LLPS-Art-1596
IMPA4

▼ OVERVIEW

Status: Reviewed
Protein Name: Importin subunit alpha-4
Gene Name: IMPA4, At1g09270, T12M4.2
Ensembl Gene: AT1G09270
Ensembl Protein: AT1G09270.2
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."
Arabidopsis thaliana cells26980300

▼ FUNCTION

Binds to conventional NLS motifs and mediates nuclear protein import across the nuclear envelope. Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium and is essential for Agrobacterium-mediated root transformation.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSLRPSTRAE  LRKKIYKTGV  DADEARRRRE  DNLVEIRKNK  REDSLLKKRR  EGMMLQQQLP  60
61    LGAGLDGPQT  AAAVEKRLEG  IPMMVQGVYS  DDPQAQLEAT  TQFRKLLSIE  RSPPIDEVIK  120
121   AGVIPRFVEF  LGRHDHPQLQ  FEAAWALTNV  ASGTSDHTRV  VIEQGAVPIF  VKLLTSASDD  180
181   VREQAVWALG  NVAGDSPNCR  NLVLNYGALE  PLLAQLNENS  KLSMLRNATW  TLSNFCRGKP  240
241   PTPFEQVKPA  LPILRQLIYL  NDEEVLTDAC  WALSYLSDGP  NDKIQAVIEA  GVCPRLVELL  300
301   GHQSPTVLIP  ALRTVGNIVT  GDDSQTQFII  ESGVLPHLYN  LLTQNHKKSI  KKEACWTISN  360
361   ITAGNKLQIE  AVVGAGIILP  LVHLLQNAEF  DIKKEAAWAI  SNATSGGSHE  QIQYLVTQGC  420
421   IKPLCDLLIC  PDPRIVTVCL  EGLENILKVG  EADKEMGLNS  GVNLYAQIIE  ESDGLDKVEN  480
481   LQSHDNNEIY  EKAVKILERY  WAEEEEEQIL  QDGGNDNSQQ  AFNFGNNPAA  PVGGFKFA  538
Nucleotide CDS Sequence (FASTA)
1     ATGATGGTAC  AAGGTGTTTA  TTCTGATGAT  CCTCAAGCTC  AGCTAGAAGC  GACTACCCAA  60
61    TTTAGAAAGT  TGTTATCTAT  AGAGCGTAGT  CCTCCAATTG  ATGAAGTGAT  CAAAGCTGGG  120
121   GTTATCCCTC  GATTTGTGGA  GTTTCTTGGA  AGGCATGACC  ATCCTCAATT  GCAGTTTGAG  180
181   GCTGCATGGG  CTTTGACCAA  TGTTGCGTCA  GGAACATCAG  ATCATACTCG  GGTTGTAATC  240
241   GAACAGGGGG  CGGTTCCTAT  CTTCGTTAAG  CTTCTTACAT  CTGCTAGTGA  TGACGTTCGA  300
301   GAGCAGGCGG  TGTGGGCCTT  GGGAAATGTT  GCTGGGGACT  CTCCAAACTG  CAGGAATCTT  360
361   GTTCTCAACT  ATGGGGCCCT  TGAGCCATTG  CTGGCTCAGT  TAAATGAAAA  TTCTAAGTTG  420
421   TCCATGCTAA  GAAATGCTAC  ATGGACCTTG  TCCAACTTTT  GTCGTGGTAA  ACCACCAACA  480
481   CCATTTGAAC  AGGTGAAGCC  TGCGTTGCCA  ATTCTTCGGC  AGCTTATCTA  TCTGAATGAT  540
541   GAAGAGGTTC  TCACTGATGC  TTGCTGGGCT  CTCTCCTACC  TTTCAGATGG  CCCCAATGAT  600
601   AAGATTCAGG  CTGTGATTGA  GGCAGGTGTC  TGTCCACGAC  TTGTGGAGCT  TTTGGGTCAT  660
661   CAATCACCTA  CGGTTCTCAT  TCCTGCTCTT  CGAACTGTTG  GGAACATCGT  AACTGGTGAT  720
721   GACTCTCAGA  CACAGTTTAT  AATTGAGAGT  GGCGTACTAC  CACACCTTTA  TAATTTGCTG  780
781   ACGCAAAATC  ACAAGAAAAG  TATAAAAAAA  GAAGCTTGTT  GGACTATCTC  GAATATTACT  840
841   GCTGGGAATA  AACTTCAGAT  AGAGGCTGTG  GTTGGCGCTG  GAATAATCCT  CCCTCTTGTG  900
901   CACTTGCTCC  AAAACGCGGA  GTTCGATATA  AAGAAGGAAG  CTGCTTGGGC  TATTTCCAAT  960
961   GCCACATCAG  GAGGGTCACA  TGAGCAGATT  CAATATTTGG  TGACCCAAGG  CTGCATCAAA  1020
1021  CCACTTTGTG  ATCTTCTAAT  CTGCCCTGAT  CCAAGGATCG  TGACAGTGTG  CCTCGAGGGT  1080
1081  CTTGAAAACA  TTCTCAAGGT  TGGTGAGGCT  GACAAGGAAA  TGGGATTAAA  CAGTGGGGTG  1140
1141  AATCTCTATG  CTCAAATAAT  AGAAGAATCT  GATGGGTTGG  ACAAAGTCGA  AAACCTTCAA  1200
1201  TCCCATGATA  ACAACGAGAT  ATATGAGAAG  GCCGTTAAGA  TATTGGAGAG  ATATTGGGCT  1260
1261  GAAGAAGAGG  AAGAACAGAT  TCTGCAGGAC  GGCGGGAATG  ACAATTCACA  ACAGGCTTTC  1320
1321  AATTTTGGGA  ACAATCCCGC  TGCTCCCGTT  GGTGGATTCA  AATTTGCCTG  A  1371

▼ KEYWORD

ID
Family
Alternative splicing
Complete proteome
Nucleus
Protein transport
Reference proteome
Repeat
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Host cell
Cellular Component
Nuclear pore
Cellular Component
Nucleoplasm
Molecular Function
Nuclear import signal receptor activity
Molecular Function
Nuclear localization sequence binding
Molecular Function
Protein transporter activity
Biological Process
Host response to induction by symbiont of tumor, nodule or growth in host
Biological Process
NLS-bearing protein import into nucleus
Biological Process
Symbiont intracellular protein transport in host

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
Interaction
HINTMenthaPINA
Physicochemical
Compute pI/MwAAindex
Function
PIRSF
Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-2466Arabidopsis lyrata96.850.01032
LLPS-Brn-2320Brassica napus92.960.0 993
LLPS-Bro-0021Brassica oleracea92.960.0 993
LLPS-Brr-0552Brassica rapa92.440.0 983
LLPS-Gor-0277Gossypium raimondii85.580.0 909
LLPS-Coc-1938Corchorus capsularis85.210.0 900
LLPS-Mae-1182Manihot esculenta85.160.0 895
LLPS-Thc-0417Theobroma cacao84.740.0 899
LLPS-Prp-2002Prunus persica83.490.0 892
LLPS-Pot-1576Populus trichocarpa82.990.0 887
LLPS-Viv-0579Vitis vinifera82.590.0 885
LLPS-Nia-0168Nicotiana attenuata82.040.0 877
LLPS-Sot-0788Solanum tuberosum81.850.0 881
LLPS-Sol-0061Solanum lycopersicum81.670.0 878
LLPS-Cus-1937Cucumis sativus81.00.0 866
LLPS-Glm-1206Glycine max75.880.0 806
LLPS-Php-1721Physcomitrella patens75.190.0 785
LLPS-Mua-1560Musa acuminata75.140.0 798
LLPS-Via-2184Vigna angularis75.050.0 784
LLPS-Hea-2097Helianthus annuus74.810.0 762
LLPS-Vir-0910Vigna radiata74.720.0 796
LLPS-Amt-1823Amborella trichopoda74.720.0 793
LLPS-Met-1230Medicago truncatula74.680.0 783
LLPS-Phv-2356Phaseolus vulgaris74.310.0 778
LLPS-Zem-2589Zea mays74.050.0 767
LLPS-Tra-1247Triticum aestivum73.930.0 771
LLPS-Tru-1091Triticum urartu73.930.0 771
LLPS-Brd-2420Brachypodium distachyon73.370.0 766
LLPS-Orr-0629Oryza rufipogon72.880.0 755
LLPS-Orp-1406Oryza punctata72.80.0 759
LLPS-Lep-1207Leersia perrieri72.680.0 767
LLPS-Org-0778Oryza glaberrima72.380.0 766
LLPS-Orm-0572Oryza meridionalis72.380.0 766
LLPS-Ors-1730Oryza sativa72.380.0 765
LLPS-Orgl-1316Oryza glumaepatula72.30.0 755
LLPS-Orb-0437Oryza barthii72.30.0 755
LLPS-Ori-0779Oryza indica72.210.0 739
LLPS-Hov-1230Hordeum vulgare71.720.0 747
LLPS-Sob-0362Sorghum bicolor71.670.0 766
LLPS-Orbr-0801Oryza brachyantha71.240.0 743
LLPS-Sem-1193Selaginella moellendorffii71.190.0 757
LLPS-Sei-0627Setaria italica70.610.0 754
LLPS-Orni-2330Oryza nivara70.360.0 745
LLPS-Dac-2249Daucus carota66.490.0 749
LLPS-Chr-1314Chlamydomonas reinhardtii63.870.0 650
LLPS-Asni-0590Aspergillus niger63.042e-178 518
LLPS-Gas-0099Galdieria sulphuraria62.290.0 621
LLPS-Osl-0501Ostreococcus lucimarinus62.010.0 623
LLPS-Phn-1333Phaeosphaeria nodorum61.860.0 535
LLPS-Mel-0289Melampsora laricipopulina60.710.0 587
LLPS-Pug-0310Puccinia graminis60.710.0 575
LLPS-Cog-0318Colletotrichum gloeosporioides60.420.0 577
LLPS-Cogr-0059Colletotrichum graminicola60.230.0 577
LLPS-Fuv-1029Fusarium verticillioides60.150.0 585
LLPS-Fuo-0668Fusarium oxysporum60.150.0 585
LLPS-Coo-1424Colletotrichum orbiculare59.880.0 575
LLPS-Ved-1391Verticillium dahliae59.850.0 555
LLPS-Dos-0786Dothistroma septosporum59.840.0 548
LLPS-Fus-1103Fusarium solani59.770.0 578
LLPS-Beb-0176Beauveria bassiana59.770.0 580
LLPS-Asn-0636Aspergillus nidulans59.730.0 576
LLPS-Lem-0538Leptosphaeria maculans59.560.0 562
LLPS-Trr-0178Trichoderma reesei59.530.0 577
LLPS-Chc-0767Chondrus crispus59.480.0 603
LLPS-Blg-0677Blumeria graminis59.450.0 554
LLPS-Trv-1149Trichoderma virens59.340.0 577
LLPS-Pytr-0295Pyrenophora triticirepentis59.340.0 560
LLPS-Mao-1285Magnaporthe oryzae59.270.0 561
LLPS-Aon-2404Aotus nancymaae59.210.0 526
LLPS-Pyt-0403Pyrenophora teres59.140.0 564
LLPS-Asc-0429Aspergillus clavatus59.120.0 572
LLPS-Nef-0967Neosartorya fischeri59.120.0 573
LLPS-Nec-0625Neurospora crassa59.110.0 555
LLPS-Asf-0705Aspergillus flavus59.040.0 574
LLPS-Aso-0120Aspergillus oryzae59.040.0 574
LLPS-Asfu-0373Aspergillus fumigatus58.930.0 572
LLPS-Ast-0980Aspergillus terreus58.850.0 567
LLPS-Zyt-0523Zymoseptoria tritici58.810.0 542
LLPS-Gag-1206Gaeumannomyces graminis58.750.0 565
LLPS-Fia-0569Ficedula albicollis58.552e-176 513
LLPS-Map-0249Magnaporthe poae58.370.0 564
LLPS-Crn-0453Cryptococcus neoformans58.150.0 559
LLPS-Gaga-0927Gallus gallus57.24e-178 528
LLPS-Anc-2101Anolis carolinensis57.27e-180 525
LLPS-Tag-0575Taeniopygia guttata57.20.0 530
LLPS-Pes-2513Pelodiscus sinensis57.21e-180 529
LLPS-Anp-2248Anas platyrhynchos57.20.0 532
LLPS-Miv-0546Microbotryum violaceum57.170.0 564
LLPS-Sah-1405Sarcophilus harrisii57.084e-180 525
LLPS-Put-0181Puccinia triticina56.980.0 528
LLPS-Spr-0381Sporisorium reilianum56.890.0 553
LLPS-Tum-0208Tuber melanosporum56.810.0 545
LLPS-Usm-0637Ustilago maydis56.80.0 551
LLPS-Mea-3152Mesocricetus auratus56.585e-174 510
LLPS-Gog-1859Gorilla gorilla56.465e-178 520
LLPS-Pat-1464Pan troglodytes56.463e-178 521
LLPS-Pap-1025Pan paniscus56.463e-178 521
LLPS-Cas-1312Carlito syrichta56.49e-180 525
LLPS-Aim-2129Ailuropoda melanoleuca56.372e-174 511
LLPS-Yal-0529Yarrowia lipolytica56.284e-177 518
LLPS-Ran-1491Rattus norvegicus56.162e-175 513
LLPS-Ova-0586Ovis aries56.165e-174 510
LLPS-Sus-1515Sus scrofa56.162e-173 508
LLPS-Eqc-3148Equus caballus56.166e-179 522
LLPS-Fec-2528Felis catus56.163e-174 511
LLPS-Urm-1804Ursus maritimus55.991e-173 509
LLPS-Mal-3637Mandrillus leucophaeus55.85e-179 523
LLPS-Paa-0703Papio anubis55.86e-179 523
LLPS-Maf-4713Macaca fascicularis55.86e-179 523
LLPS-Bot-4382Bos taurus55.730.0 540
LLPS-Fud-4196Fukomys damarensis55.730.0 539
LLPS-Cap-1657Cavia porcellus55.730.0 538
LLPS-Mod-1939Monodelphis domestica55.719e-180 525
LLPS-Tut-1114Tursiops truncatus55.620.0 533
LLPS-Dio-0622Dipodomys ordii55.620.0 534
LLPS-Asm-1163Astyanax mexicanus55.621e-179 525
LLPS-Orl-0830Oryzias latipes55.63e-180 526
LLPS-Abg-1931Absidia glauca55.580.0 537
LLPS-Xim-2775Xiphophorus maculatus55.562e-178 521
LLPS-Ict-3964Ictidomys tridecemlineatus55.530.0 537
LLPS-Orc-0219Oryctolagus cuniculus55.530.0 536
LLPS-Xet-0948Xenopus tropicalis55.490.0 528
LLPS-Mam-0582Macaca mulatta55.420.0 533
LLPS-Gaa-3659Gasterosteus aculeatus55.40.0 532
LLPS-Scm-3715Scophthalmus maximus55.360.0 533
LLPS-Myl-2774Myotis lucifugus55.340.0 533
LLPS-Mum-4601Mus musculus55.340.0 537
LLPS-Chs-3058Chlorocebus sabaeus55.340.0 533
LLPS-Hos-0720Homo sapiens55.340.0 533
LLPS-Scf-3347Scleropages formosus55.310.0 536
LLPS-Caf-0779Canis familiaris55.290.0 530
LLPS-Pof-1605Poecilia formosa55.239e-177 517
LLPS-Orn-2860Oreochromis niloticus55.170.0 533
LLPS-Scc-1122Schizosaccharomyces cryophilus55.161e-177 519
LLPS-Caj-1763Callithrix jacchus55.140.0 530
LLPS-Leo-0664Lepisosteus oculatus55.10.0 530
LLPS-Lac-2517Latimeria chalumnae54.991e-177 519
LLPS-Tar-2551Takifugu rubripes54.970.0 528
LLPS-Ten-1239Tetraodon nigroviridis54.970.0 530
LLPS-Icp-3541Ictalurus punctatus54.95e-177 517
LLPS-Dar-4244Danio rerio54.90.0 531
LLPS-Cea-1352Cercocebus atys54.622e-174 512
LLPS-Man-2885Macaca nemestrina54.627e-175 512
LLPS-Meg-1227Meleagris gallopavo54.60.0 532
LLPS-Loa-1637Loxodonta africana54.470.0 527
LLPS-Otg-4390Otolemur garnettii54.221e-173 509
LLPS-Scj-0572Schizosaccharomyces japonicus53.831e-174 511
LLPS-Scp-0605Schizosaccharomyces pombe53.443e-177 518