• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asm-0342
EIF3I

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit I
Gene Name: EIF3I, EIF3S2
Ensembl Gene: ENSAMXG00000011863.2
Ensembl Protein: ENSAMXP00000012200.2
Organism: Astyanax mexicanus
Taxa ID: 7994
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKPILLQGHE  RSLTQIKYNR  EGDLLFSVAK  DQFANVWYSV  NGERLGTYNG  HSGAVWCVDV  60
61    DWDTKNVLTG  SADNSCRLWD  CETGKQLAML  ETNSAVRTCG  FDFSGNIIMF  STDKQMGYQC  120
121   YLNYFDLRDP  QQIEDNQPYL  SIPCSESKIT  SAVWGPLGEF  VVAGHENGEI  NQFSAKSGEI  180
181   VKKIKEHTKQ  INDIQTSVDL  TMFITASKDC  AAKMFDTTSL  DHIKSFKTER  PVNSAAISPN  240
241   MEHVVMGGGQ  EAMEVTTTST  RIGKFEARFF  HAAYEEEFGR  VKGHFGPINC  VAFHPDGKSY  300
301   SSGGEDGYVR  IHYFDPQYFD  FELEA  325
Nucleotide CDS Sequence (FASTA)
1     ATGAAACCAA  TTCTTCTACA  GGGCCACGAG  AGGTCTCTTA  CTCAGATTAA  ATACAACAGA  60
61    GAAGGAGATT  TACTGTTTTC  TGTGGCTAAA  GATCAGTTTG  CGAATGTGTG  GTATTCTGTG  120
121   AATGGAGAGA  GGCTGGGCAC  CTACAACGGC  CACTCCGGGG  CGGTCTGGTG  TGTGGATGTT  180
181   GACTGGGACA  CAAAAAATGT  GTTGACTGGT  TCAGCTGACA  ACAGCTGCAG  ACTCTGGGAC  240
241   TGCGAGACAG  GTAAACAATT  GGCAATGCTC  GAGACCAACT  CAGCAGTGAG  GACGTGTGGA  300
301   TTTGACTTCA  GCGGAAACAT  CATCATGTTT  TCCACAGACA  AACAGATGGG  CTACCAGTGC  360
361   TATCTTAACT  ACTTTGATCT  GCGGGACCCC  CAACAGATTG  AGGACAACCA  GCCTTATCTC  420
421   TCAATACCAT  GCAGTGAATC  AAAGATCACA  AGTGCTGTGT  GGGGCCCTCT  GGGAGAGTTT  480
481   GTGGTTGCTG  GTCATGAAAA  TGGAGAAATC  AACCAGTTCA  GCGCCAAGTC  TGGGGAGATT  540
541   GTGAAGAAGA  TAAAGGAGCA  CACTAAGCAG  ATCAACGACA  TTCAGACTTC  TGTGGATCTC  600
601   ACAATGTTTA  TCACAGCCTC  CAAAGACTGT  GCTGCTAAGA  TGTTTGATAC  AACATCATTA  660
661   GACCACATCA  AATCCTTTAA  GACTGAGCGT  CCAGTCAATT  CTGCTGCCAT  CTCGCCCAAC  720
721   ATGGAACATG  TGGTCATGGG  AGGAGGTCAG  GAAGCCATGG  AGGTCACAAC  CACCTCTACT  780
781   AGGATTGGAA  AATTCGAAGC  TAGGTTTTTC  CATGCAGCCT  ATGAAGAGGA  GTTTGGAAGA  840
841   GTGAAGGGTC  ATTTCGGACC  CATCAACTGT  GTGGCATTCC  ATCCTGATGG  GAAAAGTTAC  900
901   AGCAGCGGAG  GAGAGGACGG  CTACGTCAGA  ATTCATTACT  TCGATCCTCA  GTACTTTGAC  960
961   TTTGAACTTG  AGGCTTAA  978

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome
Repeat
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex
Biological Process
Liver development
Biological Process
Sprouting angiogenesis

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ten-3315Tetraodon nigroviridis92.920.0 649
LLPS-Tar-3055Takifugu rubripes92.620.0 645
LLPS-Icp-0048Ictalurus punctatus92.620.0 648
LLPS-Orn-0495Oreochromis niloticus92.310.0 644
LLPS-Cea-1802Cercocebus atys91.789e-42 145
LLPS-Dar-2298Danio rerio91.690.0 647
LLPS-Scf-2430Scleropages formosus91.080.0 641
LLPS-Gaa-1424Gasterosteus aculeatus90.460.0 631
LLPS-Pof-2657Poecilia formosa90.460.0 634
LLPS-Orl-1810Oryzias latipes90.150.0 632
LLPS-Scm-0699Scophthalmus maximus89.540.0 626
LLPS-Xim-0311Xiphophorus maculatus89.330.0 582
LLPS-Tag-0503Taeniopygia guttata83.950.0 596
LLPS-Fia-1078Ficedula albicollis83.950.0 597
LLPS-Xet-1236Xenopus tropicalis83.690.0 601
LLPS-Gaga-1219Gallus gallus83.380.0 597
LLPS-Anp-2981Anas platyrhynchos83.330.0 595
LLPS-Leo-2482Lepisosteus oculatus83.280.0 575
LLPS-Lac-1430Latimeria chalumnae82.890.0 544
LLPS-Anc-1869Anolis carolinensis82.460.0 592
LLPS-Mea-2231Mesocricetus auratus81.850.0 589
LLPS-Mum-3511Mus musculus81.850.0 589
LLPS-Cap-0647Cavia porcellus81.850.0 590
LLPS-Caf-0588Canis familiaris81.790.0 587
LLPS-Ora-2032Ornithorhynchus anatinus81.570.0 530
LLPS-Mal-2773Mandrillus leucophaeus81.540.0 588
LLPS-Dio-0837Dipodomys ordii81.540.0 588
LLPS-Bot-1807Bos taurus81.540.0 588
LLPS-Gog-0440Gorilla gorilla81.540.0 588
LLPS-Caj-2143Callithrix jacchus81.540.0 588
LLPS-Maf-0942Macaca fascicularis81.540.0 588
LLPS-Chs-0413Chlorocebus sabaeus81.540.0 588
LLPS-Aon-4018Aotus nancymaae81.540.0 588
LLPS-Cas-2647Carlito syrichta81.540.0 588
LLPS-Nol-3567Nomascus leucogenys81.540.0 590
LLPS-Poa-0637Pongo abelii81.540.0 588
LLPS-Pat-3590Pan troglodytes81.540.0 588
LLPS-Pap-4011Pan paniscus81.540.0 588
LLPS-Hos-1103Homo sapiens81.540.0 588
LLPS-Fec-0984Felis catus81.540.0 588
LLPS-Mup-2502Mustela putorius furo81.480.0 585
LLPS-Aim-0158Ailuropoda melanoleuca81.480.0 585
LLPS-Ova-3722Ovis aries81.480.0 585
LLPS-Myl-0876Myotis lucifugus81.480.0 587
LLPS-Orc-0371Oryctolagus cuniculus81.480.0 587
LLPS-Rhb-2067Rhinopithecus bieti81.420.0 585
LLPS-Man-1407Macaca nemestrina81.420.0 585
LLPS-Paa-0959Papio anubis81.230.0 587
LLPS-Fud-2816Fukomys damarensis81.230.0 584
LLPS-Sah-0038Sarcophilus harrisii81.230.0 582
LLPS-Sus-2722Sus scrofa81.230.0 581
LLPS-Ict-3356Ictidomys tridecemlineatus81.230.0 587
LLPS-Mod-1158Monodelphis domestica81.230.0 582
LLPS-Otg-0653Otolemur garnettii81.170.0 583
LLPS-Loa-2424Loxodonta africana81.130.0 573
LLPS-Eqc-2258Equus caballus80.910.0 554
LLPS-Urm-2348Ursus maritimus80.860.0 576
LLPS-Pes-1788Pelodiscus sinensis79.727e-132 382
LLPS-Mam-2108Macaca mulatta71.387e-173 489
LLPS-Ran-3136Rattus norvegicus65.769e-153 439
LLPS-Drm-0642Drosophila melanogaster60.251e-146 423
LLPS-Cii-0734Ciona intestinalis57.938e-141 409
LLPS-Ast-0337Aspergillus terreus52.443e-123 364
LLPS-Ved-0955Verticillium dahliae51.993e-117 349
LLPS-Beb-1219Beauveria bassiana51.993e-117 349
LLPS-Abg-0290Absidia glauca51.983e-120 356
LLPS-Tum-1134Tuber melanosporum51.838e-123 363
LLPS-Asn-0251Aspergillus nidulans51.839e-121 358
LLPS-Asf-0800Aspergillus flavus51.382e-121 360
LLPS-Aso-0422Aspergillus oryzae51.382e-121 360
LLPS-Asc-0462Aspergillus clavatus51.22e-119 355
LLPS-Asfu-0946Aspergillus fumigatus50.94e-120 357
LLPS-Nef-0040Neosartorya fischeri50.99e-120 355
LLPS-Coo-1069Colletotrichum orbiculare50.761e-116 347
LLPS-Map-0524Magnaporthe poae50.767e-116 345
LLPS-Trv-0003Trichoderma virens50.615e-115 343
LLPS-Trr-0446Trichoderma reesei50.612e-114 342
LLPS-Scj-1527Schizosaccharomyces japonicus50.462e-114 342
LLPS-Scp-0497Schizosaccharomyces pombe50.151e-111 334
LLPS-Scs-0806Sclerotinia sclerotiorum50.151e-117 350
LLPS-Gag-1380Gaeumannomyces graminis50.07e-117 348
LLPS-Cogr-0867Colletotrichum graminicola50.03e-114 341
LLPS-Amt-1791Amborella trichopoda50.01e-60 200
LLPS-Nec-0392Neurospora crassa49.72e-113 340
LLPS-Cog-0944Colletotrichum gloeosporioides49.72e-112 337
LLPS-Mao-1240Magnaporthe oryzae49.542e-112 337
LLPS-Scc-0472Schizosaccharomyces cryophilus49.246e-112 335
LLPS-Zyt-0780Zymoseptoria tritici49.12e-108 327
LLPS-Fus-0522Fusarium solani49.093e-113 339
LLPS-Hea-1342Helianthus annuus49.076e-107 324
LLPS-Pyt-0559Pyrenophora teres48.942e-110 332
LLPS-Pytr-0488Pyrenophora triticirepentis48.942e-110 332
LLPS-Fuv-1084Fusarium verticillioides48.938e-113 338
LLPS-Fuo-0653Fusarium oxysporum48.935e-113 338
LLPS-Lem-0933Leptosphaeria maculans48.639e-112 335
LLPS-Dos-1251Dothistroma septosporum48.481e-110 332
LLPS-Php-0279Physcomitrella patens48.472e-113 339
LLPS-Blg-0400Blumeria graminis48.338e-109 327
LLPS-Yal-0575Yarrowia lipolytica48.161e-106 322
LLPS-Crn-1320Cryptococcus neoformans48.013e-111 334
LLPS-Nia-0572Nicotiana attenuata48.017e-108 325
LLPS-Gor-1927Gossypium raimondii47.875e-107 322
LLPS-Mua-1475Musa acuminata47.831e-107 323
LLPS-Sol-0864Solanum lycopersicum47.711e-107 324
LLPS-Mae-0499Manihot esculenta47.712e-106 321
LLPS-Sem-0216Selaginella moellendorffii47.692e-105 318
LLPS-Put-0031Puccinia triticina47.662e-104 316
LLPS-Chc-0842Chondrus crispus47.655e-103 312
LLPS-Sot-0932Solanum tuberosum47.551e-107 324
LLPS-Usm-0726Ustilago maydis47.462e-106 322
LLPS-Spr-1447Sporisorium reilianum47.463e-107 323
LLPS-Mel-0428Melampsora laricipopulina47.351e-103 314
LLPS-Pug-0441Puccinia graminis47.357e-102 311
LLPS-Pot-1365Populus trichocarpa47.244e-109 328
LLPS-Miv-0887Microbotryum violaceum46.991e-98 301
LLPS-Brd-1312Brachypodium distachyon46.933e-107 323
LLPS-Cus-0471Cucumis sativus46.799e-107 322
LLPS-Art-2672Arabidopsis thaliana46.657e-105 318
LLPS-Viv-1331Vitis vinifera46.486e-106 320
LLPS-Org-0345Oryza glaberrima46.344e-103 312
LLPS-Hov-0001Hordeum vulgare46.322e-106 322
LLPS-Tra-1646Triticum aestivum46.321e-106 321
LLPS-Ori-1073Oryza indica46.326e-105 317
LLPS-Ors-0149Oryza sativa46.326e-105 317
LLPS-Sac-0029Saccharomyces cerevisiae46.257e-100 305
LLPS-Via-0362Vigna angularis46.189e-105 317
LLPS-Coc-0900Corchorus capsularis46.181e-104 317
LLPS-Orgl-0825Oryza glumaepatula46.151e-103 315
LLPS-Cym-0796Cyanidioschyzon merolae46.112e-106 321
LLPS-Glm-1593Glycine max46.014e-106 320
LLPS-Orp-1225Oryza punctata46.013e-104 315
LLPS-Osl-0826Ostreococcus lucimarinus45.966e-104 315
LLPS-Gas-1114Galdieria sulphuraria45.941e-98 301
LLPS-Met-1972Medicago truncatula45.712e-105 318
LLPS-Zem-0552Zea mays45.711e-103 314
LLPS-Prp-0860Prunus persica45.713e-104 315
LLPS-Phv-1670Phaseolus vulgaris45.719e-106 319
LLPS-Sei-0626Setaria italica45.43e-103 313
LLPS-Thc-1491Theobroma cacao45.41e-104 316
LLPS-Phn-0584Phaeosphaeria nodorum45.41e-97 298
LLPS-Sob-0315Sorghum bicolor45.49e-103 311
LLPS-Lep-0885Leersia perrieri45.343e-96 295
LLPS-Arl-0079Arabidopsis lyrata45.121e-101 309
LLPS-Orr-2139Oryza rufipogon45.077e-102 310
LLPS-Brn-0500Brassica napus44.856e-99 302
LLPS-Bro-1413Brassica oleracea44.853e-95 302
LLPS-Brr-2300Brassica rapa44.851e-95 303
LLPS-Asg-0204Ashbya gossypii44.417e-98 300
LLPS-Kop-1411Komagataella pastoris44.177e-101 307
LLPS-Chr-1591Chlamydomonas reinhardtii43.37e-95 291
LLPS-Cae-1495Caenorhabditis elegans42.721e-96 296
LLPS-Orni-0377Oryza nivara40.32e-83 261
LLPS-Vir-0829Vigna radiata40.192e-83 261
LLPS-Orb-1337Oryza barthii39.881e-83 261
LLPS-Tru-1674Triticum urartu39.576e-80 253
LLPS-Orm-0637Oryza meridionalis28.261e-29 120
LLPS-Orbr-1656Oryza brachyantha28.263e-29 119
LLPS-Dac-1408Daucus carota27.595e-28 116
LLPS-Tut-0533Tursiops truncatus26.67e-2195.1
LLPS-Cis-1523Ciona savignyi25.563e-24 104