DrLLPS - Data resource of LLPS

LLPS-Art-1526
ALY4

▼ OVERVIEW


Status:	Reviewed
Protein Name:	THO complex subunit 4D; ALYREF homolog 4; AtALY4
Gene Name:	ALY4, DIP2, THO4D, At5g37720, K12B20.19
Ensembl Gene:	AT5G37720
Ensembl Protein:	AT5G37720.2
Organism:	Arabidopsis thaliana
Taxa ID:	3702
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Nucleolus	"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."	Arabidopsis thaliana cells	26980300
Nucleolus	"...Here, we describe the first proteomic analysis of plant nucleoli, in which we have identified 217 proteins."	Protoplasts	15496452

▼ FUNCTION

Export adapter involved in nuclear export of spliced and unspliced mRNA (PubMed:11432957). Plays a role in disease resistance. Mediates multiple defense responses triggered by NEP1, including stomatal closure, hypersensitive cell death (HCD) and defense-related gene expression (PubMed:24723400).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	AT5G37720.2	AT5G37720.2
Ensembl	AT5G37720.1	AT5G37720.1
UniProt		Q6NQ72, THO4D_ARATH, Q9FHP9, Q9LF76
GeneBank	BT010588, CP002688, AB018107, AK227931, AJ278493	AED94222.1, AAQ89610.1, BAB08317.1, CAC01084.1, BAE99901.1
RefSeq	NM_123131.4	NP_198588.2

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSGALNMTLD EIVKRGKTAR SGGRGISRGR GRGRGGGGRG AGPARRGPLA VNARPSSFTI 60 61 NKPVRRVRSL PWQSGLFEDG LRAAGASGVE VGTRLHVTNL DQGVTNEDIR ELFSEIGEVE 120 121 RYAIHYDKNG RPSGTAEVVY PRRSDAFQAL KKYNNVLLDG RPMRLEILGG NNSSEAPLSG 180 181 RVNVNVTGLN GRLKRTVVIQ QGGGGRGRVR GGRGGRGPAP TVSRRLPIHN QQGGGMRGGR 240 241 GGFRARGRGN GGRGRGGGRG NGKKPVEKSA ADLDKDLESY HADAMNTS 288
Nucleotide CDS Sequence (FASTA)
1 ATGTCTGGAG CATTGAATAT GACTCTTGAT GAGATTGTTA AGAGGGGTAA AACTGCAAGG 60 61 TCTGGGGGAA GAGGGATTTC TCGTGGGCGT GGTCGTGGAC GTGGTGGTGG TGGAAGAGGA 120 121 GCTGGACCTG CTAGAAGAGG TCCTCTTGCT GTGAATGCTC GTCCATCATC TTTCACCATT 180 181 AACAAGCCTG TCCGTAGGGT CAGGAGCTTG CCATGGCAAA GCGGTTTGTT TGAAGATGGC 240 241 CTAAGAGCTG CCGGGGCATC AGGAGTTGAA GTTGGAACCA GGCTCCATGT TACAAATCTG 300 301 GACCAGGGTG TGACAAATGA AGATATAAGG GAACTCTTCT CTGAGATTGG GGAGGTAGAG 360 361 CGTTATGCGA TTCATTATGA CAAAAATGGG CGTCCAAGTG GCACAGCTGA AGTGGTGTAT 420 421 CCAAGAAGAA GTGATGCATT TCAAGCTCTG AAGAAATATA ACAATGTGCT ATTGGATGGA 480 481 AGGCCAATGA GACTTGAGAT TTTGGGTGGC AACAATTCTT CCGAGGCTCC TTTATCTGGT 540 541 CGTGTGAATG TGAATGTCAC TGGACTCAAT GGAAGGCTGA AGAGGACGGT TGTTATCCAA 600 601 GTTAGAGGTG GGAGAGGAGG AAGAGGTCCA GCTCCTACTG TCAGTCGCCG CCTTCCAATT 660 661 CATAACCAGC AGGGAGGAGG GATGAGAGGA GGAAGAGGCG GGTTTCGTGC TAGAGGGCGT 720 721 GGTAATGGTG GCCGTGGTCG TGGTGGTGGA AGAGGAAATG GAAAGAAGCC AGTGGAGAAG 780 781 TCAGCTGCTG ATCTTGACAA AGATCTTGAG AGCTATCACG CTGATGCCAT GAACACCTCT 840 841 TAA 843

▼ KEYWORD

ID	Family
KW-0007	Acetylation
KW-0025	Alternative splicing
KW-0181	Complete proteome
KW-0509	mRNA transport
KW-0539	Nucleus
KW-0611	Plant defense
KW-1185	Reference proteome
KW-0694	RNA-binding
KW-0813	Transport

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005730	Cellular Component	Nucleolus
GO:0005654	Cellular Component	Nucleoplasm
GO:0003729	Molecular Function	MRNA binding
GO:0006952	Biological Process	Defense response
GO:0051028	Biological Process	MRNA transport

▼ KEGG

ath:AT5G37720

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
PROSITE	Gene3D

PTM
EPSD	PLMD	dbPTM

Interaction
HINT	Mentha	PINA	iRefIndex

Physicochemical
Compute pI/Mw	AAindex

Localization
COMPARTMENTS	NLSdb

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Arl-2658	Arabidopsis lyrata	90.66	7e-129	375
LLPS-Brr-2580	Brassica rapa	81.82	5e-102	306
LLPS-Brn-2965	Brassica napus	76.92	3e-110	328
LLPS-Bro-2876	Brassica oleracea	72.73	1e-109	327
LLPS-Glm-0274	Glycine max	70.86	6e-69	222
LLPS-Gor-0749	Gossypium raimondii	70.86	6e-68	218
LLPS-Mae-0326	Manihot esculenta	70.2	4e-70	224
LLPS-Pot-2350	Populus trichocarpa	68.67	2e-67	218
LLPS-Hea-2289	Helianthus annuus	64.24	3e-58	194
LLPS-Cus-1057	Cucumis sativus	64.05	4e-64	209
LLPS-Orb-1403	Oryza barthii	62.35	1e-31	124
LLPS-Orgl-1612	Oryza glumaepatula	62.35	2e-31	124
LLPS-Orp-1970	Oryza punctata	62.35	1e-32	124
LLPS-Dac-1665	Daucus carota	62.24	1e-48	171
LLPS-Ori-2000	Oryza indica	61.8	1e-32	125
LLPS-Nia-1606	Nicotiana attenuata	61.54	3e-27	111
LLPS-Zem-0519	Zea mays	61.18	1e-30	121
LLPS-Lep-0504	Leersia perrieri	61.11	2e-32	126
LLPS-Sob-1327	Sorghum bicolor	61.11	1e-32	126
LLPS-Orni-1935	Oryza nivara	59.78	5e-33	125
LLPS-Hov-0533	Hordeum vulgare	59.57	2e-32	126
LLPS-Sei-0258	Setaria italica	59.09	3e-25	107
LLPS-Ors-1988	Oryza sativa	58.7	9e-32	123
LLPS-Orr-2292	Oryza rufipogon	58.7	3e-32	123
LLPS-Viv-1872	Vitis vinifera	58.62	2e-63	207
LLPS-Brd-1874	Brachypodium distachyon	57.28	8e-35	132
LLPS-Sol-2065	Solanum lycopersicum	57.06	2e-49	171
LLPS-Tru-0342	Triticum urartu	56.38	3e-32	125
LLPS-Orbr-2348	Oryza brachyantha	56.32	6e-30	119
LLPS-Via-2094	Vigna angularis	56.22	1e-71	229
LLPS-Sot-1317	Solanum tuberosum	55.79	3e-31	121
LLPS-Vir-1839	Vigna radiata	55.36	9e-66	216
LLPS-Prp-0571	Prunus persica	55.19	5e-72	230
LLPS-Mua-0524	Musa acuminata	54.94	2e-51	177
LLPS-Coc-1269	Corchorus capsularis	54.31	3e-33	127
LLPS-Tra-0121	Triticum aestivum	53.85	6e-32	124
LLPS-Thc-1831	Theobroma cacao	53.79	7e-80	249
LLPS-Org-0281	Oryza glaberrima	52.98	1e-46	164
LLPS-Sem-1225	Selaginella moellendorffii	51.92	3e-34	126
LLPS-Fia-2324	Ficedula albicollis	51.22	9e-24	99.8
LLPS-Leo-1358	Lepisosteus oculatus	50.67	5e-20	90.9
LLPS-Gaga-1318	Gallus gallus	50.0	3e-27	112
LLPS-Php-1347	Physcomitrella patens	49.19	5e-36	136
LLPS-Pes-1656	Pelodiscus sinensis	49.15	6e-15	74.3
LLPS-Anp-2309	Anas platyrhynchos	49.15	6e-15	74.3
LLPS-Tag-3542	Taeniopygia guttata	49.15	5e-15	74.3
LLPS-Phv-1708	Phaseolus vulgaris	48.25	1e-30	120
LLPS-Lac-3917	Latimeria chalumnae	47.27	2e-21	95.5
LLPS-Mum-2307	Mus musculus	47.22	6e-26	107
LLPS-Xet-0573	Xenopus tropicalis	46.3	4e-26	108
LLPS-Drm-2123	Drosophila melanogaster	45.83	1e-22	99.0
LLPS-Asm-0936	Astyanax mexicanus	45.69	2e-24	104
LLPS-Amt-1520	Amborella trichopoda	45.61	5e-53	180
LLPS-Myl-2275	Myotis lucifugus	45.37	2e-25	106
LLPS-Scf-1006	Scleropages formosus	45.37	4e-25	105
LLPS-Ten-2953	Tetraodon nigroviridis	44.86	4e-22	97.1
LLPS-Tut-2309	Tursiops truncatus	44.33	2e-20	92.0
LLPS-Cas-3872	Carlito syrichta	44.33	7e-22	96.7
LLPS-Ict-4579	Ictidomys tridecemlineatus	44.21	6e-19	86.7
LLPS-Orm-0319	Oryza meridionalis	44.03	4e-24	102
LLPS-Mal-4670	Mandrillus leucophaeus	43.81	3e-22	96.7
LLPS-Dio-1078	Dipodomys ordii	43.81	6e-22	96.7
LLPS-Sah-2885	Sarcophilus harrisii	43.75	9e-21	93.2
LLPS-Fud-2661	Fukomys damarensis	43.69	4e-22	96.7
LLPS-Mea-3869	Mesocricetus auratus	43.69	8e-22	96.3
LLPS-Aon-4793	Aotus nancymaae	43.69	8e-22	96.3
LLPS-Ova-1641	Ovis aries	43.69	2e-21	95.5
LLPS-Rhb-2185	Rhinopithecus bieti	43.69	1e-21	95.9
LLPS-Pap-1457	Pan paniscus	43.69	6e-22	96.7
LLPS-Gog-2696	Gorilla gorilla	43.52	5e-23	100
LLPS-Caj-3822	Callithrix jacchus	43.52	4e-23	100
LLPS-Chs-0428	Chlorocebus sabaeus	43.52	4e-23	100
LLPS-Maf-0946	Macaca fascicularis	43.52	2e-23	100
LLPS-Sus-0377	Sus scrofa	43.52	6e-23	99.8
LLPS-Cea-0931	Cercocebus atys	43.52	7e-23	100
LLPS-Aim-0901	Ailuropoda melanoleuca	43.52	2e-22	98.2
LLPS-Paa-2069	Papio anubis	43.52	5e-23	100
LLPS-Bot-1908	Bos taurus	43.52	6e-23	99.8
LLPS-Fec-2360	Felis catus	43.52	5e-23	100
LLPS-Mod-1320	Monodelphis domestica	43.52	1e-22	99.8
LLPS-Hos-2292	Homo sapiens	43.52	5e-23	100
LLPS-Pat-1922	Pan troglodytes	43.52	7e-23	100
LLPS-Loa-1260	Loxodonta africana	43.52	2e-23	99.4
LLPS-Man-2323	Macaca nemestrina	43.52	9e-23	99.8
LLPS-Nol-3833	Nomascus leucogenys	43.52	7e-23	100
LLPS-Cap-0174	Cavia porcellus	43.52	7e-23	99.8
LLPS-Eqc-0460	Equus caballus	43.52	5e-23	100
LLPS-Caf-1204	Canis familiaris	43.52	5e-23	99.8
LLPS-Poa-3299	Pongo abelii	43.52	5e-23	100
LLPS-Mam-0204	Macaca mulatta	43.52	6e-23	100
LLPS-Ere-1043	Erinaceus europaeus	43.43	2e-19	87.8
LLPS-Otg-2317	Otolemur garnettii	43.4	3e-22	97.1
LLPS-Cii-0182	Ciona intestinalis	43.33	6e-22	97.1
LLPS-Urm-1481	Ursus maritimus	42.99	1e-20	92.8
LLPS-Gaa-3059	Gasterosteus aculeatus	42.98	5e-22	97.1
LLPS-Gas-0116	Galdieria sulphuraria	42.86	1e-19	89.4
LLPS-Lem-0489	Leptosphaeria maculans	42.5	1e-10	65.9
LLPS-Xim-2069	Xiphophorus maculatus	42.2	2e-21	94.7
LLPS-Tar-1156	Takifugu rubripes	42.19	2e-22	98.2
LLPS-Ran-0467	Rattus norvegicus	41.82	2e-19	88.2
LLPS-Scm-2828	Scophthalmus maximus	41.73	1e-22	99.0
LLPS-Pug-1099	Puccinia graminis	41.49	8e-12	67.0
LLPS-Orl-2440	Oryzias latipes	41.41	4e-22	97.4
LLPS-Orn-1166	Oreochromis niloticus	41.41	1e-22	99.0
LLPS-Icp-2497	Ictalurus punctatus	41.13	3e-22	97.8
LLPS-Cis-1130	Ciona savignyi	41.03	6e-20	90.9
LLPS-Trr-0502	Trichoderma reesei	40.86	2e-12	70.5
LLPS-Orc-0198	Oryctolagus cuniculus	40.43	1e-10	65.9
LLPS-Pof-4032	Poecilia formosa	39.39	2e-22	98.6
LLPS-Phn-1161	Phaeosphaeria nodorum	39.33	2e-11	67.4
LLPS-Chc-0346	Chondrus crispus	39.13	7e-11	65.9
LLPS-Chr-0234	Chlamydomonas reinhardtii	39.0	3e-13	72.8
LLPS-Dar-0677	Danio rerio	38.3	2e-21	95.9
LLPS-Met-0383	Medicago truncatula	37.61	1e-33	129
LLPS-Mel-0304	Melampsora laricipopulina	36.36	5e-14	73.2
LLPS-Tum-1520	Tuber melanosporum	35.35	4e-11	65.5
LLPS-Trv-1598	Trichoderma virens	34.48	1e-10	65.5
LLPS-Abg-0229	Absidia glauca	33.06	4e-13	71.2

LLPS-Art-1526ALY4

Protein Sequence

Nucleotide Sequence

LLPS-Art-1526
ALY4