LLPS-Art-0853
HACL

▼ OVERVIEW

Status: Reviewed
Protein Name: 2-hydroxyacyl-CoA lyase; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Oxalyl-CoA decarboxylase
Gene Name: HACL, HPCL, OCD, At5g17380, T10B6.40
Ensembl Gene: AT5G17380
Ensembl Protein: AT5G17380.1
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."
Arabidopsis thaliana cells26980300

▼ FUNCTION

Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MADKSETTPP  SIDGNVLVAK  SLSHLGVTHM  FGVVGIPVTS  LASRAMALGI  RFIAFHNEQS  60
61    AGYAASAYGY  LTGKPGILLT  VSGPGCVHGL  AGLSNAWVNT  WPMVMISGSC  DQRDVGRGDF  120
121   QELDQIEAVK  AFSKLSEKAK  DVREIPDCVS  RVLDRAVSGR  PGGCYLDIPT  DVLRQKISES  180
181   EADKLVDEVE  RSRKEEPIRG  SLRSEIESAV  SLLRKAERPL  IVFGKGAAYS  RAEDELKKLV  240
241   EITGIPFLPT  PMGKGLLPDT  HEFSATAARS  LAIGKCDVAL  VVGARLNWLL  HFGESPKWDK  300
301   DVKFILVDVS  EEEIELRKPH  LGIVGDAKTV  IGLLNREIKD  DPFCLGKSNS  WVESISKKAK  360
361   ENGEKMEIQL  AKDVVPFNFL  TPMRIIRDAI  LAVEGPSPVV  VSEGANTMDV  GRSVLVQKEP  420
421   RTRLDAGTWG  TMGVGLGYCI  AAAVASPDRL  VVAVEGDSGF  GFSAMEVETL  VRYNLAVVII  480
481   VFNNGGVYGG  DRRGPEEISG  PHKEDPAPTS  FVPNAGYHKL  IEAFGGKGYI  VETPDELKSA  540
541   LAESFAARKP  AVVNVIIDPF  AGAESGRLQH  KN  572
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGATA  AATCAGAAAC  CACTCCACCG  TCAATTGATG  GCAACGTTCT  CGTGGCCAAG  60
61    TCACTCTCTC  ATCTCGGCGT  AACCCACATG  TTCGGCGTCG  TTGGAATCCC  CGTCACGTCT  120
121   CTAGCTAGCC  GAGCTATGGC  TTTAGGTATA  CGTTTCATCG  CCTTCCACAA  CGAACAATCC  180
181   GCTGGTTACG  CCGCTTCAGC  TTACGGTTAC  CTCACGGGTA  AACCGGGTAT  CCTTTTAACG  240
241   GTTTCGGGTC  CGGGTTGTGT  TCATGGGCTC  GCGGGTCTTT  CCAACGCTTG  GGTTAATACA  300
301   TGGCCGATGG  TGATGATCTC  TGGTTCTTGT  GATCAGAGAG  ATGTTGGTCG  TGGAGATTTC  360
361   CAGGAGCTTG  ATCAGATCGA  AGCGGTTAAA  GCTTTCTCGA  AATTATCAGA  GAAAGCGAAA  420
421   GATGTTCGTG  AAATCCCTGA  TTGTGTTTCT  AGGGTTTTGG  ATCGAGCTGT  TTCGGGTCGA  480
481   CCCGGTGGGT  GTTATCTGGA  TATTCCGACT  GATGTGTTGC  GTCAGAAGAT  ATCGGAATCG  540
541   GAAGCTGATA  AATTGGTGGA  TGAGGTTGAG  AGATCACGGA  AGGAAGAACC  GATTCGTGGA  600
601   TCTCTGAGAT  CGGAGATTGA  ATCGGCGGTT  TCGTTGCTGA  GGAAAGCTGA  GAGGCCGTTG  660
661   ATTGTGTTTG  GTAAAGGAGC  TGCGTATTCG  AGAGCAGAAG  ATGAGCTGAA  GAAGCTTGTT  720
721   GAAATTACTG  GAATACCCTT  TTTACCAACT  CCGATGGGTA  AAGGTTTGTT  ACCGGACACA  780
781   CACGAGTTCT  CGGCGACTGC  GGCGAGGTCT  CTTGCTATTG  GGAAATGTGA  TGTCGCGTTG  840
841   GTGGTTGGAG  CTAGGCTTAA  CTGGCTTCTT  CATTTCGGAG  AGTCGCCTAA  ATGGGATAAA  900
901   GATGTAAAAT  TTATATTGGT  GGATGTCTCT  GAGGAAGAGA  TTGAGCTAAG  GAAACCTCAT  960
961   TTGGGGATTG  TTGGAGATGC  TAAAACTGTG  ATTGGATTGT  TGAATAGAGA  GATCAAAGAC  1020
1021  GATCCTTTTT  GTTTAGGGAA  GTCTAATTCA  TGGGTGGAAT  CGATTTCGAA  GAAGGCGAAA  1080
1081  GAGAATGGTG  AGAAGATGGA  GATACAGCTT  GCTAAAGATG  TGGTTCCTTT  CAATTTCTTG  1140
1141  ACTCCTATGA  GGATAATCAG  AGACGCTATT  TTGGCTGTGG  AAGGACCGAG  TCCTGTTGTG  1200
1201  GTATCGGAAG  GAGCTAATAC  AATGGATGTA  GGAAGATCTG  TTTTGGTTCA  GAAAGAGCCA  1260
1261  AGGACAAGGC  TTGATGCAGG  AACTTGGGGA  ACTATGGGTG  TTGGTTTAGG  TTATTGTATT  1320
1321  GCTGCTGCTG  TTGCTTCTCC  TGATCGGCTT  GTTGTCGCTG  TTGAAGGAGA  CTCTGGTTTT  1380
1381  GGCTTCAGCG  CCATGGAAGT  CGAGACATTG  GTTCGATACA  ATCTTGCTGT  GGTGATTATA  1440
1441  GTCTTCAACA  ATGGTGGTGT  CTACGGCGGT  GATCGAAGGG  GACCTGAAGA  AATCTCCGGT  1500
1501  CCTCATAAAG  AAGATCCAGC  ACCAACATCA  TTTGTTCCTA  ATGCAGGCTA  CCACAAGCTC  1560
1561  ATTGAAGCCT  TTGGAGGCAA  AGGTTATATT  GTGGAAACAC  CCGATGAGCT  TAAATCCGCT  1620
1621  CTCGCTGAGT  CGTTCGCCGC  AAGAAAACCC  GCGGTGGTAA  ATGTTATTAT  TGATCCTTTT  1680
1681  GCTGGTGCTG  AGAGTGGGAG  ATTACAGCAC  AAGAACTAA  1719

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Decarboxylase
Lyase
Magnesium
Metal-binding
Reference proteome
Thiamine pyrophosphate

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Peroxisome
Molecular Function
Carbon-carbon lyase activity
Molecular Function
Carboxy-lyase activity
Molecular Function
Magnesium ion binding
Molecular Function
Thiamine pyrophosphate binding
Biological Process
Fatty acid alpha-oxidation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-2569Arabidopsis lyrata96.850.01102
LLPS-Brn-3231Brassica napus91.450.01045
LLPS-Brr-0930Brassica rapa91.290.01041
LLPS-Bro-1680Brassica oleracea90.910.01040
LLPS-Gor-2500Gossypium raimondii83.420.0 923
LLPS-Coc-1551Corchorus capsularis82.560.0 898
LLPS-Phv-1420Phaseolus vulgaris81.850.0 917
LLPS-Glm-0904Glycine max81.380.0 912
LLPS-Via-1188Vigna angularis81.320.0 906
LLPS-Thc-1945Theobroma cacao80.960.0 900
LLPS-Nia-2210Nicotiana attenuata79.790.0 911
LLPS-Pot-2266Populus trichocarpa79.510.0 888
LLPS-Mae-1039Manihot esculenta79.20.0 907
LLPS-Prp-1797Prunus persica78.930.0 919
LLPS-Sol-0725Solanum lycopersicum78.920.0 907
LLPS-Met-2586Medicago truncatula78.80.0 874
LLPS-Dac-0528Daucus carota78.440.0 730
LLPS-Cus-1828Cucumis sativus78.250.0 879
LLPS-Sot-0150Solanum tuberosum78.220.0 886
LLPS-Hea-1622Helianthus annuus77.890.0 903
LLPS-Viv-1697Vitis vinifera77.390.0 905
LLPS-Tru-1379Triticum urartu76.920.0 543
LLPS-Vir-1551Vigna radiata76.50.0 890
LLPS-Orm-0828Oryza meridionalis75.40.0 840
LLPS-Org-0043Oryza glaberrima75.040.0 838
LLPS-Orr-1412Oryza rufipogon75.040.0 834
LLPS-Sei-2284Setaria italica75.00.0 723
LLPS-Sob-2090Sorghum bicolor74.960.0 838
LLPS-Orni-1595Oryza nivara74.870.0 835
LLPS-Ori-1818Oryza indica74.870.0 835
LLPS-Orp-0455Oryza punctata74.870.0 833
LLPS-Orgl-2238Oryza glumaepatula74.690.0 834
LLPS-Lep-0929Leersia perrieri74.60.0 835
LLPS-Orbr-2315Oryza brachyantha74.580.0 723
LLPS-Zem-0673Zea mays73.850.0 829
LLPS-Hov-1288Hordeum vulgare73.10.0 817
LLPS-Tra-0565Triticum aestivum72.40.0 832
LLPS-Ors-1836Oryza sativa72.190.0 649
LLPS-Brd-1289Brachypodium distachyon71.430.0 807
LLPS-Orb-1323Oryza barthii70.970.0 793
LLPS-Php-0305Physcomitrella patens67.640.0 787
LLPS-Mua-2273Musa acuminata67.130.0 712
LLPS-Amt-0176Amborella trichopoda64.840.0 763
LLPS-Sem-1884Selaginella moellendorffii63.990.0 724
LLPS-Ict-3882Ictidomys tridecemlineatus50.58e-1994.0
LLPS-Gas-0520Galdieria sulphuraria48.151e-170 521
LLPS-Leo-2029Lepisosteus oculatus44.933e-82 266
LLPS-Pof-2691Poecilia formosa42.769e-135 412
LLPS-Yal-1553Yarrowia lipolytica42.482e-132 405
LLPS-Scc-1418Schizosaccharomyces cryophilus41.83e-127 392
LLPS-Asni-0783Aspergillus niger41.171e-129 399
LLPS-Asf-1176Aspergillus flavus40.994e-129 398
LLPS-Lac-3565Latimeria chalumnae40.779e-129 395
LLPS-Abg-1282Absidia glauca40.583e-63 217
LLPS-Asn-0626Aspergillus nidulans40.432e-131 404
LLPS-Aso-1509Aspergillus oryzae40.316e-123 382
LLPS-Blg-0044Blumeria graminis40.315e-134 410
LLPS-Ora-2753Ornithorhynchus anatinus40.167e-2194.4
LLPS-Zyt-1148Zymoseptoria tritici40.033e-121 377
LLPS-Asfu-1558Aspergillus fumigatus39.834e-125 389
LLPS-Tum-1484Tuber melanosporum39.762e-115 362
LLPS-Nef-0182Neosartorya fischeri39.732e-125 389
LLPS-Asc-0597Aspergillus clavatus39.534e-128 395
LLPS-Ast-1530Aspergillus terreus39.529e-125 387
LLPS-Mea-1927Mesocricetus auratus39.491e-50 182
LLPS-Scp-0869Schizosaccharomyces pombe39.363e-114 358
LLPS-Scj-1248Schizosaccharomyces japonicus39.311e-109 346
LLPS-Dos-0860Dothistroma septosporum39.248e-123 382
LLPS-Otg-3475Otolemur garnettii38.891e-128 395
LLPS-Sac-1639Saccharomyces cerevisiae38.249e-104 331
LLPS-Asg-1158Ashbya gossypii37.661e-98 317
LLPS-Osl-0617Ostreococcus lucimarinus28.737e-34 139
LLPS-Spr-0712Sporisorium reilianum27.275e-34 141
LLPS-Mel-1230Melampsora laricipopulina27.131e-31 134
LLPS-Trv-0270Trichoderma virens26.882e-37 150
LLPS-Chc-0693Chondrus crispus26.751e-33 139
LLPS-Cym-0060Cyanidioschyzon merolae26.693e-40 158
LLPS-Map-0593Magnaporthe poae26.522e-36 148
LLPS-Beb-0120Beauveria bassiana26.477e-33 137
LLPS-Put-0112Puccinia triticina26.431e-28 124
LLPS-Fus-0513Fusarium solani26.411e-36 148
LLPS-Pug-0711Puccinia graminis26.45e-30 129
LLPS-Cogr-0210Colletotrichum graminicola26.41e-33 140
LLPS-Coo-0889Colletotrichum orbiculare26.393e-35 144
LLPS-Usm-1217Ustilago maydis26.382e-36 148
LLPS-Miv-0294Microbotryum violaceum26.374e-31 132
LLPS-Nec-0120Neurospora crassa26.332e-36 147
LLPS-Ran-3752Rattus norvegicus26.318e-40 157
LLPS-Kop-0101Komagataella pastoris26.011e-29 128
LLPS-Gag-0030Gaeumannomyces graminis25.996e-34 140
LLPS-Urm-1547Ursus maritimus25.953e-43 168
LLPS-Anc-2796Anolis carolinensis25.91e-42 166
LLPS-Ved-1214Verticillium dahliae25.896e-35 144
LLPS-Pytr-1156Pyrenophora triticirepentis25.875e-36 147
LLPS-Cog-0940Colletotrichum gloeosporioides25.753e-28 123
LLPS-Mao-0465Magnaporthe oryzae25.719e-34 140
LLPS-Chr-0999Chlamydomonas reinhardtii25.76e-33 137
LLPS-Trr-0729Trichoderma reesei25.657e-35 143
LLPS-Phn-1021Phaeosphaeria nodorum25.653e-32 135
LLPS-Cae-1360Caenorhabditis elegans25.631e-31 133
LLPS-Mup-1873Mustela putorius furo25.62e-41 162
LLPS-Aim-2020Ailuropoda melanoleuca25.514e-41 161
LLPS-Dar-3270Danio rerio25.446e-39 154
LLPS-Mum-3955Mus musculus25.432e-38 153
LLPS-Caf-1669Canis familiaris25.436e-42 164
LLPS-Fuv-1565Fusarium verticillioides25.389e-35 143
LLPS-Pyt-0190Pyrenophora teres25.351e-34 142
LLPS-Gog-2422Gorilla gorilla25.39e-41 160
LLPS-Chs-2811Chlorocebus sabaeus25.33e-41 161
LLPS-Mal-1599Mandrillus leucophaeus25.33e-41 162
LLPS-Myl-4494Myotis lucifugus25.33e-40 158
LLPS-Pap-4662Pan paniscus25.37e-41 160
LLPS-Pat-2611Pan troglodytes25.37e-41 160
LLPS-Hos-3202Homo sapiens25.37e-41 160
LLPS-Xim-3758Xiphophorus maculatus25.292e-37 150
LLPS-Cis-1687Ciona savignyi25.261e-42 166
LLPS-Cas-2594Carlito syrichta25.264e-41 161
LLPS-Fuo-0524Fusarium oxysporum25.211e-34 142
LLPS-Aon-2359Aotus nancymaae25.136e-41 160
LLPS-Maf-4582Macaca fascicularis25.132e-41 162
LLPS-Man-3069Macaca nemestrina25.132e-41 162
LLPS-Loa-4014Loxodonta africana25.134e-39 155
LLPS-Mam-4323Macaca mulatta25.136e-42 164
LLPS-Fec-4383Felis catus25.093e-41 162
LLPS-Orn-4079Oreochromis niloticus25.081e-37 151
LLPS-Sus-1689Sus scrofa24.872e-40 159
LLPS-Dio-2110Dipodomys ordii24.871e-36 147
LLPS-Poa-3900Pongo abelii24.831e-39 157
LLPS-Caj-3926Callithrix jacchus24.782e-38 153
LLPS-Xet-0913Xenopus tropicalis24.761e-34 141
LLPS-Gaga-1663Gallus gallus24.712e-33 140
LLPS-Sah-3008Sarcophilus harrisii24.621e-33 139
LLPS-Bot-1933Bos taurus24.571e-40 159
LLPS-Cap-3517Cavia porcellus24.573e-36 147
LLPS-Scm-3482Scophthalmus maximus24.562e-38 153
LLPS-Crn-0225Cryptococcus neoformans24.462e-29 127
LLPS-Gaa-3363Gasterosteus aculeatus24.395e-38 152
LLPS-Ova-2860Ovis aries24.233e-40 159
LLPS-Rhb-2423Rhinopithecus bieti24.222e-36 148
LLPS-Mod-3743Monodelphis domestica24.195e-32 134
LLPS-Fud-1240Fukomys damarensis24.052e-36 147
LLPS-Ten-2268Tetraodon nigroviridis23.992e-37 150
LLPS-Icp-2586Ictalurus punctatus23.984e-37 149
LLPS-Pes-1636Pelodiscus sinensis23.83e-35 144
LLPS-Tar-3932Takifugu rubripes23.746e-37 149
LLPS-Scf-3668Scleropages formosus23.685e-34 140
LLPS-Orl-0481Oryzias latipes23.674e-34 140
LLPS-Nol-3738Nomascus leucogenys23.662e-26 117
LLPS-Cea-4654Cercocebus atys23.631e-30 130
LLPS-Paa-2099Papio anubis23.639e-31 130
LLPS-Lem-1241Leptosphaeria maculans23.457e-30 127
LLPS-Eqc-4672Equus caballus23.342e-32 135
LLPS-Scs-1117Sclerotinia sclerotiorum23.311e-1274.7