LLPS-Art-2793
RPA2A
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Replication protein A 32 kDa subunit A |
| Gene Name: | RPA2A, ROR1, RPA32A, At2g24490, T28I24.22 |
| Ensembl Gene: | AT2G24490 |
| Ensembl Protein: | AT2G24490.2 |
| Organism: | Arabidopsis thaliana |
| Taxa ID: | 3702 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Required fo cell division in meristems. Involved in the maintenance of transcriptional epigenetic gene silencing (TGS) at specific loci (including some transposons) by regulating histone H3 acetylation, 'Lys-4' and 'Lys-9' methylation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AT2G24490.2 | AT2G24490.2 |
| Ensembl | AT2G24490.1 | AT2G24490.1 |
| UniProt | Q9ZQ19, RFA2A_ARATH | |
| GeneBank | AC006403, AK117537, AY088525, CP002685, BT005433, DQ284987 | ABB86293.1, AAM66059.1, AAD18120.2, AEC07583.1, AEC07582.1, AAO63853.1, BAC42198.1 |
| RefSeq | NM_001124904.1, NM_128010.3 | NP_001118376.1, NP_565571.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MFSSSQFEPN SGFSGGGFMS SQPSQAYESS SSTAKNRDFQ GLVPVTVKQI TECFQSSGEK 60 61 SGLVINGISL TNVSLVGLVC DKDESKVTEV RFTLDDGTGR IDCKRWVSET FDAREMESVR 120 121 DGTYVRLSGH LKTFQGKTQL LVFSVRPIMD FNEVTFHYIE CIHFYSQNSE SQRQQVGDVT 180 181 QSVNTTFQGG SNTNQATLLN PVVSSQNNDG NGRKNLDDMI LDYLKQPACT ARQQGIHIDE 240 241 IAQQLKIPKN KLEGVVQSLE GDGLIYSTID EYHFKHVEL 279 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTTCTCCA GCAGCCAATT CGAGCCTAAT TCCGGCTTCT CCGGCGGCGG ATTCATGTCT 60 61 TCTCAACCTT CTCAAGCCTA CGAATCCTCC TCCTCCACCG CTAAGAATCG TGATTTTCAA 120 121 GGTCTTGTTC CAGTGACGGT GAAGCAAATC ACCGAATGTT TCCAATCCAG TGGTGAAAAA 180 181 TCTGGTCTCG TCATCAATGG AATCTCACTA ACAAACGTTT CACTTGTTGG ATTAGTGTGT 240 241 GACAAAGATG AATCTAAAGT CACAGAAGTT AGATTCACTC TTGATGATGG AACAGGACGA 300 301 ATTGACTGTA AAAGATGGGT GAGTGAAACT TTCGACGCTA GAGAAATGGA GTCTGTGCGA 360 361 GATGGAACTT ATGTGCGCCT CAGTGGTCAT TTGAAGACTT TTCAGGGCAA AACTCAGCTT 420 421 CTTGTTTTCT CTGTGAGGCC TATTATGGAC TTCAATGAGG TTACTTTTCA CTACATTGAG 480 481 TGTATACACT TCTACTCCCA GAACTCTGAA TCACAGAGAC AACAAGTCGG TGATGTCACT 540 541 CAGTCAGTTA ACACCACATT TCAAGGTGGA TCAAACACAA ACCAGGCAAC ACTATTGAAC 600 601 CCTGTGGTTT CTTCTCAAAA CAATGATGGC AATGGGCGCA AGAACTTGGA TGATATGATT 660 661 CTAGACTATC TAAAGCAACC TGCTTGCACT GCAAGACAAC AGGGGATACA TATCGATGAA 720 721 ATTGCTCAGC AGTTGAAGAT CCCAAAAAAC AAGCTAGAGG GCGTTGTTCA ATCACTGGAA 780 781 GGAGATGGTC TAATATACTC GACAATCGAT GAGTATCACT TCAAGCACGT GGAGCTTTGA 840 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Chromatin | |
Cellular Component | Chromosome, telomeric region | |
Cellular Component | Condensed nuclear chromosome | |
Cellular Component | DNA replication factor A complex | |
Cellular Component | Nucleus | |
Cellular Component | Site of double-strand break | |
Molecular Function | Damaged DNA binding | |
Molecular Function | Double-stranded DNA binding | |
Molecular Function | G-rich strand telomeric DNA binding | |
Molecular Function | Sequence-specific DNA binding | |
Molecular Function | Single-stranded DNA binding | |
Biological Process | Base-excision repair | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | DNA topological change | |
Biological Process | DNA unwinding involved in DNA replication | |
Biological Process | Double-strand break repair via homologous recombination | |
Biological Process | Gene silencing | |
Biological Process | Heteroduplex formation | |
Biological Process | Mismatch repair | |
Biological Process | Mitotic recombination | |
Biological Process | Nucleotide-excision repair | |
Biological Process | Positive regulation of helicase activity | |
Biological Process | Reciprocal meiotic recombination | |
Biological Process | Regulation of DNA damage checkpoint | |
Biological Process | Telomere maintenance via recombination | |
Biological Process | Telomere maintenance via telomerase |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Expression | ||||
| ArrayExpress | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Arl-2742 | Arabidopsis lyrata | 96.42 | 0.0 | 509 |
| LLPS-Bro-2139 | Brassica oleracea | 83.21 | 8e-148 | 422 |
| LLPS-Brn-3319 | Brassica napus | 82.86 | 3e-148 | 424 |
| LLPS-Mae-2592 | Manihot esculenta | 53.55 | 6e-87 | 268 |
| LLPS-Viv-0198 | Vitis vinifera | 52.5 | 4e-81 | 253 |
| LLPS-Prp-0293 | Prunus persica | 52.5 | 1e-82 | 257 |
| LLPS-Cus-0123 | Cucumis sativus | 52.38 | 1e-49 | 169 |
| LLPS-Phv-1287 | Phaseolus vulgaris | 49.11 | 7e-75 | 236 |
| LLPS-Sot-1526 | Solanum tuberosum | 47.39 | 2e-75 | 238 |
| LLPS-Glm-0566 | Glycine max | 47.16 | 5e-71 | 227 |
| LLPS-Nia-0276 | Nicotiana attenuata | 46.91 | 3e-73 | 232 |
| LLPS-Met-1655 | Medicago truncatula | 45.9 | 6e-69 | 221 |
| LLPS-Via-2178 | Vigna angularis | 45.78 | 1e-59 | 197 |
| LLPS-Sol-0031 | Solanum lycopersicum | 45.04 | 2e-71 | 228 |
| LLPS-Dac-0009 | Daucus carota | 44.57 | 3e-71 | 228 |
| LLPS-Hea-1449 | Helianthus annuus | 44.49 | 4e-70 | 224 |
| LLPS-Mua-1745 | Musa acuminata | 43.67 | 2e-63 | 207 |
| LLPS-Vir-1962 | Vigna radiata | 41.73 | 5e-54 | 182 |
| LLPS-Pot-0584 | Populus trichocarpa | 40.57 | 4e-52 | 178 |
| LLPS-Sob-1306 | Sorghum bicolor | 39.26 | 7e-53 | 180 |
| LLPS-Amt-1866 | Amborella trichopoda | 38.71 | 1e-50 | 174 |
| LLPS-Sei-2356 | Setaria italica | 38.06 | 1e-51 | 177 |
| LLPS-Tra-2717 | Triticum aestivum | 37.8 | 2e-47 | 166 |
| LLPS-Brr-2543 | Brassica rapa | 37.75 | 3e-50 | 173 |
| LLPS-Org-1452 | Oryza glaberrima | 37.7 | 4e-51 | 175 |
| LLPS-Sem-0961 | Selaginella moellendorffii | 37.5 | 1e-49 | 171 |
| LLPS-Php-0201 | Physcomitrella patens | 37.24 | 3e-46 | 162 |
| LLPS-Brd-2345 | Brachypodium distachyon | 36.1 | 1e-42 | 154 |
| LLPS-Orb-1991 | Oryza barthii | 35.92 | 1e-47 | 167 |
| LLPS-Orni-1224 | Oryza nivara | 35.92 | 9e-48 | 167 |
| LLPS-Orgl-2074 | Oryza glumaepatula | 35.92 | 4e-47 | 166 |
| LLPS-Ors-2255 | Oryza sativa | 35.92 | 9e-48 | 167 |
| LLPS-Orr-1083 | Oryza rufipogon | 35.92 | 9e-48 | 167 |
| LLPS-Orm-1479 | Oryza meridionalis | 35.92 | 1e-47 | 167 |
| LLPS-Lep-1859 | Leersia perrieri | 35.63 | 1e-49 | 172 |
| LLPS-Orp-0630 | Oryza punctata | 35.51 | 5e-48 | 167 |
| LLPS-Ori-1422 | Oryza indica | 35.34 | 1e-45 | 162 |
| LLPS-Thc-1986 | Theobroma cacao | 35.29 | 4e-46 | 162 |
| LLPS-Chr-1681 | Chlamydomonas reinhardtii | 35.19 | 3e-14 | 74.7 |
| LLPS-Beb-0756 | Beauveria bassiana | 35.11 | 2e-15 | 77.8 |
| LLPS-Zem-1183 | Zea mays | 35.1 | 8e-44 | 157 |
| LLPS-Orbr-0917 | Oryza brachyantha | 35.08 | 6e-48 | 167 |
| LLPS-Coc-2268 | Corchorus capsularis | 34.8 | 1e-41 | 150 |
| LLPS-Tru-0811 | Triticum urartu | 34.72 | 2e-42 | 152 |
| LLPS-Hov-0035 | Hordeum vulgare | 33.1 | 4e-18 | 84.7 |
| LLPS-Pug-0406 | Puccinia graminis | 33.08 | 1e-13 | 71.2 |
| LLPS-Gor-1848 | Gossypium raimondii | 32.27 | 4e-41 | 149 |
| LLPS-Fuv-0790 | Fusarium verticillioides | 31.82 | 3e-14 | 74.7 |
| LLPS-Fuo-1227 | Fusarium oxysporum | 31.82 | 3e-14 | 74.7 |
| LLPS-Leo-1231 | Lepisosteus oculatus | 31.67 | 3e-22 | 97.8 |
| LLPS-Scp-0945 | Schizosaccharomyces pombe | 30.77 | 4e-23 | 100 |
| LLPS-Coo-1237 | Colletotrichum orbiculare | 30.65 | 1e-11 | 67.4 |
| LLPS-Osl-0512 | Ostreococcus lucimarinus | 30.33 | 5e-21 | 94.0 |
| LLPS-Ora-3222 | Ornithorhynchus anatinus | 29.92 | 6e-12 | 67.4 |
| LLPS-Asm-0364 | Astyanax mexicanus | 29.24 | 1e-18 | 87.0 |
| LLPS-Tar-2157 | Takifugu rubripes | 29.15 | 1e-20 | 93.2 |
| LLPS-Dar-1184 | Danio rerio | 29.1 | 2e-21 | 95.5 |
| LLPS-Pof-3562 | Poecilia formosa | 29.08 | 4e-22 | 97.4 |
| LLPS-Asc-1120 | Aspergillus clavatus | 28.8 | 3e-14 | 74.7 |
| LLPS-Tum-1037 | Tuber melanosporum | 28.74 | 2e-18 | 87.8 |
| LLPS-Sah-3548 | Sarcophilus harrisii | 28.69 | 2e-17 | 83.6 |
| LLPS-Scs-0698 | Sclerotinia sclerotiorum | 28.69 | 2e-18 | 86.7 |
| LLPS-Ten-2209 | Tetraodon nigroviridis | 28.57 | 2e-18 | 86.7 |
| LLPS-Gag-1534 | Gaeumannomyces graminis | 28.51 | 6e-15 | 76.3 |
| LLPS-Lem-1335 | Leptosphaeria maculans | 28.51 | 1e-16 | 81.3 |
| LLPS-Caj-4661 | Callithrix jacchus | 28.46 | 3e-20 | 92.4 |
| LLPS-Blg-1580 | Blumeria graminis | 28.46 | 6e-22 | 97.1 |
| LLPS-Kop-0381 | Komagataella pastoris | 28.39 | 3e-19 | 88.6 |
| LLPS-Pyt-1341 | Pyrenophora teres | 28.35 | 1e-16 | 81.3 |
| LLPS-Icp-4033 | Ictalurus punctatus | 28.29 | 5e-18 | 85.5 |
| LLPS-Ast-1192 | Aspergillus terreus | 28.05 | 2e-15 | 78.2 |
| LLPS-Cas-3002 | Carlito syrichta | 28.05 | 3e-20 | 91.3 |
| LLPS-Scc-0245 | Schizosaccharomyces cryophilus | 28.0 | 1e-20 | 93.2 |
| LLPS-Sus-0997 | Sus scrofa | 28.0 | 7e-18 | 84.7 |
| LLPS-Xim-3441 | Xiphophorus maculatus | 28.0 | 2e-20 | 92.8 |
| LLPS-Scj-0369 | Schizosaccharomyces japonicus | 27.82 | 6e-18 | 85.1 |
| LLPS-Scf-4083 | Scleropages formosus | 27.8 | 1e-19 | 90.1 |
| LLPS-Otg-2787 | Otolemur garnettii | 27.76 | 8e-20 | 90.5 |
| LLPS-Mod-1503 | Monodelphis domestica | 27.73 | 2e-18 | 86.7 |
| LLPS-Abg-0452 | Absidia glauca | 27.69 | 7e-19 | 87.8 |
| LLPS-Fus-1439 | Fusarium solani | 27.69 | 9e-19 | 87.4 |
| LLPS-Meg-2829 | Meleagris gallopavo | 27.64 | 3e-16 | 79.7 |
| LLPS-Chs-3583 | Chlorocebus sabaeus | 27.49 | 1e-20 | 92.8 |
| LLPS-Maf-3077 | Macaca fascicularis | 27.49 | 1e-20 | 93.2 |
| LLPS-Cea-4870 | Cercocebus atys | 27.49 | 9e-21 | 93.6 |
| LLPS-Gog-1608 | Gorilla gorilla | 27.49 | 9e-21 | 93.6 |
| LLPS-Mal-0782 | Mandrillus leucophaeus | 27.49 | 4e-20 | 92.4 |
| LLPS-Paa-0594 | Papio anubis | 27.49 | 4e-20 | 92.4 |
| LLPS-Hos-4845 | Homo sapiens | 27.49 | 5e-20 | 92.0 |
| LLPS-Pap-3499 | Pan paniscus | 27.49 | 9e-21 | 93.6 |
| LLPS-Man-1161 | Macaca nemestrina | 27.49 | 8e-21 | 93.6 |
| LLPS-Poa-2474 | Pongo abelii | 27.49 | 3e-20 | 92.4 |
| LLPS-Mam-0294 | Macaca mulatta | 27.49 | 1e-20 | 93.2 |
| LLPS-Nol-4153 | Nomascus leucogenys | 27.49 | 9e-21 | 93.6 |
| LLPS-Myl-0482 | Myotis lucifugus | 27.35 | 3e-20 | 91.7 |
| LLPS-Cap-4431 | Cavia porcellus | 27.35 | 8e-21 | 93.6 |
| LLPS-Asg-0848 | Ashbya gossypii | 27.31 | 3e-15 | 77.4 |
| LLPS-Lac-3190 | Latimeria chalumnae | 27.31 | 1e-14 | 75.1 |
| LLPS-Sac-0225 | Saccharomyces cerevisiae | 27.27 | 7e-15 | 76.3 |
| LLPS-Scm-3222 | Scophthalmus maximus | 27.27 | 5e-20 | 91.3 |
| LLPS-Gaga-1977 | Gallus gallus | 27.27 | 4e-16 | 79.7 |
| LLPS-Orn-3007 | Oreochromis niloticus | 27.13 | 2e-20 | 92.8 |
| LLPS-Bot-2089 | Bos taurus | 27.09 | 9e-20 | 90.5 |
| LLPS-Ova-3984 | Ovis aries | 27.09 | 8e-20 | 90.5 |
| LLPS-Loa-3263 | Loxodonta africana | 27.09 | 1e-20 | 92.8 |
| LLPS-Aim-2570 | Ailuropoda melanoleuca | 26.94 | 7e-20 | 90.1 |
| LLPS-Mea-4205 | Mesocricetus auratus | 26.89 | 8e-19 | 87.8 |
| LLPS-Miv-0963 | Microbotryum violaceum | 26.89 | 1e-13 | 72.8 |
| LLPS-Tut-1861 | Tursiops truncatus | 26.88 | 1e-18 | 88.2 |
| LLPS-Gaa-1357 | Gasterosteus aculeatus | 26.83 | 3e-19 | 89.0 |
| LLPS-Xet-3563 | Xenopus tropicalis | 26.79 | 2e-15 | 77.8 |
| LLPS-Mup-3346 | Mustela putorius furo | 26.75 | 2e-18 | 86.7 |
| LLPS-Put-0710 | Puccinia triticina | 26.75 | 6e-16 | 79.3 |
| LLPS-Aon-4028 | Aotus nancymaae | 26.69 | 8e-17 | 81.6 |
| LLPS-Fec-3061 | Felis catus | 26.69 | 2e-19 | 89.4 |
| LLPS-Caf-4214 | Canis familiaris | 26.69 | 4e-19 | 89.0 |
| LLPS-Orl-3630 | Oryzias latipes | 26.61 | 3e-19 | 89.0 |
| LLPS-Cogr-1359 | Colletotrichum graminicola | 26.61 | 1e-17 | 84.3 |
| LLPS-Nef-0677 | Neosartorya fischeri | 26.56 | 2e-13 | 73.6 |
| LLPS-Asfu-0892 | Aspergillus fumigatus | 26.56 | 3e-14 | 74.7 |
| LLPS-Tag-1590 | Taeniopygia guttata | 26.56 | 9e-15 | 75.5 |
| LLPS-Fud-4280 | Fukomys damarensis | 26.53 | 8e-20 | 90.5 |
| LLPS-Ict-0829 | Ictidomys tridecemlineatus | 26.53 | 3e-20 | 92.0 |
| LLPS-Pat-3673 | Pan troglodytes | 26.25 | 1e-14 | 75.5 |
| LLPS-Ved-0031 | Verticillium dahliae | 26.25 | 8e-14 | 73.6 |
| LLPS-Mum-4054 | Mus musculus | 26.12 | 5e-20 | 91.3 |
| LLPS-Dio-3835 | Dipodomys ordii | 26.12 | 3e-20 | 91.7 |
| LLPS-Orc-3205 | Oryctolagus cuniculus | 26.12 | 5e-20 | 90.9 |
| LLPS-Trv-0255 | Trichoderma virens | 26.12 | 3e-19 | 89.0 |
| LLPS-Trr-0311 | Trichoderma reesei | 26.07 | 5e-20 | 91.3 |
| LLPS-Anc-3561 | Anolis carolinensis | 26.05 | 5e-17 | 82.4 |
| LLPS-Mao-0714 | Magnaporthe oryzae | 26.03 | 7e-18 | 84.7 |
| LLPS-Map-0234 | Magnaporthe poae | 25.93 | 9e-14 | 73.2 |
| LLPS-Rhb-2936 | Rhinopithecus bieti | 25.9 | 3e-18 | 85.9 |
| LLPS-Pes-2702 | Pelodiscus sinensis | 25.82 | 6e-13 | 69.3 |
| LLPS-Usm-0952 | Ustilago maydis | 25.81 | 7e-21 | 94.0 |
| LLPS-Ran-2983 | Rattus norvegicus | 25.71 | 2e-19 | 89.4 |
| LLPS-Aso-1319 | Aspergillus oryzae | 25.7 | 3e-11 | 66.2 |
| LLPS-Asf-0675 | Aspergillus flavus | 25.7 | 3e-11 | 66.2 |
| LLPS-Fia-3778 | Ficedula albicollis | 25.63 | 6e-16 | 78.6 |
| LLPS-Eqc-3838 | Equus caballus | 25.63 | 2e-19 | 89.4 |
| LLPS-Crn-0387 | Cryptococcus neoformans | 25.51 | 3e-14 | 74.3 |
| LLPS-Cog-0569 | Colletotrichum gloeosporioides | 25.43 | 6e-12 | 67.8 |
| LLPS-Nec-0760 | Neurospora crassa | 25.4 | 1e-14 | 75.5 |
| LLPS-Phn-1320 | Phaeosphaeria nodorum | 25.4 | 2e-15 | 77.8 |
| LLPS-Asni-1420 | Aspergillus niger | 25.0 | 1e-10 | 64.7 |
| LLPS-Spr-1422 | Sporisorium reilianum | 25.0 | 2e-15 | 77.8 |
| LLPS-Zyt-1301 | Zymoseptoria tritici | 24.61 | 8e-16 | 79.0 |
| LLPS-Drm-2381 | Drosophila melanogaster | 24.22 | 2e-15 | 77.8 |
| LLPS-Asn-0504 | Aspergillus nidulans | 23.55 | 1e-12 | 70.1 |
| LLPS-Mel-1526 | Melampsora laricipopulina | 22.69 | 1e-09 | 61.2 |