.0 584
LLPS-Icp-0048Ictalurus punctatus83.080.0 587
LLPS-Xim-0311Xiphophorus maculatus83.00.0 543
LLPS-Asm-0342Astyanax mexicanus81.540.0 588
LLPS-Leo-2482Lepisosteus oculatus79.260.0 544
LLPS-Ran-3136Rattus norvegicus76.127e-178 503
LLPS-Drm-0642Drosophila melanogaster61.048e-147 424
LLPS-Cii-0734Ciona intestinalis59.693e-143 415
LLPS-Ast-0337Aspergillus terreus55.181e-126 373
LLPS-Asn-0251Aspergillus nidulans53.964e-123 364
LLPS-Tum-1134Tuber melanosporum53.642e-123 365
LLPS-Aso-0422Aspergillus oryzae53.213e-122 362
LLPS-Asf-0800Aspergillus flavus53.213e-122 362
LLPS-Asfu-0946Aspergillus fumigatus53.015e-123 363
LLPS-Nef-0040Neosartorya fischeri53.016e-123 363
LLPS-Asc-0462Aspergillus clavatus53.014e-123 364
LLPS-Ved-0955Verticillium dahliae52.911e-116 347
LLPS-Scj-1527Schizosaccharomyces japonicus52.459e-115 342
LLPS-Beb-1219Beauveria bassiana51.992e-116 347
LLPS-Map-0524Magnaporthe poae51.992e-116 347
LLPS-Nec-0392Neurospora crassa51.832e-115 345
LLPS-Scs-0806Sclerotinia sclerotiorum51.682e-118 352
LLPS-Cog-0944Colletotrichum gloeosporioides51.526e-114 340
LLPS-Gag-1380Gaeumannomyces graminis51.383e-116 346
LLPS-Mao-1240Magnaporthe oryzae51.383e-113 339
LLPS-Coo-1069Colletotrichum orbiculare51.382e-116 347
LLPS-Abg-0290Absidia glauca51.373e-120 356
LLPS-Cogr-0867Colletotrichum graminicola51.227e-115 343
LLPS-Trv-0003Trichoderma virens50.911e-114 342
LLPS-Trr-0446Trichoderma reesei50.913e-114 341
LLPS-Fus-0522Fusarium solani50.615e-114 341
LLPS-Zyt-0780Zymoseptoria tritici50.614e-110 331
LLPS-Amt-1791Amborella trichopoda50.521e-59 197
LLPS-Pytr-0488Pyrenophora triticirepentis50.151e-110 332
LLPS-Dos-1251Dothistroma septosporum50.156e-112 335
LLPS-Pyt-0559Pyrenophora teres50.151e-110 332
LLPS-Hea-1342Helianthus annuus50.02e-104 318
LLPS-Fuo-0653Fusarium oxysporum49.859e-113 338
LLPS-Fuv-1084Fusarium verticillioides49.852e-112 337
LLPS-Scc-0472Schizosaccharomyces cryophilus49.78e-111 332
LLPS-Lem-0933Leptosphaeria maculans49.546e-112 335
LLPS-Crn-1320Cryptococcus neoformans49.545e-112 336
LLPS-Yal-0575Yarrowia lipolytica49.543e-106 321
LLPS-Blg-0400Blumeria graminis49.248e-109 327
LLPS-Php-0279Physcomitrella patens49.233e-110 331
LLPS-Chc-0842Chondrus crispus49.223e-104 315
LLPS-Scp-0497Schizosaccharomyces pombe49.081e-109 329
LLPS-Mel-0428Melampsora laricipopulina48.66e-101 307
LLPS-Osl-0826Ostreococcus lucimarinus48.459e-107 322
LLPS-Usm-0726Ustilago maydis48.343e-105 319
LLPS-Sem-0216Selaginella moellendorffii48.316e-103 312
LLPS-Put-0031Puccinia triticina48.295e-102 310
LLPS-Pot-1365Populus trichocarpa48.162e-105 318
LLPS-Mua-1475Musa acuminata48.143e-104 315
LLPS-Spr-1447Sporisorium reilianum48.042e-105 319
LLPS-Mae-0499Manihot esculenta48.016e-103 312
LLPS-Pug-0441Puccinia graminis47.982e-99 305
LLPS-Nia-0572Nicotiana attenuata47.873e-102 310
LLPS-Viv-1331Vitis vinifera47.714e-103 313
LLPS-Sot-0932Solanum tuberosum47.716e-102 309
LLPS-Miv-0887Microbotryum violaceum47.598e-99 302
LLPS-Gor-1927Gossypium raimondii47.45e-103 312
LLPS-Cus-0471Cucumis sativus47.48e-104 314
LLPS-Met-1972Medicago truncatula47.44e-103 312
LLPS-Art-1889Arabidopsis thaliana47.111e-96 296
LLPS-Coc-0900Corchorus capsularis47.093e-102 310
LLPS-Sol-0864Solanum lycopersicum47.093e-102 310
LLPS-Prp-0860Prunus persica46.933e-100 305
LLPS-Brd-1312Brachypodium distachyon46.931e-104 317
LLPS-Orgl-0825Oryza glumaepatula46.779e-103 312
LLPS-Thc-1491Theobroma cacao46.637e-102 309
LLPS-Phn-0584Phaeosphaeria nodorum46.481e-97 298
LLPS-Org-0345Oryza glaberrima46.482e-101 308
LLPS-Via-0362Vigna angularis46.484e-101 307
LLPS-Ors-0149Oryza sativa46.326e-102 310
LLPS-Tra-1646Triticum aestivum46.322e-103 313
LLPS-Hov-0001Hordeum vulgare46.324e-103 313
LLPS-Ori-1073Oryza indica46.326e-102 310
LLPS-Bro-1413Brassica oleracea46.063e-93 297
LLPS-Brr-2300Brassica rapa46.068e-94 298
LLPS-Brn-0500Brassica napus46.068e-97 296
LLPS-Glm-1593Glycine max46.013e-102 310
LLPS-Lep-0885Leersia perrieri45.984e-94 289
LLPS-Zem-0552Zea mays45.712e-101 308
LLPS-Sei-0626Setaria italica45.711e-101 309
LLPS-Orp-1225Oryza punctata45.41e-100 306
LLPS-Phv-1670Phaseolus vulgaris45.44e-101 307
LLPS-Sob-0315Sorghum bicolor45.42e-100 306
LLPS-Orr-2139Oryza rufipogon45.071e-99 304
LLPS-Sac-0029Saccharomyces cerevisiae45.053e-98 301
LLPS-Asg-0204Ashbya gossypii45.053e-96 296
LLPS-Cym-0796Cyanidioschyzon merolae45.035e-101 307
LLPS-Arl-0079Arabidopsis lyrata44.824e-98 300
LLPS-Kop-1411Komagataella pastoris44.481e-98 302
LLPS-Gas-1114Galdieria sulphuraria43.962e-96 295
LLPS-Chr-1591Chlamydomonas reinhardtii43.962e-97 298
LLPS-Cae-1495Caenorhabditis elegans42.941e-97 298
LLPS-Vir-0829Vigna radiata40.684e-80 253
LLPS-Tru-1674Triticum urartu40.181e-79 253
LLPS-Orni-0377Oryza nivara40.03e-80 253
LLPS-Orb-1337Oryza barthii39.573e-80 253
LLPS-Cis-1523Ciona savignyi26.22e-25 108
LLPS-Dac-1408Daucus carota26.097e-24 103
LLPS-Orm-0637Oryza meridionalis25.475e-26 110
LLPS-Orbr-1091Oryza brachyantha25.477e-26 110