LLPS-Scm-1002
ATXN7L3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Ataxin-7-like protein 3; SAGA-associated factor 11 homolog |
| Gene Name: | ATXN7L3, SMAX5B_020266 |
| Ensembl Gene: | ENSSMAG00000018391.1 |
| Ensembl Protein: | ENSSMAP00000029971.1 |
| Organism: | Scophthalmus maximus |
| Taxa ID: | 52904 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSSMAT00000030341.1 | ENSSMAP00000029971.1 |
| UniProt | A0A2U9CM45, A0A2U9CM45_SCOMX | |
| GeneBank | CP026260 | AWP17691.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MALRGGFTGP PMNPSANPMN VGHSAGTRMS GMPQAPAGYP RGMGTAHQYL QRPGMPPNRI 60 61 GGPMGSMGSQ LPGPSYGNMP MRPGMGPPSM DASRKRFLHH QHQQQQQQEA LGGGLRRGAK 120 121 RRKMADKVLP QRIRDLVPES QAYMDLLAFE RKLDQTIARK RMEIQEAIKK PIMQKRKLRI 180 181 YISNTYTPCK PEGEEAEKVS SWELRVEGKL LEEPGKQKRK FSSFFKSLVI ELDKELYGPD 240 241 NHLVEWHRMA TTQETDGFQV KRPGDVNVKC TLLLMLDHQP PQYKLDPRLA RLLGVHTQTR 300 301 ASIMQALWLY IKNNKLQDGH EKEYINCNRY FRQIFGCPRM RFSEIPMKLA GLLQHPDPII 360 361 INHVISVDPT DQKKTACYDI DVEVDDPLKG QMNSFLSSTT NQQEIAALEM KIHETIEYIN 420 421 QLKTERDFML SFSNNPQDFI QDWLKSQSRD LKLMTDVTGN PEEERKTEFY QAPWVPEAVG 480 481 RYVYSKVQQR RQELEQVLGI RLT 503 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCACTGA GAGGCGGCTT CACGGGTCCC CCGATGAACC CGAGCGCGAA CCCCATGAAC 60 61 GTTGGGCACT CGGCGGGCAC TCGGATGTCA GGGATGCCCC AGGCTCCGGC GGGATACCCC 120 121 CGGGGCATGG GCACCGCTCA CCAGTACCTC CAGCGCCCAG GGATGCCACC AAATCGGATC 180 181 GGGGGCCCCA TGGGGTCGAT GGGGAGTCAG CTGCCTGGTC CCTCTTATGG GAACATGCCC 240 241 ATGCGGCCAG GCATGGGGCC TCCAAGCATG GATGCTTCAA GGAAGCGGTT CCTTCATCAT 300 301 CAGCATCAAC AGCAGCAGCA GCAGGAGGCG CTGGGCGGAG GCCTCAGGCG AGGGGCAAAA 360 361 AGACGCAAGA TGGCAGACAA GGTTCTCCCA CAGAGGATTA GAGACCTGGT CCCTGAATCC 420 421 CAGGCCTACA TGGACCTCTT GGCCTTTGAG AGGAAACTGG ATCAAACCAT TGCCCGAAAG 480 481 CGTATGGAGA TTCAGGAAGC AATCAAGAAG CCCATTATGC AAAAACGCAA ACTCAGGATC 540 541 TACATTTCCA ACACATACAC ACCCTGCAAG CCTGAGGGCG AGGAGGCCGA GAAGGTGTCC 600 601 TCCTGGGAGC TCCGAGTGGA GGGCAAGCTT CTGGAGGAGC CTGGCAAGCA GAAGAGGAAG 660 661 TTCTCATCTT TCTTCAAGAG CCTGGTGATT GAGCTTGATA AAGAGCTCTA TGGACCGGAC 720 721 AACCACTTAG TAGAGTGGCA TAGAATGGCC ACCACTCAGG AGACGGATGG TTTCCAGGTT 780 781 AAAAGACCCG GCGATGTGAA TGTTAAATGC ACCCTGCTGC TCATGCTCGA TCATCAGCCC 840 841 CCTCAGTACA AACTGGATCC ACGGCTGGCT CGCCTGCTGG GTGTGCACAC GCAGACACGG 900 901 GCCAGCATCA TGCAAGCTCT CTGGCTCTAT ATCAAGAACA ACAAGCTGCA GGATGGTCAC 960 961 GAGAAGGAGT ACATTAACTG CAACCGCTAT TTCAGACAAA TCTTCGGCTG CCCTCGCATG 1020 1021 AGGTTCTCTG AGATTCCCAT GAAACTGGCG GGCCTGCTGC AGCATCCTGA CCCCATCATC 1080 1081 ATCAATCATG TCATTAGTGT GGACCCCACA GATCAGAAGA AGACCGCTTG CTATGACATT 1140 1141 GATGTGGAGG TGGACGACCC ACTGAAGGGC CAAATGAACA GTTTCTTGTC CTCTACAACC 1200 1201 AACCAGCAGG AAATTGCTGC TCTGGAGATG AAGATCCATG AGACGATTGA GTACATCAAC 1260 1261 CAGCTGAAGA CCGAGAGAGA CTTTATGCTG AGCTTCAGCA ATAATCCACA AGACTTCATC 1320 1321 CAGGACTGGC TTAAGTCTCA GAGCAGAGAT CTGAAGTTGA TGACAGATGT GACAGGAAAC 1380 1381 CCAGAGGAGG AGAGGAAGAC CGAGTTCTAC CAGGCTCCCT GGGTACCGGA GGCAGTGGGC 1440 1441 AGATATGTTT ACTCCAAGGT TCAACAGAGG AGACAAGAGT TGGAGCAGGT GCTGGGTATC 1500 1501 CGACTCACCT AA 1512 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | DUBm complex | |
Cellular Component | SAGA complex | |
Cellular Component | SWI/SNF complex | |
Molecular Function | Transcription coactivator activity | |
Molecular Function | Zinc ion binding | |
Biological Process | ATP-dependent chromatin remodeling | |
Biological Process | Histone deubiquitination | |
Biological Process | Positive regulation of transcription, DNA-templated |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asm-0341 | Astyanax mexicanus | 92.89 | 0.0 | 713 |
| LLPS-Orn-1880 | Oreochromis niloticus | 89.9 | 0.0 | 860 |
| LLPS-Fia-2345 | Ficedula albicollis | 88.16 | 0.0 | 684 |
| LLPS-Pes-3544 | Pelodiscus sinensis | 87.89 | 0.0 | 682 |
| LLPS-Pof-0646 | Poecilia formosa | 86.73 | 0.0 | 840 |
| LLPS-Orl-2402 | Oryzias latipes | 86.68 | 0.0 | 830 |
| LLPS-Xim-2183 | Xiphophorus maculatus | 86.53 | 0.0 | 836 |
| LLPS-Ten-2151 | Tetraodon nigroviridis | 86.13 | 0.0 | 826 |
| LLPS-Scf-3339 | Scleropages formosus | 84.45 | 0.0 | 744 |
| LLPS-Fud-1607 | Fukomys damarensis | 83.67 | 0.0 | 666 |
| LLPS-Aim-0465 | Ailuropoda melanoleuca | 83.42 | 0.0 | 664 |
| LLPS-Maf-4052 | Macaca fascicularis | 83.42 | 0.0 | 665 |
| LLPS-Rhb-2213 | Rhinopithecus bieti | 83.42 | 0.0 | 665 |
| LLPS-Urm-0021 | Ursus maritimus | 83.42 | 0.0 | 662 |
| LLPS-Loa-1741 | Loxodonta africana | 83.16 | 0.0 | 664 |
| LLPS-Mam-2472 | Macaca mulatta | 82.81 | 0.0 | 646 |
| LLPS-Cap-1687 | Cavia porcellus | 82.6 | 0.0 | 645 |
| LLPS-Cas-1689 | Carlito syrichta | 81.63 | 0.0 | 641 |
| LLPS-Gaa-1757 | Gasterosteus aculeatus | 81.58 | 0.0 | 777 |
| LLPS-Anp-1693 | Anas platyrhynchos | 79.91 | 0.0 | 686 |
| LLPS-Meg-2860 | Meleagris gallopavo | 79.56 | 0.0 | 685 |
| LLPS-Leo-0979 | Lepisosteus oculatus | 78.74 | 0.0 | 741 |
| LLPS-Dar-0678 | Danio rerio | 78.32 | 0.0 | 759 |
| LLPS-Pap-4109 | Pan paniscus | 78.16 | 0.0 | 625 |
| LLPS-Icp-1492 | Ictalurus punctatus | 77.43 | 0.0 | 611 |
| LLPS-Gaga-1471 | Gallus gallus | 76.38 | 0.0 | 603 |
| LLPS-Anc-2447 | Anolis carolinensis | 76.29 | 0.0 | 587 |
| LLPS-Sah-0327 | Sarcophilus harrisii | 75.77 | 0.0 | 583 |
| LLPS-Tag-1096 | Taeniopygia guttata | 75.77 | 0.0 | 582 |
| LLPS-Mup-2265 | Mustela putorius furo | 75.59 | 0.0 | 597 |
| LLPS-Myl-1508 | Myotis lucifugus | 75.59 | 0.0 | 593 |
| LLPS-Ova-1579 | Ovis aries | 75.59 | 0.0 | 597 |
| LLPS-Ran-2284 | Rattus norvegicus | 75.59 | 0.0 | 597 |
| LLPS-Bot-1147 | Bos taurus | 75.59 | 0.0 | 597 |
| LLPS-Caf-1118 | Canis familiaris | 75.59 | 0.0 | 597 |
| LLPS-Fec-0785 | Felis catus | 75.59 | 0.0 | 598 |
| LLPS-Mod-3806 | Monodelphis domestica | 75.59 | 0.0 | 600 |
| LLPS-Mal-2643 | Mandrillus leucophaeus | 75.52 | 0.0 | 581 |
| LLPS-Paa-0441 | Papio anubis | 75.52 | 0.0 | 581 |
| LLPS-Dio-2600 | Dipodomys ordii | 75.52 | 0.0 | 581 |
| LLPS-Tut-0087 | Tursiops truncatus | 75.52 | 0.0 | 582 |
| LLPS-Caj-0789 | Callithrix jacchus | 75.52 | 0.0 | 581 |
| LLPS-Gog-1766 | Gorilla gorilla | 75.52 | 0.0 | 580 |
| LLPS-Sus-3329 | Sus scrofa | 75.52 | 0.0 | 578 |
| LLPS-Cea-0120 | Cercocebus atys | 75.52 | 0.0 | 581 |
| LLPS-Aon-2754 | Aotus nancymaae | 75.52 | 0.0 | 581 |
| LLPS-Chs-0980 | Chlorocebus sabaeus | 75.52 | 0.0 | 582 |
| LLPS-Mum-0521 | Mus musculus | 75.52 | 0.0 | 581 |
| LLPS-Mea-0952 | Mesocricetus auratus | 75.52 | 0.0 | 581 |
| LLPS-Ict-4010 | Ictidomys tridecemlineatus | 75.52 | 0.0 | 583 |
| LLPS-Poa-0784 | Pongo abelii | 75.52 | 0.0 | 581 |
| LLPS-Orc-0678 | Oryctolagus cuniculus | 75.52 | 0.0 | 581 |
| LLPS-Otg-1094 | Otolemur garnettii | 75.52 | 0.0 | 582 |
| LLPS-Man-1106 | Macaca nemestrina | 75.52 | 0.0 | 581 |
| LLPS-Hos-1773 | Homo sapiens | 75.52 | 0.0 | 581 |
| LLPS-Pat-2391 | Pan troglodytes | 75.52 | 0.0 | 581 |
| LLPS-Xet-0427 | Xenopus tropicalis | 75.26 | 0.0 | 577 |
| LLPS-Nol-1472 | Nomascus leucogenys | 75.07 | 0.0 | 593 |
| LLPS-Eqc-0381 | Equus caballus | 75.0 | 0.0 | 556 |
| LLPS-Drm-1316 | Drosophila melanogaster | 68.91 | 0.0 | 526 |
| LLPS-Tar-2321 | Takifugu rubripes | 65.32 | 7e-176 | 513 |
| LLPS-Cii-0702 | Ciona intestinalis | 63.21 | 1e-169 | 493 |
| LLPS-Cis-0443 | Ciona savignyi | 62.79 | 2e-28 | 115 |
| LLPS-Lac-2351 | Latimeria chalumnae | 53.86 | 2e-152 | 451 |
| LLPS-Cae-0830 | Caenorhabditis elegans | 52.04 | 1e-132 | 399 |
| LLPS-Abg-0573 | Absidia glauca | 40.36 | 6e-81 | 266 |
| LLPS-Chc-0617 | Chondrus crispus | 40.24 | 2e-08 | 61.2 |
| LLPS-Prp-1057 | Prunus persica | 38.03 | 3e-74 | 251 |
| LLPS-Vir-1033 | Vigna radiata | 37.4 | 5e-75 | 252 |
| LLPS-Phv-1335 | Phaseolus vulgaris | 37.4 | 7e-75 | 251 |
| LLPS-Mua-0291 | Musa acuminata | 37.2 | 3e-72 | 244 |
| LLPS-Via-0661 | Vigna angularis | 36.99 | 2e-71 | 242 |
| LLPS-Glm-0685 | Glycine max | 36.8 | 4e-74 | 250 |
| LLPS-Amt-1918 | Amborella trichopoda | 36.77 | 5e-68 | 236 |
| LLPS-Brd-0098 | Brachypodium distachyon | 36.58 | 2e-69 | 237 |
| LLPS-Tra-2616 | Triticum aestivum | 36.41 | 9e-71 | 241 |
| LLPS-Tru-1229 | Triticum urartu | 36.41 | 2e-71 | 239 |
| LLPS-Viv-0358 | Vitis vinifera | 36.41 | 1e-71 | 240 |
| LLPS-Php-1210 | Physcomitrella patens | 36.24 | 2e-72 | 244 |
| LLPS-Nia-1042 | Nicotiana attenuata | 36.13 | 1e-73 | 249 |
| LLPS-Hea-1934 | Helianthus annuus | 35.88 | 3e-72 | 245 |
| LLPS-Sob-0723 | Sorghum bicolor | 35.88 | 3e-71 | 242 |
| LLPS-Orbr-1057 | Oryza brachyantha | 35.88 | 1e-66 | 234 |
| LLPS-Pot-2049 | Populus trichocarpa | 35.64 | 4e-70 | 239 |
| LLPS-Sei-0336 | Setaria italica | 35.36 | 8e-70 | 239 |
| LLPS-Orgl-0031 | Oryza glumaepatula | 35.36 | 1e-68 | 234 |
| LLPS-Orni-1040 | Oryza nivara | 35.36 | 4e-68 | 236 |
| LLPS-Ori-0139 | Oryza indica | 35.36 | 2e-69 | 233 |
| LLPS-Orb-0344 | Oryza barthii | 35.36 | 4e-69 | 233 |
| LLPS-Org-0044 | Oryza glaberrima | 35.36 | 3e-69 | 233 |
| LLPS-Orr-1129 | Oryza rufipogon | 35.36 | 3e-68 | 235 |
| LLPS-Orm-1811 | Oryza meridionalis | 35.36 | 6e-69 | 233 |
| LLPS-Sem-0417 | Selaginella moellendorffii | 35.28 | 1e-69 | 234 |
| LLPS-Sol-0204 | Solanum lycopersicum | 35.11 | 9e-70 | 238 |
| LLPS-Dac-0152 | Daucus carota | 35.09 | 2e-72 | 244 |
| LLPS-Zem-1094 | Zea mays | 34.56 | 6e-70 | 239 |
| LLPS-Met-1710 | Medicago truncatula | 34.3 | 6e-70 | 239 |
| LLPS-Thc-0416 | Theobroma cacao | 34.29 | 6e-67 | 231 |
| LLPS-Mae-1216 | Manihot esculenta | 34.29 | 2e-68 | 236 |
| LLPS-Ors-1301 | Oryza sativa | 34.04 | 5e-54 | 191 |
| LLPS-Sot-0067 | Solanum tuberosum | 34.03 | 6e-70 | 240 |
| LLPS-Gor-0968 | Gossypium raimondii | 33.96 | 1e-64 | 224 |
| LLPS-Scp-0318 | Schizosaccharomyces pombe | 33.6 | 1e-62 | 216 |
| LLPS-Coc-0213 | Corchorus capsularis | 33.51 | 9e-68 | 233 |
| LLPS-Scj-1007 | Schizosaccharomyces japonicus | 33.42 | 1e-66 | 227 |
| LLPS-Cus-0975 | Cucumis sativus | 33.25 | 9e-66 | 228 |
| LLPS-Scc-0815 | Schizosaccharomyces cryophilus | 33.08 | 2e-67 | 229 |
| LLPS-Brr-2163 | Brassica rapa | 33.06 | 5e-64 | 222 |
| LLPS-Crn-0382 | Cryptococcus neoformans | 32.78 | 4e-55 | 198 |
| LLPS-Brn-0239 | Brassica napus | 32.72 | 6e-66 | 227 |
| LLPS-Bro-0835 | Brassica oleracea | 32.72 | 8e-66 | 228 |
| LLPS-Arl-0534 | Arabidopsis lyrata | 32.19 | 2e-64 | 224 |
| LLPS-Art-0776 | Arabidopsis thaliana | 32.19 | 3e-64 | 224 |
| LLPS-Tum-0422 | Tuber melanosporum | 31.25 | 3e-57 | 204 |
| LLPS-Yal-1211 | Yarrowia lipolytica | 29.97 | 2e-42 | 160 |
| LLPS-Usm-0417 | Ustilago maydis | 28.51 | 1e-50 | 190 |
| LLPS-Mel-0616 | Melampsora laricipopulina | 28.42 | 2e-37 | 148 |
| LLPS-Spr-0480 | Sporisorium reilianum | 27.71 | 3e-50 | 189 |
| LLPS-Chr-0953 | Chlamydomonas reinhardtii | 27.54 | 2e-22 | 105 |
| LLPS-Cogr-0718 | Colletotrichum graminicola | 27.27 | 4e-33 | 135 |
| LLPS-Gas-0289 | Galdieria sulphuraria | 27.12 | 3e-34 | 139 |
| LLPS-Nec-0291 | Neurospora crassa | 26.32 | 5e-27 | 118 |
| LLPS-Ved-0871 | Verticillium dahliae | 25.98 | 6e-31 | 129 |
| LLPS-Gag-1215 | Gaeumannomyces graminis | 25.3 | 6e-23 | 106 |
| LLPS-Map-0312 | Magnaporthe poae | 25.0 | 5e-22 | 102 |
| LLPS-Scs-1069 | Sclerotinia sclerotiorum | 25.0 | 4e-29 | 123 |
| LLPS-Zyt-0772 | Zymoseptoria tritici | 24.57 | 4e-22 | 103 |
| LLPS-Mao-1607 | Magnaporthe oryzae | 23.54 | 7e-25 | 112 |
| LLPS-Beb-0057 | Beauveria bassiana | 23.43 | 7e-23 | 105 |