LLPS-Bot-1090
SMARCD2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; 60 kDa BRG-1/Brm-associated factor subunit B; BRG1-associated factor 60B; BAF60B |
| Gene Name: | SMARCD2 |
| Ensembl Gene: | ENSBTAG00000021062.5 |
| Ensembl Protein: | ENSBTAP00000028049.4 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000028049.5 | ENSBTAP00000028049.4 |
| UniProt | E1BJD1, SMRD2_BOVIN | |
| GeneBank | AAFC03085035 | |
| RefSeq | NM_001205462.2 | NP_001192391.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSGRGAGGFP LPPLSPGGGA VAAALGAPPP PAGPGMLPGP ALRGPGPAGG VGGPGAAAFR 60 61 PMGPAGPAAQ YQRPGMSPGS RMPMAGLQVG PPAGSPFGTA APLRPGMPPT MMDPFRKRLL 120 121 VPQAQPPMPA QRRGLKRRKM ADKVLPQRIR ELVPESQAYM DLLAFERKLD QTIARKRMEI 180 181 QEAIKKPLTQ KRKLRIYISN TFSPSKAEGD TAGTTGTPGG TPAGDKVASW ELRVEGKLLD 240 241 DPSKQKRKFS SFFKSLVIEL DKELYGPDNH LVEWHRMPTT QETDGFQVKR PGDLNVKCTL 300 301 LLMLDHQPPQ YKLDPRLARL LGVHTQTRAA IMQALWLYIK HNQLQDGHER EYINCNRYFR 360 361 QIFSCGRLRF SEIPMKLAGL LQHPDPIVIN HVISVDPNDQ KKTACYDIDV EVDDPLKAQM 420 421 SNFLASTTNQ QEIASLDVKI HETIESINQL KTQRDFMLSF STDPQDFIQE WLRSQRRDLK 480 481 IITDVIGNPE EERRAAFYHQ PWAQEAVGRH IFAKVQQRRQ ELEQVLGIRL T 531 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGGGCC GTGGCGCGGG CGGGTTCCCG CTGCCCCCGC TGAGCCCTGG CGGCGGCGCG 60 61 GTTGCCGCGG CCCTGGGAGC GCCGCCTCCG CCGGCGGGAC CCGGCATGCT GCCCGGACCG 120 121 GCGCTTAGGG GGCCCGGGCC GGCTGGAGGC GTGGGGGGCC CCGGGGCCGC TGCCTTCCGC 180 181 CCCATGGGCC CCGCGGGCCC GGCGGCGCAG TACCAGCGGC CTGGCATGTC CCCAGGGAGC 240 241 CGGATGCCCA TGGCTGGCTT GCAGGTGGGA CCCCCTGCCG GCTCCCCCTT TGGCACAGCT 300 301 GCTCCACTTC GACCTGGCAT GCCACCCACC ATGATGGACC CATTCCGAAA ACGCCTGCTT 360 361 GTGCCTCAGG CCCAGCCCCC GATGCCTGCC CAGCGCCGGG GGTTAAAGAG GAGGAAGATG 420 421 GCAGATAAAG TTCTACCTCA GCGAATTCGG GAGCTTGTTC CAGAGTCTCA GGCGTACATG 480 481 GACCTCTTGG CTTTTGAACG GAAGCTGGAC CAGACCATTG CTAGAAAGCG GATGGAGATC 540 541 CAGGAGGCCA TCAAAAAGCC TCTGACGCAA AAACGAAAGC TGCGGATCTA TATTTCCAAT 600 601 ACATTCAGTC CCAGCAAGGC AGAAGGTGAC ACTGCAGGAA CCACAGGGAC CCCTGGAGGA 660 661 ACCCCTGCAG GGGACAAGGT GGCTTCCTGG GAACTCCGAG TAGAGGGAAA ACTGCTGGAC 720 721 GATCCTAGTA AACAGAAGCG GAAGTTTTCT TCCTTCTTTA AGAGCCTTGT CATCGAGCTG 780 781 GACAAGGAAC TGTACGGGCC TGACAACCAC CTGGTGGAGT GGCACCGGAT GCCCACCACC 840 841 CAGGAGACAG ACGGCTTCCA GGTGAAACGG CCCGGAGACC TGAACGTCAA GTGCACCCTC 900 901 CTGCTCATGC TGGATCATCA GCCCCCTCAG TACAAGCTGG ACCCCCGCCT GGCGAGGCTG 960 961 CTAGGGGTGC ACACGCAGAC GAGGGCTGCC ATCATGCAGG CCCTGTGGCT CTACATCAAA 1020 1021 CACAACCAGC TGCAGGACGG CCACGAGCGC GAGTACATCA ACTGCAACCG CTACTTCCGC 1080 1081 CAGATCTTCA GCTGCGGCCG ACTACGTTTC TCTGAGATTC CCATGAAGCT GGCGGGGTTG 1140 1141 CTGCAGCATC CAGACCCCAT TGTCATCAAC CACGTCATCA GCGTGGACCC TAACGACCAG 1200 1201 AAGAAGACAG CCTGTTACGA CATTGATGTG GAGGTGGATG ACCCGCTCAA GGCCCAGATG 1260 1261 AGCAATTTTC TGGCCTCTAC CACCAATCAG CAGGAGATCG CCTCCCTTGA TGTCAAGATC 1320 1321 CACGAGACTA TTGAGTCCAT CAACCAGCTG AAGACCCAGA GGGATTTCAT GCTCAGTTTT 1380 1381 AGCACTGACC CCCAGGACTT CATCCAGGAG TGGCTCCGTT CCCAGCGCCG GGACCTCAAG 1440 1441 ATCATCACTG ATGTGATTGG GAACCCGGAG GAGGAGAGAC GAGCAGCTTT CTACCACCAG 1500 1501 CCCTGGGCCC AGGAAGCAGT GGGGAGGCAC ATCTTTGCCA AGGTGCAGCA GCGAAGGCAG 1560 1561 GAACTGGAAC AGGTGCTGGG AATCCGCCTG ACCTAA 1596 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleoplasm | |
Cellular Component | SWI/SNF complex | |
Biological Process | ATP-dependent chromatin remodeling | |
Biological Process | Nucleosome disassembly |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aim-0465 | Ailuropoda melanoleuca | 99.57 | 0.0 | 850 |
| LLPS-Caf-0796 | Canis familiaris | 99.36 | 0.0 | 873 |
| LLPS-Otg-3299 | Otolemur garnettii | 99.36 | 0.0 | 874 |
| LLPS-Fec-1519 | Felis catus | 99.15 | 0.0 | 874 |
| LLPS-Hos-0690 | Homo sapiens | 99.15 | 0.0 | 871 |
| LLPS-Pat-0089 | Pan troglodytes | 99.15 | 0.0 | 871 |
| LLPS-Man-1945 | Macaca nemestrina | 99.15 | 0.0 | 871 |
| LLPS-Paa-0520 | Papio anubis | 99.15 | 0.0 | 871 |
| LLPS-Chs-2224 | Chlorocebus sabaeus | 99.15 | 0.0 | 871 |
| LLPS-Cea-2833 | Cercocebus atys | 99.15 | 0.0 | 871 |
| LLPS-Gog-4417 | Gorilla gorilla | 99.15 | 0.0 | 871 |
| LLPS-Ict-2820 | Ictidomys tridecemlineatus | 98.94 | 0.0 | 870 |
| LLPS-Mum-2096 | Mus musculus | 98.94 | 0.0 | 872 |
| LLPS-Aon-0215 | Aotus nancymaae | 98.94 | 0.0 | 870 |
| LLPS-Dio-0174 | Dipodomys ordii | 98.72 | 0.0 | 873 |
| LLPS-Ran-0212 | Rattus norvegicus | 98.72 | 0.0 | 872 |
| LLPS-Caj-3525 | Callithrix jacchus | 98.72 | 0.0 | 870 |
| LLPS-Loa-1741 | Loxodonta africana | 98.51 | 0.0 | 868 |
| LLPS-Mup-0102 | Mustela putorius furo | 98.5 | 0.0 | 848 |
| LLPS-Ova-0346 | Ovis aries | 98.5 | 0.0 | 851 |
| LLPS-Mal-2922 | Mandrillus leucophaeus | 98.49 | 0.0 | 850 |
| LLPS-Urm-0021 | Ursus maritimus | 98.08 | 0.0 | 848 |
| LLPS-Rhb-2213 | Rhinopithecus bieti | 98.08 | 0.0 | 850 |
| LLPS-Maf-4052 | Macaca fascicularis | 98.08 | 0.0 | 850 |
| LLPS-Fud-1607 | Fukomys damarensis | 98.07 | 0.0 | 848 |
| LLPS-Nol-1001 | Nomascus leucogenys | 96.53 | 0.0 | 822 |
| LLPS-Mea-0683 | Mesocricetus auratus | 96.19 | 0.0 | 838 |
| LLPS-Myl-0944 | Myotis lucifugus | 96.16 | 0.0 | 835 |
| LLPS-Mam-2472 | Macaca mulatta | 95.73 | 0.0 | 815 |
| LLPS-Cas-1689 | Carlito syrichta | 95.21 | 0.0 | 808 |
| LLPS-Cap-1687 | Cavia porcellus | 94.89 | 0.0 | 820 |
| LLPS-Sah-0808 | Sarcophilus harrisii | 94.83 | 0.0 | 838 |
| LLPS-Pap-4109 | Pan paniscus | 93.56 | 0.0 | 794 |
| LLPS-Poa-1978 | Pongo abelii | 90.89 | 0.0 | 765 |
| LLPS-Eqc-4550 | Equus caballus | 90.33 | 0.0 | 746 |
| LLPS-Meg-2860 | Meleagris gallopavo | 88.26 | 0.0 | 792 |
| LLPS-Gaga-2122 | Gallus gallus | 88.04 | 0.0 | 791 |
| LLPS-Fia-2345 | Ficedula albicollis | 87.94 | 0.0 | 783 |
| LLPS-Orc-0304 | Oryctolagus cuniculus | 86.06 | 0.0 | 698 |
| LLPS-Anp-1693 | Anas platyrhynchos | 84.32 | 0.0 | 777 |
| LLPS-Pes-3544 | Pelodiscus sinensis | 83.66 | 0.0 | 723 |
| LLPS-Xet-0278 | Xenopus tropicalis | 80.13 | 0.0 | 735 |
| LLPS-Leo-0979 | Lepisosteus oculatus | 79.57 | 0.0 | 709 |
| LLPS-Asm-0341 | Astyanax mexicanus | 78.23 | 0.0 | 698 |
| LLPS-Dar-0678 | Danio rerio | 78.04 | 0.0 | 715 |
| LLPS-Scf-3339 | Scleropages formosus | 77.75 | 0.0 | 710 |
| LLPS-Orn-1880 | Oreochromis niloticus | 77.3 | 0.0 | 692 |
| LLPS-Icp-3353 | Ictalurus punctatus | 76.99 | 0.0 | 676 |
| LLPS-Orl-2402 | Oryzias latipes | 76.94 | 0.0 | 677 |
| LLPS-Scm-1002 | Scophthalmus maximus | 76.52 | 0.0 | 691 |
| LLPS-Pof-2846 | Poecilia formosa | 76.52 | 0.0 | 612 |
| LLPS-Xim-2883 | Xiphophorus maculatus | 76.32 | 0.0 | 607 |
| LLPS-Ten-2151 | Tetraodon nigroviridis | 75.26 | 0.0 | 683 |
| LLPS-Gaa-1757 | Gasterosteus aculeatus | 73.88 | 0.0 | 652 |
| LLPS-Mod-3806 | Monodelphis domestica | 70.15 | 0.0 | 638 |
| LLPS-Sus-1088 | Sus scrofa | 70.11 | 0.0 | 617 |
| LLPS-Drm-1316 | Drosophila melanogaster | 67.34 | 6e-179 | 521 |
| LLPS-Anc-2447 | Anolis carolinensis | 65.74 | 0.0 | 603 |
| LLPS-Tut-0087 | Tursiops truncatus | 64.29 | 0.0 | 608 |
| LLPS-Tag-1096 | Taeniopygia guttata | 63.67 | 0.0 | 601 |
| LLPS-Tar-2321 | Takifugu rubripes | 62.95 | 8e-179 | 521 |
| LLPS-Cii-0702 | Ciona intestinalis | 61.0 | 2e-163 | 479 |
| LLPS-Cis-0443 | Ciona savignyi | 56.44 | 4e-27 | 112 |
| LLPS-Lac-2351 | Latimeria chalumnae | 55.56 | 1e-158 | 468 |
| LLPS-Cae-0830 | Caenorhabditis elegans | 52.84 | 3e-132 | 399 |
| LLPS-Abg-0573 | Absidia glauca | 37.78 | 7e-82 | 269 |
| LLPS-Mua-0291 | Musa acuminata | 36.06 | 4e-70 | 239 |
| LLPS-Amt-1918 | Amborella trichopoda | 35.84 | 3e-66 | 232 |
| LLPS-Viv-0358 | Vitis vinifera | 35.81 | 1e-68 | 232 |
| LLPS-Brd-0098 | Brachypodium distachyon | 35.73 | 2e-69 | 238 |
| LLPS-Orr-1129 | Oryza rufipogon | 35.48 | 2e-68 | 236 |
| LLPS-Tru-1229 | Triticum urartu | 35.48 | 4e-70 | 237 |
| LLPS-Tra-0199 | Triticum aestivum | 35.48 | 1e-69 | 239 |
| LLPS-Orni-1040 | Oryza nivara | 35.48 | 3e-68 | 236 |
| LLPS-Phv-1335 | Phaseolus vulgaris | 35.46 | 8e-71 | 241 |
| LLPS-Via-0661 | Vigna angularis | 35.25 | 7e-68 | 233 |
| LLPS-Vir-1033 | Vigna radiata | 35.19 | 3e-70 | 240 |
| LLPS-Orm-1811 | Oryza meridionalis | 35.18 | 3e-69 | 235 |
| LLPS-Org-0044 | Oryza glaberrima | 35.18 | 2e-69 | 234 |
| LLPS-Orgl-0031 | Oryza glumaepatula | 35.18 | 5e-69 | 235 |
| LLPS-Glm-0685 | Glycine max | 35.13 | 9e-71 | 242 |
| LLPS-Ori-0139 | Oryza indica | 35.01 | 9e-69 | 233 |
| LLPS-Orb-0344 | Oryza barthii | 35.01 | 1e-68 | 233 |
| LLPS-Sei-0336 | Setaria italica | 34.96 | 6e-69 | 237 |
| LLPS-Orbr-1057 | Oryza brachyantha | 34.92 | 5e-66 | 233 |
| LLPS-Sem-0417 | Selaginella moellendorffii | 34.79 | 6e-68 | 231 |
| LLPS-Prp-1057 | Prunus persica | 34.72 | 7e-70 | 239 |
| LLPS-Sob-0723 | Sorghum bicolor | 34.45 | 1e-70 | 242 |
| LLPS-Scc-0815 | Schizosaccharomyces cryophilus | 34.34 | 5e-66 | 226 |
| LLPS-Zem-1094 | Zea mays | 34.19 | 2e-69 | 238 |
| LLPS-Nia-1042 | Nicotiana attenuata | 34.19 | 4e-72 | 246 |
| LLPS-Dac-0152 | Daucus carota | 34.19 | 6e-70 | 238 |
| LLPS-Hea-1934 | Helianthus annuus | 34.18 | 2e-69 | 238 |
| LLPS-Pot-2049 | Populus trichocarpa | 33.94 | 4e-68 | 235 |
| LLPS-Scj-1007 | Schizosaccharomyces japonicus | 33.92 | 9e-65 | 223 |
| LLPS-Ors-1301 | Oryza sativa | 33.43 | 7e-52 | 186 |
| LLPS-Coc-0213 | Corchorus capsularis | 33.41 | 2e-65 | 228 |
| LLPS-Thc-0416 | Theobroma cacao | 33.41 | 5e-64 | 224 |
| LLPS-Chc-0617 | Chondrus crispus | 33.33 | 2e-41 | 161 |
| LLPS-Php-1210 | Physcomitrella patens | 33.16 | 3e-67 | 231 |
| LLPS-Mae-1216 | Manihot esculenta | 32.94 | 2e-66 | 231 |
| LLPS-Sol-1311 | Solanum lycopersicum | 32.9 | 7e-70 | 240 |
| LLPS-Brn-0239 | Brassica napus | 32.48 | 3e-64 | 223 |
| LLPS-Tum-0422 | Tuber melanosporum | 32.23 | 6e-60 | 212 |
| LLPS-Gor-0968 | Gossypium raimondii | 32.12 | 1e-60 | 214 |
| LLPS-Met-1649 | Medicago truncatula | 31.93 | 2e-62 | 220 |
| LLPS-Scp-0318 | Schizosaccharomyces pombe | 31.84 | 2e-64 | 222 |
| LLPS-Bro-0835 | Brassica oleracea | 31.79 | 8e-65 | 226 |
| LLPS-Art-0776 | Arabidopsis thaliana | 31.62 | 5e-63 | 221 |
| LLPS-Arl-0534 | Arabidopsis lyrata | 31.62 | 6e-63 | 221 |
| LLPS-Brr-2163 | Brassica rapa | 31.51 | 1e-65 | 227 |
| LLPS-Sot-0067 | Solanum tuberosum | 31.12 | 4e-69 | 238 |
| LLPS-Cus-0975 | Cucumis sativus | 30.8 | 7e-64 | 224 |
| LLPS-Crn-0382 | Cryptococcus neoformans | 30.38 | 3e-51 | 188 |
| LLPS-Usm-0417 | Ustilago maydis | 30.21 | 2e-52 | 195 |
| LLPS-Spr-0480 | Sporisorium reilianum | 29.04 | 3e-51 | 192 |
| LLPS-Yal-1211 | Yarrowia lipolytica | 27.69 | 7e-39 | 151 |
| LLPS-Mel-0616 | Melampsora laricipopulina | 27.27 | 1e-36 | 145 |
| LLPS-Cogr-0718 | Colletotrichum graminicola | 27.16 | 4e-33 | 135 |
| LLPS-Zyt-0772 | Zymoseptoria tritici | 26.65 | 1e-26 | 117 |
| LLPS-Ved-0871 | Verticillium dahliae | 26.46 | 2e-33 | 136 |
| LLPS-Gag-1215 | Gaeumannomyces graminis | 26.3 | 4e-26 | 115 |
| LLPS-Nec-0291 | Neurospora crassa | 25.61 | 3e-29 | 125 |
| LLPS-Map-0312 | Magnaporthe poae | 25.6 | 2e-24 | 110 |
| LLPS-Phn-0830 | Phaeosphaeria nodorum | 25.45 | 2e-22 | 104 |
| LLPS-Scs-1069 | Sclerotinia sclerotiorum | 25.32 | 5e-28 | 120 |
| LLPS-Gas-0289 | Galdieria sulphuraria | 25.06 | 6e-27 | 118 |
| LLPS-Beb-0057 | Beauveria bassiana | 24.63 | 4e-25 | 112 |
| LLPS-Dos-0718 | Dothistroma septosporum | 24.6 | 2e-22 | 103 |